Bioactive Compounds and Pharmacological Potential of Hojasen (Flourensia cernua): A Mini review
DOI:
https://doi.org/10.14719/pst.2546Keywords:
Antioxidants, antimicrobial, anti-inflammatory, hojasen, Flourensia cernua, polyphenolsAbstract
Flourensia cernua, commonly known as hojasen, is a shrub that is widely distributed in northern Mexico and the southern United States. The presence of this shrub indicates the characteristic flora of the Chihuahuan desert and southern Arizona, and it is an endemic plant of the Coahuila region in Mexico. The leaves and flowers of F. cernua are commercially available in Mexican markets for preparing infusions and are used as traditional medicine, mainly for gastrointestinal disorders such as indigestion, diarrhea, stomach pain, and dysentery, among others. Several studies have shown that F. cernua extracts contain bioactive compounds that can act as antioxidants in vitro by stopping free radicals from doing damage. In addition, F. cernua extracts have antifungal activity against phytopathogenic fungi. Additionally, F. cernua extracts have demonstrated antibacterial effects against Mycobacterium tuberculosis. Also, the anti-inflammatory effect of leaf extract at different doses has been studied to see how it affects the production of inflammatory cytokines and nitric oxide (NO) in macrophage cultures. Therefore, identifying its components and pharmacological properties can promote its use as an adjunct or therapeutic candidate in controlling various diseases. With its potential to alleviate gastrointestinal issues, provide antioxidant protection, and inhibit fungi and bacteria, hojasen extract may prove to be a valuable addition to the treatment of many diseases. This minireview aims to expand the existing knowledge about hojasen, a semi-desert shrub that possesses different bioactive compounds belonging to families of interest such as flavonoids, sesquiterpenoids, and coumarins, hoping to arouse the interest of other researchers to further investigate the activities, properties and uses attributed to Flourensia cernua.
Downloads
References
Arfin S, Jha NK, Jha SK, Kesari KK, Ruokolainen J, Roychoudhury S, Rathi B, Kumar D. Oxidative Stress in Cancer Cell Metabolism. Antioxidants. 2021;10(5):642.
Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016;24(5):547-53.
Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols. Biomed Pharmacother. 2020;129:110452.
Poznyak AV, Grechko AV, Orekhova VA, Chegodaev YS, Wu WK, Orekhov AN. Oxidative Stress and Antioxidants in Atherosclerosis Development and Treatment. Biology. 2020;9(3):60.
Tryon R. Manual of the vascular plants of Texas. Rhodora. 1970;72(792):533-5.
De León-Zapata MA, Pastrana-Castro L, Rua-Rodríguez ML, Alvarez-Pérez OB, Rodríguez-Herrera R, Aguilar CN. Experimental protocol for the recovery and evaluation of bioactive compounds of tarbush against postharvest fruit fungi. Food Chemistry. 2016;198:62-7.
d de Rodríguez DJ, Puente-Romero GN, Díaz-Jiménez L, Rodríguez-García R, Ramírez-Rodríguez H, Villarreal-Quintanilla JA, Flores-López ML, Carrillo-Lomelí DA, Genisheva ZA. In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla. Industrial Crops and Products. 2019;138:111444.
Yang X, Lu M, Wang Y, Wang Y, Liu Z, Chen S. Response Mechanism of Plants to Drought Stress. Horticulturae. 2021;7(3):50.
Dillon M. A systematic study of Flourensia (Asteraceae, Heliantheae). Fieldiana: Botany. 1984;16:1-66.
Rodríguez DJd, Angulo-Sánchez JL, Hernández-Castillo FD. Chapter 14 An overview of the antimicrobial properties of Mexican medicinal plants. In: Rai M, Carpinella MC, editors. Advances in Phytomedicine. 3: Elsevier; 2006. p. 325-77.
Morrone JJA, Roxana Fernández, Jesús A. Biogeographic units in the Chihuahuan Desert: implications for regionalization and area nomenclature. Revista Mexicana de Biodiversidad. 2022;93:e933907.
Rios MY. Chemistry and Biology of the Genus Flourensia (Asteraceae). Chemistry and Biodiversity. 2015;12(11):1595-634.
