DNA polymerase ? - a novel DNA repair enzyme in higher plant genome

Authors

  • Sujit Roy Department of Chemistry, Bose Institute, 93/1 A.P.C Road, Kolkata 700009, West Bengal, India

DOI:

https://doi.org/10.14719/pst.2014.1.3.59

Keywords:

Arabidopsis thaliana, oxidant stress, plant growth

Abstract

DNA polymerase lambda (Pol ?) is a novel family X DNA polymerase which has been shown to play key role in nuclear DNA repair and meiotic recombination. Recent studies in mammals support function of this enzyme in base excision repair in response to oxidative DNA damage. However, in plants the biological function of Pol ? in oxidative stress response is still largely unknown. This review will survey recent advances in our understanding of role of Pol ? in repair of oxidative DNA damages and its possible potential involvement in plant’s base excision repair (BER) pathway in response to oxidative stress.

Downloads

Download data is not yet available.

Author Biography

Sujit Roy, Department of Chemistry, Bose Institute, 93/1 A.P.C Road, Kolkata 700009, West Bengal, India

Research Scientist, C/O Prof. K.P. Das, Protein Structural Biology Lab, Department of Chemistry, Bose Institute, 93/1 A.P.C Road, Kolkata 700009, West Bengal, India

References

Amoroso, A., Concia, L., Maggio, C., Raynaud, C., Bergounioux, C., Crespan, E., … Maga, G. (2011). Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase ? and proliferating cell nuclear antigen 2. Plant Cell, 23, 806-822 http://dx.doi.org/10.1105/tpc.110.081455 PMid:21325140 PMCid:PMC3077771.

Barone, F., McCulloch, S. D., Macpherson, P., Maga, G., Yamada, M., Nohmi, T., … Bignami, M. (2007). Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. DNA Repair, 6, 355-366 http://dx.doi.org/10.1016/j.dnarep.2006.11.002 PMid:17188944 PMCid:PMC2111060.

Britt, A. B. (2002). Repair of damaged bases. In The Arabidopsis Book (Somerville, C. and Meyerowitz, E.M., eds). Rockville, MD: American Society of Plant Biologists, http://dx.doi.org/10.1111/tab.0005

Chen, H., Chu, P., Zhou, Y., Li, Y., Liu, J., Ding, Y., … & Huang, S. (2012). Overexpression of AtOGG1, a DNA glycosylase/AP lyase, enhances seed longevity and abiotic stress tolerance in Arabidopsis. Journal of Experimental Botany, 63, 4107-21 http://dx.doi.org/10.1093/jxb/ers093 PMid:22473985.

Collins, A. R. (1999). Oxidative DNA damage, antioxidants, and cancer. Bioessays, 21, 238-246 http://dx.doi.org/10.1002/(SICI)1521-1878(199903)21:3<238::AID-BIES8>3.0.CO;2-3

Cordoba-Canero, D., Morales-Ruiz, T., Roldan-Arjona, T., & Ariza, R. R. (2009). Single-nucleotide and long-patch base excision repair of DNA damage in plants. Plant Journal, 60, 716-728 http://dx.doi.org/10.1111/j.1365-313X.2009.03994.x PMid:19682284 PMCid:PMC2954439.

Crespan, E., Hübscher, U., & Maga, G. (2007). Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. Nucleic Acids Research, 35, 5173-5181. http://dx.doi.org/10.1093/nar/gkm568 PMid:17666409 PMCid:PMC1976453.

García-Díaz, M., Bebenek, K., Kunkel, T. A., & Blanco, L. (2001). Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. Journal of Biological Chemistry, 276, 34659-63. http://dx.doi.org/10.1074/jbc.M106336200 PMid:11457865.

García-Díaz, M., Bebenek, K., Sabariegos, R., Domínguez, O., Rodríguez, J., Kirchhoff, T., … Blanco, L. (2002). DNA Polymerase Lambda, a Novel DNA Repair Enzyme in Human Cells. Journal of Biological Chemistry, 277, 13184-13191. http://dx.doi.org/10.1074/jbc.M111601200 PMid:11821417.

