Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp.

Authors

DOI:

https://doi.org/10.14719/pst.1386

Keywords:

Syzygium polyanthum, Phytopharmacology, Phytochemistry, Traditional uses

Abstract

Syzygium polyanthum (Wight) Walp, a Myrtaceae member, is widely distributed in Southeast Asian countries. The Malays and Indonesians consume the leaves regularly as Ulam (food). It has also been used in traditional medicine to treat several ailments, including gastritis, hypertension, hypercholesterolemia, diarrhea, skin diseases, diabetes and endometriosis. So far, many publications on the biological activity and chemical profile of the plant have been published. There is a need to thoroughly examine the articles and combine the major findings highlighting the potential utility of the species. Thus, the present study aimed to review the ethnopharmacology, morpho-anatomy, biological evaluation and chemical composition of S. polyanthum. In vivo, in vitro antibacterial, antimicrobial, antidiabetic, antioxidants, essential oil and chemical composition of S. polyanthum were searched in Google Scholar, Scopus, Web of Science and PubMed. The investigations revealed that S. polyanthum is a medicinal plant with proven antioxidant, antibacterial, antifungal, antidiabetic and anti inflammatory activities. The plant had a substantial impact on human health. Chemical ingredients extracted and characterised are monoterpene, sesquiterpene, oxygenated monoterpenes, oxygenated sesquiterpenes, phenolic and flavonoid compounds. The review found that the in vitro and in vivo biological evaluation of S. polyanthum was well documented. In order to have conclusive results on the plant leaves efficacy, a well-designed clinical trial is required. Efforts should also be taken for long-term conservation and management.

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References

Awang NA, Ali AM, Abdulrahman MD, Mat N. Edible bitter mushroom from Besut, Malaysia. Journal of Agrobiotechnology. 2018;9(2):70-79.

Ramawat K, Sonie K, Sharma M. Chapter 1 Therapeutic Potential of Medicinal Plants: An Introduction, in biotechnology of medicinal plants. [e-book] 2004, CRC Press. 2004 [cited 2021 Jun 20];15-32. Available from: Chapter1Therapeutic Potential of Medicinal Plants: An Introduction (taylorfrancis.com).https://doi.org/10.1201/9781482280227-3

Mahmoud AD, Ali AM, Khandaker MM, Fatihah HNN, Awang NA, Mat N. Discrimination of Syzygium polyanthum Cultivars (Wight) Walp based on essential oil composition. Journal of Agrobiotechnology. 2019;10(1):1-9.

Karunamoorthi KK, Jegajeevanram J, Vijayalakshmi E, Mengistie A. Traditional medicinal plants: a source of phytotherapeutic modality in resource-constrained health care settings. J Evid Based Complementary Altern Med.2013;18(1):67-74. https://doi.org/10.1177/2156587212460241.

Mahara AK. Use of Herbal Medicines by Traditional Healing Practitioners: A case study of Phoksundo VDC of Dolpa district in Nepal [Internet]. 2009. [cited 8 Aug 2021]. Available from: Web Filter Violation (nhrc.gov.np).

Uprety Y, Asselin H, Dhakal A, Julien N. Traditional use of medicinal plants in the boreal forest of Canada: review and perspectives. J Ethnobiol Ethnomed. 2012;8(1):1-14.https://doi.org/10.1186/1746-4269-8-7

Hamilton AC. Medicinal plants, conservation and livelihoods. Biodivers and Conserv. 2004;13(8):1477-1517.https://doi.org/10.1023/B:BIOC.0000021333.23413.42

Gurib FA. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med.2006;27(1); 1-93. https://doi.org/10.1016/j.mam.2005.07.008.

Mahmoud AD, Labaran I, Yunusa A. Ethnobotany of medicinal plants with antimalarial potential in Northern Nigeria. Ethnobot Res Appl.2020;19:1-8. https://doi.org/10.32859/era.19.32.1-8.

Jamshidi KF, Lorigooini Z, Amini KH. Medicinal plants: Past history and future perspective. J. HerbMed Pharmacol. 2018;7(1):1-9. https://doi.org/10.15171/jhp.2018.01.

