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Plant Science Today (PST)

Review Articles

Vol. 10 No. 4 (2023)

Health and commercial relevance of Garcinia species: Key scientometric analyses from three decades of research

DOI
https://doi.org/10.14719/pst.2396
Submitted
30 January 2023
Published
30-08-2023 — Updated on 02-10-2023
Versions

Abstract

Garcinia species (G. indica, G. cambogia, G. kola and G. mangostana) represent some of the most sought-after herbs globally due to their impressive medicinal qualities, hence the ever-growing interest of researchers into these plants. In this study, an extensive bibliometric analysis of the available research outputs on the widely-known Garcinia species was conducted to appraise the progress made and also highlight the future focus of research on the plants. The published articles (original and conference articles) on the selected species from 1991 to 2021 were retrieved from Scopus® database, scrutinized and further analyzed using the VOS viewer software. Over 2000 research outputs were published posting an annual publication rate of 75 articles, which have altogether garnered almost 37000 citations within the period under review. Of the 85 country affiliations on the publications, 5, which include India, Thailand, Nigeria, Indonesia, and the United States have cumulatively contributed two-thirds of the total outputs. The institutions; the University of Ibadan (97), Prince Songkla University (52) and Mahidol University (50) have the most publications revealing their research focus on herbs. However, in terms of individual influence, Prof E.O. Farombi, of the University of Ibadan, led the pack with an impressive 42 publications (1585 citations) on Garcinia kola followed by Prof Y.W. Chin of the Seoul National University, South Korea with 23 publications (452 citations) on Garcinia mangostana. The versatility in the health applications of these species especially as sources for new therapeutics, nutraceuticals or functional food ingredients, has been the main driver of the research within the past three decades. Recent research undertakings have demonstrated the potential industrial uses of herbs in the clothing and petroleum industries and these may dominate the research emphases in the immediate future.

