Powder microscopic, physicochemical and chromatographic approach for the quality control of anti-hypertensive drug Rattha Piththathirku Kudinir Chooranam
DOI:
https://doi.org/10.14719/pst.2021.8.3.1137Keywords:
Caranai, Cukku, Hypertension, Purpura, Zaleya decandra, Zingiber officinaleAbstract
The present work aims to study powder microscopy, physicochemical and high-performance thin-layer chromatography photo documentation and fingerprint profiles of a Siddha drug, Rattha Piththathirku Kudinir Chooranam (RPK). The raw drugs were collected, authenticated and the RPK was prepared. Then the drug was investigated for powder microscopic characters, physicochemical parameters, Thin Layer Chromatographic photo documentation (TLC), High-Performance Thin-Layer Chromatographic (HPTLC) fingerprint profiles of successive n-hexane, successive chloroform, successive ethanol and hydro alcohol (1:1) extracts. The successive and hydro alcohol extracts of the drug displayed distinct TLC spots and HPTLC peaks which are distinct to this drug.
Downloads
References
WHO Global Report: Preventing Chronic Diseases: A vital investment. Geneva: World Health Organization; 2005. Available from https://www.who.int/chp/chronic_disease report/en/
World Health Organization. Newsroom-Factsheet-Detail-Hypertension. 2019 September 13. Available from https://who.int/news-room/fact-sheets/detail/hypertension
Welz AN, Emberger-Klein A, Menrad K. Why people use herbal medicine: insights from a focus-group study in Germany. BMC Complement Altern Med. 2018;18:1-9. https://doi.org/10.1186/s12906-018-2160-6
WHO Global Report on Traditional and Complementary Medicine. Geneva: World Health Organization; 2019. p.10. Available from https://who.int/traditional-complementary-integrative-medicine/WhoGlobalReportOnTraditionalAndComplementary Medicine2019.pdf
Theraiyar Kudinir (Moolamum Uraiyam). 2nd ed, New Delhi: Central Council for Research in Ayurveda and Siddha; 1996. p.46.
Srishailam M, Kasala S, Veena P, Santosha D, Ramanjaneyulu K, Himabindhu J. Investigation of phytochemical screening and in-vitro anthelmintic activity of Zaleya decandra (L). Int J Pharm Pharm Res. 2016;7(3):174-80.
Gajjala K, Anisetti R, DodlaJP, Rathod AK. Phytochemical investigation and cytotoxic activity of hydro alcoholic fraction of Trianthema decandra. Indian J Biotechnol. 2019;18:193-203. http://nopr.niscair.res.in/handle/123456789/53100
Global Biodiversity Information Facility. Occurrence-Species-Dataset-Taxon. Available from https://www.gbif.org/occurrence/map?taxon_key=3703233
Kirtikar KR, Basu BD. Indian medicinal plants. 1st ed. Dehradun: International Book Distributors; 1991. p.1182.
Nadkarni AK. The Indian Materia Medica. 3rd ed, Bombay: Popular Prakasan; 1976. p.122.
Malarvizhi D, Anusooriya P, Meenakshi P, Sowmya S, Oirere E, Gopalakrishnan VK. Isolation, structural characterisation of oleic acid from Zaleya decandra root extract. Anal Chem Lett. 2016;6(5):669-77. https://doi.org/10.1080/22297928.2016.1238319
Meenakshi P, Bhuvaneshwari R, Rathi MA, Thirumoorthi L, Guravaiah DC, Jiji MJ, Gopalakrishnan VK. Antidiabetic activity of ethanolic extract of Zaleya decandra in alloxan-induced diabetic rats. Appl Biochem Biotechnol. 2010;162:1153-59. https://doi.org/ 10.1007/s12010-009-8871-x
Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallaisharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008;3:83-89. https://doi.org/10.3329/bjp.v3i2.890
Awang DVC. Ginger. Can Pharm J. 1992;125:309-11.
