POTENTIAL OF NATURAL BIOACTIVE COMPOUNDS IN MANAGEMENT OF MELASMA

Authors

DOI:

https://doi.org/10.14719/pst.3164

Keywords:

bioactive compounds, melasma, management, treatment

Abstract

Melasma is a form of inherited hyper-melanosis that appears as asymmetrical, brown-colored, uneven, reticulated macules on UVR-exposed skin, particularly on the facial area. The etiopathogenesis of melasma has been linked to several causes, including UV exposure, endocrine factors, genetic predisposition, anti-epileptic medications, and various cosmetics. The initial course of treatment for hyperpigmentation involves applying topical formulations of widely used substances like kojic acid, glycolic acid, and hydroquinone. Pharmaceuticals such as melatonin, tranexamic acid, and cysteamine hydrochloride are administered orally in this process. Chemical peels and laser therapy are examples of second-line therapies that are applied under the direction of trained experts. Unfortunately, these treatments have certain drawbacks and complications, including erythema, dryness, and skin peeling, and they take time to work, necessitating the use of herbal formulations for the management of hyperpigmentation. Bioactive compounds isolated from plants, such as arbutin, aloesin, flavonoids, hesperidin, licorice, ellagic acids, genistein, and quercetin, inhibit melanogenesis without melanocytotoxicity by different mechanisms. This review provides information on natural bioactive compounds used for the management of melasma.

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References

Nautiyal A, Wairkar S. Management of hyperpigmentation: Current treatments and emerging therapies. Pigment Cell and Melanoma Research. 2021;34(6):1000-14. https://doi.org/10.1111/pcmr.12986.

Mukherjee PK, Biswas R, Sharma A, Banerjee S, Biswas S, Katiyar CK. Validation of medicinal herbs for anti-tyrosinase potential. Journal of herbal medicine. 2018;14:1-6. https://doi.org/10.1016/j.hermed.2018.09.002.

Rathee P, Kumar S, Kumar D, Kumari B, Yadav SS. Skin hyperpigmentation and its treatment with herbs: an alternative method. Future Journal of Pharmaceutical Sciences. 2021; 7:1-4. https://doi.org/10.1186/s43094-021-00284-6.

Ni Z, Mu Y, Gulati O. Treatment of melasma with Pycnogenol®. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2002;16(6):567-71. https://doi.org/10.1002/ptr.1085.

Bandyopadhyay D. Topical treatment of melasma. Indian journal of dermatology. 2009 Oct;54(4):303. https://doi.org/10.4103/0019-5154.57602

Handel AC, Miot LD, Miot HA. Melasma: a clinical and epidemiological review. Anaisbrasileiros de dermatologia. 2014;89:771-82. https://doi.org/10.1590/abd1806-4841.20143063

Rigopoulos D, Gregoriou S, Katsambas A. Hyperpigmentation and melasma. Journal of cosmetic dermatology. 2007;6(3):195-202. https://doi.org/10.1111/j.1473-2165.2007.00321.x

Kwon SH, Na JI, Choi JY, Park KC. Melasma: Updates and perspectives. Experimental dermatology. 2019;28(6):704-8. https://doi.org/10.1111/exd.13844

Dubey D, Chaudhari L, Biharee A, Verma A, Kumar P, Shrivastava M. An overview of important natural products and phytomedicines used for management of melasma. World Journal of Pharmaceutical Research 2021;10(4): 744-55. https://doi.org/10.20959/wjpr20214-20123

Kang HY, Ortonne JP. Melasma update. ActasDermo-Sifiliográficas. 2009;100:110-3. https://doi.org/10.1016/S0001-7310(09)73385-X

Bagherani N, Gianfaldoni S, Smoller B. An overview on melasma. Pigmentary disorders. 2015;2(10):218. https://doi.org/10.4172/2376-0427.1000216

Prignano F, Ortonne JP, Buggiani G, Lotti T. Therapeutical approaches in melasma. Dermatologic clinics. 2007;25(3):337-42. https://doi.org/10.1016/j.det.2007.04.006

Gupta AK, Gover MD, Nouri K, Taylor S. The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology. 2006;55(6):1048-65. https://doi.org/ 10.1016/j.jaad.2006.02.009

Sytar O, Smetanska I. Special issue “Bioactive compounds from natural sources (2020, 2021)”. Molecules. 2022;27(6):1929. https://doi.org/10.3390/molecules27061929

Vashi NA, Kundu RV. Facial hyperpigmentation: causes and treatment. British Journal of Dermatology. 2013;169(s3):41-56. https://doi.org/10.1111/bjd.12536

Jimbow K, Minamitsuji Y. Topical therapies for melasma and disorders of hyperpigmentation. Dermatologic therapy. 2001 ;14(1):35-45. https://doi.org/10.1046/j.1529-8019.2001.014001035.x

Prota G. Melanins and melanogenesis. Academic Press; 2012 Dec 2.