References

  1. Chen R, Shi J, Chen Y, Zang B, Guan H, Chen H. Powerlyra: Differentiated graph computation and partitioning on skewed graphs. ACM Transactions on Parallel Computing (TOPC). 2019 Jan 22;5(3):1-39. https://doi.org/10.1145/3298989
  2. Espirito Santo BL, Santana LF, Kato Junior WH, de Araújo FD, Bogo D, Freitas KD et al. Medicinal potential of Garcinia species and their compounds. Molecules. 2020 Oct 1;25(19):4513. https://doi.org/10.3390/molecules25194513
  3. Manourová A, Leuner O, Tchoundjeu Z, Van Damme P, Verner V, P?ibyl O, Lojka B. Medicinal potential, utilization and domestication status of bitter kola (Garcinia kola Heckel) in West and Central Africa. Forests. 2019 Feb 4;10(2):124. https://doi.org/10.3390/f10020124
  4. Murthy HN, Dandin VS, Dalawai D, Park SY, Paek KY. Bioactive compounds from fruits of high economic value for food and health. In: Bioactive molecules in food. Springer, Cham. 2019;pp. 1643-70. https://doi.org/10.1007/978-3-319-78030-6_65
  5. Khapare LS, Kadam JH, Shirke GD. Garcinia a medicinally potential genus in Western Ghats. Journal of Pharmacognosy and Phytochemistry. 2020;9(5):2750-52.
  6. Hemshekhar M, Sunitha K, Santhosh MS, Devaraja S, Kemparaju K, Vishwanath BS, et al. An overview on genus Garcinia: phytochemical and therapeutical aspects. Phytochemistry Reviews. 2011 Sep;10(3):325-51. https://doi.org/10.1007/s11101-011-9207-3
  7. Parthasarathy U, Nirmal Babu K, Senthil Kumar R, Ashis GR, Mohan S, Parthasarathy VA. Diversity of Indian Garcinia-a medicinally important spice crop in India. In: II International Symposium on Underutilized Plant Species: Crops for the Future-Beyond Food Security. 2011 Jun 27; 979:pp. 467-76. https://doi.org/10.17660/ActaHortic.2013.979.50
  8. Apoorva KA, Fakrudin B, Nandini K, Gaurav NC, Sandeep K, Jayashree U, Mohankumar S, Ramegowda GK, Honnabyraiah MK, Krishna HC, Lakshminarayana H. Plasticity for (-)-hydroxycitric acid (HCA) content in ecotypes of Garcinia indica (Kokum) of Western Ghats. IJCS. 2020;8(3):1188-95. https://doi.org/10.22271/chemi.2020.v8.i3p.9363
  9. Raina R, Verma PK, Taku I, Malik JK, Gupta RC. Garcinia cambogia. In: Nutraceuticals. Academic Press. 2021 Jan 1;pp. 975-90. https://doi.org/10.1016/B978-0-12-821038-3.00058-6
  10. Aral S, Rameshkumar KB. Gamboge-the bark exudate from Garcinia species. Diversity of Garcinia species in the Western Ghats: Phytochemical Perspective. 2016;162.
  11. Yadav A, Singh Y, Negi P. A review on the characterization of bio-based lubricants from vegetable oils and role of nanoparticles as additives. Materials Today: Proceedings. 2021 Jan 1;46:10513-17. https://doi.org/10.1016/j.matpr.2021.01.046
  12. Apang T, Xavier KM, Lekshmi M, Kannuchamy N, Layana P, Balange AK. Garcinia spp. extract incorporated icing medium as a natural preservative for shelf-life enhancement of chilled Indian mackerel (Rastrelliger kanagurta). LWT. 2020 Nov 1;133:110086. https://doi.org/10.1016/j.lwt.2020.110086
  13. Thomas A, AT JR, Joseph A. Extended protection of mild steel in molar HCl using the Garcinia indica fruit rind extract (GIW) and iodide ions; electrochemical, thermodynamic and kinetic studies. Journal of the Indian Chemical Society. 2021 Oct 1;98(10):100167. https://doi.org/10.1016/j.jics.2021.100167
  14. Swami SB, Thakor NJ, Patil SC. Kokum (Garcinia indica) and its many functional components as related to the human health: A review. Journal of Food Research and Technology. 2014 Oct;2(4):130-42.
  15. Krist S. Cocoa butter. In: Vegetable Fats and Oils. Springer, Cham. 2020; pp. 239-46. https://doi.org/10.1007/978-3-030-30314-3_37
  16. Gutierrez-Orozco F, Failla ML. Biological activities and bioavailability of mangosteen xanthones: A critical review of the current evidence. Nutrients. 2013 Aug 13;5(8):3163-83. https://doi.org/10.3390/nu5083163
  17. Aizat WM, Ahmad-Hashim FH, Jaafar SN. Valorization of mangosteen,“The Queen of Fruits,” and new advances in postharvest and in food and engineering applications: A review. Journal of Advanced Research. 2019 Nov 1;20:61-70. https://doi.org/10.1016/j.jare.2019.05.005
