This is an outdated version published on 05-09-2023. Read the most recent version.

Forthcoming

Herbal Allies for Rheumatoid Arthritis: A Comprehensive Review of Natural Products

Authors

Ankita Singh Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun- 248007,Uttarakhand, INDIA. https://orcid.org/0000-0002-7011-6012
Madhu Kaushik Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun- 248007,Uttarakhand, INDIA. https://orcid.org/0009-0007-1055-0523
Swati Sinha Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun- 248007,Uttarakhand, INDIA. https://orcid.org/0009-0005-4445-0227
Ravindra Kumar Kachhap Oraon Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun- 248007,Uttarakhand, INDIA. https://orcid.org/0000-0002-2087-558X
Narotam Sharma DNA Labs- A Centre for Applied Sciences, Dehradun-248007, Uttarakhand, INDIA. https://orcid.org/0000-0003-0103-2322
Indra Rautela Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun- 248007,Uttarakhand, INDIA https://orcid.org/0000-0002-2159-7542

DOI:

https://doi.org/10.14719/pst.2569

Keywords:

Rheumatoid Arthritis, Natural products, Photoactive compounds, anti-inflammatory and anti-arthritic effects

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting primarily the joints, producing discomfort, inflammation, and potentially damaging joint destruction. Rheumatoid arthritis affects people all around the world, and its prevalence and impact differ by place. The World Health Organisation (WHO) estimates that 0.5% to 1% of the global population has rheumatoid arthritis. To decrease the progression of rheumatoid arthritis, disease-modifying anti-rheumatic medications (DMARDs) such as methotrexate and sulfasalazine are used. TNF inhibitors and IL-6 inhibitors are two examples of biologic DMARDs that target specific immune system components. Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics help manage pain and inflammation while corticosteroids provide short-term relief during flares. Treatment strategies are tailored to the individual, and talking with a healthcare expert is essential for effective management. Herbal therapies are regarded to offer an advantage over synthetic pharmaceuticals for the treatment of rheumatoid arthritis due to their natural approach, potential symptom relief, holistic approach to health, and individualised therapy possibilities. However, scientific data supporting their effectiveness is sparse and variable, and their quality and safety can vary. Before adopting herbal therapies as part of a treatment plan, it is critical to check with a healthcare expert. Because of their natural chemicals with anti-inflammatory and analgesic characteristics, medicinal herbs may aid rheumatoid arthritis. However, further research is required to determine their efficacy, safety, and appropriate application.

Downloads

Download data is not yet available.

References

Radu AF, Bungau SG. Management of rheumatoid arthritis: an overview. Cells. 2021; 10(11):2857.

Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, Nam J, Ramiro S, Voshaar M, Van Vollenhoven R, Aletaha D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2017; 76(6): 960-977.

Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR. Kelley and Firestein's textbook of rheumatology. 2016 Elsevier Health Sciences. 2: 10th ed. ISBN 9780323680851

McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011; 365(23): 2205-2219.

Arnbak B, Jensen TS, Schiøttz-Christensen B, Pedersen SJ, Stergaard M, Weber U, Hendricks O, Zejden A, Manniche C, Jurik AG. What Level of Inflammation Leads to Structural Damage in the Sacroiliac Joints? A Four Year Magnetic Resonance Imaging Follow Up Study of Low Back Pain Patients. Arthritis Rheumatol. 2019; 71(12): 2027-2033.

Kumar P, Clark ML eds., 2020. Kumar & Clark's Cases in Clinical Medicine E-Book. Elsevier Health Sciences.4th ed. ISBN 9780702077333.

Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res Treat. 2014; 46(1): 2-18.

Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet. 2010; 376(9746): 1094-1108.

Nikiphorou E, Norton S, Carpenter L, Dixey J, Andrew Walsh D, Kiely P, Young A. Secular changes in clinical features at presentation of rheumatoid arthritis: Increase in comorbidity but improved inflammatory states. Arthritis Care Res. 2017; 70(6): 869-877.

Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges Jr SL. American College of Rheumatology recommendations for the use of disease modifying antirheumatic drugs and biological agents in the treatment of rheumatoid arthritis. Arthritis care Res. 2012; 64(5): 625-639.

Keystone EC, Genovese MC, Schlichting DE, de la Torre I, Beattie SD, Rooney TP, Taylor PC. Safety and efficacy of baricitinib through 128 weeks in an open label, long-term extension study in patients with rheumatoid arthritis. J Rheumatol. 2018; 45(1): 14-21.

