Skip to main navigation menu Skip to main content Skip to site footer
Plant Science Today (PST)

Special issue on Mini Reviews

Vol. 10 No. sp2 (2023)

Biogenesis and Green Synthesis of Metal Nanoparticles and Their Pharmacological Applications

DOI
https://doi.org/10.14719/pst.2417
Submitted
9 February 2023
Published
23-11-2023 — Updated on 21-12-2023
Versions

Abstract

Nanomaterial innovation is the primary catalyst of advancement in nanotechnology. Although there are many known chemical processes for creating nanoparticles that use harmful substances, it is now more important than ever to use processes that are safer, greener, and more environmentally friendly. The goal of research in this field is to use diverse life forms as "nanoparticle factories." Phytochemicals can convert salt into the appropriate nanoparticles thanks to their regular biosynthetic routes. In recent years, green chemistry methods for the synthesis of metallic nanoparticles have emerged as a fresh and exciting area of study. Metal nanoparticles, including gold (Au), silver (Ag), iron (Fe), and cadmium (Cd) along with certain oxides, can be synthesized using a variety of chemical and physical techniques as well as biological techniques carried out using plants. It has been discovered that methods involving plant-mediated synthesis are a more efficient and cost-effective way to create these metal nanoparticles. The plant-mediated nanoparticles are used as potential pharmaceutical agents for many diseases, including hepatitis, cancer, malaria, and HIV. Due to the higher efficacy and fewer side effects of nanodrugs compared to other commercial cancer drugs, the synthesis of nanoparticles targeting biological pathways has gained tremendous popularity. This review paper aims to cover the different green methods for the biogenesis of these nanoparticles, the different compounds and salts used, and the metals obtained. Ultimately, the significance and prospects of these metal nanoparticles especially in the fields of medicine, pharmacology, drug designing, and drug delivery engineering will also be commented on.

