This is an outdated version published on 01-10-2023. Read the most recent version.
Forthcoming

Helichrysum kraussii Sch.Bip.: Review on its medicinal uses, phytochemistry and pharmacological properties

Authors

DOI:

https://doi.org/10.14719/pst.2402

Keywords:

Asteraceae, Compositae, Helichrysum kraussii, Materia medica, Traditional medicine

Abstract

Helichrysum kraussii Sch.Bip. is a woody shrub that naturally occurs in grasslands and woodlands in South-Central Africa. The various parts of H. kraussii serve as components used in traditional medicines within the South Central Africa region. This review provides an overview of the existing literature on the medicinal uses, phytochemical composition, and pharmacological properties of H. kraussii. The study reveals that various parts of the plant, including branches, flowers, leaves, roots, seeds, twigs, and whole plant parts, are used in ritual practices and traditional medicine to treat a range of human ailments. These include venereal diseases, nasal congestion, chest pain, skin infections, tuberculosis, respiratory infections, and cough. Phytochemical analysis of H. kraussii demonstrates the presence of acylated flavonol glucoside, diterpenes, flavonoids, phloroglucinol, and terpenoids. The pharmacological assessments indicate that crude extracts and isolated phytochemical compounds from this species possess antioxidant, antibacterial, antifungal, antiviral, cytotoxic, and anti-inflammatory activities. This mini review underscores the traditional uses, phytochemical composition, and pharmacological properties of H. kraussii. Based on the findings, it is recommended to conduct comprehensive ethnopharmacological evaluations of H. kraussii, focusing on phytochemistry, pharmacological properties, toxicological assessments, as well as in vivo and clinical research.

Downloads

Download data is not yet available.

References

Gelfand M, Mavi S, Drummond RB, Ndemera B. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Gweru: Mambo Press; 1985.

Van Wyk B-E, Van Oudtshoorn B, Gericke N. Medicinal plants of South Africa. Pretoria: Briza Publications; 2017.

Schmidt E, Lotter M, McCleland W. Trees and shrubs of Mpumalanga and Kruger National Park. Johannesburg: Jacana Media; 2017.

Hyde MA, Wursten BT, Ballings P, Palgrave CM. Flora of Zimbabwe: Species information: Helichrysum kraussii Sch. Bip. [Internet]. 2023 [cited 18 January 2023].: https://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=159680.

POWO. Helichrysum kraussii Sch. Bip. Plants of the World Online. Facilitated by the Royal Botanic Gardens, Kew. 2023 [cited 23 January 2023]. https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:212914-1.

Wells MJ, Balsinhas VM, Joffe H, Engelbrecht VM, Harding G, Stirton CH. A Catalogue of problem plants in southern Africa, incorporating the national weed list of South Africa. Pretoria: Botanical Research Institute; 1986.

Randall RP. A global compendium of weeds. Department of Agriculture and Food, Western Australia; 2017.

Gusha J. Invasive plant species of savanna rangelands: Are they a threat or an opportunity? [PhD Thesis]. Harare: University of Zimbabwe; 2018.

Hedberg I, Staugård F. Traditional medicine in Botswana: Traditional medicinal plants. Gaborone: Ipeleng Publishers; 1989.

Germishuizen G, Meyer NL. Plants of southern Africa: An annotated checklist. Pretoria: National Botanical Institute; 2003.

Arnold TH, Prentice CA, Hawker LC, Snyman EE, Tomalin M, Crouch NR, Pottas-Bircher C. Medicinal and magical plants of southern Africa: An annotated checklist. Pretoria: National Botanical Institute; 2002.

Moeng TE. An investigation into the trade of medicinal plants by muthi shops and street vendors in the Limpopo province, South Africa. [MSc Dissertation]. Sovenga: University of Limpopo; 2010.

Moeng TE, Potgieter MS. The trade of medicinal plants by muthi shops and street vendors in the Limpopo province, South Africa. J Med Plants Res. 2011;5(4):558?64.

Dzoyem JP, Tshikalange E, Kuete V. Medicinal plants market and industry in Africa. In: Kuete V, editors. Medicinal plant research in Africa: Pharmacology and chemistry. London: Elsevier; 2013. p. 859-91.

Cooper K. The conservation status of the indigenous forests of the Transvaal, Natal and O.F.S. Durban: Wildlife Society of Southern Africa; 1983.

