Taxonomy, traditional uses and biological activity of Ficus carica L. (Moraceae): A review

Authors

DOI:

https://doi.org/10.14719/pst.3085

Keywords:

Ficus carica, antioxidant, antibacterial, plants, medicinal plants

Abstract

Ficus carica L. (Moraceae), a tree native to the tropics and subtropics that has been used traditionally in folk medicine. The crude extracts have been the focus of many studies due to its wide range of biological effects. Even though the species has been the subject of numerous pharmacologically based studies, very few studies have published on their findings. Attempts to bridge this knowledge gap are being made to enhance the species' utility in modern research. The following review looks at all research articles on anti-diabetic, antioxidant, antibacterial, antimicrobial, drugs, antiviral, traditional medicine, ethnopharmacology, toxicity, and cytotoxic activity. Therapeutically, some of the more fascinating impacts are on cancer prevention, liver diseases, blood sugar and antimicrobial activity. While the leaves, fruits and latex of the F. carica plant have been the primary focus of biological research, the stem and roots have got almost minimal attention. The results of this investigation indicate that extracts from all parts of F. carica are non-toxic. However, further well-planned clinical trials are required to confirm preclinical findings because the safety and effectiveness of F. carica have not been fully evaluated in humans. It is important to investigate the extract's mechanism of action. Establishing the standard dose and safety is necessary.

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References

Abdel-Aty AM, Hamed MB, Salama WH, Ali MM, Fahmy AS, Mohamed SA. Ficus carica, Ficus sycomorus and Euphorbia tirucalli latex extracts: Phytochemical screening, antioxidant and cytotoxic properties. Biocatalysis and Agricultural Biotechnology. 2019. https://doi.org/10.1016/j.bcab.2019.101199

Nafis A, Kasrati A, Jamali CA, Samri SE, Mezrioui N. Antioxidative effect and first evidence of synergistic antimicrobial effects of Ficus carica (L.) leaf essential oil with conventional antibiotics. Journal of Essential Oil Bearing Plants. 2019;22(5):1289-98. https://doi.org/10.1080/0972060X.2019.1684386

Radwan S, Handal G, Rimawi F, Hanania M. Seasonal variations in antioxidant activity, total flavonoids content, total phenolic content, antimicrobial activity and some bioactive components of Ficus carica L. in Palestine. International Journal of PharmTech Research. 2020;13(04):329-40. http://dx.doi.org/10.20902/IJPTR.2019.120404

Jabbari S, Firoozabad MSM. Antimicrobial effect of Ficus carica on nosocomial bacterial infections. Avicenna Journal of Pharmaceutical Research. 2021;2(2):73-78. 10.34172/ajpr.2021.14

George TT, Oyenihi AB, Oyenihi OR, Obilana AO. Composition and health-promoting effects of fig (Ficus carica) extracts. In book: Fig (Ficus carica): Production, Processing and Properties. Springer. 2023; p. 561-78. https://doi.org/10.1007/978-3-031-16493-4_25

Mawa S, Husain K, Jantan I. Ficus carica L. (Moraceae): Phytochemistry, traditional uses and biological activities. Evidence-Based Complementary and Alternative Medicine. 2013;2013. https://doi.org/10.1155/2013/974256

Badgujar SB, Patel VV, Bandivdekar AH, Mahajan RT. Traditional uses, phytochemistry and pharmacology of Ficus carica: A review. Pharmaceutical Biology. 2014;52(11):1487-503. https://doi.org/10.3109/13880209.2014.892515

Bouyahya A, Bensaid M, Bakri Y, Dakka N. Phytochemistry and ethnopharmacology of Ficus carica. International Journal of Biochemistry Research and Review. 2016;14:1-12. https://doi.org/10.9734/IJBCRR/2016/29029

Salehi B, Prakash Mishra A, Nigam M, Karazhan N, Shukla I, Kie?tyka-Dadasiewicz A. Ficus plants: State of the art from a phytochemical, pharmacological and toxicological perspective. Phytotherapy Research. 2021;35(3):1187-217. https://doi.org/10.1002/ptr.6884

