Skip to main navigation menu Skip to main content Skip to site footer

Mini Reviews

Vol. 1 No. 4 (2014)

Antitumor properties and toxicity effects of Peganum harmala L. (Zygophyllaceae)

DOI
https://doi.org/10.14719/pst.2014.1.4.71
Submitted
27 June 2014
Published
02-10-2014

Abstract

Peganum harmala L. (Zygophylaceae) is a medicinal plant known to possess hypothermic and hallucinogenic properties from ancient times. Though the alkaloids identified from the species showed extensive pharmacological actions, they are highly cytotoxic. The present review summarises important findings on the antitumor properties and toxicity effects of the chemical constituents of P. harmala.

References

  1. Adhami, H. R., Farsam, H., & Krenn, L. (2011). Screening of Medicinal Plants from Iranian Traditional Medicine for Acetylcholinesterase Inhibition. Phytotherapy Research, 25, 1148. http://dx.doi.org/10.1002/ptr.3409 PMid:21287652
  2. Arshad, N., Zitterl-Eglseer, K., Hasnain, S., & Hess, M. (2008). Effect of Peganum harmala or its ß-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytotherapy Research, 22, 1533. http://dx.doi.org/10.1002/ptr.2528 PMid:18814210
  3. Astulla, A., Zaima, K., Matsuno, Y., Hirasawa, Y., Ekasari, W., Widyawaruyanti, A., ... & Morita, H. (2008). Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. Journal of Natural Medicines 62, 470 http://dx.doi.org/10.1007/s11418-008-0259-7 PMid:18523842
  4. Boeira, J. M., da Silva, J., Erdtmann, B., & Henriques, J. A. P. (2001). Genotoxic Effects of the Alkaloids Harman and Harmine Assessed by Comet Assay and Chromosome Aberration Test in Mammalian Cells in vitro. Pharmacology & Toxicology, 89, 287. PMid:11903953 http://dx.doi.org/10.1034/j.1600-0773.2001.d01-162.x
  5. Daoud, A., Song, J., Xiao, F., & Shang, J. (2014). B-9-3, a novel ß-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. European Journal of Pharmacology, 724, 219-230. http://dx.doi.org/10.1016/j.ejphar.2013.12.038
  6. El Gendy, M. A., Somayaji, V., & El-Kadi, A. O. (2010). Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. Planta Medica, 76(7), 671-7. http://dx.doi.org/10.1055/s-0029-1240633
  7. El-Rifaie, M. E.-S. (1980). Peganum harmala. International Journal of Dermatology, 19, 221–222. http://dx.doi.org/10.1111/j.1365-4362.1980.tb00305.x
  8. Farouk, L., Laroubia, A., Aboufatimaa, R., Benharref, A., & Chait, A. (2008). Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: Possible mechanisms involved. Journal of Ethnopharmacology, 115, 449-454. PMid:18054186 http://dx.doi.org/10.1016/j.jep.2007.10.014
  9. Go¨ckler, N., Jofre, G., Papadopoulos, C., Soppa, U., Tejedorand, F. J., & Becker, W. (2009). Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation. FEBS Journal, 276, 6324. http://dx.doi.org/10.1111/j.1742-4658.2009.07346.x PMid:19796173
  10. Hamsa, T. P., & Kuttan, G. (2011). Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chinese Medicine, 6, 11. http://dx.doi.org/10.1186/1749-8546-6-11 PMid:21429205 PMCid:PMC3076298
  11. Herraiz, T., González, D., Ancín-Azpilicueta, C., Arán, V. J., & Guillén, H. (2010). ß-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48(3), 839-45. http://dx.doi.org/10.1016/j.fct.2009.12.019
  12. Hilal, A. H. S., & Young ken, H. W. (1983). Certain poisnous plants of Egypt. Pharmaceutical society of Egypt, Ed. Dokki. The national information and Documentation centre, Cairo, Egypt.
  13. Jahaniani, F., Ahmed Ebrahimi, S., Rahbar-Roshandel, N. & Mahmoudian, M. (2005). Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry 66, 1581-1592. http://dx.doi.org/10.1016/j.phytochem.2005.04.035 PMid:15949825
  14. Kartal, M., Altun, S., & Kurucu, S. (2003). HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L. Journal of Pharmaceutical and Biomedical Analysis, 31, 263. http://dx.doi.org/10.1016/S0731-7085(02)00568-X
  15. Khlifi, D., Sghaier, R. M., Amouri, S., Laouini, D., Hamdi, M., & Bouajila, J. (2013). Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. Food and Chemical Toxicology, 55, 202-208. http://dx.doi.org/10.1016/j.fct.2013.01.004
  16. Kim, H., Sablin, S. O., & Ramsay, R. R. (1997). Inhibition of Monoamine Oxidase A by ß-Carboline Derivatives. Archives of Biochemistry and Biophysics, 337, 137 http://dx.doi.org/10.1006/abbi.1996.9771 PMid:8990278
