Moringa oleifera Lam.: A comprehensive review on its potential for diabetes management and beyond
DOI:
https://doi.org/10.14719/pst.3458Keywords:
Moringa oleifera, diabetes, insulin, cosmeticAbstract
Diabetes is a metabolic disease characterized by deregulated insulin levels and hyperglycemia. The global healthcare system widely acknowledges the use of medicinal plants as therapeutic agents. One such traditional plant with antidiabetic properties is Moringaoleifera, which has been used for centuries.M.oleifera,due to its important bioactive compounds such asflavonoid, carotenoidandpolyphenols,is used totreatvariousailments,includingdiabetes, cancer, kidney problemsandbacterial and viral infections. This review summarizes the applications of M.oleiferaanditsmechanismsforpreventingdiabetes. Additionally, it explores the influences of M.oleifera in treating diabetes, with a specific focus on its mechanism and effectiveness in reducing insulin levels and managing the conditions. The objectives of this review aretopresentsthe most recent information and elucidate the mechanism by which M.oleiferapreventsdiabetes. Additionally, it provides a thorough analysis of M.oleifera’sapplicationsasanatural treatment and its industrial uses. The reviewhighlightscurrentknowledge gapsandsuggests areas for further research. In conclusion, this study enhancesourunderstanding of the comprehensive applications of M.oleifera,advancing knowledge and help to preventdiabetes-related complications.
Downloads
References
He B sai, Wang X, Zhang Y, Gao C, Wu C kai, Guo S ruiet al. Anti-oxidant, anti-inflammatory and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin. Journal of Functional Foods Journal. 2022;95(June):105168. https://doi.org/10.1016/j.jff.2022.105168
Liu R, Liu J, Huang Q, Liu S, Jiang Y. Moringa oleifera: A systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity. Journal of Pharmacy and Pharmacology. 2022;74(3):296-320. https://doi.org/10.1093/jpp/rgab131
Padayachee B, Baijnath H. An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of Moringa oleifera. South African Journal of Botany. 2020;129:304-16. Available from: https://doi.org/10.1016/j.sajb.2019.08.021
Gharsallah K, Rezig L, Msaada K, Chalh A, Soltani T. Chemical compositionand profile characterization of moringa oleifera seed oil. South African Journal of Botany. 2021;137:475-82. https://doi.org/10.1016/j.sajb.2020.11.014
Ayobami AL, Kade EA, Oladimeji KA, Kehinde S, Gurpreet K. Anti-diabetic potential of aqueous extract of Moringa oleifera , Ocimum gratissimum and Vernonia amygdalina in alloxan-induced diabetic rats. BioRxiv Journal.2020;https://doi.org/10.1101/2020.08.09.242941
Meireles D, Gomes J, Lopes L, Hinzmann M, Machado J. A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: Integrative approach on conventional and traditional Asian medicine. Advances in Traditional Medicine. 2020;20(4):495-515. Available from: https://doi.org/10.1007/s13596-020-00468-0
Su X, Lu G, Ye L, Shi R, Zhu M, Yu X et al. Moringa oleifera Lam.: A comprehensive review on active components, health benefits and application. Royal Society of Chemistry. 2023;13(35):24353-84. DOI: 10.1039/d3ra03584k
Mthiyane FT, Dludla PV, Ziqubu K. A review on the antidiabetic properties of Moringa oleiferaextracts?: Focusing on oxidative stress and inflammation as main therapeutic targets.Frontiers in Pharmacology. 2022July; Volume 13:Article 940572. doi: 10.3389/fphar.2022.940572
Haryanti E, Kedokteran F, Wijaya U, Surabaya K. The use of Moringa oleiferapowder to prevent pancreatic organ cell damage in pregnant mice with Diabetes mellitus.International Journal of Current Science Research and Review. 2022;05(04):952-57. DOI: 10.47191/ijcsrr/V5-i4-11
Luthfiyani D, Pradana C, Rahmi EP, Muti AF. Hypoglycemic effect of Moringa oleiferaaqueous extract in diabetic animal studies?: A mechanisms review.Advances in Health Sciences Research. 2021;33(ICoSIHSN 2020):620-24. https://doi.org/10.2991/ahsr.k.210115.117
Lam M, Aziz I, Saqib QN, Younus M, Ali E, Imran Met al. Physicochemical , antidiarrheal and antidiabetic potential of super food ( Moringa oleifera Lam .). Pakistan Journal of Pharmaceutical Sciences. 2021;(March):723-29. doi.org/10.36721/PJPS.2021.34.2.SUP.723-729.1
Nilamsari RV, Adharini WI, Lestari ND, Tsuboi H, Rifa M. Combination Moringa oleifera extract and ifalmin as potential formulation of preventing inflammation in diabetic mice model.The Journal of Experimental Life Sciences. 2020;10(1). https://doi.org/10.21776/ub.jels.2019.010.01.07
Anthonia A, Chuks N, Amarachi C ndukwe P, Nnah IS. Serum biochemical changes in alloxan-induced diabetic rats and ameliorative effects of Moringa oleifera and Morinda lucidaleaf extracts. Traditional Medicine Journal. 2022April;27:15-23. DOI: 10.22146/mot.69945
Nwanjo HU, Nwosu DC, Obeagu EI. Evaluation of enzyme antioxidants in streptozocin induceddiabetic rats treated with Moringa oleifera leaf powder . European of Biomedical and Pharmaceutical Sciences. 2020November;7(11):285-88.