Giannenas IE, Sidiropoulou E, Bonos E, Christaki, Florou PP. The history of herbs, medicinal and aromatic plants, and their extracts: Past, current situation and future perspectives, In: Feed Additives. 2020; Elsevier. 1-18. https://doi.org/10.1016/B978-0-12-814700-9.00001-7.

Bussmann RW, Sharon D. Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture. J Ethnobiol Ethnomed. 2006;2(1):1-18. https://doi.org/10.1186/1746-4269-2-47.

Megersa M, Asfaw Z, Kelbessa E, Beyene A, Woldeab B. An ethnobotanical study of medicinal plants in Wayu Tuka district, east Welega zone of oromia regional state, West Ethiopia. J Ethnobiol Ethnomed. 2013;9(1):1-18.https://doi.org/10.1186/1746-4269-9-68

Sumono A, Sd AW. The use of bay leaf (Eugenia polyantha Wight) in dentistry. Dent. J. 2008;41(3):147-150. https://doi.org/10.20473/j.djmkg.v41.i3.p147-150.

Ismail A, Mohamed M, Sulaiman S, Wan WA. Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum leaves in anaesthetized rats. J Evid Based Complementary Altern Med.2013; https://downloads.hindawi.com/journals/ecam/2013/716532.pdf.

Mahmoud AD, Fatihah HNN, Khandaker MM, Ali AM, Mat N. Ethnobotany of Syzygium polyanthum (Wight) Walp in Terengganu, Peninsular Malaysia. Journal of Agrobiotechnology. 2020;11(2):39-47.https://doi.org/10.37231/jab.2020.11.2.212

Abdulrahman MD, Ali AM, Fatihah H, Khandaker MM, Mat N. Traditional medicinal knowledge of Malays in Terengganu, Peninsular Malaysia. Malay. Nat. J. 2018;70(3): 349-364.

Kusuma IW, Kuspradini H, Arung ET, Aryani F, Min YH, Kim JS, Kim YU. Biological activity and phytochemical analysis of three Indonesian medicinal plants, Murraya koenigii, Syzygium polyanthum and Zingiber purpurea. J Acupunct. Meridian Stud. 2011;4(1):75-79. https://doi.org/10.1016/S2005-2901(11)60010-1.

Ismail A, Ahmad WANW. Syzygium polyanthum (Wight) Walp: a potential phytomedicine. Pharmacogn Mag. 2019;11(2):429-38. https://doi.org/10.5530/pj.2019.11.67.

Dewijanti ID, Mangunwardoyo W, Dwianti A, Hanafi M, Artanti N, Mozef T, Devi AF. Antimicrobial activity of bay leaf (Syzygium polyanthum (wight) walp) extracted using various solvent. In: AIP Conference Proceedings. 2019. AIP Publishing LLC. https://doi.org/10.1063/1.5134585.

Safriani N, Arpi N, Erfiza NM, Potency of curry (Muraya koeniigi) and salam (Eugenia polyantha) leaves as natural antioxidant sources. Pak J Nutr.2015;14(3):131-35.

Falah S, Wahyuni WT, Tachibana S. Cellular mechanism of the cytotoxic effect of extracts from Syzygium polyanthum leaves. Am. Drug Discov. Dev. 2014;4(2):90-101.101. https://doi.org/10.3923/ajdd.2014.90.101.

Pandey AK, Singh P. The genus Artemisia: A 2012–2017 literature review on chemical composition, antimicrobial, insecticidal and antioxidant activities of essential oils. J Med. 2017;4(3): 2-1510.3390/medicines4030068.

Widyawati T, Yusoff NA, Asmawi MZ, Ahmad M. Antihyperglycemic effect of methanol extract of Syzygium polyanthum (Wight.) leaf in streptozotocin-induced diabetic rats. Nutrients. 2015;7(9):7764-80. https://doi.org/10.3390/nu7095365.

Ramadhania NR, Purnomo AS, Fatmawati S. Antibacterial activities of Syzygium polyanthum wight leaves. AIP Conference Proceedings. 2018. In: AIP Publishing LLC. https://doi.org/10.1063/1.5082429.

Wijayakusuma H, Dalimartha S, Wirian A. Tanaman Berkhasiat Obat di Indonesia Jilid IV. Jakarta Pustaka Kartini. 1996;7(8):148-56.