Hatem S, El Hoffy NM, Elezaby RS, Nasr M, Kamel AO, Elkheshen SA. Background and different treatment modalities for melasma: Conventional and nanotechnology-based approaches. Journal of drug delivery science and technology. 2020;60:101984. https://doi.org/10.1016/j.jddst.2020.101984

D'Angelo Costa GM, Maia Campos PM. Efficacy of topical antioxidants in the skin hyperpigmentation control: A clinical study by reflectance confocal microscopy. Journal of Cosmetic Dermatology. 2021;20(2):538-45. https://doi.org/10.1111/jocd.13804

Daroach M, Vinay K, Bishnoi A, Parsad D, Kumaran MS. Extrafacial Melasma: A Scenario Less Explored. Indian Dermatology Online Journal. 2022;13(4):484. https://doi.org/10.4103/idoj.idoj_463_21

Kauh YC, Zachian TF. Melasma. RheumaDerm: current issues in rheumatology and dermatology. 1999:491-9. https://doi.org/10.1007/978-1-4615-4857-7_72

Konisky H, Balazic E, Jaller JA, Khanna U, Kobets K. Tranexamic acid in melasma: A focused review on drug administration routes. Journal of Cosmetic Dermatology. 2023. https://doi.org/ 10.1111/jocd.15589

Victor FC, Gelber J, Rao B. Melasma: a review. Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology. 2004;8:97-102. https://doi.org/10.1007/s10227-004-0158-9

Dessinioti C. Clio Dessinioti, Torello M. Lotti, Alexander J. Stratigos, KaterinaDamevska, and Andreas D. Katsambas. European Handbook of Dermatological Treatments.:613.

Lee AY. Recent progress in melasma pathogenesis. Pigment cell & melanoma research. 2015;28(6):648-60. https://doi.org/10.1111/pcmr.12404

Ogbechie-Godec OA, Elbuluk N. Melasma: an up-to-date comprehensive review. Dermatology and therapy. 2017:7:305-18. https://doi.org/10.1007/s13555-017-0194-1

Duteil L, Cadars B, Queille?Roussel C, Giraud I, Drulhon F, Graizeau C, Guyoux A, Passeron T. A new in vitro method to predict in vivo photoprotection of skin hyperpigmentation induced by visible light. Journal of the European Academy of Dermatology and Venereology. 2022;36(6):922-6. https://doi.org/ 10.1111/jdv.18034

Handbook of dermatological treatments. Vol. 613.

Arefiev KL, Hantash BM. Advances in the treatment of melasma: a review of the recent literature. Dermatologic surgery. 2012 ;38(7 pt1):971-84.https://doi.org/10.1111/j.1524-4725.2012.02435.x

Espinal?Perez LE, Moncada B, Castanedo?Cazares JP. A double?blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. International journal of dermatology. 2004;43(8):604-7. https://doi.org/10.1111/j.1365-4632.2004.02134.x

Chatterjee M, Vasudevan B. Recent advances in melasma. Pigment International. 2014 Jul 1;1(2):70-80. https://doi.org/10.4103/2349-5847.147044

Vachiramon V, Suchonwanit P, Thadanipon K. Melasma in men. Journal of Cosmetic Dermatology. 2012;11(2):151-7. https://doi.org/10.1111/j.1473-2165.2012.00613.

Damevska K. New aspects of melasma/novi aspekti melazme. Serbian Journal of Dermatology and Venereology. 2014;6(1):5-18.https://doi.org/10.2478/sjdv-2014-0001.