Waterman C, Graham JL, Arnold CD, Stanhope KL, Tong JH, Jaja-chimedza Aet al. Moringa isothiocyanate-rich seed extract delays the onset of diabetes in UC davis type-2 Diabetes mellitus rats. Scientific Reports. 2020;1-7. Available from: http://dx.doi.org/10.1038/s41598-020-65722-6
Akhtar N, Hayee S, Nawaz F, Idnan M. Awareness regarding dengue prevention and control in periurban union councils of Tehsil Rawalpindi.Pakistan Biomedical Journal.2022;(c):10-3. DOI:https://doi.org/10.54393/pbmj.v5i1.237
Laksmitawati D, Marwati U, Widowati W, Noverina R, Suciati T, Faried A. Combined treatment effect of topical CM-hWJMSCs and oral Moringa oleifera extract on wound healing of diabetic rat. Journal of Medical Sciences. 2023;11:23-30.https://doi.org/10.3889/oamjms.2023.7551
Mansour M, Arisha A, AlGamal M, Elsayed A, Saad S, El Bohi K. Effect of Moringa oleifera leaves extract-senps conjugate administration on testicular toxicity induced by melamine in rats. Zagazig Veterinary Journal. 2020 Jun 1;48(2):213-27.https://doi.org/10.21608/zvjz.2020.20447.1089
Ruth OO. In vitro inhibitory potentials of ethanolic extract of Moringa oleifera flower against enzymes activities linked to diabetes. Journal of Herbmed Pharmacology. 2021;10(4):408-14. doi: 10.34172/jhp.2021.48
Elendu MU, Uko OE, Kalu AA, Barry IC. Ameliorative effect of aqueous leaf extract of Moringa oleifera on diabetes induced appetite and testicular weight loss in wistar rats. GSC Advanced Research and Reviews. 2022;2-5. https://doi.org/10.30574/gscarr.2022.13.1.0249
Sissoko L, Diarra N, Nientao I, Stuart B, Togola A, Willcox MLet al. Moringa oleifera leaf powder for type 2 diabetes?: A pilot clinical trial.Journal Complement Alternal Medical. 2020;17:29-36. https://doi.org/10.21010/ajtcam.v17i2.3
Aljazzaf B, Regeai S, Elghmasi S, Alghazir N, Balgasim A, Ismail IMH et al. Evaluation of antidiabetic effect of combined leaf and seed extracts of Moringa oleifera (Moringaceae) on alloxan-induced diabetes in mice?: A biochemical and histological study.Oxidative Medicine and Cellular Longevity. 2023;2023. https://doi.org/10.1155/2023/9136217
Akter T, Rahman MA, Moni A, Apu MAI, Fariha A, Hannan MAet al. Prospects for protective potential of Moringa oleifera against kidney diseases. Plants. 2021;10(12). doi.org/10.3390/plants10122818
Barhoi D, Upadhaya P, Barbhuiya SN, Giri A, Giri S. Aqueous extract of Moringa oleiferaexhibit potential anticancer activity and can be used as a possible cancer therapeutic agent: A study involving in vitro andin vivoapproach.Journal of the American College of Nutrition. 2021;40(1):70-85. Available from: https://doi.org/10.1080/07315724.2020.1735572
Moremane MM, Abrahams B, Tiloke C. Moringa oleifera: A review on the antiproliferative potential in breast cancer cells. Current Issues in Molecular Biology. 2023;45(8):6880-902. doi.org/10.3390/cimb45080434
Mumtaz MZ, Kausar F, Hassan M, Javaid S, Malik A. Anticancer activities of phenolic compounds from Moringa oleifera leaves: In vitro and in silico mechanistic study. Mumtaz et al. Beni-Suef University Journal of Basic and Applied Sciences. 2021;10(1).https://doi.org/10.1186/s43088-021-00101-2
Sultan R, Ahmed A, Wei L, Saeed H, Islam M, Ishaq M. The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches. BMC Complementary Medicine and Therapies. 2023;23(1):1-17. https://doi.org/10.1186/s12906-023-04198-z
Akintelu SA, Folorunso AS, Oyebamiji AK. Phytochemical and antibacterial investigation of Moringa oleifera seed: Experimental and computational approaches. Eclética Química Journal. 2021;46(2):17-25. DOI: 10.26850/1678-4618eqj.v46.2.2021.p17-25