Dewijanti I, Mangunwardoyo W, Dwiranti A, Hanafi M, Artanti N. Effects of the various source areas of Indonesian bay leaves (Syzygium polyanthum) on chemical content and antidiabetic activity. Biodivers J 2020;21(3):1190-95. https://doi.org/10.13057/biodiv/d210345.

Othman A, Mukhtar NJ, Ismail NS, Chang SK, Phenolics, flavonoids content and antioxidant activities of 4 Malaysian herbal plants. Int Food Res J. 2014;21(2):759-66.

Dewijanti ID, Artanti N, Mangunwardoyo W, Hanafi M, Abbas J, Megawati M, Minarti M, Musdalifah D, Meilawati L. Bioactivities of Syzygium polyanthum (Wight) Walp leaf extract for decreasing diabetic risk. In: AIP Conference Proceedings. 2018. In: AIP Publishing LLC. https://doi.org/10.1063/1.5064297.

Ahmad N. Chemical composition, antioxidant and antibacterial activity of essential oil from leaf of Syzygium polyanthum (Wight) Walp. Faculty of Industrial Sciences and Technology. PhD [dissertation]. Universiti Malaysia Pahang; 2014. Available from: 159185268.pdf (core.ac.uk).

Sachan A, Kumar S, Kumari K, Singh D. Medicinal uses of spices used in our traditional culture: Worldwide. J. Med. Plants Stud. 2018;6(3):116-22.

Lelono RAA, Tachibana S. Preliminary studies of Indonesian Eugenia polyantha Leaf extracts as inhibitors of key enzymes for type 2 diabetes. J Med Sci. 2013;13(2):103 -10.

Wijaya S. Indonesian food culture mapping: a starter contribution to promote Indonesian culinary tourism. J Ethn Foods. 2019;6(1): 1-10. https://doi.org/10.1186/s42779-019-0009-3.

Hidayati MD, Ersam T, Shimizu K, Fatmawati S. Antioxidant activity of Syzygium polyanthum extracts. Indones J Chem. 2017;17(1):49-53. https://doi.org/10.22146/ijc.23545.

Abdulrahman MD, Ali AM, Fatihah H, Khandaker MM, Mat N, B. Morphological and anatomical studies of Syzygium polyanthum (Wight) Walp. (Myrtaceae). Mal Nat J. 2018;70(3):309-322.

Abdulrahman MD, Fatihah HNN, Ali M, Mat N, Khandaker M. Phenetic and unsupervised multivariate analysis Syzygium polyanthum (Wight) Walp. Iraqi J.of Agric. Sci. 2021;52(1): 249-58. https://doi.org/10.36103/ijas.v52i1.1255.

Pham GN, Nguyen TTT, Nguyen NH. Ethnopharmacology, phytochemistry and pharmacology of Syzygium nervosum. J Evid Based Complementary Altern Med. 2020. https://doi.org/10.1155/2020/8263670.

Abdulrahman M. Antioxidant, alpha glucosidase and antibacterial evaluation of Syzygium mytifolium (Roxb.) Walp. Plant Science Today. 2021;8(2):410–15. https://doi.org/10.14719/pst.2021.8.2.1113.

Lucas E, Belsham S, Lughadha EN, Orlovich D, Sakuragui C, Chase M, Wilson P. Phylogenetic patterns in the fleshy-fruited Myrtaceae–preliminary molecular evidence. Plant Syst Evol. 2005;251(1): 35-51. https://doi.org/10.1007/s00606-004-0164-9.

Lucas EJ, Harris SA, Mazine FF, Belsham SR, Nic EM, Lughadha A, Telford P, Gasson A, Chase MW. Suprageneric phylogenetics of Myrteae, the generically richest tribe in Myrtaceae (Myrtales). Taxon.2007;56(4):1105-28. https://doi.org/10.2307/25065906.

Grattapaglia D, Vaillancourt RE, Shepherd M, Thumma BR, Foley W, Külheim C. Potts BM, Myburg AA. Progress in Myrtaceae genetics and genomics: Eucalyptus as the pivotal genus. Tree Genet Genom. 2012:8(3): 463-508. https://doi.org/10.1007/s11295-012-0491-x.