Wang WH, Wang ZM. Studies of commonly used traditional medicine-ginger. Zhongguo Zhong Yao Za Zhi. 2005;30:1569-73. https://pubmed.ncbi.nlm.nih.gov/16422532/
Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, et al.. Health benefits of herbs and spices: the past, the present, the future. Med J Aust. 2006;185(4):S4–S24. https://doi.org/ 10.5694/j.1326-5377.2006.tb00548.x
Khodaie L, Sadeghpoor O. Ginger from ancient times to the new outlook. Jundishapur J Nat Pharm Prod. 2015;10(1): e18402. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC4377061/
Liu Y, Liu J, Zhang Y. Research progress on chemical constituents of Zingiber officinale Roscoe. Biomed Res Int. 2019; 1-21. https://doi.org/10.1155/2019/5370823
Connwell DW, Sutherland MD. A re-examination of gingerol, shogaol and zingerone, the pungent principles of ginger (Zingiber officinale Roscoe). Aust J Chem. 1969;22:1033-43. https://doi.org/10.1071/CH9691033
Kikuzaki H, Tsai SM, Yoshiteru O. Gingerdiol related compounds from the rhizomes Zingiber officinale. Phytochemistry. 1992;32:1783-86. https://doi.org/10.1016/0031-9422(92)83147-Q
Vernin G Parkanyl C. “Chemistry of ginger,” in Ginger: The Genus Zingiber, Ravindran PN and Nirmal Babu K, editors. New York: CRC Press; 2005. p.87-180.
Katsuya E, Emi K, Yoshiteru O. Structures of antifungal diarylheptenones, gingerenones A, B, C and isogingerenone B, isolated from the rhizomes of Zingiber officinale. Phytochemistry. 1990:29(3):797-99. https://doi.org/10.1016/0031-9422(90)80021-8
Kami T, Nakayama M, Hayashi S. Volatile constituents of Zingiber officinale. Phytochemistry. 1972;11:3377-81. https://doi.org/10.1016/S0031-9422(00)86412-2
Denyer CV, Jackson P, Loakes DM. Isolation of anti-rhinoviral sesquiterpenes from ginger (Zingiber officinale). J Nat Prod. 1994;57:658-62. https://doi.org/10.1021/np50107a017
Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol. 2008;46:409–20. https://doi.org/10.1016/j.fct.2007.09.085
Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol. 2005;45(1):74-80. https://doi.org/10.1097/00005344-200501000-00013
Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the anti-hypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2000;50(7):847-57. DOI: 10.1080/00498254.2020.1729446. https://doi.org/10.1080/00498254.2020.1729446
Anonymous. Quality control methods for medicinal plant materials. Geneva: World Health Organization; 1998.
Elankani P, Murugammal S, Shakila R, Pitchiahkumar M, Kabilan N. Chemical standardisation of thetran vithai kutinir chooranam - an antidiabetic Siddha polyherbal formulation. Pharmacog J. 2019;11(5):1106-13. https://doi.org/10.5530/pj.2019.11.173
Sivaranjani K, Shakila R, Manickavasakam K. Standardisation of Siddha polyherbal formulation parangipattai Chooranam. Int J Res Ayurveda Pharm. 2015;6(4):443-48. https://doi.org/10.7897/2277-4343.06485
Akila B, Manickavasakam K, Shakila R. Analytical study on siddha herbomineral formulation: Chandrakanthi Chooranam. Int J Pharm Bio Sci. 2014;5(4):175–85.
Sujith T, Shakila R, Mandal AK, Divya KG, Mahesh F, Sunilkumar KN, Ganesan R. Powder Microscopic, Physicochemical, HPTLC and Antioxidant Studies on Noccik Kudinir Chooranam – A Polyherbal Siddha Formulation. J Young Pharm. 2019;11(4):371-76. https://doi.org/10.5530/jyp.2019.11.76
Mandal AK, Shakila R, Thatipelli S, Rubeena M, Sunilkumar KN, Thilagam A, Ganesan R. Quality standards and antioxidant activity of Siddha formulation Cuvacakutori Chooranam. Int J Pharm Investig. 2019;9(3):128-34. https://doi.org/10.5330/ijpi.2019.3.24
Mandal AK, Shakila R, Divya KG, Rubeena M, Sunil Kumar KN, Sathiyarajeswaran P. Pharmacognostical-physico-chemical evaluation and development of HPTLC finger print for Cichorium intybus L. fruits. Pharmacog J. 2017;10(4):695-700. https://doi.org/10.5530/pj.2018.4.115
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Achintya Kumar Mandal, Thatipelli Sujith, Allu Rajesh, Kallingil Gopi Divya , Koppala Narayana Sunilkumar, Ramachandran Shakila
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