References

  1. Salata O. Applications of nanoparticles in biology and medicine. J Nanobiotechnology. 2004;2(1):3. https://doi.org/10.1186/1477-3155-2-3
  2. Pankhurst Q, Connolly J, Jones S, Dobson J. Topical review: Applications of magnetic nanoparticles in biomedicine. J Phys--Appl Phys. 2003;36. https://doi.org/10.1088/0022-3727/36/13/201
  3. Mody VV, Siwale R, Singh A, Mody HR. Introduction to metallic nanoparticles. J Pharm Bioallied Sci. 2010;2(4):282–9.https://doi.org/ 10.4103/0975-7406.72127
  4. Soni V, Raizada P, Singh P, Cuong HN, S R, Saini A, et al. Sustainable and green trends in using plant extracts for the synthesis of biogenic metal nanoparticles toward environmental and pharmaceutical advances: A review. Environ Res. 2021; 202:111622.
  5. Khandel P, Yadaw RK, Soni DK, Kanwar L, Shahi SK. Biogenesis of metal nanoparticles and their pharmacological applications: present status and application prospects. J Nanostructure Chem. 2018;8(3):217–54. https://doi.org/10.1007/s40097-018-0267-4
  6. Kumar A, Dutta S, Kim S, Kwon T, Patil SS, Kumari N, et al. Solid-State Reaction Synthesis of Nanoscale Materials: Strategies and Applications. Chem Rev. 2022;122(15):12748–863.https://doi.org/10.1021/acs.chemrev.1c00637
  7. Bhardwaj B, Singh P, Kumar A, Kumar S, Budhwar V. Eco-Friendly Greener Synthesis of Nanoparticles. Adv Pharm Bull. 2020;10(4):566–76. https://doi.org/ 10.34172/apb.2020.067
  8. Naikoo G, Mustaqeem M, Hassan I, Awan T, Arshad F, Salim H, et al. Bioinspired and green synthesis of nanoparticles from plant extracts with antiviral and antimicrobial properties: A critical review. J Saudi Chem Soc. 2021; 25:101304.
  9. Ying S, Guan Z, Ofoegbu PC, Clubb P, Rico C, He F, et al. Green synthesis of nanoparticles: Current developments and limitations. Environ Technol Innov. 2022; 26:102336.
  10. Razavi R, Amiri M, Alshamsi H, Eslaminejad T, Salavati-Niasari M. Green Synthesis of Ag nanoparticles in oil-in-water nano-emulsion and evaluation of their antibacterial and cytotoxic properties as well as molecular docking. Arab J Chem. 2021;14:103323.
  11. Kiani M, Rabiee N, Bagherzadeh M, Ghadiri AM, Fatahi Y, Dinarvand R, et al. High-gravity-assisted green synthesis of palladium nanoparticles: the flowering of nanomedicine. Nanomedicine Nanotechnol Biol Med. 2020;30:102297.
  12. Vinodhini S, Vithiya BSM, Prasad TAA. Green synthesis of palladium nanoparticles using aqueous plant extracts and its biomedical applications. J King Saud Univ - Sci. 2022;34(4):102017.
  13. Rana A, Yadav K, Jagadevan S. A comprehensive review on green synthesis of nature-inspired metal nanoparticles: Mechanism, application and toxicity. J Clean Prod. 2020;272:122880.
  14. Dikshit PK, Kumar J, Das AK, Sadhu S, Sharma S, Singh S, et al. Green Synthesis of Metallic Nanoparticles: Applications and Limitations. Catalysts. 2021;11(8):902. https://doi.org/10.3390/catal11080902
  15. Wang Y, O’Connor D, Shen Z, Lo IMC, Tsang DCW, Pehkonen S, et al. Green synthesis of nanoparticles for the remediation of contaminated waters and soils: Constituents, synthesizing methods, and influencing factors. J Clean Prod. 2019;226:540–9.https://doi.org/10.1016/j.jclepro.2019.04.128
  16. Lin J, Miao L, Zhong G, Lin CH, Dargazangy R, Alexander-Katz A. Understanding the synergistic effect of physicochemical properties of nanoparticles and their cellular entry pathways. Commun Biol. 2020;3(1):1–10. https://doi.org/10.1038/s42003-020-0917-1
  17. Yang M, Li J, Gu P, Fan X. The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment. Bioact Mater. 2021;6(7):1973–87.https://doi.org/10.1016/j.bioactmat.2020.12.010
  18. Rao PV, Nallappan D, Madhavi K, Rahman S, Jun Wei L, Gan SH. Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents. Oxid Med Cell Longev. 2016; 3685671.