Pennington RT, Cronk QC, Richardson JA, Introduction and synthesis: plant phylogeny and the origin of major biomes. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 2004;359(1450):1455-64. https://doi.org/10.1098/rstb.2004.1539.

Ayyanar M, Subash BP. Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses. Pac J Trop Biomed. 2012;2(3):240-46. https://doi.org/10.1016/S2221-1691(12)60050-1.

Nair KN. The genus Syzygium: Syzygium cumini and other underutilized species. CRC Press; 2017: 56-71.https://doi.org/10.1201/9781315118772

Whistler WA, Elevitch CR, Syzygium malaccense (Malay apple). Species profiles for Pacific Island Agroforestry. 2006;2:1-13.

Mahmoud II, Marzouk MS, Moharram FA, El-Gindi MR, Hassan AM. Acylated flavonol glycosides from Eugenia jambolana leaves. Phytochemistry. 2001;58(8): 1239-44. https://doi.org/10.1016/S0031-9422(01)00365-X.

Craven L. Studies in Papuasian Syzygium (Myrtaceae): 1. Subgenus Perikion revised. blumea-biodiversity. Evolution and Biogeography of Plants. 2019;64(2):115-22. https://doi.org/10.3767/blumea.2019.64.02.03.

Soh WK. Parnell J. A revision of Syzygium Gaertn. (Myrtaceae) in Indochina (Cambodia, Laos and Vietnam). Adansonia. 2015;37(2):179-275. https://doi.org/10.5252/a2015n2a1.

Brambach FJ, Byng W, Culmsee H. Five new species of Syzygium (Myrtaceae) from Sulawesi, Indonesia. PhytoKeys. 2017;(81):47-78. https://doi.org/10.3897/phytokeys.81.13488.

Raman VR, Bussmann W, Khan IA. Which bay leaf is in your spice rack?–A quality control study. Planta Med. 2017; 83(12/13):1058-67. https://doi.org/10.1055/s-0043-103963.

Soh WK, Parnell J. Comparative leaf anatomy and phylogeny of Syzygium Gaertn. Plant Syst Evol. 2011;297(1): 1-32.https://doi.org/10.1007/s00606-011-0495-2.

Syabana MA, Yuliana ND, Batubara I, Fardiaz D. Characterization of Antioxidant Compound from Syzygium polyanthum Leaves fraction using UHPLC-HRMS. Molekul. 2021;16(1):38-45. http://dx.doi.org/10.20884/1.jm.2021.16.1.666.

Shahidi F, Zhong Y. Measurement of antioxidant activity. J Funct Foods. 2015;18: 757-781. https://doi.org/10.1016/j.jff.2015.01.047.

Abdulrahman MD, Hasan NH, Khandaker MM, Ali AM, N. Mat N. In vitro biological investigations on Syzygium polyanthum cultivars. Int J Agric Biol. 2019;22(6):1399-1406. https://doi.org/10.17957/IJAB/15.1214.

Darusman LK, Wahyuni WT, Alwi F. Acetylcholinesterase inhibition and antioxidant activity of Syzygium cumini, S. aromaticum and S. polyanthum from Indonesia. J Biol Sci. 2013;13(5):412-16.https://doi.org/10.3923/jbs.2013.412.416

Dogara A, Labaran I, Hamad SW, Lema AA, Jakada BH. Traditional medicinal plants used for the treatment of cancer in Mubi, Adamawa State, Nigeria. Al-Qadisiyah Journal of Pure Science. 2021;26(4):258-68. https://doi.org/10.29350/qjps.2021.26.4.1423.

Setyawati A, Hirabayashi K, Yamauchi K, Hattori H, Mitsunaga T, Batubara I, Heryanto R, Hashimoto H, Hotta M. Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract. J Nat Med. 2018;72(2):474-80. https://doi.org/10.1007/s11418-018-1171-4.

Syabana MA, Yuliana ND, Batubara I, Fardiaz D. ?-glucosidase inhibitors from Syzygium polyanthum (Wight) Walp leaves as revealed by metabolomics and in silico approaches. J Ethnopharmacol. 2021. https://doi.org/org/10.1016/j.jep.2021.114618.

