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Hemionitis calomelanos (Sw.) Christenh.: From traditional medicinal uses to chemical identification of active principles

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DOI:

https://doi.org/10.14719/pst.3165

Keywords:

Adiantaceae, Hemionitis calomelanos, indigenous pharmacopeia, Pteridaceae, Sinopteridaceae, traditional medicine

Abstract

Hemionitis calomelanos (Sw.) Christenh. is a fern widely used as a traditional medicine throughout its distributional range. This study aims to record, analyze, and provide insights into the historical, scientific, and ethnopharmacological properties of H. calomelanos. Multiple searches on existing literature on the medicinal, phytochemical, and pharmacological properties of H. calomelanos were conducted in online databases such as Scopus, JSTOR, PubMed, Google Scholar, and Science Direct as well as using pre-electronic literature sources obtained from the university library. This study revealed that the leaves, rhizomes, roots, stems and whole plant parts of H. calomelanos are mainly used as ethnoveterinary medicines, lucky and protective charm, and traditional medicine for colds, boils, cough, sores, and diarrhoea. Phytochemical research showed that the species is characterized by flavonoids, steroids, tannins, esters, alcohols, ketones, and alkanes. Ethnopharmacological research revealed that the extracts of the species demonstrated antibacterial and antifungal activities. H. calomelanos is an important medicinal plant species in several countries with numerous medicinal applications. Despite its historical and traditional medicinal uses, many questions regarding the species’ ethnopharmacological properties and potential therapeutic effects remain to be answered. Therefore, future research should focus on validating the medicinal uses of H. calomelanos through elucidation of phytochemical composition, pharmacology, clinical application, toxicology, and safety.

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References

Eiserhardt WL, Rohwer JG, Russell SJ, Yesilyurt JC, Schneider H. Evidence for radiations of cheilanthoid ferns in the greater Cape floristic region. Taxon 2011;60:1269– 1283. https://doi.org/10.1002/tax.605004

Christenhusz MMJ, Fay MF, Byng JW. The global flora: A practical flora to vascular plant species of the world: Special edition: GLOVAP nomenclature part 1. Plant Gateway, Bradford. 2018

Crouch NR, Klopper RR, Burrows JE, Burrows SM. Ferns of Southern Africa: A comprehensive guide. Struik Nature, Cape Town. 2011

Hyde MA, Wursten BT, Ballings P, Palgrave CM. Flora of Zimbabwe: Species information: Pellaea calomelanos var. calomelanos. 2023. Available from: https://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=100910, accessed on 2 September 2023

Van Wyk BE, Van Oudtshoorn B, Gericke, N. Medicinal plants of southern Africa. Briza Publications, Pretoria. 2013

Maroyi A. Utilization of pteridophytes as herbal medicines in sub-Saharan Africa. In: Neffati M, Najjaa H, Mathé A, editors., Medicinal and aromatic plants of the world: Africa volume 3. Springer, Dordrecht. 2017; pp. 383-408. https://doi.org/10.1007/978-94-024-1120-1_16

Sureshkumar J, Silambarasan R, Bharati KA, Krupa J, Amalraj S, Ayyanar M. A review on ethnomedicinally important pteridophytes of India. J Ethnopharmacol 2018;219:269–287. https://doi.org/10.1016/j.jep.2018.03.024

Li Z-F, Huang H, Zhang H-Y, Zhang J-C. Review on the extraction of ?avonoids from fern. J Sanming Univ 2008;25(2):200–203

Santos MHG, Kelecom A, Paiva SR, Moraes MG, Rocha L. Phytochemical studies in Pteridophytes grown in Brazil: A review. Am J Plant Sci Biotechnol 2010;4(1):113–125.

