A glimpse through the origin, composition and biomedical applications of green tea and its polyphenols: A review

Authors

DOI:

https://doi.org/10.14719/pst.3297

Keywords:

Flavonoids, polyphenols, antioxidant, health benefits

Abstract

Green tea is an aromatic healthy beverage that is the least processed type of tea, containing numerous bioactive components beneficial to humans. It is produced from the plant Camelia sinensis, a shrub native to Asia. This article reviews the literature review on the origin, manufacturing, composition, biomedical applications and health benefits of green tea and its polyphenols. The main bioactive components of green tea are polyphenols, primarily flavonoids. Catechins are the main flavonoids present in tea. These high-potential compounds can stimulate certain enzymes and alter cellular functions by preventing the oxidation of biomolecules due to their antioxidant properties. The catechins found in tea include (-) –epicatechin (EC), (-) epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG) and epigallocatechin -3-gallate (EGCG). Epigallocatechin gallate (EGCG) is the most prominent catechin in fresh leaves, constituting around 50-60 % of the flavonoids. EGCG is the active component with significant health benefits. These catechins contribute to therapeutic actions and the prevention of infections. Recent research on green tea suggests various applications based on its medicinal value to reduce the risk of many diseases.

 

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References

Hayat K, Iqbal H, Malik U, Bilal U, Mushtaq S. Tea and its consumption: benefits and risks. Critical Reviews in Food Science and Nutrition. 2015;55(7):939-54. DOI: 10.1080/10408398.2012.678949

Reygaert WC. Green tea catechins: Their use in treating and preventing infectious diseases. Biomedical Research International. 2018. DOI: 10.1155/2018/9105261

Gopal J, Muthu M, Paul D, Kim H, Chun S. Bactericidal activity of green tea extracts: the importance of catechin containing nano particles. Scientific Reports. 2016;6:19710.

https://doi.org/10.1038/srep19710

History of tea –UK Tea and infusions association.www.tea.co.uk

Sinija VR, Mishra HN. Green tea: Health benefits. Journal of Nutritional and Environmental Medicine. 2008;17(4). https://doi.org/10.1080/13590840802518785

Jigisha A, Nishant R, Navin K, et al. Green tea: a magical herb with miraculous outcomes. International Research Journal of Pharmacy. 2012;3(5):139-48. ISSN 2230-8407

DA Gupta, DJ Bhaskar, RK Gupta, B Karim, A Jain, et al. Green tea: a review on its natural antioxidant therapy and cariostatic benefits. Biological Sciences and Pharmaceutical Research. 2014;2(1):8-12. Article ID BSPR021,05 pages. ISSN 2350-1588

Muhamood, Abdullah MR, Khalaf HS. Use of flavonoids and green tea extracts as antioxidants induced by oxidative stress: A review article. Galore International Journal of Health Sciences and Research. 2022;7(2):4-12. DOI: 10.52403/gijhsr.20220402

Hilal Y. Morphology, manufacturing types, composition and medicinal properties of tea (Camellia sinensis). Journal Basic and Applied Plant Sciences. 2017;1(2):107,1-10. Corpus ID 53346201

Wong M, Sirisena S, Ken Ng. Phytochemical profile of differently processed tea: A review. Journal of Food Science. 2022;87(5):1925-42. https://doi.org/10.1111/1750-3841.16137

Martin. The story of black dragon tea posted on Nov 2, 2020.

Wierzejska R. Tea and health – A review of the current state of knowledge. Przegl Epidemiology. 2014;68(3):501-06. PMID 25391016

Adhikary B, Kashyap, K Bishwapran, Gogoi RC, Sabhapandit S, Babu A, et al. Green tea processing by pan-firing from region-specific tea (Camellia sinensis L.) cultivars - a novel approach to sustainable tea production in Dooars region of North Bengal. Food Chemistry Advance. 2023;Vol 2. https://doi.org/10.1016/j.focha.2023.100181

Balentine DA ,Wiseman SA, Bouwens LCM. The chemistry of tea flavonoids. Critical Reviews in Food Science and Nutrition. 1997;37(8):693-704. https://doi.org/10.1080/10408399709527797

Shi-Dong Lv, Yuan-Shuang Wu, Song, et al. Multivariate analysis based on GC-MS fingerprint and volatile composition for the quality evaluation of Pu –Erh green tea. Food Analytical Methods. 2015;8:321-33. http://dx.doi.org/10.1007/s12161-014-9900-0