Abd Rahim ENA, Ismail A, Omar MN, Rahmat UN, Ahmad WANW. GC-MS analysis of phytochemical compounds in Syzygium polyanthum leaves extracted using ultrasound-assisted method. Pharmacogn Mag. 2018;10(1):110-19. https://doi.org/10.5530/pj.2018.1.20.

Arundita S, Kurniawan F, Ismed F, Rita RS, Putra DP. In vitro Alpha Glucosidase Activity of Uncaria gambir Roxb. and Syzygium polyanthum (Wight) Walp. from West Sumatra, Indonesia. Open Access Maced. J Med Sci. 2020;8(A):810-17.https://doi.org/10.3889/oamjms.2020.4298

Widyawati T, Pase MA, Daulay M, Sumantri IB. Effect of bay leaf ethanol extract on blood glucose level in patients with Type 2 Diabetes Mellitus. In. 6th International Conference on Public Health 2019. 2019. Sebelas Maret University. https://doi.org/10.26911/the6thicph-FP.05.07.

Wahjuni S, Laksmiwati AM, Manuaba IBP. Antidiabetic effects of Indonesian bay leaves (Syzygium polyanthum) extracts through decreasing advanced glycation end products and blood glucose level on alloxan-induced hyperglycemic wistar rats. Asian J Pharm Clin. 2018;11(4):340-43.https://doi.org/10.22159/ajpcr.2018.v11i4.24084

Elya B, Handayani R, Sauriasari R, Hasyyati US, Permana IT, Permatasari YI. Antidiabetic activity and phytochemical screening of extracts from Indonesian plants by inhibition of alpha amylase, alpha glucosidase and dipeptidyl peptidase IV. Pak J Biol Sci. 2015;18(6):279-84.https://doi.org/10.3923/pjbs.2015.279.284

Wahjuni S, Wita IW. Hypoglycemic and antioxidant effects of Syzygium polyanthum leaves extract on alloxan induced hyperglycemic Wistar Rats. Bali Med J. 2017;3(3): 113-16. https://doi.org/10.15562/bmj.v3i3.755.

Hamad A, M. Mahardika M, Yuliani I, Hartanti D. Chemical constituents and antimicrobial activities of essential oils of Syzygium polyanthum and Syzygium aromaticum. Rasayan J Chem. 2017;10(2):564-569. https://doi.org/10.7324/RJC.2017.1021693.

Ramli S, Radu S, Shaari K, Rukayadi Y. Antibacterial activity of ethanolic extract of Syzygium polyanthum L. (Salam) leaves against foodborne pathogens and application as food sanitizer. Biomed Res. Int.2017; https://doi.org/10.1155/2017/9024246.

Ramli S, Lim L, Samsudin N, Rukayadi Y. Effect of salam [Syzygium polyanthum (Wigt) Walp.] leaves extract on the microorganism population in chicken meat and shrimp and their sensory. Int Food Res. 2018;25(3):928-35.

Umaru IJ, Umaru KI, Umaru HA. Phytochemical screening, isolation, characterization of bioactive and biological activity of Bungkang,(Syzygium polyanthum) root-bark essential oil. The Korean Journal of Food and Health Convergence. 2020;6(3):5-21. https://doi.org/10.13106/kjfhc.2020.vol6.no3.5.

Grosvenor PW, Supriono A, Gray DO, Medicinal plants from Riau Province, Sumatra, Indonesia. Part 2: antibacterial and antifungal activity. J Ethnopharmacol. 1995;45(2):97-111. https://doi.org/10.1016/0378-8741(94)01210-Q.

Guynot MS, Marin LS, Sanchis V, Ramos A. Screening for antifungal activity of some essential oils against common spoilage fungi of bakery products. Food Sci Technol Int. 2005;11(1):25-32. https://doi.org/10.1177/1082013205050901.

Kusuma SAF, Purnamasari E, Herawati IE. Syzygium polyanthum (Wight) Walp. leaves extract as the antifungal agent for oral candidiasis. Drug Discov.2019;12(7):1339-42.

Ismail A, Ahmad WANW. Autonomic receptors and nitric-oxide involvements in mediating vasorelaxation effect induced by Syzygium polyanthum leaves extract. Pharmacogn Res. 2017;9(1):9-14. https://doi.org/10.4103/pr.pr_69_17.