Chettri S, Manviannan S, Muddursu VR. Nutrient and elemental composition of wild edible ferns of the Himalaya. Am Fern J. 2018;108:95–106. https://doi.org/10.1640/0002-8444-108.3.95

Marimuthu J, Janakiraman N, Saleride JC, Sivaraman A, Shivananthini B, Paulraj K. 2022. Phytochemistry of Indian pteridophytes: A review. In: Marimuthu J, Fernández H, Kumar A, Thangaiah S, editors., Ferns: Biotechnology, propagation, medicinal uses, and environmental regulation, Springer, Singapore. 2022; pp. 433-480. https://doi.org/10.1007/978-981-16-6170-9_19

Wu MJ, Weng CY, Wang L, Lian TW. Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.). J. Ethnopharmacol 2005;98:73–81. https://doi.org/10.1016/j.jep.2004.12.031

Nonato FR, Nonato TA, Barros A.M., Lucchese, C.E., Oliveira, R.R.S., Soares, M.B., Villarreal, C.F., 2009. Anti-in?ammatory and antinociceptive activities of Blechnum occidentale L. extract. J. Ethnopharmacol. 125, 102–107. https://doi.org/10.1016/j.jep.2009.06.005

Marimuthu J, Janakiraman N, Saleride JC, Sivaraman A, Shivananthini B, Paulraj K.. Biopotency of Pteridophytes: A review. In: Marimuthu J, Fernández H, Kumar A, Thangaiah S, editors., Ferns: Biotechnology, propagation, medicinal uses, and environmental regulation. Springer, Singapore. 2022; pp. 481-520. https://doi.org/10.1007/978-981-16-6170-9_20

Hirai RY, Cruz R, Prado J. A new species of Hemionitis (Pteridaceae) from central Brazil. Willdenowia 2018;48:371–380. https://doi.org/10.3372/wi.48.48305

Schuettpelz E, Rouhan G, Pryer KM, Rothfels CJ, Prado J, Sundue MA, Windham MD, Moran RC, Smith AR. Are there too many fern genera? Taxon 2018;67:473–480. https://doi.org/10.12705/673.1

Hyam R, Pankhurst RJ. Plants and their names: A concise dictionary. Oxford University Press, Oxford. 1995

Christenhusz M, Elias BR, Dyer R, Ivanenko Y, Rouhan G, Rumsey F, Väre H. 2017. Leathery hard-fern: Pellaea calomelanos (Europe assessment). The IUCN Red List of Threatened species: e.T78680201A85448386. 2017. Available from: https://www.iucnredlist.org/species/78680201/85448386, accessed on 4 September 2023.

Criado GM, Väre H, Nieto A, Elias BR, Dyer R, Ivanenko Y, Ivanova D, Lansdown R, Molina JA, Rouhan G, Rumsey F, Troia A, Vrba J, Christenhusz MJM. European Red List of Lycopods and Ferns. IUCN, Brussels. 2017. http://dx.doi.org/10.2305/IUCN.CH.2017.ERL.1.en

Forbes VS. Carl Peter Thunberg travels at the Cape of Good Hope 1772-1775. Van Riebeeck Society, Cape Town. 1986

Von Koenen E. Medicinal, poisonous and edible plants in Namibia. Klaus Hess Publishers, Windhoek. 2001

Welcome AK, Van Wyk B-E. An inventory and analysis of the food plants of southern Africa. S Afr J Bot 2019;122:136–179. https://doi.org/10.1016/j.sajb.2018.11.003

Moffett RO. Sesotho plant and animal names and plants used by the Basotho. Sun Press, Stellenbosch. 2010

Arnold TH, Prentice CA, Hawkes LC, Snyman EE, Tomalin M, Crouch NR, Pottas-Bircher C. Medicinal and magical plants of southern Africa: An annotated checklist. Strelitzia 13. National Botanical Institute, Pretoria. 2002

Williams VK, Balkwill K, Witkowski ETF. 2001. A lexicon of plants traded in the Witwatersrand umuthi shops, South Africa. Bothalia 2001;31(1):71-98. https://doi.org/10.4102/abc.v31i1.508

Cunningham AB. African medicinal plants: Setting priorities at the interface between conservation and primary health care. People and Plants working paper 1. UNESCO, Paris. 1993

Gelfand M, Mavi S, Drummond RB, Ndemera B. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Mambo Press, Gweru. 1985

Romero JB. The botanical lore of the California Indians. Vantage Press, New York. 1954

Jacobs ML. Index of plants of North Carolina with reputed medicinal uses. Chapel Hill, North Carolina. 1958