Cunningham AB. African medicinal plants: Setting priorities at the interface between conservation and primary health care. Paris: UNESCO; 1993. People and Plants working paper 1.

Shackleton SE. The significance of the local trade in natural resource products for livelihoods and poverty alleviation in South Africa. [PhD Thesis]. Grahamstown: Rhodes University; 2005.

Long C. Swaziland’s Flora: SiSwati names and uses. Mbambane: Swaziland National Trust Commission; 2005. [Internet]. Available from: http://www.sntc.org.sz/index.asp [cited 14 January 2023].

Mashiloane MRR. Medicinal plants used by Mamotintana community in Mankweng, Limpopo province. [BSc Honours Dissertation]. Sovenga: University of Limpopo; 2010.

Sitoe E. Medicinal ethnobotany of Mozambique: A review and analysis. [MSc Dissertation]. Johannesburg: University of Johannesburg; 2020.

Ramarumo LJ, Maroyi A, Tshisikhawe MP. Warburgia salutaris (G. Bertol.) Chiov.: An endangered therapeutic plant used by the Vhaven?a ethnic group in the Soutpansberg, Vhembe Biosphere Reserve, Limpopo province, South Africa. Res J Pharm Tech. 2019;12(12):5893-8. https://doi.org/10.5958/0974-360X.2019.01022.9

Lourens ACU, Viljoen AM, Van Heerden FR. South African Helichrysum species: A review of the traditional uses, biological activity and phytochemistry. J Ethnopharmacol. 2008;119:630–52. https://doi.org/10.1016/j.jep.2008.06.011

York T, de Wet H, van Vuuren SF. Plants used for treating respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa. J Ethnopharmacol. 2011;135:696–710. https://doi.org/10.1016/j.jep.2011.03.072

York T. An ethnopharmacological study of plants used for treating respiratory infections in rural Maputaland. MSc Dissertation, University of Zululand, Kwa-Dlangezwa. 2012.

Maroyi A. Lippia javanica (Burm.f.) Spreng.: Traditional and commercial uses and phytochemical and pharmacological significance in the African and Indian subcontinent. Evidence-Based Compl Alt Med. 2017;2017:6746071. http://dx.doi.org/10.1155/2017/6746071

Van Vuuren SF, Motlhatlego KE, Netshia V. Traditionally used polyherbals in a southern African therapeutic context. J Ethnopharmacol. 2022;114977. https://doi.org/10.1016/j.jep.2022.114977

Nyagumbo E, Pote W, Shopo B, Nyirenda T, Chagonda I, Mapaya RJ, Maunganidze F, Mavengere WN, Mawere C, Mutasa I, Kademeteme E, Maroyi A, Taderera T, Bhebhe M. Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19. Physics Chem Earth. 2022;128:103232. https://doi.org/10.1016/j.pce.2022.103232

Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, Bensoussan A. Synergistic effects of Chinese herbal medicine: A comprehensive review of methodology and current research. Front Pharmacol. 2016;7:201. https://doi.org/10.3389/fphar.2016.00201.

Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. Livingstone, London. 1962.

Semenya SS, Maroyi A. Data on medicinal plants used to treat respiratory infections and related symptoms in South Africa. Data Brief. 2018;21:419-23. https://doi.org/10.1016/j.dib.2018.10.012

Bremner PD, Meyer JJM. Prenyl-butyrylphloroglucinol and kaurenoic acid: Two antibacterial compounds from Helichrysum kraussii. S Afr J Bot. 2000;66:115–17. https://doi.org/10.1016/S0254-6299(15)31072-3

Mathekga ADM. Antimicrobial activity of Helichrysum species and the isolation of a new phloroglucinol from Helichrysum caespititium. PhD Thesis, University of Pretoria, Pretoria. 2001.

Lourens ACU. Structural and synthetic studies of sesquiterpenoids and flavonoids isolated from Helichrysum species. PhD Thesis. University of KwaZulu Natal, Pietermaritzburg. 2008.

Lourens ACU, Van Vuuren SF, Viljoen AM, Davids H, Van Heerden FR. Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species. S Afr J Bot. 2011;77:229–35. https://doi.org/10.1016/j.sajb.2010.05.006

Legoale PB, Mashimbye MJ, Van Ree T. Anti-inflammatory and antioxidant flavonoids from Helichrysum kraussii and H. odoratissimum flowers. Nat Prod Comm. 2013;8(10):1403-4.