Li Z, Yang Y, Liu M, Zhang C, Shao J, Hou X. A comprehensive review on phytochemistry, bioactivities, toxicity studies and clinical studies on Ficus carica Linn. leaves. Biomedicine and Pharmacotherapy. 2021;137:111393. https://doi.org/10.1016/j.biopha.2021.111393

Morovati MR, Ghanbari-Movahed M, Barton EM, Farzaei MH, Bishayee A. A systematic review on potential anticancer activities of Ficus carica L. with focus on cellular and molecular mechanisms. Phytomedicine. 2022:154333. https://doi.org/10.1016/j.phymed.2022.154333

El-Beltagi HS, Mohamed HI, Abdelazeem AS, Youssef R, Safwat G. GC-MS analysis, antioxidant, antimicrobial and anticancer activities of extracts from Ficus sycomorus fruits and leaves. Contribution to Journal. 2019. https://doi.org/10.15835/nbha47211405

Keskin D, Ceyhan Guvensen N, Zorlu Z, Ugur A. Phytochemical analysis and antimicrobial activity of different extracts of fig leaves (Ficus carica L.) from West Anatolia against some pathogenic microorganisms. Journal of Pure and Applied Microbiology. 2012;6(3):1105-10.

Souhila B, Asma B, Boumediene M, Aicha TT. Antimicrobial activity of dried fig (Ficus carica L.) extracts from the region of Mascara (Western Algeria) on Enterobacter cloacae identified by MALDI-TOF/MS. European Journal of Biological Research. 2021;11(2):234-41. http://dx.doi.org/10.5281/zenodo.4641370

Weli AM, Al-Blushi AAM, Hossain MA. Evaluation of antioxidant and antimicrobial potential of different leaves crude extracts of Omani Ficus carica against food borne pathogenic bacteria. Asian Pacific Journal of Tropical Disease. 2015;5(1):13-16. https://doi.org/10.1016/S2222-1808(14)60619-8

Shin B-S, Lee SA, Moon SM, Han S-H, Hwang EJ, Kim SG. Latex of Ficus carica L. induces apoptosis through caspase and Bcl-2 family in FaDu human hypopharynx squamous carcinoma cells. International Journal of Oral Biology. 2017;183-90. https://doi.org/10.11620/IJOB.2017.42.4.183

Tkachenko H, Buyun L, Osadowski Z, Honcharenko V, Prokopiv A. Antimicrobial screening of the ethanolic leaves extract of Ficus carica L. (Moraceae)– An ancient fruit plant. Plant Introduction. 2017;73:78-87. https://doi.org/10.5281/zenodo.2283589

Shahinuzzaman M, Yaakob Z, Anuar FH, Akhtar P, Kadir N, Hasan AM. In vitro antioxidant activity of Ficus carica L. latex from 18 different cultivars. Scientific Reports. 2020;10(1):10852. https://doi.org/10.1038/s41598-020-67765-1

Lansky EP, Paavilainen HM, Pawlus AD, Newman RA. Ficus spp. (Fig): Ethnobotany and potential as anticancer and anti-inflammatory agents. Journal of Ethnopharmacology. 2008;119(2):195-213. https://doi.org/10.1016/j.jep.2008.06.025

Pawlus A, Cartwright C, Vijjeswarapu M, Liu Z, Woltering E, Newman R. Anti-angiogenic activity from the fruit latex of Ficus carica (Fig). Planta Medica. 2008;74(09):PA97. https://doi.org/10.1055/s-0028-1084095

Canal J, Torres MD, Romero A, Pérez C. A chloroform extract obtained from a decoction of Ficus carica leaves improves the cholesterolaemic status of rats with streptozotocin-induced diabetes. Acta Physiologica Hungarica. 2000;87(1):71-76. https://doi.org/10.1556/aphysiol.87.2000.1.8

Pa?ayeva L, Özalp B, Fatullayev H. Potential enzyme inhibitory properties of extracts and fractions from fruit latex of Ficus carica based on inhibition of ?-amylase and ?-glucosidase. Journal of Food Measurement and Characterization. 2020;14:2819-27. https://doi.org/10.1007/s11694-020-00527-9

Patil VV, Patil VR. Evaluation of anti-inflammatory activity of Ficus carica Linn. leaves. Indian Journal of Natural Product. 2011;2(2):151-55.

