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Plant Science Today (PST)

Mini Reviews

Vol. 1 No. 4 (2014)

Plant polyphenolic extracts as potential anti-human hepatocarcinoma agents

DOI
https://doi.org/10.14719/pst.2014.1.4.62
Submitted
15 May 2014
Published
06-10-2014

Abstract

Plant polyphenols are secondary metabolites, primarily synthesized to protect plants from biotic and abiotic stresses. These compounds are found in fruits, vegetables and beverages and are an important part of the human diet. Plant derived polyphenols have been described as antioxidant, antimicrobial and anticarcinogenic agents. Human hepatocellular carcinoma is one of the most common types of cancer worldwide and it is associated to high mortality. The development of new treatments for hepatocarcinoma is needed, and plant polyphenols appear as a promising important source of compounds for prevention and treatment of this disease. The aim of this article is to review the current knowledge about the use of plant polyphenolic extracts as potential agents for the treatment of human hepatocellular carcinoma.

References

  1. Amin, I., Koh, B.K., Asmah, R. (2004). Effect of Cacao liquior extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. Journal of medicinal food, 7: 7-12. http://dx.doi.org/10.1089/109662004322984635, PMID: 15117546.
  2. Banjerdpongchai, R., Wudtiwai, B., Sringarm, K. (2013). Cytotoxic and apoptotic inducing effects of purple rice extracts and chemotherapeutic drugs on human cancer cell lines. Asian Pacific Journal of Cancer Prevention, 14: 6541-6548. PMID: 24377565.
  3. Byambaragchaa, M., de la Cruz, J.,Yang, S.H., Hwang, S.G. (2013). Antimetastatic potential of etanol extract of Saussurea involucrata against hepatic cáncer in vitro. Asian Pac J Cancer Prev., 14: 5397-402, PMID: 24175833.
  4. Chu, Y.F., Sun, J., Wu, X., Liu, R.H. (2002). Antioxidant and antiproliferative activities of common vegetables. Journal of agricultural and food chemistry. 50: 6910-6916. http://dx.doi.org/10.1021/jf020665f, PMID: 12405796.
  5. Daglia, M. (2012). Polyphenols as antimicrobial agents. Current Opinion in Biotechnology, 23:174-181. http://dx.doi.org/10.1016/j.copbio.2011.08.007, PMID: 21925860.
  6. D' Archivio, M., Filesi, C., Di Benedetto, R., Gargiulo, C.G., Masella, R. (2007). Polyphenols, dietary sources and bioavailability. Ann Ist super Sanità, 43: 348-361, PMID: 18209268.
  7. Darvesh, A.S., Bishayee, A. (2013). Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer. Nutrition and Cancer, 65: 329-344. http://dx.doi.org/10.1080/01635581.2013.767367, PMID: 23530632.
  8. Feitelson, M.A., Sun, B., Tufan, N.L.S., Liu, J., Pan, J., Lian, Z. (2002). Genetic mechanisms of hepatocarcinogenesis. Oncogene, 21: 2593-2604. http://dx.doi.org/10.1038/sj/onc/1205434, PMID: 11971194.
  9. Freise, C., Ruehl, M., Erben, U., Neumann, U., Seehofer, D., Kim, K.Y., ... Somasundaram, R. (2011). A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor 1 receptor signaling and NF-kappaB activity in human liver cancer cell line. BMC Complement Altern Med.,11: 39. http://dx.doi.org/10.1186/1472-6882-11-39, PMID: 21569410.
  10. Gonzalez de Mejia, E., Ramirez-Mares, M.V., Arce-Popoca, E., Walling, M., Villa-Trevio, S. (2004). Inhibition of liver carcionogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa. Food and Chemical Toxicology, 42: 509-516. http://dx.doi.org/10.1016/j.fct.2003.10.016, PMID: 14871594.