  18. Ahmad I. Recent insight into the biological activities of synthetic xanthone derivatives. European Journal of Medicinal Chemistry. 2016 Jun 30;116:267-80. https://doi.org/10.1016/j.ejmech.2016.03.058
  19. Hu D, Li D, Shigeta M, Ochi Y, Okauchi T, Neyama H, Kabayama S, Watanabe Y, Cui Y. Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water. Biochemical and Biophysical Research Communications. 2021 Jan 8;535:1-5. https://doi.org/10.1016/j.bbrc.2020.12.035
  20. Pinto A, Bonucci A, Maggi E, Corsi M, Businaro R. Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer’s disease. Antioxidants. 2018 Apr 28;7(5):63. https://doi.org/10.3390/antiox7050063
  21. Zhang L, Cheng YX, Liu AL, Wang HD, Wang YL, Du GH. Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa. Molecules. 2010 Nov 22;15(11):8507-17. https://doi.org/10.3390/molecules15118507
  22. Saraswathy SU, Lalitha LC, Rahim S, Gopinath C, Haleema S, SarojiniAmma S, Aboul-Enein HY. A review on synthetic and pharmacological potential of compounds isolated from Garcinia mangostana Linn. Phytomedicine Plus. 2022 Mar 11:100253. https://doi.org/10.1016/j.phyplu.2022.100253
  23. Wallert M, Bauer J, Kluge S, Schmölz L, Chen YC, Ziegler M et al.. The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response. Redox Biology. 2019 Jun 1; 24:101166. https://doi.org/10.1016/j.redox.2019.101166
  24. Attah AF, Fagbemi AA, Olubiyi O, Dada-Adegbola H, Oluwadotun A, Elujoba A, Babalola CP. Therapeutic potentials of antiviral plants used in traditional african medicine with COVID-19 in focus: a Nigerian perspective. Frontiers in Pharmacology. 2021 Apr 26; 12:596855. https://doi.org/10.3389/fphar.2021.596855
  25. Ayepola OR, Cerf ME, Brooks NL, Oguntibeju OO. Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stress and inflammation in diabetes-induced nephrotoxic rats. Phytomedicine. 2014 Dec 15;21(14):1785-93. https://doi.org/10.1016/j.phymed.2014.09.006
  26. Burnham JF. Scopus database: A review. Biomedical digital libraries. 2006 Dec;3(1):1-8. https://doi.org/10.1186/1742-5581-3-1
  27. George TT, Obilana AO, Oyenihi AB, Rautenbach FG. Moringa oleifera through the years: A bibliometric analysis of scientific research (2000-2020). South African Journal of Botany. 2021 Sep 1;141:12-24. https://doi.org/10.1016/j.sajb.2021.04.025
  28. Yamaguchi F, Saito M, Ariga T, Yoshimura Y, Nakazawa H. Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind. Journal of Agricultural and Food Chemistry. 2000 Jun 19;48(6):2320-25. https://doi.org/10.1021/jf990908c
  29. Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U et al. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Journal of Biological Chemistry. 2004;279(49):51163-171. https://doi.org/10.1074/jbc.M409024200
  30. Yun JH, Kang JM, Kim KS, Kim SH, Kim TH, Park YW et al. Health-related quality of life in Korean patients with chronic diseases. The Journal of the Korean Rheumatism Association. 2004;263-74.
  31. Seeram NP. Berry fruits: compositional elements, biochemical activities and the impact of their intake on human health, performance and disease. Journal of Agricultural and Food Chemistry. 2008 Feb 13;56(3):627-29. https://doi.org/10.1021/jf071988k
  32. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X et al. Herbal medicines: challenges in the modern world. Part 3. China and Japan. Expert Review of Clinical Pharmacology. 2016 Sep 1;9(9):1225-33. https://doi.org/10.1080/17512433.2016.1195263
  33. Mukherjee PK, Harwansh RK, Bahadur S, Banerjee S, Kar A, Chanda J et al. Development of Ayurveda–tradition to trend. Journal of Ethnopharmacology. 2017 Feb 2;197:10-24. https://doi.org/10.1016/j.jep.2016.09.024
  34. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY. Herbal medicines: challenges in the modern world. Part 4. Canada and United States. Expert Review of Clinical Pharmacology. 2016 Dec 1;9(12):1597-609. https://doi.org/10.1080/17512433.2016.1238762
  35. Emmanuel O, Uche ME, Dike ED, Etumnu LR, Ugbogu OC, Ugbogu EA. A review on Garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities and toxicology. Biomarkers. 2022 Feb 17;27(2):101-17. https://doi.org/10.1080/1354750X.2021.2016974