Lazreg Aref H, Gaaliche B, Fekih A, Mars M, Aouni M, Pierre Chaumon J. In vitro cytotoxic and antiviral activities of Ficus carica latex extracts. Natural Product Research. 2011;25(3):310-19. https://doi.org/10.1080/14786419.2010.528758

Dogara AM. Biological activity and chemical composition of Detarium microcarpum Guill. and Perr—A systematic review. Advances in Pharmacological and Pharmaceutical Sciences. 2022;2022. https://doi.org/10.1155/2022/7219401

Mopuri R, Ganjayi M, Meriga B, Koorbanally NA, Islam MS. The effects of Ficus carica on the activity of enzymes related to metabolic syndrome. Journal of Food and Drug Analysis. 2018;26(1):201-10. https://doi.org/10.1016/j.jfda.2017.03.001

Benmaghnia S, Meddah B, Tir-touil A, Hernández JAG. Phytochemical analysis, antioxidant and antimicrobial activities of three samples of dried figs (Ficus carica L.) from the region of Mascara. Journal of Microbiology, Biotechnology and Food Sciences. 2021;2021:208-15. 10.15414/jmbfs.2019.9.2.208-215

Begum HA, Hamayun M, Rauf M, Gul H, Ali K, Khan W. Antimicrobial, antioxidant, phytochemical and pharmacognostic study of the leaf powder of Ficus carica L.. Pure and Applied Biology (PAB). 2020;9(1):999-1008. http://dx.doi.org/10.19045/bspab.2020.90105

Ergül M, Ergül M, Eruygur N, Mehmet A, Esra U. In vitro evaluation of the chemical composition and various biological activities of Ficus carica leaf extracts. Turkish Journal of Pharmaceutical Sciences. 2019;16(4):401. 10.4274/tjps.galenos.2018.70037

Nakilcio?lu-Ta? E, Ötle? S. Influence of extraction solvents on the polyphenol contents, compositions and antioxidant capacities of fig (Ficus carica L.) seeds. Anais da Academia Brasileira de Ciências. 2021;93. https://doi.org/10.1590/0001-3765202120190526

Petkova N, Ivanov I, Denev P. Changes in phytochemical compounds and antioxidant potential of fresh, frozen and processed figs (Ficus carica L.). International Food Research Journal. 2019;26(6):1881-88.

Zhao J, Gong L, Wu L, She S, Liao Y, Zheng H. Immunomodulatory effects of fermented fig (Ficus carica L.) fruit extracts on cyclophosphamide-treated mice. Journal of Functional Foods. 2020;75:104219. https://doi.org/10.1016/j.jff.2020.104219

Amessis-Ouchemoukh N, Ouchemoukh S, Meziant N, Idiri Y, Hernanz D, Stinco CM. Bioactive metabolites involved in the antioxidant, anticancer and anticalpain activities of Ficus carica L., Ceratonia siliqua L. and Quercus ilex L. extracts. Industrial Crops and Products. 2017;95:6-17. https://doi.org/10.1016/j.indcrop.2016.10.007

Abdel-Rahman R, Ghoneimy E, Abdel-Wahab A, Eldeeb N, Salem M, Salama E. The therapeutic effects of Ficus carica extract as antioxidant and anticancer agent. South African Journal of Botany. 2021;141:273-77. https://doi.org/10.1016/j.sajb.2021.04.019