Ismail A, Ramli NS, Mohamed M, Ahmad WANW. Acute and sub-acute antihypertensive effects of Syzygium polyanthum leaf extracts with determination of gallic acid using HPLC analysis. Pharmacogn Mag. 2018;10(4):663-71. https://doi.org/10.5530/pj.2018.4.109.

Ramli N, Muhammad N, Safuan S, Noordin L, Wan AW. Preliminary evaluation on the effect of methanolic extract from Syzygium polyanthum on improvement of hypertensive-renal damage among Spontaneous Hypertensive rat models. Ann Microsc. 2017:16:15-22.

Malik A. Antidiarrheal acitivity of ethanolik extract of bay leaves (Syzygium polianthum (Wight) Walp. Int Res J Pharm. 2013;4(4):106-08. 10.7897/2230-8407.04418.

Wachtel MR, Charkowski AO, Cross-contamination of lettuce with Escherichia coli O157: H7. J. Food Prot. 2002;65(3):465-470. https://doi.org/10.4315/0362-028X-65.3.465.

Jayaraman S, Manoharan MS, Illanchezian S. In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Trop J Pharm. 2008;7(4): 1143-49. 10.4314/tjpr.v7i4.14700.

Mooi LY, Ali A, Norhanom A, Salleh KA. Murakami, K. Koshimizu. Anti-tumor promoting activity of some Malaysian traditional vegetables (ulam). Nat. Prod. Sci. 1999;5(1):33-38.

Alias N, Leow T, Ali M, Tajudin A, Salleh A, Rnzra R. Anti-obesity potential of selected tropical plants via pancreatic lipase inhibition. Advances in Obesity, Weight Management and Control. 2017;6(4):1-11.

Kato E, Nakagomi R, Gunawan PMD, Kawabata J. Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha. Food Chem. 2013;136(3-4):1239-42. https://doi.org/10.1016/j.foodchem.2012.09.013.

Sukmawati RK, Saharuddin N. Kombinasi Ekstrak Etanol Daun Kemangi (Ocimum bacilicum L.) dan Daun Salam (Syzygium polyanthum (Wight) Walp) sebagai Antiinflamasi pada Tikus (Rattus norvegicus). Jantan yang Diinduksi Karagen. 2018; 1-10.

Avriliyanti F, Suparwitri S, Alhasyimi AA. Rinsing effect of 60% bay leaf (Syzygium polyanthum wight) aqueous decoction in inhibiting the accumulation of dental plaque during fixed orthodontic treatment. Dent J. 2017;50(1):1-5. http://dx.doi.org/10.20473/j.djmkg.v50.i1.p1-5.

Hasan RD, Lindarto GA, Mukhtar SZ. The effect of bay leaf extract Syzygium polyanthum (Wight) Walp. on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model of myocardial infarction. Med Glas. 2020;17(1):1-5.

Hasan, R., G.A. Siregar, Lindarto D. Syzygium Polyanthum Reduced TNF-? and ADAM17 Protein expression in myocardial infarction rat model Med Arch Dec. 2020;74(6):416–20. https://doi.org/10.5455/medarh.2020.74.416-420.

Chinedu E, Arome D, Ameh FS. A new method for determining acute toxicity in animal models. Toxicol Int. 2013;20(3):24-226. https://doi.org/10.4103/0971-6580.121674.

Dewijanti I. Mangunwardoyo W, Artanti N, Hanafi M. Bioactivities of Salam leaf (Syzygium polyanthum (Wight) Walp). In: AIP Conference Proceedings. 2019. AIP Publishing LLC. ); https://doi.org/10.1063/1.5132499.

Nordin ML, Othman AA, Kadir AA, Shaari R, Osman AY, Mohamed M. Antibacterial and cytotoxic activities of the Syzygium polyanthum leaf extract from Malaysia. Vet world. 2019;12(2):2231-0916. https://doi.org/10.14202/vetworld.2019.236-242.

Hartanti L, Yonas SMK, Mustamu JJ, Wijaya S,. Setiawan HK, Soegianto. Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity. Heliyon. 2019;5(4):1-15. https://doi.org/10.1016/j.heliyon.2019.e01485.