Cestari T, Arellano I, Hexsel D, Ortonne JP, Latin American Pigmentary Disorders Academy. Melasma in Latin America: options for therapy and treatment algorithm. Journal of the European Academy of Dermatology and Venereology. 2009;23(7):760-72. https://doi.org/10.1111/j.1468-3083.2009.03251.x

Grimes PE, Ijaz S, Nashawati R, Kwak D. New oral and topical approaches for the treatment of melasma. International Journal of Women's Dermatology. 2019;5(1):30-6. https://doi.org/ 10.1016/j.ijwd.2018.09.004

Rivas S, Pandya AG. Treatment of melasma with topical agents, peels and lasers: an evidence-based review. American journal of clinical dermatology. 2013;14:359-76. https://doi.org/ 10.1007/s40257-013-0038-4

Konisky H, Balazic E, Jaller JA, Khanna U, Kobets K. Tranexamic acid in melasma: A focused review on drug administration routes. Journal of Cosmetic Dermatology. 2023;22(4):1197-206.https://doi.org/10.1111/jocd.15589

Babbush KM, Babbush RA, Khachemoune A. The therapeutic use of antioxidants for melasma. J Drugs Dermatol. 2020;19(8):788-92. https://doi.org/10.36849/JDD.2020.5079

Gupta AK, Gover MD, Nouri K, Taylor S. The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology. 2006;55(6):1048-65. https://doi.org/10.1016/j.jaad.2006.02.009

Bergler-Czop B, Bilewicz-Stebel M, Sta?kowsk A, Bilewicz-Wyrozumska T. Side effects of retinoid therapy on the quality of vision. Acta Pharmaceutica. 2016;66(4):471-8. https://doi.org/10.1515/acph-2016-0039

Rendon M, Berneburg M, Arellano I, Picardo M. Treatment of melasma. Journal of the American Academy of Dermatology. 2006;54(5):S272-81. https://doi.org/10.1016/j.jaad.2005.12.039

Mahajan VK, Patil A, Blicharz L, Kassir M, Konnikov N, Gold MH, Goldman MP, Galadari H, Goldust M. Medical therapies for melasma. Journal of Cosmetic Dermatology. 2022;21(9):3707-28. https://doi.org/10.1111/jocd.15242

Torok HM. A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream. American Journal of Clinical Dermatology. 2006;7:223-30. https://doi.org/10.2165/00128071-200607040-00003

Taylor SC, Torok H, Jones T, Lowe N, Rich P, Tschen E, Menter A, Baumann L, Wieder JJ, Jarratt MM, Pariser D. Efficacy and safety of a new triple-combination agent for the treatment of facial melasma. Cutis-New York. 2003;72(1):67-73.

Šitum M, Koli? M, Bolan?a Ž, Ljubi?i? I, Mišanovi? B. Melasma–updated treatments. Collegium Antropologicum. 2011;35(2):315-8.

Kim HJ, Moon SH, Cho SH, Lee JD, Kim HS. Efficacy and safety of tranexamic acid in melasma: a meta-analysis and systematic review. ActaDermato-Venereologica. 2017;97(7):776-81. https://doi.org/ 10.2340/00015555-2668

Wang JV, Jhawar N, Saedi N. Tranexamic acid for melasma: evaluating the various formulations. The Journal of Clinical and Aesthetic Dermatology. 2019;12(8):E73.

Poojary S, Minni K. Tranexamic acid in melasma: A review. Pigment Disord. 2015;2(12):228. https://doi.org/10.4172/2376-0427.1000228

Zhu CY, Li Y, Sun QN, Takada A, Kawada A. Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study. European Journal of Dermatology. 2019;29:55-8. https://doi.org/10.1684/ejd.2018.3494

Azzam OA, Leheta TM, Nagui NA, Shaarawy E, Hay RM, Hilal RF. Different therapeutic modalities for treatment of melasma. Journal of Cosmetic Dermatology.2009;8(4):275-81. https://doi.org/10.1111/j.1473-2165.2009.00471.x

Yenny SW. Comparison of the use of 5% methimazole cream with 4% kojic acid in melasma treatment. Turk Dermatoloji Dergisi. 2018;12(4):167. https://doi.org/10.4274/tdd.3640

Trivedi MK, Yang FC, Cho BK. A review of laser and light therapy in melasma. International journal of women's dermatology. 2017;3(1):11-20. https://doi.org/10.1016/j.ijwd.2017.01.004

Iranmanesh B, Khalili M, Mohammadi S, Amiri R, Aflatoonian M. The efficacy of energy?based devices combination therapy for melasma. Dermatologic therapy. 2021;34(3):e14927. https://doi.org/10.1111/dth.14927

Handog EB, Galang DA, De Leon?Godinez MA, Chan GP. A randomized, double?blind, placebo?controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women. International Journal Of Dermatology. 2009;48(8):896-901. https://doi.org/10.1111/j.1365-4632.2009.04130.x