Purnamasari R, Winarni D, Permanasari AA, Agustina E, Hayaza S, Darmanto W. Anticancer activity of methanol extract of Ficus carica leaves and fruits against proliferation, apoptosis and necrosis in Huh7it cells. Cancer Informatics. 2019;18:1176935119842576. https://doi.org/10.1177/1176935119842576

Yahiaoui S, Kati DE, Ali LM, El Cheikh K, Morére A, Menut C. Assessment of antioxidant, antiproliferative, anti-inflammatory and enzyme inhibition activities and UPLC-MS phenolic determination of Ficus carica latex. Industrial Crops and Products. 2022;178:114629. https://doi.org/10.1016/j.indcrop.2022.114629 37. Ara I, Naqvi SH, Rehman N, Qureshi MM. Comparative antioxidative and antidiabetic activities of Ficus Carica pulp, peel and leaf and their correlation with phytochemical contents. Pharm Res. 2020;4(2):000197. https://doi.org/10.23880/oajpr-1600197

ElAchaouia YI, Fakhfakh J, Adhar M, Affes M, Tounsi S, Allouche N. Determination of chemical composition, antioxidant, antibacterial and antidiabetic activities during maturation of Ficus carica stems and barks essential oils. Chemistry Africa. 2023;1-11. https://doi.org/10.1007/s42250-023-00600-y

Jeong MR, Kim HY, Cha JD. Antimicrobial activity of methanol extract from Ficus carica leaves against oral bacteria. Journal of Bacteriology and Virology. 2009;39(2):97-102. https://doi.org/10.4167/jbv.2009.39.2.97

Soltana H, Tekaya M, Amri Z, El-Gharbi S, Nakbi A, Harzallah A. Characterization of fig achenes’ oil of Ficus carica grown in Tunisia. Food Chemistry. 2016;196:1125-30. https://doi.org/10.1016/j.foodchem.2015.10.053

Ginwala R, Bhavsar R, Chigbu DGI, Jain P, Khan ZK. Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin. Antioxidants. 2019;8(2):35. https://doi.org/10.3390/antiox8020035

Liu Y-P, Guo J-M, Yan G, Zhang M-M, Zhang W-H, Qiang L. Anti-inflammatory and antiproliferative prenylated isoflavone derivatives from the fruits of Ficus carica. Journal of Agricultural and Food Chemistry. 2019;67(17):4817-23. https://doi.org/10.1021/acs.jafc.9b00865

Cho UM, Choi DH, Yoo DS, Park SJ, Hwang HS. Inhibitory effect of ficin derived from fig latex on inflammation and melanin production in skin cells. Biotechnology and Bioprocess Engineering. 2019;24:288-97. https://doi.org/10.1007/s12257-019-0010-0

Debib A, Tir-Touil A, Mothana R, Meddah B, Sonnet P. Phenolic content, antioxidant and antimicrobial activities of two fruit varieties of Algerian Ficus carica L.. Journal of Food Biochemistry. 2014;38(2):207-15. https://doi.org/10.1111/jfbc.12039

Duman E, ?im?ek M, Özcan MM. Monitoring of composition and antimicrobial activity of fig (Ficus carica L.) fruit and seed oil. Journal of Agroalimentary Processes and Technologies. 2018;24(2):75-80.

Barolo MI, Castelli MV, López SN. Antimicrobial properties and biotransforming ability of fungal endophytes from Ficus carica L. (Moraceae). Mycology. 2023;14(2):108-32. https://doi.org/10.1080/21501203.2023.2175500

Belattar H, Himour S, Yahia A. Pytochemical screening and evaluation antimicrobial activity of the methanol extract of Ficus carica. Revista Mexicana De Ciencias Agrícolas. 2021;12(1):1-9. https://doi.org/10.29312/remexca.v12i1.2435

Boyacioglu O, Kara B, Can H, Yerci TN, Yilmaz S, Boyacioglu SO. Leaf hexane extracts of two Turkish fig (Ficus carica L.) cultivars show cytotoxic effects on a human prostate cancer cell line. Agriculture and Food Sciences Research. 2019;6(1):66-70. https://doi.org/10.20448/journal.512.2019.61.66.70

