Effects of Semecarpus anacardium L.f. ethanol extract on serum biochemical parameters and antioxidant activity of DAL induced mice
DOI:
https://doi.org/10.14719/pst.1522Keywords:
Dalton's Ascites Lymphoma, Semcarpus anacardium, Serum biochemical parameters, Antioxidant parametersAbstract
Semecarpus anacardium L.f. nuts is one of the best, versatile and most commonly used herbs as a household remedy, distributed in sub-Himalayan region, Tropical region, Bihar, Bengal, Orissa and central and south parts of India. In this work, the anticancer efficacy of ethanol extract of Semecarpus anacardium nuts (EESA) was tested in Swiss albino mice with induced Dalton's Ascites Lymphoma (DAL). Ethanol extract of S. anacardium nuts was given daily for 14 days at doses of 200 mg/kg and 400 mg/kg body weight, after 24 hrs of tumor inoculation. After receiving the final dose and fasting for 18 hrs, the mice were euthanized. Serum biochemical and antioxidant characteristics were measured to determine antitumor activity. 5-Fluoro Uracil, a typical medication, was employed as a positive control. In comparison to the control group, ethanol extract-treated mice restored biochemical and antioxidant parameters to near-normal levels. Biochemical and antioxidant parameters in the Dalton's Ascited Lymphoma (DAL) animal model treated with EESA exhibited similar effects as the positive control drug 5-fluorouracil. Overall, the active ingredients present in ethanol extract of Semecarpus anacardium nuts, modulate serum biochemical and antioxidant parameters and bring about anti-tumor activity against Dalton's Ascites Lymphoma (DAL) in mice.
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Kanchana A, Balakrishna M. Anti-cancer effect of saponins isolated from Solanumtrilobatum leaf extract and induction of apoptosis in human larynx cancer cell lines. Int J Pharm Pharm Sci. 2011;3(4):356-64.
Mykhailenko O, Lesyk R, Finiuk N, Stoika R, Yushchenko T, Ocheretniuk A et al. In vitro anticancer activity screening of Iridaceae plant extracts. Journal of Applied Pharmaceutical Science. 2020;10(07):059-63.
Lang-Schwarz C, Melcher B, Haumaier F, Schneider-Fuchs A, Lang-Schwarz K, Krugmann J et al. Budding, tumor-infiltrating lymphocytes, gland formation: Scoring leads to new prognostic groups in World Health Organization low-grade colorectal cancer with impact on survival. Human pathology. 2019;89:81-89. https://doi.org/10.1016/j.humpath.2019.04.006
Meena J, Santhy KS. Evaluation of the antioxidant potential of methanol extract of Cycleapeltata in DAL Model. The Pharma Innovation. 2015;4(1, Part B):71.
Kimman M, Jan S, Kingston D, Monaghan H, Sokha E, Thabrany H, Bounxouei B et al. Socioeconomic impact of cancer in member countries of the Association of Southeast Asian Nations (ASEAN): the ACTION study protocol. Asian Pacific Journal of Cancer Prevention. 2012;13(2):421-25. https://doi.org/10.7314/APJCP.2012.13.2.421
Meiyanto E, Hermawan A, Anindyajati A. Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. Asian Pacific Journal of Cancer Prevention. 2012;13(2):427-36. https://doi.org/10.7314/APJCP.2012.13.2.427
Sawadogo WR, Schumacher M, Teiten MH, Dicato M, Diederich M. Traditional West African pharmacopeia, plants and derived compounds for cancer therapy. Biochemical pharmacology. 2012 Nov 15;84(10):1225-40. https://doi.org/10.1016/j.bcp.2012.07.021
Wang C, Wang X, Chen Y, Fang Z. In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer. Journal of Photochemistry and Photobiology B: Biology. 2020;204:111587. https://doi.org/10.1016/j.jphotobiol.2019.111587
Shanker A, Singh SM, Sodhi A. Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution. Tumor biology. 2000;21(6):315-27. DOI: 10.1159/000030137.https://doi.org/10.1159/000030137
Jain P, Sharma HP. A potential ethnomedicinal plant Semecarpus anacardium Linn. A review. Int J Res Pharm Chem. 2013;3(3):564-72.