McWilliams DF, Kiely PD, Young A, Walsh DA. Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatol. 2018; 1(1): 6. https://doi.org/10.1186/s41927-017-0008-7

Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK. Rheumatoid arthritis disease activity predicting incident clinically apparent rheumatoid arthritis–associated interstitial lung disease: a prospective cohort study. Arthritis Rheumatol. 2019; 71(9): 1472-1482.

Al-Nahain A, Jahan R, Rahmatullah M. Zingiber officinale: A potential plant against rheumatoid arthritis. Arthritis. 2014; 159089. https://doi.org/10.1155/2014/159089

Gutiérrez-Gamboa G, Liu SY, Sun X, Fang Y. Oenological potential and health benefits of Chinese non-Vitis vinifera species: An opportunity to the revalorization and to breed new varieties. Food Res Int. 2020; 137:109443.

Kunnumakkara AB, Banik K, Bordoloi D, Harsha C, Sailo BL, Padmavathi G, Roy NK, Gupta SC, Aggarwal BB. Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases. Front. Pharmacol. 2018; 9: 686.

Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclast genesis through suppression of nuclear factor-?B (NF-?B) activation and NF-?B–regulated gene expression. Mol Cancer Ther. 2006; 5(6):1434-1445.

Sulima P, Przyborowski JA. Purple willow (Salix purpurea L.) and its potential uses for the treatment of arthritis and rheumatism. In: Bioactive food as dietary interventions for arthritis and related inflammatory diseases. 2019; 535-551. Academic Press.

Gautam RK, Roy K, Thapa G, Arora D, Parashar S, Gurung B, Deb L. Perspective of plant medicine in therapy of rheumatoid arthritis. Indian J Pharm. Sci. 2020; 82(5):741-765.

Chopra A, Saluja M, Tillu G. Ayurveda–modern medicine interface: A critical appraisal of studies of Ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis. J Ayurveda Integr. Med. 2010; 1(3):190.

Etzel R. Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis. Phytomed. 1996; 3(1):91-4.

Moosavian SP, Paknahad Z, Habibagahi Z, Maracy M. The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double?blind, placebo-controlled trial. Phytother Res. 2020; 34(11):2953-62.

Zugaro S, Benedetti E, Caioni G. Garlic (Allium sativum L.) as an Ally in the Treatment of Inflammatory Bowel Diseases. Curr Issues Mol Biol. 2023 11; 45(1):685-698.

Wang Y, Chen S, Du K, Liang C, Wang S, Boadi EO, Li J, Pang X, He J, Chang YX. Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis. J Ethnopharm. 2021; 279: 114368.

Behl T, Upadhyay T, Singh S, Chigurupati S, Alsubayiel AM, Mani V, Vargas-De-La-Cruz C, Uivarosan D, Bustea C, Sava C, Stoicescu M. Polyphenols targeting MAPK mediated oxidative stress and inflammation in rheumatoid arthritis. Molecules. 2021; 26(21): 6570.

Mozaffari-Khosravi H, Naderi Z, Dehghan A, Nadjarzadeh A, FallahHuseini H. Effect of ginger supplementation on proinflammatory cytokines in older patients with osteoarthritis: A randomized controlled trial. Nutrition. 2016; 32(11-12): 1171-1175.

Bari MU, Aslam B, Muhammad F, Mohsin M, Hussain A, Anwar MW. Phytochemical analysis and evaluation of ameliorating potential of Ricinus communis leaves extract against aspirin-induced gastric ulcer in rabbits. Pak J Agric. Sci. 2021; 58(5): 1635-1642.

Chopra A. Ayurvedic medicine and arthritis. Rheum Dis Clin North Am. 2000; 26(1):133-44.

Basnyat S, Kolasinski SL. Ayurvedic medicine for rheumatoid arthritis. Curr Rheumatol Rep. 2014; 16:1-6.

Zhang C, Fan L, Fan S, Wang J, Luo T, Tang Y, Chen Z, Yu L. Cinnamomum cassia Presl: A review of its traditional uses, phytochemistry, pharmacology and toxicology. Molecules. 2019; 24(19): 3473.

Choudhary M, Kumar V, Malhotra H, Singh S. Medicinal plants with potential anti-arthritic activity. J Intercult Ethnopharmacol. 2015; 4(2): 147.

