Antioxidant, alpha glucosidase and antibacterial evaluation of Syzygium mytifolium (Roxb.) Walp.
DOI:
https://doi.org/10.14719/pst.2021.8.2.1113Keywords:
Antioxidants, Antibiotic, Plant extracts, Growth inhibition, microorganismsAbstract
Medicinal plants have been the major source of combating and treating infectious diseases and health disorders throughout the ages. To explore new sources of inexpensive and safe antioxidants and antibiotics. The antioxidant and antibacterial potential of different extracts Syzygium mytifolium (Roxb.) Walp. were evaluated through 1,1-Diphenyl-2-Picryl Hydrazyl (DPPH), ferric reducing antioxidant power (FRAP), ?-glucosidase inhibition, disk diffusion and agar well methods. The leaves, bark, root and whole plant of Syzygium mytifolium were extracted with various solvents viz ethanol, methanol and aqueous to give crude extracts, respectively. Among all, the ethanolic extract showed high antioxidant activity in terms of radical scavenging activity, reducing power and alpha-glucosidase inhibition at 1.84 µg/ml, 40.2 mmol/gm and 14.34 µg/ml, respectively. All the tested parts of the plant exhibited moderate to higher range of antibacterial activity against bacterial pathogens with the inhibition zones ranged between 2-27.8 mm. Syzygium mytifolium will serve as a very good source for the development of antioxidant supplements and antibiotics for addressing infectious pathogens and improvement of health status.
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Abdulrahman MD, Ali AM, Fatihah H, Khandaker MM, Mat N. In vitro biological investigations on Syzygium polyanthum cultivars. Int J Agric Biol. 2019; 22(6):1399-1406.
Mahmoud AD, Labaran I, Yunusa A, Ethnobotany of medicinal plants with antimalarial potential in Northern Nigeria. Ethnobotany Research and Applications. 2020.19:1-8. https://doi.org/10.32859/era.19.32.1-8
Gurib-Fakim A, Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006;27(1):1-93. https://doi.org/10.1016/j.mam.2005.07.008
George P. Concerns regarding the safety and toxicity of medicinal plants-An overview. Journal of Applied Pharmaceutical Science. 2011;1(6):40-44.
Patra JK, Das G, Lee S, Kang SS, Shin H S. Selected commercial plants: A review of extraction and isolation of bioactive compounds and their pharmacological market value. Trends Food Sci Tech. 2018;82:89-109. https://doi.org/10.1016/j.tifs.2018.10.001
Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethnopharmacological approaches to wound healing—exploring medicinal plants of India. J Ethnopharmacol. 2007;114(2):103-13. https://doi.org/10.1016/j.jep.2007.08.010
Lelario F, Scrano L, De Franchi S, Bonomo M, Salzano G, Milan S, Bufo S. Identification and antimicrobial activity of most representative secondary metabolites from different plant species. Chemical and Biological Technologies in Agriculture. 2018;5(1):1-12. https://doi.org/10.1186/s40538-018-0125-0
Zhao J, Davis LC, Verpoorte R. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnology Advances. 2005;23(4):283-333. https://doi.org/10.1016/j.biotechadv.2005.01.003
Sivasankari B, Anandharaj MP. Gunasekaran. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamil Nadu, India. J Ethnopharmacology. 2014;153(2): 408-23. https://doi.org/10.1016/j.jep.2014.02.040
Ramli S, Radu S, Shaari K, Rukayadi Y. Antibacterial activity of ethanolic extract of Syzygium polyanthum L. (Salam) leaves against foodborne pathogens and application as food sanitizer. BioMed Research International. 2017;17-24. https://doi.org/10.1155/2017/9024246
Jaberian H, Piri K, Nazari J. Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants. Food Chem. 2013;136(1):237-44. https://doi.org/10.1016/j.foodchem.2012.07.084
Abdulrahman MD, Ali AM, Fatihah H, Khandaker MM, Mat N. Traditional medicinal knowledge of Malays in Terengganu, Peninsular Malaysia. Malayan Nature Journal. 2018;70(3):349-64.