Jasso de Rodríguez D, Hernández-Castillo D, Angulo-Sánchez JL, Rodríguez-García R, Villarreal Quintanilla JA, Lira-Saldivar RH. Antifungal activity in vitro of Flourensia spp. extracts on Alternaria sp., Rhizoctonia solani, and Fusarium oxysporum. Industrial Crops and Products. 2007;25(2):111-6.
Mata R, Bye R, Linares E, Macías M, Rivero-Cruz I, Pérez O, Timmermann BN. Phytotoxic compounds from Flourensia cernua. Phytochemistry. 2003;64(1):285-91.
Estell RE, Fredrickson EL, James DK. Effect of light intensity and wavelength on concentration of plant secondary metabolites in the leaves of Flourensia cernua. Biochemical Systematics and Ecology. 2016;65:108-14.
Rao MM, Kingston DGI, Spittler TD. Flavonoids from flourensia cernua. Phytochemistry. 1970;9(1):227-8.
Aranda-Ledesma NE, González-Hernández MD, Rojas R, Paz-González AD, Rivera G, Luna-Sosa B, Martínez-Ávila GC. Essential Oil and Polyphenolic Compounds of Flourensia cernua Leaves: Chemical Profiling and Functional Properties. Agronomy. 2022;12(10).
Torres-León C, Ramírez FR, Aguirre-Joya JA, Ramírez-Moreno A, Chávez-González ML, Aguillón-Gutierrez DR, Camacho-Guerra L, Ramírez-Guzmán N, Vélez SH, Aguilar CN. Medicinal plants used by rural communities in the arid zone of Viesca and Parras Coahuila in northeast Mexico. Saudi Pharm J. 2023;31(1):21-8.
Estrada-Castillon E, Villarreal-Quintanilla JA, Encina-Dominguez JA, Jurado-Ybarra E, Cuellar-Rodriguez LG, Garza-Zambrano P. Ethnobotanical biocultural diversity by rural communities in the Cuatrocienegas Valley, Coahuila; Mexico. J Ethnobiol Ethnomed. 2021;17(1):21.
Latorre DL, Latorre FA. Plants Used by the Mexican Kickapoo Indians. Economic Botany. 1977;31(3):340-57.
Nicholson MS, Arzeni CB. The Market Medicinal Plants of Monterrey, Nuevo León, México. Economic Botany. 1993;47(2):184-92.
Alvarez-Pérez OB, Ventura-Sobrevilla JM, Ascacio-Valdés JA, Rojas R, Verma DK, Aguilar CN. Valorization of Flourensia cernua DC as source of antioxidants and antifungal bioactives. Industrial Crops and Products. 2020;152:112422.
Wong Paz JE, Muñiz Márquez DB, Martínez Ávila GCG, Belmares Cerda RE, Aguilar CN. Ultrasound-assisted extraction of polyphenols from native plants in the Mexican desert. Ultrasonics Sonochemistry. 2015;22:474-81.
Jasso de Rodríguez D, Torres-Moreno H, López-Romero JC, Vidal-Gutiérrez M, Villarreal-Quintanilla JÁ, Carrillo-Lomelí DA. Antioxidant, anti-inflammatory, and antiproliferative activities of Flourensia spp. Biocatalysis and Agricultural Biotechnology. 2023;47.
De León MÁ, Sáenz A, Jasso-Cantu D, Raúl R, Pandey A, Aguilar CN. Fermented Flourensia cernua Extracts and Their in vitro Assay Against Penicillium expansum and Fusarium oxysporum. Food Technology Biotechnology. 2013;51(2):233-9.
Castillo F, Hernández D, Gallegos G, Mendez M, Rodríguez R, Reyes A, Aguilar CN. In vitro antifungal activity of plant extracts obtained with alternative organic solvents against Rhizoctonia solani Kühn. Industrial Crops and Products. 2010;32(3):324-8.
Tellez M, Estell R, Fredrickson E, Powell J, Wedge D, Schrader K. Extracts of Flourensia cernua (L): Volatile constituents and antifungal, antialgal, and antitermite bioactivities. Journal of Chemical Ecology. Journal of Chemical Ecology. 2001;27(11):2263-73.