  19. Sabourian P, Yazdani G, Ashraf SS, Frounchi M, Mashayekhan S, Kiani S, et al. Effect of Physico-Chemical Properties of Nanoparticles on Their Intracellular Uptake. Int J Mol Sci. 2020;21(21):8019. https://doi.org/10.3390/ijms21218019
  20. Gahlawat G, Choudhury AR. A review on the biosynthesis of metal and metal salt nanoparticles by microbes. RSC Adv. 9(23):12944–67.https://doi.org/ 10.1039/c8ra10483b
  21. Rotti RB, Sunitha DV, Manjunath R, Roy A, Mayegowda SB, Gnanaprakash AP, et al. Green synthesis of MgO nanoparticles and its antibacterial properties. Front Chem. 2023; 11:1143614. https://doi.org/10.3389/fchem.2023.1143614
  22. Armendariz V, Herrera I, peralta-videa J, Yacaman M, Troiani H, Santiago P, et al. Size controlled gold nanoparticle formation by Avena sativa biomass: Use of plants in nanobiotechnology. J Nanoparticle Res. 2004;6:377–82. https://doi.org/10.1007/s11051-004-0741-4
  23. Malik S, Niazi M, Khan M, Rauff B, Anwar S, Amin F, et al. Cytotoxicity Study of Gold Nanoparticle Synthesis Using Aloe vera, Honey, and Gymnema sylvestre Leaf Extract. ACS Omega. 2023;8(7):6325–36. https://doi.org/10.1021/acsomega.2c06491
  24. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres M del P, Acosta-Torres LS, et al. Nano-based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018;16(1):71.https://doi.org/10.1186/s12951-018-0392-8
  25. Din F ud, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine. 2017;12:7291–309.https://doi.org/ 10.2147/IJN.S146315
  26. Yu B, Tai HC, Xue W, Lee LJ, Lee RJ. Receptor-targeted nanocarriers for therapeutic delivery to cancer. Mol Membr Biol. 2010;27(7):286–98.https://doi.org/ 10.3109/09687688.2010.521200
  27. Han X, Xu K, Taratula O, Farsad K. Applications of Nanoparticles in Biomedical Imaging. Nanoscale. 2019;11(3):799.https://doi.org/ 10.1039/c8nr07769j
  28. Ramesh M, Janani R, Deepa C, Rajeshkumar L. Nanotechnology-Enabled Biosensors: A Review of Fundamentals, Design Principles, Materials, and Applications. Biosensors. 2022;13(1):40.https://doi.org/ 10.3390/bios13010040
  29. Hasan A, Morshed M, Memic A, Hassan S, Webster TJ, Marei HES. Nanoparticles in tissue engineering: applications, challenges and prospects. Int J Nanomedicine. 2018;13:5637–55.https://doi.org/ 10.2147/ijn.S153758
  30. Mendes C, Thirupathi A, Corrêa MEAB, Gu Y, Silveira PCL. The Use of Metallic Nanoparticles in Wound Healing: New Perspectives. Int J Mol Sci. 2022 ;23(23):15376.https://doi.org/10.3390/ijms232315376
  31. Dykman LA, Khlebtsov NG. Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects. Acta Naturae. 2011;3(2):34–55.
  32. Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H. Silver nanoparticles: Synthesis, medical applications and biosafety. Theranostics. 2020;10(20):8996–9031.https://doi.org/ 10.7150/thno.45413
  33. Dadfar SM, Roemhild K, Drude NI, von Stillfried S, Knüchel R, Kiessling F, et al. Iron Oxide Nanoparticles: Diagnostic, Therapeutic and Theranostic Applications. Adv Drug Deliv Rev. 2019;138:302–25. https://doi.org/ 10.1016/j.addr.2019.01.005
  34. Wo?niak-Budych MJ, Staszak K, Staszak M. Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges. Molecules. 2023 ;28(18):6687.https://doi.org/10.3390/molecules28186687
  35. Ziental D, Czarczynska-Goslinska B, Mlynarczyk DT, Glowacka-Sobotta A, Stanisz B, Goslinski T, et al. Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine. Nanomaterials. 2020;10(2):387. https://doi.org/ 10.3390/nano10020387
  36. Zhang Y, Nayak TR, Hong H, Cai W. Biomedical Applications of Zinc Oxide Nanomaterials. Curr Mol Med. 2013;13(10):1633–45.https://doi.org/ 10.2174/1566524013666131111130058
