A review on anti-cancer plants of India
DOI:
https://doi.org/10.14719/pst.2372Keywords:
Cancer, medicinal plants, Zingiber officinale, Catharanthus roseus, Phyllanthus emblica, Curcuma longaAbstract
India has a high level of endemism and a diverse range of floral species. Cancer is one of the most significant challenges facing global health today. The indigenous peoples and residents who live in India have, for a very long time, made use of specific medicinal plants to fight cancer. This practice is still prevalent today. Several different drugs may be utilized in the treatment of cancer. Because of the potential drawbacks associated with such treatments and the development of drug resistance, the quest for new therapies that are both safer and much more effective is still the most challenging field of study. Several cancer medicines used today come from natural sources. We're returning to our old ways because medicinal plants are a good, natural way to make medicines that prevent cancer without causing major side effects. Within the scope of this study, a few herbs traditionally used to treat cancer are looked at to see what they might be good for. The cytotoxicity of these plants, the processes that lead to them, and the different compounds they make were looked into. This study has tried to focus on how these plants fight cancer.
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Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: An overview. Int J Cancer. 2021;149(4):778–89.
Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, et al. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. JCO Glob Oncol. 2020;(6):1063–75.
Kooti W, Servatyari K, Behzadifar M, Asadi-Samani M, Sadeghi F, Nouri B, et al. Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. J Evidence-Based Complement Altern Med. 2017;22(4):982–95.
Martín Ortega AM, Segura Campos MR. Medicinal Plants and Their Bioactive Metabolites in Cancer Prevention and Treatment [Internet]. Bioactive Compounds: Health Benefits and Potential Applications. Elsevier Inc.; 2019. p. 85–109. Available from: https://doi.org/10.1016/B978-0-12-814774-0.00005-0
Kuruppu AI, Paranagama P, Goonasekara CL. Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka. Saudi Pharm J [Internet]. 2019;27(4):565–73. Available from: https://doi.org/10.1016/j.jsps.2019.02.004
Omara T, Kiprop AK, Ramkat RC, Cherutoi J, Kagoya S, Moraa Nyangena D, et al. Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies. Evid-based Complement Alternat Med. 2020 Mar 15;2020 :3529081.
Yedjou CG, Mbemi AT, Noubissi F, Tchounwou SS, Tsabang N, Payton M, et al. Prostate cancer disparity, chemoprevention, and treatment by specific medicinal plants. Nutrients. 2019;11(2):1–17.
Keene MR, Heslop IM, Sabesan SS, Glass BD. Complementary and alternative medicine use in cancer: A systematic review. Complement Ther Clin Pract [Internet]. 2019;35(December 2018):33–47. Available from: https://doi.org/10.1016/j.ctcp.2019.01.004
Prasathkumar M, Anisha S, Dhrisya C, Becky R, Sadhasivam S. Therapeutic and pharmacological efficacy of selective Indian medicinal plants – A review. Phytomedicine Plus [Internet]. 2021;1(2):100029. Available from: https://doi.org/10.1016/j.phyplu.2021.100029
Khajuria AK, Manhas RK, Kumar H, Bisht NS. Ethnobotanical study of traditionally used medicinal plants of Pauri district of Uttarakhand, India. J Ethnopharmacol [Internet]. 2021;276(August 2020):114204. Available from: https://doi.org/10.1016/j.jep.2021.114204
Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review. Food Chem Toxicol. 2007;45(5):683–90.
Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin. 2008;29(11):1275–88.
Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, et al. Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead. Bioorganic Med Chem Lett [Internet]. 2018;28(17):2816–26. Available from: https://doi.org/10.1016/j.bmcl.2018.06.044
Maher T, Raus RA, Daddiouaissa D, Ahmad F, Adzhar NS, Latif ES, et al. Medicinal plants with anti-leukemic effects: A review. Molecules. 2021;26(9).
Vilpo JA, Koski T, Vilpo LM. Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000;65(6):370–8.
Varsha K, Sharma A, Kaur A, Madan J, Pandey RS, Jain UK, et al. a Review on Preclinical [Internet]. Nanostructures for Cancer Therapy. Elsevier Inc.; 2017. p. 775–809. Available from: http://dx.doi.org/10.1016/B978-0-323-46144-3/00028-3
Kothari A, Hittelman WN, Chambers TC. Cell cycle-dependent mechanisms underlie vincristine-induced death of primary acute lymphoblastic leukemia cells. Cancer Res. 2016;76(12):3553–61.