Tse TW, Hui E. Tranexamic acid: an important adjuvant in the treatment of melasma. Journal of Cosmetic Dermatology. 2013;12(1):57-66. https://doi.org/ 10.1111/jocd.12026

Jain P, Taleuzzaman M, Kala C, Kumar Gupta D, Ali A, Aslam M. Quality by design (Qbd) assisted development of phytosomal gel of aloe vera extract for topical delivery. Journal of Liposome Research. 2021;31(4):381-8. https://doi.org/ 10.1080/08982104.2020.1849279,

Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka F. Oral intake of proanthocyanidin?rich extract from grape seeds improves chloasma. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2004;18(11):895-9. https://doi.org/ 10.1002/ptr.1537

Rafique M, Shah SN, Hussain I, Javed I, Nisar N, Riaz R. Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging. Pakistan Journal of Pharmaceutical Sciences. 2021;34. https://doi.org/ 10.36721/pjps.2021.34.4.sup.1621-1628.1

Tao K, Guo L, Hu X, Fitzgerald C, Rouzard K, Healy J, Tamura M, Stock JB, Stock M, Pérez E, Fernández JR. Encapsulated Activated Grape Seed Extract: A Novel Formulation with Anti-Aging, Skin-Brightening, and Hydration Properties. Cosmetics. 2021;9(1):4. https://doi.org/ 10.3390/cosmetics9010004

Pinto CA, Delfes MF, Reis LM, Garbers LE, Passos PC, Torre DS. Uso do pycnogenol no tratamento do melasma. Surgical & Cosmetic Dermatology. 2015;7(3):218-22. https://doi.org/ 10.5935/scd 1984-8773.201573663

Zhu W, Gao J. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders. In Journal of Investigative Dermatology Symposium Proceedings 2008 Apr 1 (Vol. 13, No. 1, pp. 20-24). Elsevier. https://doi.org/ 10.1038/jidsymp.2008.8

Ku B, Kim D, Choi EM. Anti-melanogenic effect of the aqueous ethanol extract of Ginkgo biloba leaf in B16F10 cells. Toxicology and Environmental Health Sciences. 2020;12:287-95. https://doi.org/ 10.1007/s13530-020-00063-5

Mikayoulou M, Mayr F, Temml V, Pandian A, Vermaak I, Chen W, Komane B, Stuppner H, Viljoen A. Anti-tyrosinase activity of South African Aloe species and isolated compounds plicataloside and aloesin. Fitoterapia. 2021;150:104828. https://doi.org/ 10.1016/j.fitote.2021.104828

Ghafarzadeh M, Eatemadi A. Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy. Journal of cosmetic and laser therapy. 2017;19(3):181-7. https://doi.org/ 10.1080/14764172.2017.1279329

Joshua JM, Anilkumar AT, Cu VE, T Vasudevan DE, Surendran SA. Formulation and evaluation of antiaging phytosomal gel. Asian J Pharm Clin Res. 2018;11(3):409-22. https://doi.org/ 10.22159/ajpcr.2018.v11i3.24257

Korkij W, Bhunratanakornkij L, Wakawakyanon S. Efficacy of Aloe vera leaves extraction the treatment of melasma. Chulalongkorn Medical Journal. 1991;35(8):501-6. https://doi.org/ 10.58837/chula.cmj.35.8.5

Chiang HM, Chen CW, Chen CC, Wang HW, Jhang JH, Huang YH, Wen KC. Role of Coffea arabica extract and related compounds in preventing photoaging and photodamage of the skin. In Coffee in Health and Disease Prevention 2015 (pp. 523-530). Academic Press. https://doi.org/ 10.1016/B978-0-12-409517-5.00058-9

Saewan N. Effect of coffee berry extract on anti-aging for skin and hair—In vitro approach. Cosmetics. 2022;9(3):66. https://doi.org/ 10.3390/cosmetics9030066

Murray MT. Glycyrrhiza glabra (Licorice). Textbook of Natural Medicine. 2020:641.

