A field experiment assessed the knowledge gap in economic, energetics and carbon dynamics of Unmanned Aerial Vehicle and knapsack-based herbicide applications in dry direct-seeded rice. Twelve treatments were arranged in a randomized block design replicated thrice with varying UAV spray volumes (25, 50, 75 and 100 L ha-1) and knapsack spray volume of 500 L ha-1 at 75 % HRD (pendimethalin + penoxsulam on 3 DAS at 468.8 g ha-1 fb bispyribac-sodium on 20 DAS at 18.8 g ha-1) and 100 % HRD (pendimethalin + penoxsulam on 3 DAS at 625 g ha-1 fb bispyribac-sodium on 20 DAS at 25 g ha-1), along with hand weeding twice and unweeded control. Results showed that UAV spray volume at 50 L ha-1 with 100 % HRD was significant over other weed management practices by higher grain yield (3866.0 kg ha-1), higher NPK nutrient uptake (105.4, 21.7 and 130.8 kg ha-1), higher B:C ratio (2.13), improved energy efficiency (11.58), higher energy profitability (10.58 kg MJ-1), higher carbon sustainability index (18.4) and lower carbon emission (0.064 kg CO2 eq. kg-1 yield). Therefore, UAV spray at 50 L ha-1 of pendimethalin + penoxsulam on 3 DAS at 625 g ha-1 fb bispyribac-sodium on 20 DAS at 25 g ha-1 (100 % HRD) is recommended for DDSR cultivating farmers in the coastal deltaic ecosystem of South India.