he experiment was conducted at the Horticulture research field in the Department of Crop Science and Technology in the University of Rajshahi, Bangladesh, during the rabi season from October 2021 to February 2022. In this study, the effect of varieties, different doses of potassium and boron fertilisers and their combinations were evaluated to determine the optimum combination for enhancing the growth and yield of potato. The experiment was conducted as a factorial randomised block design with three replications. Two varieties; Lal Sheal (V1) and BARI Potato-7 (V2) and five different combination of fertiliser application; T1 = control (0 kg MP and 0 kg boric acid)/ha, T2 = (120 kg MP + 14 kg boric acid)/ha, T3 = (140 kg MP + 16 kg boron) /ha, T4 = ( 160 kg MP + 18 kg boric acid)/ha and T5 = (180 kg MP + 20 kg boric acid)/ha and the interaction of varieties and different fertiliser dozes were evaluated. The results showed that varietal differences were significant for all measured traits. The V2 variety consistently exhibited higher plant height, more leaves, larger tuber length and width, maximum number of fresh and defected tuber and higher yield compared to V1. Among fertiliser treatments, T5 (the highest mixed fertiliser dose) significantly improved plant height (59.95 cm), leaf number (57.83 per plant) and tuber size (11.56 cm length, 12.67 cm diameter), resulting in the maximum yield (19.75 kg/plot, 24.47 t/ha). The combined effect of variety and fertiliser treatments revealed that the V2T5 interaction produced the highest yield (20.23 kg/plot, 28.65 t/ha), while V1T1 produced the lowest yield. These results indicate that both genetic potential and balanced nutrient management significantly influence potato growth and productivity. Therefore, the use of BARI Potato-7 with optimised mixed synthetic fertiliser combinations can enhance tuber yield and quality in the northwestern region of Bangladesh. Further studies are recommended to refine fertiliser optimization for sustainable and region-specific potato production.