  37. Gutiérrez de la Rosa SY, Muñiz Diaz R, Villalobos Gutiérrez PT, Patakfalvi R, Gutiérrez Coronado Ó. Functionalized Platinum Nanoparticles with Biomedical Applications. Int J Mol Sci. 2022;23(16):9404. https://doi.org/10.3390/ijms23169404
  38. Verma SK, Prabhat KC, Goyal L, Rani M, Jain A. A critical review of the implication of nanotechnology in modern dental practice. Natl J Maxillofac Surg. 2010;1(1):41–4.
  39. Altammar KA. A review on nanoparticles: characteristics, synthesis, applications, and challenges. Front Microbiol. 2023;14:1155622.https://doi.org/10.3389/fmicb.2023.1155622
  40. Malik S, Muhammad K, Waheed Y. Emerging Applications of Nanotechnology in Healthcare and Medicine. Molecules. 2023;28(18):6624.https://doi.org/10.3390/molecules28186624
  41. Mishra M, Kumar P, Rajawat JS, Malik R, Sharma G, Modgil A. Nanotechnology: Revolutionizing the Science of Drug Delivery. Curr Pharm Des. 2018;24(43):5086–107.https://doi.org/10.2174/1381612825666190206222415.
  42. Mhetre H, Kanse D, Patil D. Nanomaterials: Applications in Electronics. Int J Adv Eng Nano Technol. 2021;4:7–19.https://doi.org/10.35940/ijaent.D0464.094621
  43. Malik S, Muhammad K, Waheed Y. Nanotechnology: A Revolution in Modern Industry. Molecules. 2023;28(2):661.
  44. Banin U, Waiskopf N, Hammarström L, Boschloo G, Freitag M, Johansson EMJ, et al. Nanotechnology for catalysis and solar energy conversion. Nanotechnology. 2020 ;32(4):042003.DOI 10.1088/1361-6528/abbce8
  45. Ningthoujam R, Singh YD, Babu PJ, Tirkey A, Pradhan S, Sarma M. Nanocatalyst in remediating environmental pollutants. Chem Phys Impact. 2022;4:100064. https://doi.org/10.1016/j.chphi.2022.100064
  46. Arvizo R, Bhattacharya R, Mukherjee P. Gold nanoparticles: Opportunities and Challenges in Nanomedicine. Expert Opin Drug Deliv. 2010;7(6):753–63.https://doi.org/ 10.1517/17425241003777010
  47. Zhou W, Gao X, Liu D, Chen X. Gold Nanoparticles for In Vitro Diagnostics. Chem Rev. 2015 ;115(19):10575–636.https://doi.org/ 10.1021/acs.chemrev.5b00100
  48. Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–7. https://doi.org/ 10.1126/science.1114397.
  49. Jain P, Huang X, El-Sayed I, El-Sayed M. Review of Some Interesting Surface Plasmon Resonance-Enhanced Properties of Noble Metal Nanoparticles and Their Applications to Biosystems. Plasmonics. 2007;2:107–18.https://doi.org/10.1007/s11468-007-9031-1
  50. Farokhzad OC, Langer R. Impact of Nanotechnology on Drug Delivery. ACS Nano. 2009;3(1):16–20.https://doi.org/10.1021/nn900002m
  51. Kang YS, Risbud S, Rabolt JF, Stroeve P. Synthesis and Characterization of Nanometer-Size Fe 3 O 4 and ?-Fe 2 O 3 Particles. Chem Mater. 1996;8(9):2209–11. HTTPS://DOI.ORG/10.1021/CM960157J
  52. Rudge S, Peterson C, Vessely C, Koda J, Stevens S, Catterall L. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). J Control Release Off J Control Release Soc. 2001;74(1–3):335–40.https://doi.org/10.1016/s0168-3659(01)00344-3
  53. Erkoc P, Ulucan-Karnak F. Nanotechnology-Based Antimicrobial and Antiviral Surface Coating Strategies. Prosthesis. 2021;3(1):25–52.https://doi.org/10.3390/prosthesis3010005
  54. El-Atab N, Mishra RB, Hussain MM. Toward nanotechnology-enabled face masks against SARS-CoV-2 and pandemic respiratory diseases. Nanotechnology. 2021 ;33(6):062006. .https://doi.org/10.1088/1361-6528/ac3578
  55. Chattopadhyay S, Chen JY, Chen HW, Hu CMJ. Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation. Nanotheranostics. 2017;1(3):244–60.https://doi.org/ 10.7150/ntno.19796
  56. Mikhailova EO. Silver Nanoparticles: Mechanism of Action and Probable Bio-Application. J Funct Biomater. 2020;11(4):84.https://doi.org/ 10.3390/jfb11040084