Mennane Z, Tabet Z, Aabid T, Souhaila T, Emrani A, Abrini J. Ethnobotanical study of fig tree (Ficus carica L.) and olive (Olea europaea L.) from Tetouan Province in Morocco and study their antimicrobial activity. E3S Web of Conferences. EDP Sciences. 2021. https://doi.org/10.1051/e3sconf/202131901091

Shahbazi Y. Antibacterial and antioxidant properties of methanolic extracts of apple (Malus pumila), grape (Vitis vinifera), pomegranate (Punica granatum L.) and common fig (Ficus carica L.) fruits. Pharmaceutical Sciences. 2017;23(4):308-15. 10.15171/PS.2017.4551

Doro B, Garsa S, Abusua F, Elmarbet N, Shaban M. In vitro antibacterial activity of Ficus carica L. (Moraceae) from Libya. Journal of Complementary and Alternative Medical Research. 2018;5(3):1-8. https://doi.org/10.9734/JOCAMR/2018/40820

Acay H. Biosynthesis and characterization of silver nanoparticles using fig (Ficus carica) leaves: A potential antimicrobial activity. Applied Ecology and Environmental Research. 2019;17:13793-802. http://dx.doi.org/10.15666/aeer/1706_1379313802

Akhter S, Rafique T, Naseer M, Sadiq R, Ali Q, Zikrea A. Antibacterial and antifungal activity of Ficus carica plant extract. Journal of Pharmaceutical Research International. 2021;33(18):1-9. http://dx.doi.org/10.9734/JPRI/2021/v33i1831311

Yousef NS, El-Ghandour AA, El-Shershaby SS. Antimicrobial activity of fig and olive leaves extracts. Journal of Food and Dairy Sciences. 2019;10(12):503-08. 10.21608/JFDS.2019.71369

Abbas SN, Jamshed K, Nasir SB. Antimicrobial activities of methanolic and aqueous extracts of Nigella sativa and Ficus carica. Biologia (Pakistan). 2019;65(1):101-12.

Rimbawan F, Pinus Jumaryatno AF. Isolation endophytic fungi from Ficus carica L. as antibiotic producer against Staphylococcus aureus. Proceedings of International Conference on Technology and Social Science. 2018. https://conf.e-jikei.org/ICTSS2018/proceedings/materials/proc_files/A037/CameraReadyManuscript_ICTSS2018_GS_A037.pdf

Debib A, Tir-Touil M, Meddah B, Hamaidi-Chergui F, Menadi S, Alsayadi M. Evaluation of antimicrobial and antioxidant activities of oily macerates of Algerian dried figs (Ficus carica L.). International Food Research Journal. 2018;25(1):351-56.

Tkachenko H, Buyun L, Terech-Majewska E, Osadowski Z. In vitro antimicrobial activity of ethanolic extracts obtained from Ficus spp. leaves against the fish pathogen Aeromonas hydrophila. Fisheries and Aquatic Life. 2016;24(4):219-30. https://doi.org/10.1515/aopf-2016-0019

Desta W, Shumbahri M, Gebrehiwot S. Application of Ficus carica L. and Solanum incanum L. extracts in coagulation of milk: The case of traditional practice in Ab’ala area, Afar regional state, Ethiopia. Biochemistry Research International. 2020;2020:1-7. https://doi.org/10.1155/2020/9874949

Siyadatpanah A, Mirzaei F, Hossain R, Islam MT, Fatemi M, Norouzi R. Anti-parasitic activity of the Olea europaea and Ficus carica on Leishmania major: New insight into the anti-leishmanial agents. Biologia. 2022;77(7):1795-803. https://doi.org/10.1007/s11756-022-01066-y

Abbasi S, Kamalinejad M, Babaie D, Shams S, Sadr Z, Gheysari M. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine. 2017;35:85-91. https://doi.org/10.1016/j.ctim.2017.10.003