  36. Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia. 2004 Jun 1;75(3):375-77. https://doi.org/10.1016/j.fitote.2004.01.010
  37. Oguzie EE, Njoku VO, Enenebeaku CK, Akalezi CO, Obi C. Effect of hexamethylpararosaniline chloride (crystal violet) on mild steel corrosion in acidic media. Corrosion Science. 2008 Dec 1;50(12):3480-86. https://doi.org/10.1016/j.corsci.2008.09.017
  38. Zein R, Suhaili R, Earnestly F, Munaf E. Removal of Pb (II), Cd (II) and Co (II) from aqueous solution using Garcinia mangostana L. fruit shell. Journal of Hazardous Materials. 2010 Sep 15;181(1-3):52-56. https://doi.org/10.1016/j.jhazmat.2010.04.076
  39. Veerasamy R, Xin TZ, Gunasagaran S, Xiang TF, Yang EF, Jeyakumar N, Dhanaraj SA. Biosynthesis of silver nanoparticles using mangosteen leaf extract and evaluation of their antimicrobial activities. Journal of Saudi Chemical Society. 2011 Apr 1;15(2):113-20. https://doi.org/10.1016/j.jscs.2010.06.004
  40. Koh JJ, Qiu S, Zou H, Lakshminarayanan R, Li J, Zhou X et al. Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2013 Feb 1;1828(2):834-44. https://doi.org/10.1016/j.bbamem.2012.09.004
  41. Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. Journal of Agricultural and Food Chemistry. 2000 Feb 21;48(2):180-85. https://doi.org/10.1021/jf990845y
  42. Farombi EO, Shrotriya S, Surh YJ. Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-?B and AP-1. Life Sciences. 2009 Jan 30;84(5-6):149-55. https://doi.org/10.1016/j.lfs.2008.11.012
  43. Chen LG, Yang LL, Wang CC. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food and Chemical Toxicology. 2008 Feb 1;46(2):688-93. https://doi.org/10.1016/j.fct.2007.09.096
  44. Obileke K, Onyeaka H, Omoregbe O, Makaka G, Nwokolo N, Mukumba P. Bioenergy from bio-waste: a bibliometric analysis of the trend in scientific research from 1998–2018. Biomass Conversion and Biorefinery. 2020 Jul 6;1-6. https://doi.org/10.1007/s13399-020-00832-9
  45. Salmerón-Manzano E, Manzano-Agugliaro F. The higher education sustainability through virtual laboratories: The Spanish University as case of study. Sustainability. 2018 Nov 4;10(11):4040. https://doi.org/10.3390/su10114040
  46. Van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics. 2017 May;111(2):1053-70. https://doi.org/10.1007/s11192-017-2300-7
  47. Bastian M, Heymann S, Jacomy M. Gephi: an open-source software for exploring and manipulating networks. In: Proceedings of the international AAAI conference on web and social media. 2009 Mar 19;3((1): pp. 361-62. https://doi.org/10.1609/icwsm.v3i1.13937
  48. Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron—a Garcinia kola seed extract. Food and Chemical Toxicology. 2000 Jun 1;38(6):535-41. https://doi.org/10.1016/S0278-6915(00)00039-9
  49. Voravuthikunchai SP, Kitpipit L. Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection. 2005 Jun 1;11(6):510-12. https://doi.org/10.1111/j.1469-0691.2005.01104.x
  50. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. Journal of Ethnopharmacology. 2004 Jan 1;90(1):161-66. https://doi.org/10.1016/j.jep.2003.09.048
  51. Mackeen MM, Ali AM, El-Sharkawy SH, Manap MY, Salleh KM, Lajis NH, Kawazu K. Antimicrobial and cytotoxic properties of some Malaysian traditional vegetables (ulam). International Journal of Pharmacognosy. 1997 Jan 1;35(3):174-78. https://doi.org/10.1076/phbi.35.3.174.13294
  52. Yuliana ND, Jahangir M, Korthout H, Choi YH, Kim HK, Verpoorte R. Comprehensive review on herbal medicine for energy intake suppression. Obesity Reviews. 2011 Jul;12(7):499-514. https://doi.org/10.1111/j.1467-789X.2010.00790.x
  53. Palapol Y, Ketsa S, Stevenson D, Cooney JM, Allan AC, Ferguson IB. Colour development and quality of mangosteen (Garcinia mangostana L.) fruit during ripening and after harvest. Postharvest Biology and Technology. 2009 Mar 1;51(3):349-53. https://doi.org/10.1016/j.postharvbio.2008.08.003
