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Plant Science Today (PST)

Research Articles

Vol. 8 No. 4 (2021)

Evaluation of anti-fungal activity derivative from Premna odorata Blanco extract by deep eutectic solvents

DOI
https://doi.org/10.14719/pst.2021.8.4.1381
Submitted
14 July 2021
Published
28-08-2021 — Updated on 05-02-2022
Versions

Abstract

Fungal organisms are an opportunistic pathogen commonly found in different parts in human body like oral cavity and vagina. Recent study has revealed a critical need for novel antifungal medicines developed from medicinal plant extracts due to concerns about fungal pathogen resistance to commercial medication. In the present work, Premna odorata Blanco, belonging to the family Lamiaceae was evaluated in vitro antifungal activity against two fungal organism isolated from clinical cases. With the aim to replace toxic conventional solvents through deep eutectic solvents was used and phytochemical compounds were determined (total phenol content, total flavonoid content). ChMa extracts of Premna odorata Blanco demonstrate a significant antifungal activity against Candida albicans, Monilinia spp. Higher than water extract. While the DES2 extract reported the highest phenolic contents (3.58 mg GAE/100 g DW) and total flavonoid content (0.028 mg RE/100 g DW) compared with water extract. In conclusion, the study suggests that the Premna odorata Blanco extracts by deep eutectic solvents are promising for the development of treatments against various fungal diseases with a friendly green procedure, low toxicity and new application in pharmaceutical industry.

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