García-Díaz, M., Domínguez, O., López-Fernández, L. A., Laín de Lera, T., Saníger, M. L., Ruiz, F. J., … Blanco, L. (2000). DNA polymerase lambda (Pol ?), a novel eukaryotic DNA polymerase with a potential role in meiosis. Journal of Molecular Biology, 301, 851-867. http://dx.doi.org/10.1006/jmbi.2000.4005 PMid:10966791.

Garcia-Ortiz, M. V., Ariza, R. R., & Roldan-Arjona, T. (2001). An OGG1 orthologue encoding a functional 8-oxoguanine DNA glycosylase/lyase in Arabidopsis thaliana. Plant Molecular Biology, 47, 795-804. PMid:11785940. http://dx.doi.org/10.1023/A:1013644026132

Gouet, P., Courcelle, E., Stuart, D., & Metoz, F. (1999). ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics, 15, 305-308. PMid:10320398. http://dx.doi.org/10.1093/bioinformatics/15.4.305

Hodges, D. M., Andrews, C. J., Johnson, D. A., & Hamilton, R. I. (1997) .Antioxidant enzyme and compound responses to chilling stress and their combining abilities in differentially sensitive maize hybrids. Crop Science, 37, 857-863. http://dx.doi.org/10.2135/cropsci1997.0011183X003700030027x.

Hübscher, U., & Maga, G. (2011). DNA replication and repair bypass machines. Current Opinion in Chemical Biology, 15, 627-635. http://dx.doi.org/10.1016/j.cbpa.2011.08.009 PMid:21889903.

Kimura, S., & Sakaguchi, K. (2006). DNA repair in plants. Chemical Reviews, 106, 753-766. PMid:16464023 http://dx.doi.org/10.1021/cr040482n

Kranner, I., Minibayeva, F. V., Beckett, R. P., & Seal, C. E. (2010). What is stress? Concepts, definitions and applications in seed science. New Phytologist, 188, 655-673. http://dx.doi.org/10.1111/j.1469-8137.2010.03461.x PMid:20854396.

Lee, J. W., Blanco, L., Zhou, T., Garcia-Diaz, M., Bebenek, K., Kunkel, T. A., … Povirk, L. F. (2004). Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. Journal of Biological Chemistry, 279, 805-811. http://dx.doi.org/10.1074/jbc.M307913200 PMid:14561766.

Maga, G., Villani, G., Crespan, E., Wimmer, U., Ferrari, E., Bertocci, B., & Hübscher, U. (2007). 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nature, 447, 606-608. http://dx.doi.org/10.1038/nature05843 PMid:17507928.

Markkanen, E., van Loon, B., Ferrari, E., Parsons, J. L., Dianov, G. L., & Hübscher, U. (2012). Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. Proceedings of National Academy of Sciences USA, 109, 437-442. http://dx.doi.org/10.1073/pnas.1110449109 PMid:22203964 PMCid:PMC3258598.

Picher, A. J., & Blanco, L. (2007). Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. DNA Repair, 6, 1749-1756. http://dx.doi.org/10.1016/j.dnarep.2007.06.007 PMid:17686665.

Ramadan, K., Shevelev, I., & Hübscher, U. (2004). The DNA-polymerase-X family: controllers of DNA quality? Nature Reviews Molecular Cell Biology, 5, 1038-1043. http://dx.doi.org/10.1038/nrm1530 PMid:15573140

Roldan-Arjona, T., & Ariza, R. R. (2009). Repair and tolerance of oxidative DNA damage in plants. Mutation Research, 681, 169-179. http://dx.doi.org/10.1016/j.mrrev.2008.07.003 PMid:18707020.

Roy, S., Roy Choudhury, S., Singh, S. K., & Das, K. P. (2011). AtPol ?, a homolog of mammalian DNA polymerase ? in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway. Plant Cell Physiology, 52, 448-467. PMid:21227935 http://dx.doi.org/10.1093/pcp/pcr002

Roy, S., Roy Choudhury, S., Singh, S. K., & Das, K. P. (2012). Functional analysis of light-regulated promoter region of AtPol ? gene. Planta, 235, 411-432. http://dx.doi.org/10.1007/s00425-011-1517-6 PMid:21947619.