May LW. The economic uses and associated folklore of Ferns and Fern allies. Bot Rev 1978;44(4):491-528. https://doi.org/10.1007/bf02860848

Timberlake J. Vernacular names and uses of plants in northern Kenya. J East Afr Nat Hist 1994;83:31–69. https://doi.org/10.2982/0012-8317(1994)83[31:vnauop]2.0.CO;2

Arenas P, Azorero RM. Plants of common use in Paraguayan folk medicine for regulating fertility. Econ Bot 1977;31(3):298-301. https://doi.org/10.1007/BF02866879.

Haag G, Marín GH, Brignoles P, Del Valle ME, Magarinos SMC, Debenedetti SL. Antimicrobial activity of Latin American medicinal plant extracts. J Sci 2014;4(2):128-131.

Bussmann RW, Sharon D. Traditional medicinal plant use in Northern Peru: Tracking two thousand years of healing culture. J Ethnobiol Ethnomed 2006;2:47. https://doi.org/10.1186/1746-4269-2-47

Bussmann RW, Sharon D, Perez AF, Díaz D, Ford T, Rasheed T, Silva R. Antibacterial activity of Northern-Peruvian medicinal plants: A low cost laboratory approach to assess biological activity. Arnaldoa 2008;15:127–148.

Ambasta SP. The useful plants of India. CSIR Publications and Information Directorate, New Delhi. 1986

Chifundera K. Contribution to the inventory of medicinal plants from the Bushi area, South Kivu province, Democratic Republic of Congo. Fitoterapia 2001;72:351–368. https://doi.org/10.1016/S0367-326X(00)00294-X

Owuor BO, Kisangau DP. Kenyan medicinal plants used as antivenin: a comparison of plant usage. J Ethnobiol Ethnomed 2006;2(1):7. https://doi.org/10.1186/1746-4269-2-7

Rakotondrafara A, Rakotondrajaona R, Rakotoarisoa M, Ratsimbason M, Rasamison VE, Rakotonandrasana SR. Ethnobotany of medicinal plants used by the Zafimaniry clan in Madagascar. J Phytopharm 2018;7(6):483–494. https://doi.org/10.31254/phyto.2018.7606

Omale JM, Mutai P, Njogu P, Mukungu N, Mwangi J, Odongo E. Ethnobotanical survey of medicinal plants used in Emuhaya Subcounty, Vihiga county in western Kenya. Appl Medical Res 2020;7(1):6–25. https://doi.org/10.5455/ajpbp.20190707020750

Hutchings A, Scott AH, Lewis G, Cunningham B. Zulu medicinal plants: An inventory. University of Natal Press, Pietermaritzburg. 1996

Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. E and S Livingstone, London. 1962

Pujol J. Nature Africa: The herbalist handbook. Jean Pujol Natural Healers' Foundation, Durban. 1990

Braithwaite MC. 2007. A laboratory model for studying inhalation therapy in traditional healing rites. MSc Dissertation, University of the Witwatersrand, Johannesburg. 2007

Braithwaite M, Van Vuuren SF, Viljoen AM. Validation of smoke inhalation therapy to treat microbial infections. J Ethnopharmacol 2008;119;501–506. https://doi.org/10.1016/j.jep.2008.07.050

Philander LA. An ethnobotany of Western Cape Rasta bush medicine. J Ethnopharmacol 2011;138:578– 594. https://doi.org/10.1016/j.jep.2011.10.004

Kondlo M. Pellaea calomelanos. 2012. Available from: https://pza.sanbi.org/pellaea-calomelanos, accessed on 19 September 2023

Mabona U. Antimicrobial activity of southern African medicinal plants with dermatological relevance. [MSc Dissertation], University of the Witwatersrand, Johannesburg. 2013

Mabona U, Van Vuuren SF. Southern African medicinal plants used to treat skin diseases. S Afr J Bot 2013;87:175–193. https://doi.org/10.1016/j.sajb.2013.04.002