Akram M, Tahir I M, Shah SMA, Mahmood Z, Altaf A, Ahmad K, Mehboob H. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis and coxsackievirus: a systematic review. Phytotherapy Research. 2018;32(5):811-22. https://doi.org/10.1002/ptr.6024
Stefanello MÉA, Pascoal AC, Salvador MJ. Essential oils from neotropical Myrtaceae: chemical diversity and biological properties. Chem Biodivers. 2011.8(1):73-94. https://doi.org/10.1002/cbdv.201000098
Li HB, Jiang Y, Wong CC, Cheng KW, Chen F. Evaluation of two methods for the extraction of antioxidants from medicinal plants. Anal Bioanal. 2007. 388(2):483-88. https://doi.org/10.1007/s00216-007-1235-x
Yunusa AK, Rohin MAK, Bakar CAA. Free radical scavenging activity of polyphenols. Journal of Chemical and Pharmaceutical Research. 2015.7(3):1975-80.
Yunusaa AK. DPPH radical scavenging activitiy and total phenolic content of rambutan (Nephelium lappaceum) peel and seed. Ann Food Sci Technol. 2018;19:774-79.
Su Y, Sun J, Rao S, Cai Y, Yang Y. Photodynamic antimicrobial activity of hypocrellin A. Journal of Photochemistry and Photobiology B: Biology. 2011;103(1):29-34. https://doi.org/10.1016/j.jphotobiol.2011.01.008
Su PW, Yang CH, Yang JF, Su PY, Chuang LY. Antibacterial activities and antibacterial mechanism of Polygonum cuspidatum extracts against nosocomial drug-resistant pathogens. Molecules. 2015;20(6):11119-30. https://doi.org/10.3390/molecules200611119
Parekh J, Chanda S. In vitro antimicrobial activity and phytochemical analysis of some Indian medicinal plants. Turk J Biol. 2007;31(1):53-58.
Srinivasan D, Nathan, Suresh ST, Perumalsamy PL. Antimicrobial activity of certain Indian medicinal plants used in folkloric medicine. J Ethnopharmacology. 2001;74(3):217-20. https://doi.org/10.1016/S0378-8741(00)00345-7
Chew YL, Chan EWL, Tan PL, Lim YY, Stanslas J, Goh JK. Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia. BMC Complem Altern M. 2011;11(1):1-10. https://doi.org/10.1186/1472-6882-11-12
Friedman M. Overview of antibacterial, antitoxin, antiviral and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res. 2007;51(1):116-34. https://doi.org/10.1002/mnfr.200600173
Briskin DP. Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol Plant. 2000;124(2):507-14. https://doi.org/10.1104/pp.124.2.507
Ribeiro da Cunha B, Fonseca LP, Calado CR. Antibiotic discovery: where have we come from, where do we go? Antibiotics. 2019.8(2):45-51. https://doi.org/10.3390/antibiotics8020045
Sinha AK, Sharma UK, Sharma N. A comprehensive review on vanilla flavor: extraction, isolation and quantification of vanillin and others constituents. International Journal of Food Sciences and Nutrition. 2008;59(4):299-326. https://doi.org/10.1080/09687630701539350
Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacology. 2005;99(2):165-78. https://doi.org/10.1016/j.jep.2005.02.035
Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agr Food Chem. 2005;53(6):1841-56. https://doi.org/10.1021/jf030723c
Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. The Journal of Nutritional Biochemistry. 2002;13(10):572-84. https://doi.org/10.1016/S0955-2863(02)00208-5
Assefa ST, Yang EY, Chae SY, Song M, Lee J, Cho, M-C, Jang S. Alpha glucosidase inhibitory activities of plants with focus on common vegetables. Plants. 2020;9(1):2-11. https://doi.org/10.3390/plants9010002
Taye B, Giday M, Animut A, Seid J. Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia. Asian Pac J Trop Med. 2011;1(5):370-75. https://doi.org/10.1016/S2221-1691(11)60082-8
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