This article examines the distributional patterns of Cichorium intybus L. (common chicory) across major ecological zones of Uzbekistan and Central Asia, including deserts, foothills, mountain areas and pastures. C. intybus L. is a widely distributed perennial herb known for its high ecological adaptability, nutritional value and medicinal properties. It has long been used in traditional medicine and as a forage crop, making it an important species for both ecological and economic studies. This study examines the spatial distribution and adaptive patterns of C. intybus across major ecological zones of Uzbekistan and Central Asia, highlighting its ecological significance and potential for sustainable utilization. Its natural range, ecological adaptations and the impact of anthropogenic factors were analyzed. The results indicated that the occurrence of the species in Uzbekistan was largely determined by moisture availability and human activities. A comparative analysis with data from Europe, Asia and other regions was also included. The findings confirm that moisture availability and anthropogenic factors are the main determinants of the species’ occurrence in Uzbekistan.