Pouryousef A, Eslami E, Shahriarirad S, Zoghi S, Emami M, Cheraghi MR. Effects of topical gel formulation of Ficus carica latex on Cutaneous leishmaniasis induced by Leishmania major in BALB/c mice. BMC Research Notes. 2021;14(1):199. https://doi.org/10.1186/s13104-021-05614-8

Meziant L, Bachir-bey M, Bensouici C, Saci F, Boutiche M, Louaileche H. Assessment of inhibitory properties of flavonoid-rich fig (Ficus carica L.) peel extracts against tyrosinase, ?-glucosidase, urease and cholinesterases enzymes and relationship with antioxidant activity. European Journal of Integrative Medicine. 2021;43:101272. https://doi.org/10.1016/j.eujim.2020.101272

Kurniawan MF, Yusuf FA. The possible antidiabetic effect of Ficus carica L. tablet on alloxaninduced diabetes model in rats. Open Access Macedonian Journal of Medical Sciences. 2021;9(A):727-34. https://doi.org/10.3889/oamjms.2021.6609.

Lin L, Zhang Y. Chemical constituents and antidiabetic activity of dichloromethane extract from Ficus carica leaves. Diabetes, Metabolic Syndrome and Obesity. 2023:979-91. https://doi.org/10.2147/DMSO.S405150

El Ghouizi A, Ousaaid D, Laaroussi H, Bakour M, Aboulghazi A, Soutien RS. Ficus carica (Linn.) leaf and bud extracts and their combination attenuates type-1 diabetes and its complications via the inhibition of oxidative stress. Foods. 2023;12(4):759. https://doi.org/10.3390/foods12040759.

Priyoherianto A, Saputra ME, Ikhda C, Hamidah N. The antidiabetic activity of Ficus carica folium in Mus musculus. 2018;17:44-47. https://doi.org/10.9790/0853-1704094448

Stephen Irudayaraj S, Christudas S, Antony S, Duraipandiyan V, Naif Abdullah AD, Ignacimuthu S. Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and ?-cells in type 2 diabetic rats. Pharmaceutical Biology. 2017;55(1):1074-81. https://doi.org/10.1080/13880209.2017.1279671

Oktarina Y, Mulyani S. The difference in the activity of ethanol extracts of leaves of anti diabetic tin (Ficus carica L.) leaf, rambutan (Nephelium lappaceum) and Persimmon (Diospyros Ft L) on the white mancit on streptozotocin induced. Caring: Indonesian Journal of Nursing Science. 2019;1(1):49-55. https://doi.org/10.32734/ijns.v1i1.1172.

Ramadan S, Hegab AM, Al-Awthan YS, Al-Duais MA, Tayel AA, Al-Saman MA. Comparison of the efficiency of Lepidium sativum, Ficus carica and Punica granatum methanolic extracts in relieving hyperglycemia and hyperlipidemia of streptozotocin-induced diabetic rats. Journal of Diabetes Research. 2021;2021. https://doi.org/10.1155/2021/6018835.

Alalwani AD, Hummdi LA, Qahl SH. Effect of nano extracts of Olea europaea leaves, Ficus carica and liraglutide in lipidemic liver of type 2 diabetic rat model. Saudi Journal of Biological Sciences. 2022;29(7):103333. https://doi.org/10.1016/j.sjbs.2022.103333

Zhang Y, Li Y, Ma P, Chen J, Xie W. Ficus carica leaves extract inhibited pancreatic ?-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation. Biomedicine and Pharmacotherapy. 2020;122:109689. https://doi.org/10.1016/j.biopha.2019.109689

Alqahtani AM, Attia G. Bioactive metabolites of Aspergillus neoniger, an endophyte of the medicinal plant Ficus carica. Indian Journal of Pharmaceutical Sciences. 2021;83(1):101-09. https://doi.org/10.36468/pharmaceutical-sciences.755