Perumal S, Mahmud V, Piaru SP, Cai LW, Ramanathan S. Potential antiradical activity and cytotoxicity assessment of Ziziphus mauritiana and Syzygium polyanthum. Int J Pharmacol. 2012;8(6):535-41. https://doi.org/10.3923/ijp.2012.535.541.

Dono N. In vitro antibacterial activities of Syzygium polyanthum leaves extract-nanoparticle against Salmonella typhimurium, Escherchia coli and Lactobacillus acidophilus. In: IOP Conference Series: Earth and Environmental Science. 2021. IOP Publishing. : https://doi.org/10.1088/1755-1315/782/2/022093.

Widyawati T, Roslan N, Yusoff N, Asmawi M, Ahamad M. The evaluation of antioxidant and free radical scavenging activities of Eugenia polyantha leaves extracts. Int J Chemtech Res. 2016;9(9):465-71.

Ramadhania ZM, Insanu M, Gunarti N, Wirasutisna KR, Sukrasno S, Hartati R. Antioxidant activity from ten species of myrtaceae. Asian J Pharm Clin Res. 2017; 10(14):5;1-7. http://dx.doi.org/10.22159/ajpcr.2017.v10s2.19470.

Lelono R, Tachibana S, Itoh K. In vitro antioxidative activities and polyphenol content of Eugenia polyantha Wight grown in Indonesia. Pak J Biol Sci. 2009;12(24): 1564-70. https://doi.org/10.3923/pjbs.2009.1564.1570.

Sandikapura MJ, Nyamathulla S, Noordin MI. Comparative antioxidant and antidiabetic effects of Syzygium polyanthum leaf and Momordica charantia fruit extracts. Pak J Pharm Sci. 2018;31:1-13.

Rahayu I, Heng PH, Timotius KH, In vitro antioxidant properties and ?-Glucosidase inhibition of combined leaf infusions from Psidium guajava L., Syzygium polyanthum L., and Annona muricata L. Pharmacogn J. 2019;11(6):1269-77. https://doi.org/10.5530/pj.2019.11.197.

Sukmasari S, Mohd FN, Qader OAJA, Rahman MNA. Total phenolic content, flavonoid content and antioxidant capacity of Syzygium. cumini (L.) Skeels leaves grown in Wonosobo, Java, Indonesia and comparison against current findings of Syzygium cumini leaves and Syzygium polyanthum (Wight) Walp leaves. J Pharm Sci. 2018;10(1):31-35.

Wong SP, Leong LP, Koh JHW. Antioxidant activities of aqueous extracts of selected plants. Food Chem. 2006;99(4):775-83. https://doi.org/10.1016/j.foodchem.2005.07.058

Muhammad S, Shaik N, Mohamed N. Comparative antioxidant and antidiabetic effects of Syzygium polyanthum leaf and Momordica charantia fruit extracts. Pak J Pharm Sci. 2018;31:623-35.

Widjajakusuma EC, Jonosewojo A, Hendriati L, Wijaya S, Surjadhana A, Sastrowardoyo W, Monita N, Muna NM, Fajarwati RP, Ervina M. Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes. Phytomedicine. 2019;55:137-47. https://doi.org/10.1016/j.phymed.2018.07.002.

Parisa N, Tamzil NS,. Harahap DH, Prasasty GD, Hidayat R, Maritska Z, Prananjaya BA. The effect of leaf Salam extracts (Syzygium polyanthum) in diabetes mellitus therapy on wistar albino rats. Journal of Physics: Conference Series. 2019. IOP Publishing. https://doi.org/10.1088/1742-6596/1246/1/012034.

Widharna RM, Tamayanti WD, Hendriati L, Hamid IS, Widjajakusuma EC. Antidiabetic effect of the aqueous extract mixture of Andrographis paniculata and Syzygium polyanthum leaf. European J Med Plants. 2015;82-91. https://doi.org/10.9734/EJMP/2015/15601.

Berawi KN, Shidarti L, Nurdin SU, Lipoeto NI, Wahid I. Comparison effectiveness of antidiabetic activity extract herbal mixture of soursop leaves (Annona muricata), Bay leaves (Syzygium polyanthum) and Pegagan leaves (Centella asiatica). Biomed. Pharmacol. 2017;10(3):1481-88. https://dx.doi.org/10.13005/bpj/1256.