  54. Jantan I, Harun NH, Septama AW, Murad S, Mesaik MA. Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants. Journal of Natural Medicines. 2011 Apr;65(2):400-05. https://doi.org/10.1007/s11418-010-0492-8
  55. Poungchompu O, Wanapat M, Wachirapakorn C, Wanapat S, Cherdthong A. Manipulation of ruminal fermentation and methane production by dietary saponins and tannins from mangosteen peel and soapberry fruit. Archives of Animal Nutrition. 2009 Oct 1;63(5):389-400. https://doi.org/10.1080/17450390903020406
  56. Otake T, Mori H, Morimoto M, Ueba N, Sutardjo S, Kusumoto IT et al. Screening of Indonesian plant extracts for anti-human immunodeficiency virus—type 1 (HIV-1) activity. Phytotherapy Research. 1995 Feb;9(1):6-10. https://doi.org/10.1002/ptr.2650090103
  57. Chatatikun M, Chiabchalard A. Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity. BMC Complementary and Alternative Medicine. 2017 Dec;17(1):1-9. https://doi.org/10.1186/s12906-017-1994-7
  58. Pan MH, Chang WL, Lin-Shiau SY, Ho CT, Lin JK. Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. Journal of Agricultural and Food Chemistry. 2001 Mar 19;49(3):1464-74. https://doi.org/10.1021/jf001129v
  59. Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T et al. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. Journal of Natural Products. 2003 Aug 22;66(8):1124-27. https://doi.org/10.1021/np020546u
  60. Wathoni N, Shan CY, Shan WY, Rostinawati T, Indradi RB, Pratiwi R, Muchtaridi M. Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind. Heliyon. 2019 Aug 1;5(8):e02299. https://doi.org/10.1016/j.heliyon.2019.e02299
  61. Preuss HG, Bagchi D, Bagchi M, Rao CS, Dey DK, Satyanarayana S. Effects of a natural extract of (–) ?hydroxycitric acid (HCA?SX) and a combination of HCA?SX plus niacin?bound chromium and Gymnema sylvestre extract on weight loss. Diabetes, Obesity and Metabolism. 2004 May;6(3):171-80. https://doi.org/10.1111/j.1462-8902.2004.00328.x
  62. Chin YW, Jung HA, Chai H, Keller WJ, Kinghorn AD. Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen). Phytochemistry. 2008 Feb 1;69(3):754-58. https://doi.org/10.1016/j.phytochem.2007.09.023
  63. Adaramoye OA, Adeyemi EO. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia kola in streptozotocin-induced diabetes mellitus rats. Journal of Pharmacy and Pharmacology. 2006 Jan;58(1):121-28. https://doi.org/10.1211/jpp.58.1.0015
  64. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chemical and Pharmaceutical Bulletin. 2003;51(7):857-59. https://doi.org/10.1248/cpb.51.857
  65. Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO. Curcumin and kolaviron ameliorate di?n?butylphthalate?induced testicular damage in rats. Basic and Clinical Pharmacology and Toxicology. 2007 Jan;100(1):43-48. https://doi.org/10.1111/j.1742-7843.2007.00005.x
  66. Mohamed GA, Al-Abd AM, El-Halawany AM, Abdallah HM, Ibrahim SR. New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast and colorectal cancer cell lines. Journal of Ethnopharmacology. 2017 Feb 23;198:302-12. https://doi.org/10.1016/j.jep.2017.01.030
  67. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research. 2021 Sep 1;133:285-96. https://doi.org/10.1016/j.jbusres.2021.04.070
  68. Van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics. 2017 May;111(2):1053-70. https://doi.org/10.1007/s11192-017-2300-7
  69. Andersen SZ, ?oli? V, Yang S, Schwalbe JA, Nielander AC, McEnaney JM et al. A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements. Nature. 2019 Jun;570(7762):504-08. https://doi.org/10.1038/s41586-019-1260-x
  70. Munoz-Leiva F, Porcu L, Barrio-García SD. Discovering prominent themes in integrated marketing communication research from 1991 to 2012: A co-word analytic approach. International Journal of Advertising. 2015 Aug 8;34(4):678-701. https://doi.org/10.1080/02650487.2015.1009348
  71. del Barrio-Garcia S, Munoz-Leiva F, Golden L. A review of comparative advertising research 1975–2018: Thematic and citation analyses. Journal of Business Research. 2020 Dec 1;121:73-84. https://doi.org/10.1016/j.jbusres.2020.08.023

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