Twilley D. Evaluating the anticancer and antioxidant activity of southern African plants and their mechanism of action. MSc Dissertation, University of Pretoria, Pretoria. 2017.

Yardi SE. Metabolomic analysis on anti-HIV activity of selected Helichrysum species. PhD Thesis, University of Pretoria, Pretoria. 2019.

Semenya SS, Maroyi. A. Source of plants, used by Bapedi traditional healers for respiratory infections and related symptoms in the Limpopo province, South Africa. J Biol Sci. 2019;19(2):101-21. https://doi.org/10.3923/jbs.2019.101.121

de Canha MN. Antimicrobial and anti-inflammatory effect of southern African plants against Propionibacterium acnes. MSc Dissertation, University of Pretoria, Pretoria. 2014.

Prinsloo G, Meyer MJJM. In vitro production of phytoalexins by Helichrysum kraussii. S Afr J Bot. 2008;72:482-3. https://doi.org/10.1016/j.sajb.2006.01.001

McGaw LJ, Lall N, Meyer JJM, Eloff JN. The potential of South African plants against Mycobacterium infections. J Ethnopharmacol. 2008;119:482–500. doi:10.1016/j.jep.2008.08.022

Chinsembu KC. Tuberculosis and nature’s pharmacy of putative anti-tuberculosis agents. Acta Trop. 2016;153:46–56. doi:10.1016/j.actatropica.2015.10.004

Semenya SS, Maroyi A. Ethnobotanical survey of plants used by Bapedi traditional healers to treat tuberculosis and its opportunistic infections in the Limpopo province, South Africa. S Afr J Bot. 2019;122:401–21. doi:10.1016/j.sajb.2018.10.010

Semenya SS, Maroyi A. Source, harvesting, conservation status, threats and management of indigenous plant used for respiratory infections and related symptoms in the Limpopo province, South Africa. Biodiversitas. 2019;20(3):790-811. doi:10.13057/biodiv/d200325

Cock IE, Van Vuuren SF. The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations. J Ethnopharmacol. 2020;263:113204. doi:10.1016/j.jep.2020.113204

Semenya SS, Maroyi A. Ethnobotanical survey of plants used to treat respiratory infections and related symptoms in the Limpopo province, South Africa. J Herbal Med. 2020;24:100390. doi:10.1016/j.hermed.2020.100390

Mabogo DEN. The ethnobotany of the Vhavenda. MSc Dissertation, University of Pretoria, Pretoria. 1990.

Twilley D, Langhansová L, Palaniswamy D, Lall N. Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity. S Afr J Bot. 2017;112:494–500. doi:10.1016/j.sajb.2017.05.021

Candy HA, Wright W. Helichrysoside: A new acylated flavonoid glycoside from Helichrysum kraussii Sch. Bip. J South Afr Chem Institute. 1975;28:215–19. Available from: https://hdl.handle.net/10520/AJA03794350_1884

Candy HA, Laing M, Weeks CM. The crystal and molecular structure of helichrysoside, a new acylated flavonoid glycoside from Helichrysum kraussii. Tetrahedron Lett. 1975;14:1211–14. doi:10.1016/S0040-4039(00)72097-1

Bougatsos C, Meyer JJM, Magiatis P, Vagias C, Chinou I. Composition and antimicrobial activity of the essential oils of Helichrysum kraussii Sch. Bip. and H. rugulosum Less. from South Africa. Flavour Fragr J. 2003;18:48–51.

Fokou JBH, Dongmo PMJ, Boyom FF. Essential oil’s chemical composition and pharmacological properties. In: El-Shemy H, editor, Essential oils: Oils of nature, Intechopen, London; 2020, pp. 18-32. Available from: http://dx.doi.org/10.5772/intechopen.86573

Jugreet BS, Mahomoodally MF. Pharmacological properties of essential oil constituents and their mechanisms of action. In: Swamy M, editor, Plant-derived bioactives. Springer, Singapore; 2020, pp. 387-415. doi:10.1007/978-981-15-2361-8_18

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines. 2018;5:93. doi:10.3390/medicines5030093

Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, Emwas AH, Jaremko M. Important flavonoids and their role as a therapeutic agent. Molecules. 2020;25(22):5243. doi:10.3390/molecules25225243