Alwie RR, Mumpuni E, Sulastri L. Simanjuntak P, Aktivitas Ekstrak Etanol Daun Salam [Syzygium polyanthum (Wight) Walp.] Sebagai Penghambat Enzim ?-Glukosidase Dan Studi Secara In Silico. Jurnal Fitofarmaka Indonesia, 2021;8(2):36-42. https://doi.org/10.33096/jffi.v8i2.750.

Lau K, Zainin N, Abas F, Rukayadi Y. Antibacterial and sporicidal activity of Eugenia polyantha Wight against Bacillus cereus and Bacillus subtilis. Int J Curr Microbiol Appl Sci. 2014;3:499-510.

Sri AFK, Danni R, Resmi M. Comparative study on activities of anti bacillary dysentry Shigella dysenteriae of Syzygium polyanthum and Dracaena angustifolia leaves ethanol extracts. Asian J Pharm Clin Res. 2017;10(2):348-52. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15725.

Ismail A, ENAA, Rahim MN, Omar D, Ahmad WANW. Antihypertensive assay-guided fractionation of Syzygium polyanthum leaves and phenolics profile analysis using LCQTOF/MS. Pharmacogn J. 2020;12(6s):1670-92. https://doi.org/10.5530/pj.2020.12.227.

Prahastuti S, Tjahjani S, Hartini E. The effect of bay leaf infusion (Syzygium polyanthum (Wight) Walp to decrease blood total cholesterol level in dyslipidemia model wistar rats. Jurnal Medika Planta. 2011;1(4):27-32.

Ramli S, Radu S, Shaari K, Rukayadi Y. Toxicity analysis of Syzygium polyanthum (Wight) Walp. leaves extract and its stability against different pH and temperature. Emir J Food Agric. 2020;461-68. https://doi.org/10.9755/ejfa.2020.v32.i6.2116.

Jumaat SR, Tajuddin SN, Sudmoon R, Chaveerach A, Abdullah UH, Mohamed R. Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia. Bio Resources. 2017;12(3):5878-95.

Atanasov AG, Waltenberger B, Pferschy WEM, Linder T, Wawrosch C, Uhrin PV. Temml L, Wang S, Schwaiger M, Heiss EH. Discovery and resupply of pharmacologically active plant-derived natural products: A review Biotechnol Adv. 2015;33(8):1582-1614. https://doi.org/10.1016/j.biotechadv.2015.08.001.

Amalina AN, MY M, Ashikin AKN. Chemical composition, antioxidant and antibacterial activities of Syzygium polyanthum (Wight) Walp. essential oils. Open Conference Proceedings Journal. 2013;https://doi.org/10.2174/2210289201304010139.

Dhakad AK, Pandey VV, Beg S, Rawat JM, Singh A. Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: a review. J Sci Food Agric. 2018;98(3):833-48. https://doi.org/10.1002/jsfa.8600.

Kamatou GP, Vermaak I, Viljoen AM, Lawrence BM. Menthol: a simple monoterpene with remarkable biological properties. Phytochemistry. 2013;96:15-25. https://doi.org/10.1016/j.phytochem.2013.08.005.

Hamad A, Saputri EY, Hartanti D. The use of bay-leaf essential oil as raw chicken meat’s natural preservative. MalayBio. 2010;64(2):234-46.

Abdulrahman MD, Fatihah KHNN, Mat N. Discrimination of Syzygium polyanthum (Wight) Walp. Cultivars Based on ATR-FTIR Spectroscopy. Bioscience Research. 2018;15(4):3635-46.

National Park. Flora and Fauna Web Repository [Internet]. Singapore: [cited 2021 Nov 28]. Available from: NParks | Syzygium polyanthum.

Sabandar C, Jalil W, Ahmat J, N. (2015). In vitro antioxidant activity of Syzygium polyanthum (Wight) Walpers. Proceedings of pharmaceutical sciences research day; 2015 15 -16 Aprril; Malaysia. 68-71. Proceedings-RD-201521.pdf.

Published

25-12-2021 — Updated on 01-01-2022

How to Cite

1.
Mahmoud Dogara A. Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp. Plant Sci. Today [Internet]. 2022 Jan. 1 [cited 2024 Nov. 4];9(1):167–177. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/1386

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Review Articles