Wang Y, Chen S, Du K, Liang C, Wang S, Boadi EO, Li J, Pang X, He J, Chang YX. Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis. J Ethnopharmacol. 2021; 279: 114368.

Funk JL, Frye JB, Oyarzo JN, Chen J, Zhang H, Timmermann BN. Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis. Pharma Nutrition. 2016; 4(3):123-131.

Mandal S, Vishvakarma P, Verma M, Alam MS, Agrawal A, Mishra A. Solanum Nigrum Linn: An Analysis of The Medicinal Properties Of The Plant. J Pharm Negat. 2023; 14(2): 1595-1600.

Milella RA, Basile T, Alba V, Gasparro M, Giannandrea MA, Debiase G, Genghi R, Antonacci D. Optimized ultrasonic-assisted extraction of phenolic antioxidants from grape (Vitis vinifera L.) skin using response surface methodology. J Food Sci Technol. 2019; 56(10): 4417-4428.

Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007; 7(3): 344-351.

Chauhan R, Singh V, Bajaj H, Chauhan SB. Cat’s claw: a miracle herb from the rain forest of Peru. Indian J Drugs. 2015; 3(4): 96-101.

Sharma AK, Basu I, Singh S, Ekanayake S, Manoharlal R, Mathew A, Kumar A, Sandhu SS. Withania somnifera (Ashwagandha): From Traditional System of Medicine to Modern Pharmacology and Biotechnology. Herb Med Treat Various Dis. 2021; 1-34.

Siddiqui MZ. Boswellia serrata, a potential anti-inflammatory agent: an overview. Indian J Pharm Sci. 2011; 73(3): 255.

Gxaba N, Manganyi MC. The Fight against Infection and Pain: Devil's Claw (Harpagophytum procumbens) a Rich Source of Anti-Inflammatory Activity: 2011-2022. Molecules. 2022; 27(11):3637.

Takada Y, Ichikawa H, Badmaev V, Aggarwal BB. Acetyl-11-keto-?-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-?B and NF-?B-regulated gene expression. J Immunol. 2006; 176(5):3127-3140.

Zhang Y, Mao X, Li W, Chen W, Wang X, Ma Z, Lin N. Tripterygium wilfordii: an inspiring resource for rheumatoid arthritis treatment. Med Res Rev. 2021; 41(3): 1337-1374.

Mncwangi N, Chen W, Vermaak I, Viljoen AM, Gericke N. Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. J Ethnopharmacol. 2012; 143(3):755-771.

Fiebich BL, Grozdeva M, Hess S, Hull M. Potential application of natural compounds in inflammatory bowel disease, arthritis, and wound healing. Curr Pharm Des. 2012; 18(6): 976-992.

Guha P, Paul S, Das A, Halder B, Bhattacharjee S, Chaudhuri TK. Analyses of human and rat clinical parameters in rheumatoid arthritis raise the possibility of use of crude Aloe vera gel in disease amelioration. Immunome Res. 2014; 10(2):1-7.

Akbar S. Cannabis sativa L. (Cannabaceae) (Syn.: C. indica Lam.). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications. 2020; 491-497.

Abbasi M, Mousavi MJ, Jamalzehi S, Alimohammadi R, Bezvan MH, Mohammadi H, Aslani S. Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol. 2019; 234(7): 10018-10031.

Grzanna R, Lindmark L, Frondoza CG. Ginger—an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005;8(2):125–132.

Sheng S, Wang X, Liu X, Hu X, Shao Y, Wang G, Mao D, Li C, Chen B, Chen X. The role of resveratrol on rheumatoid arthritis: From bench to bedside. Front Pharmacol. 2022; 13:829677. https://doi.org/10.3389/fphar.2022.829677. PMID: 36105210; PMCID: PMC9465647.

Gheorghe KR, Korotkova M, Catrina AI, Backman L, AfKlint E, Claesson HE, Rådmark O, Jakobsson PJ, Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids. Arthritis Res Ther. 2009; 11: 1-11.

Prabhakaran Y, Dinakaran SK, Macharala SP, Ghosh S, Karanam SR, Kanthasamy N, Avasarala H. Molecular docking studies of withanolides against Cox-2 enzyme. Pak J Pharm Sci. 2012; 25(3): 595-598.