Jacob SJP, Prasad VS, Sivasankar S, Muralidharan P. Biosynthesis of silver nanoparticles using dried fruit extract of Ficus carica- Screening for its anticancer activity and toxicity in animal models. Food and Chemical Toxicology. 2017;109:951-56. https://doi.org/10.1016/j.fct.2017.03.066

Soltana H, Pinon A, Limami Y, Zaid Y, Khalki L, Zaid N. Antitumoral activity of Ficus carica L. on colorectal cancer cell lines. Cellular and Molecular Biology. 2019;65(6):6-11. https://doi.org/10.14715/cmb/2019.65.6.2

AlGhalban FM, Khan AA, Khattak MNK. Comparative anticancer activities of Ficus carica and Ficus salicifolia latex in MDA-MB-231 cells. Saudi Journal of Biological Sciences. 2021;28(6):3225-34. https://doi.org/10.1016/j.sjbs.2021.02.061

Ou A, Zhao X, Lu Z. Autophagy is involved in Ficus carica fruit extract-induced anti-tumor effects on pancreatic cancer. Biomedicine and Pharmacotherapy. 2022;150:112966. https://doi.org/10.1016/j.biopha.2022.112966

Abdou R, Mojally M, Attia GH. Investigation of bioactivities of endophytes of Ficus carica L. Family Moraceae. Bulletin of the National Research Centre. 2021;45:1-7. https://doi.org/10.1186/s42269-021-00505-1

Baohong L, Zhongyuan L, Ying T, Beibei Y, Wenting N, Yiming Y. Latex derived from Ficus carica L. inhibited the growth of NSCLC by regulating the caspase/gasdermin/AKT signaling pathway. Food and Function. 2023;14(4):2239-48. DOIhttps://doi.org/10.1039/D2FO02284B

Aziz B, Khurshid A, Mahmood R, Khan JA, Javaid S, Alam M. Study of synergistic effects of Ficus carica leaves extract mediated chemo-photodynamic therapy on rhabdomyosarcoma cells. Photodiagnosis and Photodynamic Therapy. 2021;36:102565. https://doi.org/10.1016/j.pdpdt.2021.102565

Azami H, Malek-Hosseini S, Taghi MM, Zareinejad M, Amirghofran Z. Antitumor activity and immunomodulatory effects of Ficus carica latex. Journal of Shahid Sadoughi University of Medical Sciences. 2020. https://doi.org/10.18502/ssu.v28i12.5776

Ghanbari A, Le Gresley A, Naughton D, Kuhnert N, Sirbu D, Ashrafi GH. Biological activities of Ficus carica latex for potential therapeutics in Human Papilloma Virus (HPV) related cervical cancers. Scientific Reports. 2019;9(1):1013. https://doi.org/10.1038/s41598-018-37665-6

Sadeghizade M, Baharara J, Salek F, Amini E. Assessment the effect of Ficus carica leaf extract on B16F10 melanoma cancer cells: The roles of p53, Caspase-3 and Caspase-9 on induction of intrinsic apoptosis cascade. Jundishapur Journal of Natural Pharmaceutical Products. 2022;17(2). https://doi.org/10.5812/jjnpp.117429

Kalefa NK, Al-Shawi AA. The essential oils isolated from the fruit of Ficus carica induced reactive oxygen species and apoptosis of human liver cancer cells. Egyptian Journal of Chemistry. 2023;66(2):257-65. https://doi.org/10.21608/EJCHEM.2022.136132.5995

Jeivad F, Yassa N, Ostad SN, Hassannejad Z, Gheshlaghi GH, Sabzevari O. Ficus carica L. latex: Possible chemo-preventive, apoptotic activity and safety assessment. Iranian Journal of Pharmaceutical Research: IJPR. 2020;19(3):231. https://doi.org/10.22037/ijpr.2020.1101151

El-Sayed SM, El-Naggar ME, Hussein J, Medhat D, El-Banna M. Effect of Ficus carica L. leaves extract loaded gold nanoparticles against cisplatin-induced acute kidney injury. Colloids and Surfaces B: Biointerfaces. 2019;184:110465. https://doi.org/10.1016/j.colsurfb.2019.110465