Castillo-Reyes F, León-Juárez ED, Nery-Flores SD, Flores-Gallegos AC, Campos-Muzquiz, LG, Ascacio-Valdés JA, Rodríguez-Herrera R. Polyphenols extraction from creosote bush, tarbush, and soursop using ultrasound-microwave and their effect against Alternaria alternata and Fusarium solani. Revista mexicana de fitopatología, 2022;40(3).
Molina-Salinas GM, Ramos-Guerra MC, Vargas-Villarreal J, Mata-Cardenas BD, Becerril-Montes P, Said-Fernandez S. Bactericidal activity of organic extracts from Flourensia cernua DC against strains of Mycobacterium tuberculosis. Arch Med Res. 2006;37(1):45-9.
Molina-Salinas GM, Peña-Rodríguez LM, Mata-Cárdenas BD, Escalante-Erosa F, González-Hernández S, Torres de la Cruz VM, Martínez-Rodríguez HG, Said-Fernández S. Flourensia cernua: hexane extracts a very active mycobactericidal fraction from an inactive leaf decoction against pansensitive and panresistant Mycobacterium tuberculosis. Evidence-Based Complementary and Alternative Medicine. 2011;2011:782503.
Mathews FP. The Toxicity of the Ripe Fruit of Blackbrush or Tarbrush (Flourensia cernua) for Sheep and Goats. Texas Agricultural Experiment Station Bulletin. 1944;664.
Fredrickson E, Thilsted J, Estell R, Havstad K. Effect of chronic ingestion of tarbush (Flourensia cernua) on ewe lambs. Vet Hum Toxicol. 1994;36(5):409-15.
Zavala C D, Carrillo I ML, Alvarado S B, Sánchez Ch AO. Evaluación de la toxicidad aguda de un extracto alcohólico de hojas de hojasén (Flourensia cernua). Revista Mexicana de Ciencias Farmacéuticas. 2010;41(3):50-4.
Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, Emwas AH, Jaremko M. Important Flavonoids and Their Role as a Therapeutic Agent. Molecules. 2020;25(22): 5243.
Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory effects of flavonoids. Food Chemistry. 2019;299:125124.
De León-Zapata MP-C, Lorenzo, Barbosa-Pereira L, Rua-Rodríguez ML, Ventura J, Rodríguez R, Aguilar CN. Effect of Flourensia cernua Bioactive Compounds on Stability of an Oil-in-Water (O/W) Emulsion. Biointerface Research in Applied Chemistry. 2021;11(6):13997-4006.
Moujir L, Callies O, Sousa PMC, Sharopov F, Seca AML. Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases. Applied Sciences. 2020;10(9).
de Cássia Da Silveira e Sá R, Andrade LN, De Sousa DP. Sesquiterpenes from essential oils and anti-inflammatory activity. Natural product communications. 2015;10(10):1767-74.
Araújo CA, Morgado CSA, Gomes AKC, Gomes ACC, Simas NK. Asteraceae family: A review of its allelopathic potential and the case of Acmella oleracea and Sphagneticola trilobata. Rodriguésia. 2021;72.
Johnston GA, Chebib M, Duke RK, Fernandez SP, Hanrahan JR, Hinton T, Mewett KN. Herbal Products and GABA Receptors. In: Squire LR, editor. Encyclopedia of Neuroscience. Oxford: Academic Press; 2009. p. 1095-101.
Benali T, Jaouadi I, Ghchime R, El Omari N, Harboul K, Hammani K, Rebezov M, Shariati MA, Mubarak MS, Simal-Gandara J, Zengin G. The Current State of Knowledge in Biological Properties of Cirsimaritin. Antioxidants. 2022;11(9):1842.
Cilia-López VG, Cariño-Cortés R, Zurita-Salinas LR. Ethnopharmacology of the Asteraceae family in Mexico. Botanical Sciences. 2021;99(3):455-86.
Liu X, Wang Z, Qian H, Tao W, Zhang Y, Hu C, Mao W, Guo Q. Natural medicines of targeted rheumatoid arthritis and its action mechanism. Frontiers in Immunology. 2022;13:945129.
Downloads
Published
Versions
- 11-01-2024 (2)
- 27-12-2023 (1)
How to Cite
Issue
Section
License
Copyright (c) 2022 Andrea Linares-Braham, Lissethe Palomo-Ligas, Sendar Daniel Nery-Flores
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
