Reproductive, antioxidant, anti-inflammatory, antimicrobial, protective and antidiabetic activities of Helichrysum Mill. species

Achasih Quinta  Nkemzi; Okobi Eko Ekpo; Oluwafemi Omoniyi  Oguntibeju

doi:10.14719/pst.1484

Authors

Achasih Quinta Nkemzi Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa. https://orcid.org/0000-0001-6500-3251
Okobi Eko Ekpo Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates. https://orcid.org/0000-0003-3193-7499
Oluwafemi Omoniyi Oguntibeju Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa. https://orcid.org/0000-0002-7299-1128

DOI:

https://doi.org/10.14719/pst.1484

Keywords:

Ethnopharmacology, Phytochemistry, Therapeutic, Biological activities, Helichrysum, Traditional medicine

Abstract

South African Helichrysum species are known for diverse medicinal use and treatment of different illnesses. Ethnopharmacological studies have revealed the potential use of Helichrysum plants in drug discovery. Although some of these species have been documented, there is still paucity of information on most species. This review seeks to provide a compilation of documented traditional uses, reproductive potential, antioxidant, anti-inflammatory, antimicrobial, protective and antidiabetic activities and other therapeutic properties of some Helichrysum species of South Africa. Information on Helichrysum cymosum, H. foetidum, H. odoratissimum, H. patulum and H. petiolare were collected from such scientific databases as Google scholar, Scifinder, PubMed, Elsevier, Scopus, Science direct in the form of journal articles, scientific reports, theses and books from the Library of the Cape Peninsula University of Technology. Our findings show that these species have historic values in traditional medicine through their diverse use for the management and treatment of such illnesses as cold, diabetes, headaches, digestive problems, sores and wounds, HIV, cancer etc. Additionally, the reported bioactive constituents isolated from these species have been shown to indicate several activities such as antimicrobial, antioxidant, antidiabetic, neuroprotection, reproductive potentials and others. Thus, the current review highlights the phytochemical and bioactive constituents as well as some of the pharmacological properties of the five selected Helichrysum species with a view to providing validation for their use in the pharmaceutical drug development process.

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