Santos LMM, Silva PM, Moura MC, Carvalho Junior AR, Amorim PK, Procópio TFet al. Anti-candida activity of the water-soluble lectin from Moringa oleifera seeds (WSMoL). Journal de Mycologie Medicale. 2021;31(2). https://doi.org/doi:10.1016/j.mycmed.2020.101074
Fajri M. The potential of Moringa oleifera as immune booster against COVID 19. Earth and Environmental Science. 2021;807(2):17-21. doi:10.1088/1755-1315/807/2/022008
Athikomkulchai S, Tunit P, Tadtong S, Jantrawut P, Sommano SR, Chittasupho C. Moringa oleifera seed oil formulation physical stability and chemical constituents for enhancing skin hydration and antioxidant activity. Cosmetics. 2021;8(1):1-18. https://doi.org/ 10.3390/cosmetics8010002
Bhalla N, Ingle N, Patri SV, Haranath D. Phytochemical analysis of Moringa Oleifera leaves extracts by GC-MS and free radical scavenging potency for industrial applications. Saudi Journal of Biological Sciences. 2021;28(12):6915-28. https://doi.org/10.1016/j.sjbs.2021.07.075
Xu Y, Chen G, Guo M. Potential anti-aging components from Moringa oleifera leaves explored by affinity ultrafiltration with multiple drug targets. Frontiers in Nutrition. 2022;9(May):1-13. doi: 10.3389/fnut.2022.854882
Llorent-Martínez EJ, Gordo-Moreno AI, Fernández-de Córdova ML, Ruiz-Medina A. Preliminary phytochemical screening and antioxidant activity of commercial Moringa oleiferafood supplements. Antioxidants. 2023;12(1). doi.org/10.3390/antiox12010110
Hodas F, Zorzenon MRT, Milani PG. Moringa oleifera potential as a functional food and a natural food additive: A biochemical approach. Annals of the Brazilian Academy of Sciences. 2021;93:1-18. DOI 10.1590/0001- 3765202120210571.
Valdivié-Navarro M, Martínez-Aguilar Y, Mesa-Fleitas O, Botello-León A, Betancur Hurtado C, Velázquez-Martí B. Review of Moringa oleifera as forage meal (leaves plus stems) intended for the feeding of non-ruminant animals. Animal Feed Science and Technology. 2020February;260:114338. https://doi.org/10.1016/j.anifeedsci.2019.114338
Nudel A, Cohen R, Abbo S, Kerem Z. Developing a nutrient-rich and functional wheat bread by incorporating Moringa oleifera leaf powder and gluten. Food Science and Technology. 2023May;187:115343. Available from: https://doi.org/10.1016/j.lwt.2023.115343
Mashamaite CV, Pieterse PJ, Mothapo PN, Phiri EE. Moringa oleifera in South Africa: A review on its production, growing conditions and consumption as a food source. South African Journal of Science. 2021;117(3-4):1-7. https://doi.org/10.17159/ sajs.2021/8689
Ueda Yamaguchi N, Cusioli LF, Quesada HB, Camargo Ferreira ME, Fagundes-Klen MR, Salcedo Vieira AMet al. A review of Moringa oleifera seeds in water treatment: Trends and future challenges. Process Safety andEnvironmental Protection. 2021April;147:405-20. https://doi.org/10.1016/j.psep.2020.09.044
Hamadeen HM, Elkhatib EA, Badawy MEI, Abdelgaleil SAM. Green low cost nanomaterial produced from Moringa oleifera seed waste for enhanced removal of chlorpyrifos from wastewater: Mechanism and sorption studies. Journal of Environmental Chemical Engineering. 2021;9(4):105376. Available from: https://doi.org/10.1016/j.jece.2021.105376
Alam MW, Pandey P, Khan F, Souayeh B, Farhan M. Study to investigate the potential of combined extract of leaves and seeds of Moringa oleifera in groundwater purification. International Journal of Environmental Research and Public Health. 2020;17(20):1-13. doi:10.3390/ijerph17207468
Islam Z, Islam SMR, Hossen F, Mahtab-Ul-Islam K, Hasan MR, Karim R. Moringa oleifera is a prominent source of nutrients with potential health benefits. International Journal of Food Science. 2021;2021(June 2013). https://doi.org/10.1155/2021/6627265