Ahmad B, Hafeez N, Rauf A, Bashir S, Linfang H, Rehman M ur, et al. Phyllanthus emblica: A comprehensive review of its therapeutic benefits. South African J Bot [Internet]. 2021;138:278–310. Available from: https://doi.org/10.1016/j.sajb.2020.12.028
C. Ngamkitidechakul, K. Jaijoy, P. Hansakul, N. Soonthornchareonnon and SS. Antitumour effects of phyllanthus emblica L.: Induction of cancer cell apoptosis and Inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells. Phyther Res. 2010;24(9):1405–13.
Sultana S, Munir N, Mahmood Z, Riaz M, Akram M, Rebezov M, et al. Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A Review. Biomed Pharmacother [Internet]. 2021;135:111078. Available from: https://doi.org/10.1016/j.biopha.2020.111078
Gull N, Arshad F, Naikoo GA, Hassan IU, Pedram MZ, Ahmad A, et al. Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma. J Gastrointest Cancer [Internet]. 2022;(0123456789). Available from: https://doi.org/10.1007/s12029-022-00809-z
Yang ZJ, Huang SY, Zhou DD, Xiong RG, Zhao CN, Fang AP, et al. Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review. Antioxidants. 2022;11(8):1–24.
Shanmugam MK, Arfuso F, Sng JC, Bishayee A, Kumar AP, Sethi G. Epigenetic Effects of Curcumin in Cancer Prevention [Internet]. Epigenetics of Cancer Prevention. Elsevier Inc.; 2018. p. 107–128. Available from: http://dx.doi.org/10.1016/B978-0-12-812494-9.00005-6
Lin SR, Chang CH, Hsu CF, Tsai MJ, Cheng H, Leong MK, et al. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br J Pharmacol. 2020;177(6):1409–23.
Tiwari P, Nayak P, Prusty SK, Sahu PK. Phytochemistry and pharmacology of tinospora cordifolia: A review. Syst Rev Pharm. 2018;9(1):70–8.
Sagadevan P, Selvakumar S, Raghunath M, Megala R, Janarthanan P, Vinitha Ebziba C, et al. Medicinal properties of Carica papaya Linn: Review. Madridge J Nov Drug Res. 2019;3(1):120–5.
Pandey G, Madhuri S. Pharmacological activities of Ocimum sanctum (Tulsi): A review. Int J Pharm Sci Rev Res. 2010;5(1):61–6.
Klimek-szczykutowicz M, Szopa A, Ekiert H. Citrus limon (Lemon) phenomenon—a review of the chemistry, pharmacological properties, applications in the modern pharmaceutical, food, and cosmetics industries, and biotechnological studies. Plants. 2020;9(1).
Paikra BK, Dhongade HKJ, Gidwani B. Phytochemistry and pharmacology of Moringa oleifera Lam. J Pharmacopuncture. 2017;20(3):194–200.
Subapriya R, Nagini S. Medicinal properties of neem leaves: A review. Curr Med Chem - Anti-Cancer Agents. 2005;5(2):149–56.
Aneja V, Suthar A, Sonika Verma and Satyan Kalkunte. Phcog Rev.?: Plant Review Phyto-pharmacology of Hemidesmus indicus. Pharmacogn Rev. 2008;2(3):2008.
Ashish B. Wadekar, Minakshee G. Nimbalwar, Wrushali A. Panchale, Bhushan R. Gudalwar, Jagdish V. Manwar, Ravindra L. Bakal. Morphology, phytochemistry and pharmacological aspects of Carica papaya, an review. GSC Biol Pharm Sci. 2021;14(03):234–48.
Vivek Shukla, MD Daneyal Khurshid BK and A. A Review on Phytochemistry and Pharmacological Activity of Azadirachta indica (Neem). Int J Pharm Biol Sci. 2020;10:172–80.
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Copyright (c) 2022 Carol C Morris, Ramyasree C S, Kruthika P, Manikantan Pappuswamy, Aditi Chaudhary, Arun Meyyazhagan, Arumugam Vijaya Anand, Balamuralikrishnan Balasubramanian
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