Singh VD, Middha A, Nimesh R, Solanki P. Phytochemical and isolation and standarization of “Semecarpus anacardium Linn”. World Journal of Pharmaceutical Research. 2017;6(9): 629-38. https://doi.org/10.20959/wjpr20179-9223
Quamar MF, Bera SK. Surface pollen and its relationship with modern vegetation in tropical deciduous forests of southwestern Madhya Pradesh, India: a review. Palynology. 2014;38(1):147-61. https://doi.org/10.1080/01916122.2013.875491
Barman N, Sharma A, Kumar A. Radical scavenging and antioxidant potential of nuts and leaves extracts of Semecarpus anacardium (L.). American Journal of Plant Sciences. 2013; 4, 1679-83. http://dx.doi.org/10.4236/ajps.2013.48204
Lekha GS, Deepika E, Swetha S, Kanagarajan A, Gayathridevi V, Santhy KS. In vivo evaluation of antimicrobial, antipyretic, analgesic and anti Inflammatory activities of nilavembu kudineer capsule in comparison with Siddha Classical Nilavembu Kudineer. Pharmacognosy Research. 2020;12(4):387-93. DOI:10.4103/pr.pr_23_20.https://doi.org/10.4103/pr.pr_23_20
Okaichi Y, Ishikura Y, Akimoto K, Kawashima H, Toyoda-Ono Y, Kiso Y, Okaichi H. Arachidonic acid improves aged rats' spatial cognition. Physiology & Behavior. 2005 Mar 31;84(4):617-23. https://doi.org/10.1016/j.physbeh.2005.02.008
JT R. Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179(4073):588-90. https://doi.org/10.1126/science.179.4073.588
George EL. Tissue sulfhydryl groups. Arch BiochemBiophys. 1959;82(1):70-77. https://doi.org/10.1016/0003-9861(59)90090-6
Romani AM. Cellular magnesium homeostasis. Archives of biochemistry and biophysics. 2011 Aug 1;512(1):1-23. https://doi.org/10.1016/j.abb.2011.05.010
Maideen NM, Velayutham R, Manavalan G. Chemopreventive effect of Phyllanthus polyphyllus against N-Nitrosodiethylamine induced liver tumors by regulating liver enzymes, lipid peroxidation and antioxidants. Middle-East Journal of Scientific Research. 2011;9(6):696-703.
Sreejaya SB, Archana D, Santhy KS. Biochemical changes in the serum of experimental animals treated with acoruscalamus rhizome. Studies on Ethno-Medicine. 2017 Jul 3;11(3):216-20. https://doi.org/10.1080/09735070.2017.1353109
Kalaiselvi M, Gomathi D, Ravikumar G, Devaki K, Uma C. Therapeutic effect of Ananuscomosus peel on breast cancer induced by 7, 12-dimethylbenz (?) anthracene. Plant Science Today. 2014;1(1):13-21. http://dx.doi.org/10.14719/pst.2014.1.1.8
Zahan R, Alam M, Islam S, S Chowdhury N, B Hosain S, Mosaddik A, Jesmin M, Haq ME. Anticancer activity of Alangium salvifolium flower in Ehrlich Ascites carcinoma bearing mice. http://hdl.handle.net/10361/7121
Raja V, Qadir SU, Alyemeni MN, Ahmad P. Impact of drought and heat stress individually and in combination on physio-biochemical parameters, antioxidant responses and gene expression in Solanum lycopersicum. 3 Biotech. 2020;10(5):1-8. https://doi.org/10.1007/s13205-020-02206-4
Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine. 2018;54(4):287-93. DOI: 10.1016/j.ajme.2017.09.001
Ogueji E, Nwani C, Mbah C, Iheanacho S, Nweke F. Oxidative stress, biochemical, lipid peroxidation and antioxidant responses in Clariasgariepinus exposed to acute concentrations of ivermectin. Environmental Science and Pollution Research. 2020 ;27(14):16806-15. https://doi.org/10.1007/s11356-019-07035-4
Ogueji EO, Nwani CD, Iheanacho SC, Mbah CE, Okeke OC, Usman IB. Acute toxicity of ibuprofen on selected biochemical and oxidative stress parameters of liver in Clarias gariepinus Juveniles (Burchell,1822). Journal of Entomology and Zoology Studies. 2017; 5(4): 1060-68.
Morsy MA, Abdel-Aziz AM, Abdel-Hafez S, Venugopala KN, Nair AB, Abdel-Gaber SA. The possible contribution of P-glycoprotein in the protective effect of paeonol against methotrexate-induced testicular injury in rats. Pharmaceuticals. 2020;13(9):223. https://doi.org/10.3390/ph13090223
Periyasamy K, Baskaran K, Ilakkia A, Vanitha K, Selvaraj S, Sakthisekaran D. Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7, 12-dimethylbenz (a) anthracene-induced proliferative breast cancer in Sprague–Dawley rats. Cancer chemotherapy and pharmacology. 2015;75(2):263-72. https://doi.org/10.1007/s00280-014-2629-z
Valko M, Rhodes C, Moncol J, Izakovic MM, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions. 2006; 160(1):1-40. https://doi.org/10.1016/j.cbi.2005.12.009.
Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiya V, Budhani MK et al. Chemopreventive effect of chrysin, a dietary flavone against benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacological Reports. 2016;68(2):310-18. https://doi.org/10.1016/j.pharep.2015.08.014
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