Ma ZF, Ahmad J, Zhang H, Khan I, Muhammad S. Evaluation of phytochemical and medicinal properties of Moringa (Moringa oleifera) as a potential functional food. South African Journal of Botany journal. 2020;129:40-46. https://doi.org/10.1016/j.sajb.2018.12.002
Fu X, Su J, Hou L, Zhu P, Hou Y, Zhang Ket al. Physicochemical and thermal characteristics of Moringa oleifera seed oil. Advanced Composites and Hybrid Materials. 2021;4(3):685-95. Available from: https://doi.org/10.1007/s42114-021-00302-4
Mohanty M, Mohanty S, Bhuyan SK, Bhuyan R. Phytoperspective of Moringa oleifera for oral health care: An innovative ethnomedicinal approach. Phytotherapy Research. 2021;35(3):1345-57. https://doi.org/10.1002/ptr.6896
García P, Peñalver R, Nieto G. Beneficios para la salud de los usos y aplicaciones de Moringa oleifera en productos de panadería. Plants. 2021;1-17. https://www.mdpi.com/2223-7747/10/2/318/htm#B6-plants-10-00318. https://doi.org/10.3390/plants10020 318
Alia F, Putri M, Anggraeni N, Syamsunarno MRAA. The potency of Moringa oleifera Lam. as protective agent in cardiac damage and vascular dysfunction. Frontiers in Pharmacology. 2022;12(January):1-18. doi: 10.3389/fphar.2021.724439
Granella SJ, Bechlin TR, Christ D, Coelho SRM, Paz CH de O. An approach to recent applications of Moringa oleifera in the agricultural and biofuel industries. South African Journal of Botanyt. 2021;137:110-16. https://doi.org/10.1016/j.sajb.2020.10.006
Gu X, Yang Y, Wang Z. Nutritional, phytochemical, antioxidant, ?-glucosidase and ?-amylase inhibitory properties of Moringa oleifera seeds.South African Journal of Botany. 2020;133(October 2015):151-60. Available from: https://doi.org/10.1016/j.sajb.2020.07.021
Chen GL, Xu YB, Wu JL, Li N, Guo MQ. Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents. Food Chemistry. 26 2020;333. https://doi.org/10.1016/j.foodchem.2020.127478
Anzano A, Ammar M, Papaianni M, Grauso L, Sabbah M, Capparelli Ret al. Moringa oleifera Lam.: A phytochemical and pharmacological overview. Horticulturae. 2021;7(10):1-25. doi.org/10.3390/horticulturae7100409
Giuberti G, Rocchetti G, Montesano D, Lucini L. The potential of Moringa oleifera in food formulation: A promising source of functional compounds with health-promoting properties. Current Opinion in Food Science. 2021;42:257-69. https://doi.org/10.1016/j.cofs.2021.09.001
Mubeen N, Mona Hassan S, Sharif Mughal S, Khurram Hassan S, Ibrahim A, Hassan Het al. Vitality and implication of natural products from Moringa oleifera: An eco-friendly approach. Computational Biology and Bioinformatics. 2020;8(2):72. doi: 10.11648/j.cbb.20200802.16
Ramamurthy S, Thiagarajan K, Varghese S, Rajeshkumar, Karthick BP, Varadarajan Set al. Assessing the in vitroantioxidant and anti-inflammatory activity of Moringa oleiferacrude extract. The Journal of Contemporary Dental Practice. 2022;23(4):437-42. https://doi.org/10.5005/jp-journals-10024-3323
Jadhav V, Bhagare A, Ali IH, Dhayagude A, Lokhande D, Aher Jet al. Role of Moringa oleifera on green synthesis of metal/metal oxide nanomaterials. Journal of Nanomaterials. 2022;2022. https://doi.org/10.1155/2022/2147393
Yang M, Tao L, Kang XR, Li LF, Zhao CC, Wang ZLet al. Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities. Food Chemistry: X. 2022;14(May):100322. https://doi.org/10.1016/j.fochx.2022.100322
Avilés-Gaxiola S, León-Félix J, Jiménez-Nevárez YB, Angulo-Escalante MA, Ramos-Payán R, Colado-Velázquez Jet al. Antioxidant and anti-inflammatory properties of novel peptides from Moringa oleifera Lam. leaves. South African Journal of Botany. 2021;141:466-73. https://doi.org/10.1016/j.sajb.2021.05.033
Nwachukwu CF. Partial elucidation on the remedial effect of stem-bark extract of Moringa oleifera on diabetic rats. GSC Biological and Pharmaceutical Sciences. 2021;15(02):111-16. DOI: https://doi.org/10.30574/gscbps.2021.15.2.0118