  57. Sidhu AK, Verma N, Kaushal P. Role of biogenic capping agents in the synthesis of metallic nanoparticles and evaluation of their therapeutic potential. Front Nanotechn. 2022;3:801620. https://doi.org/10.3389/fnano.2021.801620
  58. Sharma NK, Vishwakarma J, Rai S, Alomar TS, AlMasoud N, Bhattarai A. Green Route Synthesis and Characterization Techniques of Silver Nanoparticles and Their Biological Adeptness. ACS Omega. 2022;7(31):27004–20.https://doi.org/10.1021/acsomega.2c01400
  59. Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, Wu S, Deng Y, Zhang J, Shao A. Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front Mol Biosci. 2020; 7:193. https://doi.org/10.3389/fmolb.2020.00193
  60. Sim S, Wong NK. Nanotechnology and its use in imaging and drug delivery (Review). Biomed Rep. 2021;14(5):42.https://doi.org/ 10.3892/br.2021.1418
  61. Torchilin VP. Lipid-core micelles for targeted drug delivery. Curr Drug Deliv. 2005;2(4):319–27.https://doi.org/10.2174/156720105774370221.
  62. Smith AM, Duan H, Rhyner MN, Ruan G, Nie S. A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Phys Chem Chem Phys PCCP. 2006;8(33):3895–903.https://doi.org/10.1039/b606572b
  63. Wang Q, Zhou YW, Jin Z, Chen C, Li H, Cai WB. Alternative Aqueous Phase Synthesis of a PtRu/C Electrocatalyst for Direct Methanol Fuel Cells. Catalysts. 2021;11(8):925.https://doi.org/10.3390/catal11080925
  64. Bellardita M, Addamo M, Di Paola A, Marcì G, Palmisano L, Cassar L, et al. Photocatalytic activity of TiO2/SiO2 systems. J Hazard Mater. 2009 Sep 1;174:707–13.https://doi.org/10.1016/j.jhazmat.2009.09.108
  65. Narayanan B, Sakthivel N. Coriander leaf mediated biosynthesis of gold nanoparticles. Mater Lett. 2008;62:4588–90.https://doi.org/10.1016/j.matlet.2008.08.044
  66. Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M. Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog. 2006;22(2):577–83.https://doi.org/ 10.1021/bp0501423.
  67. Ankamwar B. Biosynthesis of Gold Nanoparticles (Green-gold) Using Leaf Extract of Terminalia Catappa. J Chem. 2010;7:1334-91334–9.https://doi.org/10.1155/2010/745120
  68. Dubey S, Lahtinen M, Sillanpää M. Tansy fruit mediated greener synthesis of silver and gold nanoparticles. Process Biochem. 2010;45:1065–71.https://doi.org/10.1016/j.procbio.2010.03.024
  69. Qu J, Luo C, Hou J. Synthesis of ZnO nanoparticles from Zn-hyperaccumulator (Sedum alfredii Hance) plants. Micro Nano Lett IET. 2011;6:174–6.https://doi.org/10.1049/mnl.2011.0004
  70. Raghunandan D, Basavaraja S, Mahesh B, Balaji S, Manjunath SY, Venkataraman A. Biosynthesis of Stable Polyshaped Gold Nanoparticles from Microwave-Exposed Aqueous Extracellular Anti-malignant Guava (Psidium guajava) Leaf Extract. NanoBiotechnology. 2009;1–4(5):34–41.https://doi.org/ 10.1007/s12030-009-9030-8
  71. Shankar SS, Ahmad A, Pasricha R, Sastry M. Bioreduction of chloroaurate ions by geranium leaves and its endophytic fungus yields gold nanoparticles of different shapes. J Mater Chem. 2003;13(7):1822–6.https://doi.org/10.1039/B303808B
  72. Singh J, Mehta A, Rawat M, Basu S. Green synthesis of silver nanoparticles using sun-dried tulsi leaves and its catalytic application for 4-Nitrophenol reduction. J Environ Chem Eng. 2018;6:1468–74.https://doi.org/10.1016/j.jece.2018.01.054
  73. Parashar UK, Saxena P, Srivastava A. Bioinspired synthesis of silver nanoparticles. Dig J Nanomater Biostructures. 2009;4:159–66.
  74. Raghunandan D, Bedre MD, Basavaraja S, Sawle B, Manjunath SY, Venkataraman A. Rapid biosynthesis of irregular shaped gold nanoparticles from macerated aqueous extracellular dried clove buds (Syzygium aromaticum) solution. Colloids Surf B Biointerfaces. 2010;79(1):235–40.https://doi.org/ 10.1016/j.colsurfb.2010.04.003.

Downloads

Download data is not yet available.