  11. Gul, M.Z., Ahmad, F., Kondapi, A.K., Qureshi, I.A., Ghazi, I.A. (2013). Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts an in vitro study. Complementary and alternative medicine, 13. http://dx.doi.org/10.1186/1472-6882-13-53, PMID: 23452983.
  12. Hong, S.W., Jung, K.H., Lee, H.S., Choi, M.J.,Zheng, H.M., Son, M.K., ... Hong, S.S. (2012). Apoptotic and antiangiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. Int J Oncol. 40: 452-60. http://dx.doi.org/10.3892/ijo.2011.1204, PMID: 2193557.
  13. Hsu, S.C., Kuo, C.L., Lin, J.P., Lee, J.H., Lin, C.C., Su, C.C., ... Chung, J.G. (2007). Crude extracts of Euchresta formosanaradix induce cytotoxicity and apoptosis in human hepatocellular carcinoma cell line (Hep3B). Anticancer Res. 27: 2415-25, PMID: 17695533.
  14. Hyun, T.K., Kim, M.O., Lee, H., Kim, Y., Kim, E., Kim, J.S. (2013). Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Léveille. Food Chem. 141: 1947-55. http://dx.doi.org/10.1016/j.foodchem.2013.05.021, PMID: 23870914.
  15. Jin, X., Zheng, R., Li, Y. (2008). Green tea consumption and liver disease: a systematic review. Liver international, 28: 990-996. http://dx.doi.org/10.1111/j.1478-3231.2008.01776.x, PMID: 18482271.
  16. Kim, H.J., Han, M.H., Kim, G.Y., Choi, Y.W., Choi, Y.H. (2012). Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells. Oncol Rep. 28: 1757-63. http://dx.doi.org/10.3892/or.2012.1985, PMID:22923154.
  17. Kim, H.S., Quon, M.J., Kim, J. (2014). New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenols, epigallocatechin-3-gallate. Redox Biology, 2: 187-195. http://dx.doi.org/10.1016/j.redox.2013.12.022, PMID: 24494192.
  18. Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E.S., Baehrecke, E.H., ... Melino, G. (2009). Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 16: 3-11. http://dx.doi.org/10.1038/cdd.2008.150. PMID: 18846107.
  19. Lee, S.J., Lee, K.W., Hur, H.J., Chun, J.Y., Kim, S.Y., Lee, H.J. (2007). Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells. Ann N Y Acad Sci. 1095: 536-44, PMID: 17404067.
  20. Lee, S.G., Kim, B., Yang, Y., Pham, T.X, Park Y.K., Manatou, J., ... Lee, J.Y. (2014). Berry anthocyanins suppress the expression and secretion of proinflammatory madiators in macrophages by inhibiting nuclear translocation of NF-kB independent of NRF2-mediated mechanisms. Journal of Nutritional Biochemistry, 25: 404-411. http://dx.doi.org/10.1016/j.jnutbio.2013.12.001, PMID: 24565673.
  21. Leifert, W., Abeywardena, M.Y. (2008). Grape seed and red wine polyphenols extracts inhibit cellular choloesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutrition Research, 28: 842-850. http://dx.doi.org/10.1016/j.nutres.2008.09.001, PMID: 19083497.
  22. Lin, C.C., Ng, L.T., Hsu, F.F., Shieh, D.E., Chiang, L.C. (2004). Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 31: 65-9. http://dx.doi.org/10.1111/j.1440-1681.2004.03951.x, PMID:14756686.
  23. Lin, H.M., Tseng, H.C., Wang, C.J., Chyau, C.C., Liao, K.K, Peng, P.L., Chou, F.P. (2007). Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells. Journal of agricultural and food chemistry, 55: 3620-3628. http://dx.doi.org/10.1021/jf062406m, PMID: 17419635.
  24. Llovet, J.M, Burroughs, A., Bruix, J. (2003). Hepatocellular carcinoma. Lancet, 362: 1907-1917. http://dx.doi.org/10.1016/S0140-6736(03)14964-1, PMID: 14667750.