Roy, S., Roy Choudhury, S., & Das, K. P. (2013a). The interplay of DNA polymerase ? in diverse DNA damage repair pathways in higher plant genome in response to environmental and genotoxic stress factors. Plant Signal Behaviour, 12/2012, 8(1).

Roy, S., Roy Choudhury, S., Sengupta, D. N., & Das, K. P. (2013b). Involvement of AtPol ? in repair of high salt and DNA cross linking agent induced double strand breaks in Arabidopsis thaliana. Plant Physiology, 162, 1195-1210. http://dx.doi.org/10.1104/pp.113.219022 PMid:23660835 PMCid:PMC3668049.

Sallon, S., Solowey, E., Cohen, Y., Korchinsky, R., Egli, M., Woodhatch, I., … & Kislev, M. (2008). Germination, genetics, and growth of an ancient date seed. Science, 320, 1464. http://dx.doi.org/10.1126/science.1153600 PMid:18556553.

Singhal, R. K., Prasad, R., & Wilson, S. H. (1995). DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. Journal of Biological Chemistry, 270, 949–957. http://dx.doi.org/10.1074/jbc.270.2.949 PMid:7822335.

Thompson, J., Higgins, D., & Gibson, T. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research, 22, 4673-4680. http://dx.doi.org/10.1093/nar/22.22.4673 PMid:7984417 PMCid:PMC308517.

Tuteja, N., Ahmad, P., Panda, B. B., & Tuteja, R. (2009). Genotoxic stress in plants: shedding light on DNA damage, repair and DNA repair helicases. Mutation Research, 681, 134-149. http://dx.doi.org/10.1016/j.mrrev.2008.06.004 PMid:18652913.

Uchiyama, Y., Kimura, S., Yamamoto, T., Ishibashi, T., & Sakaguchi, K. (2004). Plant DNA polymerase lambda, a DNA repair enzyme that functions in plant meristematic and meiotic tissues. European Journal of Biochemistry, 271, 2799-2807. http://dx.doi.org/10.1111/j.1432-1033.2004.04214.x PMid:15206945.

Waterworth, W. M., Drury, G. E., Bray, C. M., & West, C. E. (2011). Repairing breaks in the plant genome: the importance of keeping it together. New Phytologist, 192, 805-822. http://dx.doi.org/10.1111/j.1469-8137.2011.03926.x PMid:21988671.

Wimmer, U., Ferrari, E., Hunziker, P., & Hübscher, U. (2008). Control of DNA polymerase ? stability by phosphorylation and ubiquitination during the cell cycle. EMBO Reporter, 9, 1027-1033. http://dx.doi.org/10.1038/embor.2008.148 PMid:18688254 PMCid:PMC2572118.

Wise, R. R., & Naylor, A. W. (1987). Chilling-enhanced photooxidation: The peroxidative destruction of lipids during chilling injury to photosynthesis and ultrastructure. Plant Physiology, 83, 272-277. http://dx.doi.org/10.1104/pp.83.2.272 PMid:16665235 PMCid:PMC1056347.

Zucca, E., Bertoletti, F., Wimmer, U., Ferrari, E., Mazzini, G., Khoronenkova, S., … & Maga, G. (2013). Silencing of human DNA polymerase ? causes replication stress and is synthetically lethal with an impaired S phase checkpoint. Nucleic Acids Research, 41, 229-241. http://dx.doi.org/10.1093/nar/gks1016 PMid:23118481 PMCid:PMC3592438.

Downloads

Published

10-08-2014

How to Cite

1.
Roy S. DNA polymerase ? - a novel DNA repair enzyme in higher plant genome. Plant Sci. Today [Internet]. 2014 Aug. 10 [cited 2024 Nov. 17];1(3):140-6. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/59

Issue

Section

Mini Reviews