York T, Van Vuuren SF, De Wet H. An antimicrobial evaluation of plants used for the treatment of respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa. J Ethnopharmacol. 2012;144:118–27. doi:10.1016/j.jep.2012.08.038

Maroyi A. Helichrysum caespititium (DC.) Harv.: Review of its medicinal uses, phytochemistry and biological activities. J Appl Pharmaceut Sci. 2019;9:111-18. doi:10.7324/JAPS.2019.90616

Maroyi A. Helichrysum cymosum (L.) D. Don (Asteraceae): medicinal uses, chemistry and biological activities. Asian J Pharmaceut Clinical Res. 2019;12:19-26. doi:10.22159/ajpcr.2019.v12i7.33771

Maroyi A. Medicinal uses, biological and phytochemical properties of Helichrysum foetidum (L.) Moench (Asteraceae). Asian J Pharmaceut Clinical Res. 2019;12:13-18. doi:10.22159/ajpcr.2019.v12i7.33607

Maroyi A. Helichrysum longifolium and H. pedunculatum: a comparative analysis of their medicinal uses, chemistry and biological activities. Asian J Pharmaceut Clinical Res. 2019;12:41-6. doi:10.22159/ajpcr.2019.v12i7.33684

Maroyi A. Helichrysum nudifolium (L.) Less.: review of its medicinal uses, phytochemistry and biological activities. J Pharm Nutr Sci. 2019;9:189-94. https://doi.org/10.29169/1927-5951.2019.09.03.8

Maroyi A. A synthesis and review of medicinal uses, phytochemistry and biological activities of Helichrysum odoratissimum (L.) Sweet. Asian J Pharmaceut Clinical Res. 2019;12:15-23. http://dx.doi.org/10.22159/ajpcr.2019.v12i8.33508

Maroyi A. Helichrysum petiolare Hilliard & B.L. Burtt: review of its medicinal uses, phytochemistry and biological activities. Asian J Pharmaceut Clinical Res. 2019;12:32-7. http://dx.doi.org/10.22159/ajpcr.2019.v12i6.33417

Van Wyk B-E. The potential of South African plants in the development of new medicinal products. S Afr J Bot. 2011;77:812-29. https://doi.org/10.1016/j.sajb.2011.08.011

Van Wyk B-E. A review of commercially important African medicinal plants. J Ethnopharmacol. 2015;176:118-34. https://doi.org/10.1016/j.jep.2015.10.031

Van Wyk B-E. A review of African medicinal and aromatic plants. In: Nefati M, Najjaa H, Máthé A, editors. Medicinal and Aromatic Plants of the World Africa. Dordrecht: Springer; 2017. p. 19-60.

Osman M, Karat AS, Khan M, Meehan S-A, Von Delft A, Brey Z, Charalambous S, Hesseling AC, Naidoo P, Loveday M. Health system determinants of tuberculosis mortality in South Africa: a causal loop model. BMC Health Serv Res. 2021;21:388. https://doi.org/10.1186/s12913-021-06398-0

Fatima S, Kumari A, Dwivedi VP. Advances in adjunct therapy against tuberculosis: deciphering the emerging role of phytochemicals. Med Comm. 2021;2:494–513. https://doi.org/10.1002/mco2.82

Gautam S, Qureshi KA, Jameel Pasha SB, Dhanasekaran S, Aspatwar A, Parkkila S, Alanazi S, Atiya A, Khan MMU, Venugopal D. Medicinal plants as therapeutic alternatives to combat Mycobacterium tuberculosis: a comprehensive review. Antibiotics. 2023;12:541. https://doi.org/10.3390/antibiotics12030541

Van Wyk B-E, Wink M. Phytomedicines, Herbal Drugs and Plant Poisons. Pretoria: Briza Publications; 2015.

Hussein RA, El-Anssary AA. Plants secondary metabolites: the key drivers of the pharmacological actions of medicinal plants. In: Builders PF (Ed), Herbal medicine. London: Intech Open; 2019. pp 11–30. https://doi.org/10.5772/intechopen.76139

Published

01-10-2023

Versions

How to Cite

1.
Maroyi A. Helichrysum kraussii Sch.Bip.: Review on its medicinal uses, phytochemistry and pharmacological properties. Plant Sci. Today [Internet]. 2023 Oct. 1 [cited 2024 Nov. 4];. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/2402

Issue

Section

Special issue on Mini Reviews