Phytochemicals as weapons against drug resistance

Authors

DOI:

https://doi.org/10.14719/pst.2495

Keywords:

ABC transporters, efflux pump modulation, Gram-negative bacteria, MDR, nano-biotics, PDR, uro-pathogens

Abstract

Phytochemicals are plant-based products with high medicinal value. These metabolites effectively target disease-causing microbes. Drug-resistant pathogens have developed mechanisms to sustain themselves even with inhibitors. Drug resistance has emerged as a global giant, causing all available treatment options to fail. The solution to this problem is in the phytochemicals of plants with antibacterial and drug resistance modulation properties. Phytochemicals might be able to get rid of efflux pumps, drug-modulating enzymes, resistance genes, quorum sensing, and biofilm, all of which cause pathogens to be resistant to drugs. Moreover, anti-obesogenic and cardioprotective properties are also observed in phytochemicals. Additionally, studies show the success of phytochemical-based nanoparticles in drug resistance regulation. This review emphasizes phytochemicals' different mechanisms of action and their derivatives in curbing drug-resistant pathogens and cancer cells.

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Author Biographies

Deshpande K Medini, Department of Life Sciences, Christ (Deemed to be University), Bangalore-560029, India

 

 

Pappuswamy Manikantan, Department of Life Sciences, Christ (Deemed to be) University

 

 

Chaudhary Aditi, Department of Life Sciences, Christ (Deemed to be University), Bangalore-560029, India

 

 

Kadanthottu Sebastian Joseph, Department of Life Sciences, Christ (Deemed to be University), Bangalore-560029, India

 

 

Alagamuthu Karthick Kumar, Selvamm Arts and Science College (Autonomous), Namakkal, Tamil Nadu

 

 

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Published

16-10-2023 — Updated on 23-10-2023

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1.
Kruttika J, Medini DK, Stena Jesima R, Keerthi GR, Manikantan P, Aditi C, Kuppusamy Alagesan P, Joseph KS, Karthick Kumar A. Phytochemicals as weapons against drug resistance. Plant Sci. Today [Internet]. 2023 Oct. 23 [cited 2024 Nov. 24];10(sp2):212-9. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/2495

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