Anticoagulant, fibrinogenolytic and anti-platelet aggregation activities of Lablab purpureus (L.) Sweet seed radicle aqueous extract

Authors

DOI:

https://doi.org/10.14719/pst.2021.8.1.917

Keywords:

LPRE, Protease, Anticoagulant, Anti-platelet aggregation, Fibrinogenolytic

Abstract

The current study explores the anticoagulant, fibrinogenolytic and anti-platelet aggregation activities of Lablab purpureus (L.) Sweet seed radicle extract (LPRE). It is firstly reported that LPRE has protein at a concentration of 1.5 mg/ml and further evaluated for protein in gel electrophoresis. The proteolytic activity of LPRE was evaluated using casein and gelatin as substrate. LPRE showed a specific activity of 0.35 U. LPRE increased the plasma clotting time significantly showing its anticoagulant property. LPRE hydrolyzed the A?, B? and ? chains of fibrinogen. Furthermore, LPRE significantly inhibited the platelet aggregation induced by agonist adenosine diphosphate (ADP).

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Published

01-01-2021

How to Cite

1.
Thoyajakshi RS, Poornima D. Anticoagulant, fibrinogenolytic and anti-platelet aggregation activities of Lablab purpureus (L.) Sweet seed radicle aqueous extract. Plant Sci. Today [Internet]. 2021 Jan. 1 [cited 2024 Nov. 21];8(1):89-94. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/917

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Section

Research communications