  25. Ma, H., Liu, B., Feng, D., Xie, D., Li, R., Yuchi, Y., ... Wang, J. (2010). Pinus massoniana bark extract selectively induces apoptosis in human hepatoma cells, possibly through caspase-dependent pathways. International Journal of Molecular Medicine, 25: 751-759. doi 10.3892/ijmm_00000401, PMID: 20372819.
  26. Nair, S.V., Hettihewa, M., Rupasinghe, H.P. (2014). Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. Biomed Res Int. 2014: 637098. http://dx.doi.org/10.1155/2014/637098, PMID: 24818148.
  27. Naowaratwattana, W., De-Eknamkul, W., De Mejia, E.G. (2010). Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIa activity. J Med Food. 13: 1045-56. http://dx.doi.org/10.1089/jmf.2010.1021, PMID: 20828312.
  28. Newell, A.M.B., Yousef, G.G., Lila, M.A., Ramirez-Mares, M.V. (2010). Comparative in vitro bioactivities of tes extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells. Journal of ethnopharmacology, 130: 536-544. doi:10.1016/j.jep.2010.05.051, PMID: 20561930.
  29. Nzaramba, M.N., Reddivari, L., Bamberg, J.B., Miller Jr, J.C. (2009). Antiproliferative activity and cytotoxicity of Solanum jamessi tuber extracts on human colon and prostate cancer cells in vitro. Journal of agricultural and food chemistry, 57: 8308- 8315. http://dx.doi.org/10.1021/jf901567k, PMID: 19711917.
  30. Oboh, G., Agunloye, O.M., Akinyemi, A.J., Ademiluyi, A.O., Adefegha, S.A. (2012). Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats brain in vitro. Neurochem Res 38, 2: 413-419. doi:10.1007/s11064-012-0935-6, PMID:23184188.
  31. Okuda, K. (2000). Hepatocellular carcinoma. Journal of Hepatology, 32, 225-237. PMID: 10728807.
  32. Ortega, R.M. (2006). Importance of functional foods in the Mediterranean diet. Public Health Nutrition, 9: 1136-1140. PMID: 17378953.
  33. Pang, R., Tse, E., Poon, R.T.P. (2006). Molecular pathways in hepatocellular carcinoma. Cancer letters, 240: 157-169. http://dx.doi.org/10.1016/j.canlet.2005.08.031, PMID: 16239065.
  34. Park, H.S., Park, K.I., Lee, D.H., Kang, S.R., Nagappan, A., Kim, J.A., ... Kim, G.S. 2012. Polyphenolic extract isolated from Korean Lonicera japonica Thunb. Induce G2/M cell cycle arrest and apoptosis in HepG2 cells:involvemen ts of PI3K/Akt and MAPKs. Food Chem Toxicol. 50: 2407-16. http://dx.doi.org/10.1016/j.fct.2012.04.034, PMID: 22561682
  35. Rajkumar, V., Guha, G., Kumar, R.A. (2011). Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts. Food Chem Toxicol. 49: 363-9. http://dx.doi.org/10.1016/j.fct.2010.11.009, PMID: 21081148.
  36. Rajkumar, V., Guha, G., Kumar, R.A. (2011). Apoptosis induction in MDA-MB-435S, Hep3B and PC-3 cell lines by Rheumemodi rhizome extracts. Asian Pac J Cancer Prev. 12: 1197-200. PMID: 21875266.
  37. Ramos, S., Alia, M., Bravo, L., Goya, L. (2005). Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J. Agric. Food Chem., 53: 1271-1280. http://dx.doi.org/10.1021/jf0490798, PMID: 15713052.
  38. Rasool, M., Rashid, S., Arooj, M., Ansari, S.A., Khan, K.M., Malik, A., ... Sheikh, I.A (2014). New possibilities in hepatocellular carcinoma treatment. Anticancer research, 34: 1563-1572. PMID: 24692683.
  39. Sahpazidou D., Geromihalos, G.D., Stagos, D., Apostolou, A., Haroutounian, S.A., Tsatsakis, A.M., ... Kouretas, D. (2014). Anticarcinogenic activity of polyphenolic extracts from grape stems against breas, colon, renal and thyroid cancer cells. Toxicology letters. doi:10.1016/j.toxlet.2014.01.042, PMID: 24508987.
  40. Sakulnarmrat, K., Fenech, M., Thomas, P., Konczak, I. (2013). Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts. Food Chem.136: 9-17. http://dx.doi.org/10.1016/j.foodchem.2012.07.089, PMID: 23017386.