Gondo HK. Moringa oleifera decrease blood sugar level and blood pressure in pregnant diabetic rats. Journal of Advanced Pharmacy Education and Research. 2021;11(2):88-91. https://doi.org/10.51847/FDGccLKxoF
Jayamol MANU, Ashley R, Nithya J, Shijina S. Effect of combination of aqueous leaf extracts of Psidium guajavaLinn. and Moringa oleifera Lam. on diabetes mellitus.International Journal of Pharmacy and Pharmaceutical Sciences. 2020;12(7):2-5. DOI: http://dx.doi.org/10.22159/ijpps.2020v12i7.36823
Onyeabo C, Anyiam PN, Egbuonu ACC, Odika C, Egba SI, Nnana OOet al. Natural products-characterized Moringa oleifera leaves methanolic extract and anti-diabetic properties mechanisms of its fractions in streptozotocin-induced diabetic rats. The Nigerian Journal of Pharmacy.2022;18-29. https://doi.org/10.51412/psnnjp.2022.2
Alshalmani SK. Phytochemical screening, antibacterial and anti-diabetic activities of Moringa oleifera cultivated in east region of Libya. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2021;1(4):15-19. https://doi.org/10.5281/zenodo.58059027
Sonia G, Ligia ED, Jurado C, Iturmendi N, Nova E. Moringa oleiferaleaf supplementation as a glycemic control strategy in subjects with prediabetes. Nutrients. 2022;1-15. https://doi.org/10.3390/nu14010057
Ayuwardani N, Hariningsih Y. Effectiveness of combination of Moringaleaf extract (Moringa oleifera Lamk.) and papaya seed extract (Carica papaya L .) in reducing blood sugar levels of diabetic rats. Pharmacy Education. 2021;21:215-19. https://doi.org/10.46542/pe.2021.212.215219
Gopalakrishnan L, Doriya K, Santhosh D. Moringa oleifera?: A review on nutritive importance and its medicinal application. Food Science and Human Wellness. 2016;5(2):49-56. http://dx.doi.org/10.1016/j.fshw.2016.04.001
T Setyawati, R Adawiyah, RM Walanda, Riski, R Chandra. Effectiveness of Moringa oleifera on triglyceride levels in diabetic wistar rats (Rattus norvegicus) induced with streptozotocin (STZ). Earth and Environmental Science. 2022;1075:012020. doi:10.1088/1755-1315/1075/1/012020
Trigo C, Castelló ML, Soriano MDOMD, García-Mares FJ, Soriano MD. Moringa oleifera?: An unknown crop in developed countries change. Foods. 2021;10(1):31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824577/
Li C, Dong Z, Zhang B, Huang Q, Liu G, Fu X. Structural characterization and immune enhancement activity of a novel polysaccharide from Moringa oleifera leaves. Carbohydrate Polymers. 2020;234:115897. https://doi.org/10.1016/j.carbpol.2020.115897
Xiao X, Wang J, Meng C, Liang W, Wang T, Zhou Bet al. Moringa oleifera Lam. and its therapeutic effects in immune disorders. Frontiers in Pharmacology. 2020December;11:1-9. doi: 10.3389/fphar.2020.566783
Kerdsomboon K, Chumsawat W, Auesukaree C. Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals and metalloid in Saccharomyces cerevisiae. Chemosphere. 2021;270(xxxx):128659. https://doi.org/10.1016/j.chemosphere.2020.128659
Omodanisi EI, Aboua GY, Oguntibeju OO. Therapeutic potentials and pharmacological properties of Moringa oleifera Lam. in the treatment of diabetes mellitus and related complications. Tropical Journal of Pharmaceutical Research. 2017July;16:1737-46. http://dx.doi.org/10.4314/tjpr.v16i7.35
Jamil Ahmad, Imran Khan, Renald Blundell. Moringa oleifera and glycemic control?: A review of current evidence and possible mechanisms. Phytotherapy Research. 2019March;1-8. DOI: 10.1002/ptr.6473
Downloads
Published
Versions
- 18-08-2024 (2)
- 11-08-2024 (1)
How to Cite
Issue
Section
License
Copyright (c) 2024 Rahmatullah Kazimi, Deepika Saxena
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).