Guo C, He L, Hu N, Zhao X, Gong L, Wang C, Peng C, Li Y. Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1?-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-?B and MAPKs signaling pathways and inducing apoptosis. Cytokine. 2022; 151: 155809.

Afifah S, Lukiati B, Maslikah SI. The potentials of red betel (Piper crocatum Ruiz & Pav) terpenoid compounds as Microsomal Prostaglandin E Synthase-1 (mPGES-1) enzyme inhibitor of rheumatoid arthritis through virtual screening. In AIP Conference Proceedings. 2020; 2231(1): 040023). AIP Publishing LLC.

Zhai KF, Duan H, Khan GJ, Xu H, Han FK, Cao WG, Gao GZ, Shan LL, Wei ZJ. Salicin from Alangiumchinense ameliorates rheumatoid arthritis by modulating the Nrf2-HO-1-ROS pathways. J Agric Food Chem. 2018; 66(24): 6073-6082.

Zhao L, Wang L, Di SN, Xu Q, Ren QC, Chen SZ, Huang N, Jia D, Shen XF. Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon ?-activated murine macrophages and animal models of inflammation. Biomed Pharmacother. 2018; 105: 606-615.

Schopohl P, Grüneberg P, Melzig MF. The influence of harpagoside and harpagide on TNF?-secretion and cell adhesion molecule mRNA-expression in IFN?/LPS-stimulated THP-1 cells. Fitoterapia. 2016; 110:157-165.

Dai Q, Zhou D, Xu L, Song X. Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Dev Ther. 2018; 4095-4105.

Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M. The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. J Nat Med. 2019; 73: 59-66.

Wang LL, Zhao R, Li JY, Li SS, Liu M, Wang M, Zhang MZ, Dong WW, Jiang SK, Zhang M, Tian ZL. Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing. European J Pharmacol. 2016; 786:128-136.

Huang M, Wu K, Zeng S, Liu W, Cui T, Chen Z, Lin L, Chen D, Ouyang H. Punicalagin inhibited inflammation and migration of fibroblast-like synoviocytes through NF-?B pathway in the experimental study of rheumatoid arthritis. J Inflamm Res. 2021; 14:1901.

Li X, Wang Y. Cinnamaldehyde attenuates the progression of rheumatoid arthritis through down-regulation of PI3K/AKT signaling pathway. Inflammation. 2020; 43(5): 1729-1741.

Sharma D, Chaubey P, Suvarna V. Role of natural products in alleviation of rheumatoid arthritis—A review. Journal of food biochemistry. 2021; 45(4):e13673.

Marino A, Paterniti I, Cordaro M, Morabito R, Campolo M, Navarra M, Esposito E, Cuzzocrea S. Role of natural antioxidants and potential use of bergamot in treating rheumatoid arthritis. PharmaNutrition. 2015; 3(2):53-9.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat prod. 2007; 70(3):461-77.

Skoczy?ska M, ?wierkot J. The role of diet in rheumatoid arthritis. Reumatologia/Rheumatology. 2018; 56(4):259-67.

Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ, Sung MS, Yoo HG, Yoo WH. Kaempferol inhibits IL-1?-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. Int J Mol Med. 2013; 32(4):971-7.

Shin GC, Kim C, Lee JM, Cho WS, Lee SG, Jeong M, Cho J, Lee K. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem-Biol Interact. 2009; 182(1):29-36.

Dudics S, Langan D, Meka RR, Venkatesha SH, Berman BM, Che CT, Moudgil KD. Natural products for the treatment of autoimmune arthritis: their mechanisms of action, targeted delivery, and interplay with the host microbiome. Int J Mol Sci. 2018; 19(9):2508.

Cai M, Ni WJ, Han L, Chen WD, Peng DY. Research progress of therapeutic enzymes and their derivatives: based on herbal medicinal products in rheumatoid arthritis. Front Pharmacol. 2021; 12:626342.

Downloads

Published

05-09-2023

Versions

23-09-2023 (2)
05-09-2023 (1)

How to Cite

Singh A, Kaushik M, Sinha S, Kachhap Oraon RK, Sharma N, Rautela I. Herbal Allies for Rheumatoid Arthritis: A Comprehensive Review of Natural Products. Plant Sci. Today [Internet]. 2023 Sep. 5 [cited 2024 Nov. 21];. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/2569

Download Citation

Issue

Early Access

Section

Special issue on Mini Reviews

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright and Licence details of published articles

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Open Access Policy

Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).