  17. Lamchouri, F. (2000). Thèse de Doctorat Es-sciences Physiologie-Pharmacologie, Maroc.
  18. Lamchouri, F., Settaf, A., Cherrah, Y., El Hamidi, M., Tligui, N. S., Lyoussi, B., & Hassar, M. (2002). Experimental toxicity of Peganum harmala seeds. Annales Pharmaceutiques Françaises, 60, 123. PMid:11976557
  19. Lamchouri, F., Settaf, A., Cherrah, Y., Hassar, M., Zemzami, M., Atif, N., ... & Lyoussi, B. (2000). In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia 71, 50. http://dx.doi.org/10.1016/S0367-326X(99)00117-3
  20. Lamchouri, F., Settaf, A., Cherrah, Y., Zemzami, M., B. Lyoussi, A. Zaid, ... Hassar M. (1999). Antitumor principles from Peganum harmala seeds. Therapie, 54, 753-758. PMid:10709452
  21. Lamchouri, F., Toufik, H., Bouzzine, S. M., Hamidi, M., & Bouachrine, M. (2010). Experimental and computational study of biological activities of alkaloids isolated from Peganum harmala seeds. Journal of Materials and Environmental Science, 1, 343.
  22. Lamchouri, F., Zemzami, M., Jossang, A., Settaf, A., Israili, Z. H., & Lyoussi, B. (2013). Cytotoxicity of alkaloids isolated from Peganum harmala seeds. Pakistan Journal of Pharmaceutical Sciences, 26(4), 699-706. PMid:23811445
  23. Ma, X., Liu, D., Tang, H., Wang, Y., Wu, T., Li, Y., ... & Zhang, F. (2013). Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds. Acta Biochimica et Biophysica Sinica (Shanghai), 45(2), 87-94. http://dx.doi.org/10.1093/abbs/gms094
  24. Misra, P., Khaliq, T., Dixit, A., SenGupta, S., Samant, M., Kumari, S., ... Dube, A. (2008). Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design. Journal of Antimicrobial Chemotherapy, 62(5), 998-1002. http://dx.doi.org/10.1093/jac/dkn319
  25. Moloudizargari, M., Mikaili, P., Aghajanshakeri, S., Asghari, M. H., & Shayegh, J. (2013). Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy Reviews, 7, 199-212. Available from: http://www.phcogrev.com/text.asp?2013/7/14/199/120524
  26. Prashanth, D., & John, S. (1999). Antibacterial activity of Peganum harmala. Fitoterapia 70, 438. http://dx.doi.org/10.1016/S0367-326X(99)00065-9
  27. Qi, C., Rihui, C., Hongsheng, C., Xuerui, H., Huifang, Y., Shufeng, Z. & Xu, A. (2004). Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. International Journal of Cancer, 114, 675-682. http://dx.doi.org/10.1002/ijc.20703
  28. Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003). Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics. The Journal of Pharmacology and Experimental Therapeutics, 306, 73. PMid:12660312 http://dx.doi.org/10.1124/jpet.103.049882
  29. Rihui, C., Qi, C., Xuerui, H., Hongsheng, C., Huaji, G., Yan, M., ... & Anlong, X. (2004). Synthesis, acute toxicities, and antitumor effects of novel 9-substituted ß-carboline derivatives. Bioorganic & Medicinal Chemistry, 12, 4613–4623. http://dx.doi.org/10.1016/j.bmc.2004.06.038 PMid:15358288
  30. Schwarz, M. J., Houghton, P. J., Rose, S., Jenner, P., & Lees, A. D. (2003). Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism. Pharmacology Biochemistry and Behavior, 75, 627. http://dx.doi.org/10.1016/S0091-3057(03)00129-1
  31. Shao, H., Huang, X., Zhang, Y., & Zhang, C. (2013). Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops. Molecules, 18(3), 2623-34. http://dx.doi.org/10.3390/molecules18032623
  32. Shonouda, M., Osman, S., Salama, O., & Ayoub, A. (2008). Toxical effect of Peganum harmala L. leaves on the cotton leaf worm, Spodoptera littoralis Boisd and its parasitoids Microplitis rufiventris Kok. Pakistan Journal of Biological Sciences, 11(4), 546-52. PMid:18817124. http://dx.doi.org/10.3923/pjbs.2008.546.552
  33. Soliman, A. M., Abu-El-Zahab, H. S., & Alswiai, G. A. (2013). Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats. Asian Pacific Journal of Tropical Medicine, 6(4), 285-95. http://dx.doi.org/10.1016/S1995-7645(13)60058-9
  34. Tahraoui, A., El-Hilaly, J., Israili, Z. H., & Lyoussi. B. J. (2007). Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). Journal of Ethnopharmacology, 110, 105. PMid:17052873 http://dx.doi.org/10.1016/j.jep.2006.09.011
  35. Zheng, H., Youdim, M. B. H., & Fridkin, M. J. (2009). Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective-Neurorestorative Moieties for Alzheimer’s Therapy. Journal of Medicinal Chemistry, 52, 4095. http://dx.doi.org/10.1021/jm900504c PMid:19485411

Downloads

Download data is not yet available.