Mabona U, Viljoen A, Shikanga E, Marston A, Van Vuuren SF. Antimicrobial activity of southern African medicinal plants with dermatological relevance: From an ethnobotanical screening approach, to combination studies and the isolation of a bioactive compound. J Ethnopharmacol 2013;148:45–55. https://doi.org/10.1016/j.jep.2013.03.056

Roberts M, Roberts S. Indigenous healing plants. Briza Publications, Pretoria. 2017

Mahlangu SG. The antimicrobial activity of secondary metabolites produced by bacterial endophytes isolated from Pellaea calomelanos. [MSc Dissertation], University of Johannesburg, Johannesburg. 2019

Tshishonga K. The genomic profiles of endophytic bacteria isolated from Pellaea calomelanos. [MSc Dissertation], University of Johannesburg, Johannesburg. 2020

Mahlangu SG, Serepa-Dlamini MH. The first report of bacterial endophytes from the leaves of Pellaea calomelanos in South Africa. S Afr J Sci 2018;114:9-10. https://doi.org/10.17159/sajs.2018/4235.

Van Wyk B-E, Gericke N. People's plants: A guide to useful plants of Southern Africa. Briza Publications, Pretoria. 2018

Tshishonga K, Serepa-Dlamini MH. Draft genome sequence of Pseudarthrobacter phenanthrenivorans strain MHSD1, a bacterial endophyte isolated from the medicinal plant Pellaea calomelanos. Evol Bioinformatics 2020;16:117693432091325. https://doi.org/10.1177/1176934320913257

Roux JP. Swaziland ferns and fern allies. Southern African Botanical Diversity Network Report No. 19. National Botanical Institute, Pretoria. 2003

Long C. Swaziland's flora: siSwati names and uses. Swaziland National Trust Commission. 2005. Available from: http://www.sntc.org.sz/index.asp, accessed 19 November 2016

Mogale MMP, Raimondo DC, Van Wyk B-E. The ethnobotany of central Sekhukhuneland, South Africa. S Afr J Bot 2019;122:90–119. https://doi.org/10.1016/j.sajb.2019.01.001

Jacot Guillarmod A. Flora of Lesotho. Cramer, Lehre. 1971

Moteetee A, Van Wyk B-E. 2011. The medical ethnobotany of Lesotho: A review. Bothalia 2011;41:209–228. https://doi.org/10.4102/abc.v41i1.52

Gul A, Alam J, Ahmad H, Irfan M. An updated checklist of pteridophytes of district Mansehra, Khyber Pukhtunkhwa-Pakistan. Int J Biosci 2016;9(5):116-133. http://dx.doi.org/10.12692/ijb/9.5.116-133

Moteetee A. A review of plants used for magic by Basotho people in comparison with other cultural groups in southern Africa. Indian J Trad Knowl 2017;16:229–234.

Ozturk M, Altay V, Latiff A, Salman T, Choudhary I. A comparative analysis of the medicinal Pteridophytes in Turkey, Pakistan, and Malaysia. In: Ozturk M, Hakeem KR, editors., Plant and human health volume 1, Springer International Publishing AG, Cham. 2018; pp. 349-390. https://doi.org/10.1007/978-3-319-93997-1_9

Moteetee A, Moffett RO, Seleteng-Kose L. A review of the ethnobotany of the Basotho of Lesotho and the Free State province of South Africa (South Sotho). S Afr J Bot 2019;122:21–56. https://doi.org/10.1016/j.sajb.2017.12.012

Cock IE, Van Vuuren SF. The traditional use of southern African medicinal plants in the treatment of viral respiratory diseases: A review of the ethnobotany and scientific evaluations. J Ethnopharmacol 2020;262:113194. https://doi.org/10.1016/j.jep.2020.113194

Sobiecki JF. A preliminary inventory of plants used for psychoactive purposes in southern African healing traditions. Transact Royal Soc S Afr 2002;57(1):1-24. https://doi.org/10.1080/00359190209520523

Stafford GI, Pedersen ME, Van Staden J, Jäger AK. Review on plants with CNS effects used in traditional South African medicine against mental diseases. J Ethnopharmacol 2008;119:513–537. https://doi.org/10.1016/j.jep.2008.08.010