Di Vito M, Gentile M, Mattarelli P, Barbanti L, Micheli L, Mazzuca C. Phytocomplex influences antimicrobial and health properties of concentrated glycerine macerates. Antibiotics. 2020;9(12):858. https://doi.org/10.3390/antibiotics9120858

Abdulrahman MD, Zakariya AM, Hama HA, Hamad SW, Al-Rawi SS, Bradosty SW. Ethnopharmacology, biological evaluation and chemical composition of Ziziphus spina-christi (L.) Desf.: A review. Advances in Pharmacological and Pharmaceutical Sciences. 2022;2022. https://doi.org/10.1155/2022/4495688

Calvo P, Blanco M, Rodríguez M, Serradilla M, Sánchez F. In vitro and in vivo antifungal activity of allyl isothiocyanate (AITC) against Penicillium expansum in figs (Ficus carica L.). VI International Symposium on Fig. 2019;1310. https://doi.org/10.17660/ActaHortic.2021.1310.42

Dogara AM, Hamad SW, Hama HA, Bradosty SW, Kayfi S, Al-Rawi SS. Biological evaluation of Garcinia kola Heckel. Advances in Pharmacological and Pharmaceutical Sciences. 2022;2022. https://doi.org/10.1155/2022/3837965

Arafa E-SA, Hassan W, Murtaza G, Buabeid MA. Ficus carica and Sizigium cumini regulate glucose and lipid parameters in high-fat diet and streptozocin-induced rats. Journal of Diabetes Research. 2020;2020. https://doi.org/10.1155/2020/6745873

Dalai MK, Bhadra S, Chaudhary SK, Bandyopadhyay A, Mukherjee PK. Anti-cholinesterase activity of the standardized extract of Syzygium aromaticum L. Pharmacognosy Magazine. 2014;10(Suppl 2):S276. https://doi.org/10.4103/0973-1296.133275

Abdou R, Alqahtani AM, Attia GH. Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica. Bulletin of the National Research Centre. 2021;45(1):1-6. https://doi.org/10.1186/s42269-021-00536-8

Zhang Y, Wan Y, Huo B, Li B, Jin Y, Hu X. Extracts and components of Ficus carica leaves suppress survival, cell cycle and migration of triple-negative breast cancer MDA-MB-231 cells. OncoTargets and Therapy. 2018:4377-86. https://doi.org/10.2147/OTT.S171601

Gharibzahedi SMT, Smith B, Guo Y. Ultrasound-microwave assisted extraction of pectin from fig (Ficus carica L.) skin: Optimization, characterization and bioactivity. Carbohydrate Polymers. 2019;222:114992. https://doi.org/10.1016/j.carbpol.2019.114992

Pucci M, Mandrone M, Chiocchio I, Sweeney EM, Tirelli E, Uberti D. Different seasonal collections of Ficus carica L. leaves diversely modulate lipid metabolism and adipogenesis in 3T3-L1 adipocytes. Nutrients. 2022;14(14):2833. https://doi.org/10.3390/nu14142833

Zhou J-l, Huang XY, Qiu HC, Gan RZ, Zhou H, Zhu HQ. SSPH I, a novel anti-cancer saponin, inhibits autophagy and induces apoptosis via ROS accumulation and ERK1/2 signaling pathway in hepatocellular carcinoma cells. OncoTargets and Therapy. 2020;13:5979. https://doi.org/10.2147/OTT.S253234

Abou Seif HS. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-suef University Journal of Basic and Applied Sciences. 2016;5(2):134-46. https://doi.org/10.1016/j.bjbas.2016.03.004

Published

09-04-2024 — Updated on 14-04-2024

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Dogara AM, A Hama H, Ozdemir D. Taxonomy, traditional uses and biological activity of Ficus carica L. (Moraceae): A review . Plant Sci. Today [Internet]. 2024 Apr. 14 [cited 2024 Dec. 26];11(2). Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3085

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