Amer M, Metwalli M. Topical liquiritin improves melasma. International journal of dermatology. 2000;39(4):299-301. https://doi.org/ 10.1046/j.1365-4362.2000.00943.x

Maddaleno AS, Camargo J, Mitjans M, Vinardell MP. Melanogenesis and melasma treatment. Cosmetics. 2021;8(3):82. https://doi.org/ 10.3390/cosmetics8030082

Sarkar R, Bansal A, Ailawadi P. Future therapies in melasma: What lies ahead?. Indian journal of dermatology, venereology and leprology. 2020;86:8. https://doi.org/ 10.4103/ijdvl.ijdvl_633_18

Halder RM, Nordlund JJ. Topical treatment of pigmentary disorders. The pigmentary system: Physiology and pathophysiology. 2006:1163-74. https://doi.org/ 10.1111/exd.13844

Malik A, Khan MH, Khan SB, Ahmad A, Choudhary MI. Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure–activity relationship. Phytomedicine. 2006 Mar 13;13(4):255-60. https://doi.org/ 10.1016/j.phymed.2004.09.001

Huang HC, Chang TY, Chang LZ, Wang HF, Yih KH, Hsieh WY, Chang TM. Inhibition of melanogenesis versus antioxidant properties of essential oil extracted from leaves of Vitex negundo Linn and chemical composition analysis by GC-MS. Molecules. 2012;17(4):3902-16. https://doi.org/ 10.3390/molecules17043902

GoelzerNeto CF, do Nascimento P, da Silveira VC, de Mattos AB, Bertol CD. Natural sources of melanogenic inhibitors: A systematic review. International Journal of Cosmetic Science. 2022 Apr;44(2):143-53. https://doi.org/ 10.1111/ics.12763

Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, Hung WJ, Chen YJ, Huang MH. Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food and Chemical Toxicology. 2011;49(4):785-90. https://doi.org/ 10.1016/j.fct.2010.11.045

Yang Z, Wang Y, Wang Y, Zhang Y. Bioassay-guided screening and isolation of ?-glucosidase and tyrosinase inhibitors from leaves of Morusalba. Food chemistry. 2012 Mar 15;131(2):617-25. https://doi.org/ 10.1016/j.foodchem.2011.09.040

Nomakhosi M, Heidi A. Natural options for management of melasma. Journal of Cosmetic and Laser Therapy. 2018;20(7-8):470-81. https://doi.org/ 10.1080/14764172.2018.1427874

Babbush KM, Babbush RA, Khachemoune A. The therapeutic use of antioxidants for melasma. J Drugs Dermatol. 2020;19(8):788-92. https://doi.org/ 10.36849/JDD.2020.5079

Lee HR, Jung JM, Seo JY, Chang SE, Song Y. Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin. Journal of Ginseng Research. 2021;45(5):555-64. https://doi.org/ 10.1016/j.jgr.2020.11.003

Liu J, Jiang R, Zhou J, Xu X, Sun Z, Li J, Chen X, Li Z, Yan X, Zhao D, Zheng Z. Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport. European Journal of Pharmacology. 2021;910:174458. https://doi.org/ 10.1016/j.ejphar.2021.174458

Vaibhav S, Lakshaman K. Tyrosinase enzyme inhibitory activity of selected Indian herbs. Int J Res Pharm Biomed Sci. 2012;3:977-82.

Baby AR, Freire TB, Marques GD, Rijo P, Lima FV, Carvalho JC, Rojas J, Magalhães WV, Velasco MV, Morocho-Jácome AL. Azadirachta indica (Neem) as a potential natural active for dermocosmetic and topical products: a narrative review. Cosmetics. 2022;9(3):58. https://doi.org/ 10.3390/cosmetics9030058

Bahuguna A, Bharadwaj S, Chauhan AK, Kang SC. Inhibitory insights of strawberry (Fragaria× ananassa var. Seolhyang) root extract on tyrosinase activity using computational and in vitro analysis. International Journal of Biological Macromolecules. 2020;165:2773-88. https://doi.org/ 10.1016/j.ijbiomac.2020.10.135, PMID 33470201

Harahap ES, Ginting CN, Lubis YM, Chiuman L. The Activity of Strawberry Extract as Sunscreen on Guinea Pigs Exposed to Sunlight. In IOP Conference Series: Earth and Environmental Science 2022 Sep 1 (Vol. 1083, No. 1, p. 012007). IOP Publishing. https://doi.org/ 10.1088/1755-1315/1083/1/012007

Singhal A, Kumar D, Bansal M. Skin Whitening-A Brief Review. Skin. 2013;1(2):3-4.

Published

09-03-2024 — Updated on 01-04-2024

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Gupta J, Rani A, Kumar A, Kumar B. POTENTIAL OF NATURAL BIOACTIVE COMPOUNDS IN MANAGEMENT OF MELASMA. Plant Sci. Today [Internet]. 2024 Apr. 1 [cited 2024 Nov. 21];11(sp1). Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3164

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Special issue on Ethnobotany