Gomes NGM, Campos MG, Órfão JMC, Ribeiro CAF. Plants with neurobiological activity as potential targets for drug discovery. Progress Neuro-Psychopharmacol Biol Psychiatry 2009;33:1372–1389. https://doi.org/10.1016/j.pnpbp.2009.07.033

Kinsou LDC, Assogba MF, Zinsou CMD, Goudjo AIM, Sezan A, Gbénou JD. Review of literature and phytochemistry screening of medicinal plants used in traditional treatment of brain diseases in Africa. Int J Phytopharm 2019;9(6):e5285. https://doi.org/10.7439/ijpp.v9i6.5285

Masondo NA, Stafford GI, Aremu AO, Makunga NP. Acetylcholinesterase inhibitors from southern African plants: An overview of ethnobotanical, pharmacological potential and phytochemical research including and beyond Alzheimer's disease treatment. S Afr J Bot 2019;120:39–64. https://doi.org/10.1016/j.sajb.2018.09.011

Zepp RA. Lesotho ferns. Morija Printing Works, Morija. 1982.

Amusan OOG, Dlamini P, Msonthi JD, Makhubu LP, Dlamini BB. Some medicinal plants used in traditional medicine in Swaziland. UNISWA J Agric Sci Tech 2000;4:20–26. https:// doi.org/10.4314/uniswa-rjast.v4i1.4686

Amusan OOG. Herbal medicine in Swaziland: An overview. In: Juliani HR, Simon JE, Ho C-T, Editors., African natural plant products: New discoveries and challenges in chemistry and quality. American Chemical Society, Washington DC. 2009; pp. 31-49. https://doi.org/10.1021/bk-2009-1021.ch003

Neuwinger HD. African ethnobotany: Poisons and drugs: Chemistry, pharmacology, toxicology. Chapman and Hall, Weinheim. 1996

Semenya SS, Maroyi A. Medicinal plants used for the treatment of tuberculosis by Bapedi traditional healers in three districts of the Limpopo province, South Africa. Afr J Trad Compl Alt Med 2013;10(2):316-323. http://dx.doi.org/10.4314/ajtcam.v10i2.17

Sagbo IJ, Hussein AA. Are plants used as a combating strategy against tuberculosis in the Mpumalanga province, South Africa? Appl Sci 2023;13:5008. https://doi.org/10.3390/app13085008

Markham KR. Distribution of flavonoids in the lower plants and its evolutionary significance. In: Harborne JB, editor., The flavonoids: Advances in research since 1980. Springer, Boston, MA. 1988; pp. 427-468. https://doi.org/10.1007/978-1-4899-2913-6_12

Dumisa M, Aiyegoro OA, Van Vuuren S. Medicinal plant: Dye combinations: Impact on antimicrobial potency and toxicity. S Afr J Bot 2020;135:188-200. https://doi.org/10.1016/j.sajb.2020.09.002

Hardoim PR, Van Overbeek LS, Berg G, Pirttilä AM, Company S, Campisano A, Döring M, Sessitsch A. The hidden world within plants: ecological and evolutionary considerations for defining functioning of microbial endophytes. Microbiol Mol Biol Rev 2015;79:293-320. https://doi.org/10.1128/mmbr.00050-14.

Strobel GA. Endophytes as sources of bioactive products. Microbes Infect 2003;5:535-544. https://doi.org/10.1016/S1286-4579(03)00073-X

Subbulakshmi GK, Thalavaipandian A, Bagyalakshmi RV, Rajendran A. Bioactive endophytic fungal isolates of Biota orientalis (L) Endl., Pinus excelsa Wall. and Thuja occidentalis L. Int J Adv Life Sci 2012;4:9-15

Alvin A, Miller KI, Neilan BA. Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds. Microbiol Res 2014;169:483-495. https://doi.org/10.1016/j.micres.2013.12.009

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20-06-2024

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Maroyi A. Hemionitis calomelanos (Sw.) Christenh.: From traditional medicinal uses to chemical identification of active principles. Plant Sci. Today [Internet]. 2024 Jun. 20 [cited 2024 Nov. 21];. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3165

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