Evaluation of the anti-diabetic potential of aqueous extract of Clerodendrum infortunatum L. in vivo in streptozotocin-induced diabetic Wistar rats
DOI:
https://doi.org/10.14719/pst.2019.6.1.415Keywords:
Complementary and alternative medicine, Clerodendrum infortunatum, diabetes, streptozotocinAbstract
Diabetes Mellitus, the metabolic syndrome where the body either fails to produce or effectively utilize insulin, is associated with chronic morbidity. While a definitive cure for the disease is lacking, with the modern medicine offering mainly the means to control the extent of the disease, Complementary and Alternative Medicine (CAMs) offers additional/alternate means to tackle the disease. On the other hand, the lack of evidenced medical practices is a lacuna in most of the traditional medical applications. Clerodendrum infortunatum.L (Lamiaceae family), a perennial shrub found in the tropics, has been known for its numerous pharmacological properties and is found as a constituent in many Ayurvedic and Siddha drugs, especially for skin and respiratory ailments. The plant has a noted potential as anti-hyperglycemic and has been found to be used in traditional medicine for the treatment of diabetes. However, evidence based evaluations have not been conducted on the anti-hyperglycemic effect of the plant, especially with respect to the general mode of intake, i.e, the aqueous form. In the current study, the aqueous extract of C. infortunatum (CI), was scientifically assessed for its effect on streptozotocin induced diabetes in Wistar albino rats. The diabetic rats were divided into 5 groups of 6 animals each. For testing the efficacy of extracts, two groups were intra-orally provided with dosages of 200 mg/Kg and 400 mg/Kg of body weight of animals, respectively, of aqueous extracts of CI. Control groups were maintained for evaluation, which included vehicle control as well as with Glibenclamide, a standard anti-diabetic drug. The extracts at a dose of 400 mg/Kg body weight was found to be associated with significant amelioration of many of the diabetes induced conditions, suggesting that the plant extract could be a strong potential CAM candidate for therapeutic management of diabetes.
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References
2. American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2. In Standards of Medical Care in Diabetes—2017. Diabetes Care; 40 (Suppl. 1):S11–S24; 2017. https://doi.org/10.2337/dc17-S005
3. Chaudhury A, Duvoor C, Reddy DVS, Kraleti S, Chada A, Ravilla R, Marco A, Shekhawat NS, Montales MT, Kuriakose K, Sasapu A, Beebe A, Patil N, Musham CK, Lohani GP, Mirza W. Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Front Endocrinol (Lausanne) 2017; 8: 6. https://dx.doi.org/10.3389%2Ffendo.2017.00006
4. Nahas R, Moher M. Complementary and alternative medicine for the treatment of type 2 diabetes. Canadian Family Physician 2009;55(6):591-596.
5. Clerodendrum infortunatum L. India Biodiversity Portal [online]; [cited 1 Aug 2018]. Available from http://indiabiodiversity.org/species/show/251172
6. Das B, Pal D, Haldar A. A review on biological activities and medicinal properties of Clerodendrum infortunatum Linn. International Journal Of Pharmacy And Pharmaceutical Sciences 2014;6(10): 41-43.
7. Bhattacharjee D, Das A, Kanti Das S, Sindhu Chakraborthy G. Clerodendrum Infortunatum Linn.: A Review. Journal Of Advances In Pharmacy And Healthcare Research 2011;1(3):82-85.
8. Nanda GC, Padhi MM, Pathak NN, Chopra KK. Screening of Madhumehagna (anti-diabetic) plants in Vrihattrayee. Bull. Ind. Ins. Hist. Med. 2000; 30:15-26.
9. Thakkar Jalaram H, Solanki Ajit N, Solanki Himanshu K, Santani DD. Ayurvedic plants used in diabetes mellitus: a systematic review. Elixir Pharmacy 2011;37A:4123-4131.
10. Das S, Bhattacharya S, Prasanna A, Suresh Kumar R, Pramanik G, Haldar P. Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats. Diabetes Therapy 2011;2(2):92-100. https://dx.doi.org/10.1007%2Fs13300-010-0019-z
11. Nurdiana S, Goh YM, Ahmad H, Dom SM, Azmi NSA, Zin NSNM, Ebrahimi M. Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. BMC complementary and alternative medicine 2017;17(1):290. https://doi.org/10.1186/s12906-017-1762-8
12. Wachtel-Galor S, Benzie IFF. Herbal Medicine: An Introduction to Its History, Usage, Regulation, Current Trends, and Research Needs. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 1. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92773
13. Rather MA, Bhat BA, Qurishi MA. Multicomponent phytotherapeutic approach gaining momentum: Is the “one drug to fit all” model breaking down?. Phytomedicine 2013;21(1):1-14. https://doi.org/10.1016/j.phymed.2013.07.015
14. Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134(Suppl-12):3479S-3485S. https://doi.org/10.1093/jn/134.12.3479S
15. Bösenberg LH, van Zyl DG. The mechanism of action of oral antidiabetic drugs: A review of recent literature, Journal of Endocrinology, Metabolism and Diabetes of South Africa 2008;13(3):80-88. https://doi.org/10.1080/22201009.2008.10872177
16. Bodeker G, Burford G, editors. Traditional, complementary and alternative medicine: policy and public health perspectives. World Scientific Publishing Co. Ltd. 2007; p. 104-105. https://doi.org/10.1142/p419
17. WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues [online]; [cited 1 Aug 2018]. Available from http://apps.who.int/medicinedocs/documents/s14878e/s14878e.pdf
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