  41. Sawadogo, W.R., Schumacher, M., Teiten, M.H., Dicato, M., Diederich, M. (2012). Traditional West African pharmacopeia, plants and derived compounds for cancer therapy. Biochemical Pharmacology, 84: 1225-1240. doi :10.1016/j.bcp.2012.07.021, PMID: 22846603.
  42. Shin, D.Y., Ryu, C.H., Lee, W.S., Kim, D.C., Kim, S.H., Hah, Y.S., Lee, S.J., Shin, S.C., Kang, H.S., Choi, Y.H. (2009). Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from Meoru. Annals of the New York Academy of Sciences, 1171: 137-148. http://dx.doi.org/10.1111/j.1749-6632.2009.04689.x, PMID: 19723048.
  43. Singh, B.N., Singh, B.R., Sarma, B.K., Singh, H.B. (2009). Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact., 181: 20-8. http://dx.doi.org/10.1016/j.cbi.2009.05.007, PMID: 19446540.
  44. Song, M.J., Bae, S.H. (2014). Newer treatments for advanced hepatocellular carcinoma. Korean Journal of International Medicine, 29: 149-155. http://dx.doi.org/10.3904/kjim.2014.29.2.149, PMID: 24648795.
  45. Stagos, D., Amougias, G., Matakos, A., Spyrou, A., Tsatsakis, A.M., & Kouretas, D. (2012). Chemoprevention of liver cancer by plant polyphenols. Food and Chemical Toxicology, 50: 2155-2170. http://dx.doi.org/10.1016/j.fct.2012.04.002, PMID: 22521445.
  46. Sun, J., Chu, Y, Wu, X., Liu, R.H. (2002). Antioxidant and antiproliferative activities of common fruits. Journal of Agricultural and food Chemistry, 50: 7449-7454. http://dx.doi.org/10.1021/jf0207530, PMID: 12452674.
  47. Thakur, V.S., Gupta, K., Gupta, S. (2012). Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases. International Journal of Oncology, 41: 353-361. http://dx.doi.org/10.3892/ijo.2012.1449, PMID: 22552582.
  48. Wang, H.C., Chung, P.J., Wu, C.H., Lan, K.P., Yang, M.Y., Wang, C.J. (2010). Solanum nigrum L. polyphenolic extract inhibtis hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. Journal of Science of Food and Agriculture, 91: 178-185. http://dx.doi.org/10.1002/jsfa.4170, PMID: 20853273.
  49. Wang, Q., Chen, Q., He, M., Mir, P., Su, J., Yang, Q. (2011). Inhibitory effect of antioxidant extract from various potatoes on the proliferation of human colon and liver cancer cells. Nutrition and Cancer, 63: 1044-1052. http://dx.doi.org/10.1080/01635581.2011.597538, PMID: 21888504.
  50. Yang, C.S., Landau, J.M., Huang M.T., Newmark H.L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr, 21: 381-406. http://dx.doi.org/10.1146/annurev.nutr.21.1.381, PMID: 11375442.
  51. Yang, M.Y., Hsu, L.S., Peng, C.H., Shi, Y.S., Wu, C.H., Wang, C.J. (2010). Polyphenol-rich extracts from Solanum nigrum attenuated PKC a-mediated migration and invasion of hepatocullular carcinoma cells. Journal of Agricultural and food chemistry, 58: 5806-5814. http://dx.doi.org/10.1021/jf100718b, PMID: 20349911.
  52. Yang, X., Wang, Y.Y., La, K.K, Peng, L., Song, X., Shi, X., ... Ye, C. (2012). Inhibitory effects of cocoa tea (Camellia ptilophylla) in human hepatocellular carcinoma HepG2 in vitro and in vivo through apoptosis. Journal of Nutritional Biochemistry, 23: 1051-1057. http://dx.doi.org/10.1016/j.jnutbio.2011.05.010, PMID: 22018604.
  53. Yu, M.H., Im, H.G., Kim, H.I., Lee, I.S. (2009). Induction of apoptosis by immature plum in human hepatocellular carcinoma. Journal of Medicinal Food, 12: 518-527. http://dx.doi.org/10.1089/jmf.2008.1268, PMID: 19627199

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