Musial C, Jankowska AK, Ponikowska GM. Beneficial properties of green tea catechins. International Journal of Molecular Science. 2020;21(5):1744. https://doi.org/10.3390%2Fijms21051744

Cabrera C, Artacho R, Gimenez R. Beneficial effects of green tea- a review. Journal of American College of Nutrition. 2006;25(2):79-99. https://doi.org/10.1080/07315724.2006.10719518

Reygaert WC. The antimicrobial possibilities of green tea. Frontiers in Microbiology. 2014;5:434. https://doi.org/10.3389/2Ffmicb.2014.00434

Graham HN. Green tea composition, consumption and polyphenol chemistry. Preventive Medicine. 1992;21(3):334-50. http://dx.doi.org/10.1016/0091-7435(92)90041-F

Cazzola M, Ferraris S, Boschetto F, Rondinella A, Marin E, Zhu W, et al. Green tea polyphenols coupled with a bioactive titanium alloy surface; In vitro characterization of osteoinductive behaviour through a KUSA A1 cell study. International Journal of Molecular Science. 2018;19(8):2255. https://doi.org/10.3390/ijms19082255.

Chen ZM, Lin Z. Tea and human health, biomedical functions of tea active components and current issues. Journal of Zhejiang University Science B. 2015;16(2):87-102. . https://doi.org/10.1631/jzus.B1500001

Kim YK, YJ Oh, JO Ching, SJ Lee, KO Kim. Chemical composition of green tea according to processing methods and extraction condition. Food Science Biotechnology. 2009;18(5):1212-17. 1226-7708(pISSN)/2092-6456(eISSN)

Taylor PW, Hamilton Miller JMT, Stapleton PD. Antimicrobial properties of green tea catechins. Food Science and Technology Bulletin. 2005;2:71-81. doi: 10.1616/1476-2137.14184

Gramza A, Korezak J, Amarowicz R. Tea polyphenols- Their antioxidant properties and biological activity. Polish Journal of Food Nutrition Sciences. 2005;14/55(3):219-35.

Zaveri N. Green tea and its polyphenolic catechins: medicinal uses in cancer and non cancer applications. Life Science. 2006;78(18):2073-80. https://doi.org/10.1016/J.LFS.2005.12.006

Chacko SM, Thambi PT, Kuttan R, Nishigak I. Beneficial effects of green tea: A literature review. Chinese Medicine. 2010;5:13. https://doi.org/ 10.1186/1749-8546-5-13

All about green tea: major components and health benefits of green tea. https://www.itoen-global.com/

Twafeeq ZS, Sultan MM. Effect of green tea polyphenol (EGCG) on orthodontic micro-implant stability: An experimental study. Journal of Oral and Dental Research. 2017;4(2):102-09. https://doi.org/10.12816/0038705

Jamir A, Longkummer S, Ezung S, Kechu M, Pankaj PP. Biomedical applications of Epigallocatechin Gallate (EGCG) b- A potent green tea extract. Biological Spectrum of Northeast India. EBH Publishers. 2021;11-18. 30. Vester H, Holzer N, Neumaier M, Lilianna S, Nussler AK, Seeliger C. Green tea extract (GTE) improves differentiation in human osteoblasts during oxidative stress. Journal of Inflammation (Lond). 2014;11:15. https://doi.org/10.1186/1476-9255-11-15

Kathy W, Warwick RD. Medically reviewed. CDE nutrition written by Megan Ware RDN. What are the health benefits of green tea? Medical News Today. 2023.

Hara Y. Green tea: Health benefits and applications. First Edition, Taylor and Francis Group, CRC Press. 2001. https://doi.org/10.1201/9780203907993

Bond T, Derbyshire E. Tea compounds and the gut microbiome; Findings from trial and mechanistic studies. Nutrients. 2019;11(10):2364. https://doi.org/10.3390/nu11102364

Freitas D Cristina L, De Sousa Gustavo L, Leite Luciano G, et al. Influence of green tea extract with different concentration of epigallocatechin gallate on calvaria bone repair of ovariectomized rats. International Journal of Morphology. 2019;37(4):1325-30. https://doi.org/10.4067/S0717-95022019000401325

Araghizadeh A, Kohanteb J, Mehdi M. Inhibitory activity of green tea (Camelia sinensis) extract on some clinically isolated cariogenic and periodontopathic bacteria. Medical Principles and Practice. 2013;22(4):368-72. https://doi.org/10.1159/000348299

Sreenivasagan S, Kumar A, Subramanian, Rajeshkumar S. Assessment of antimicrobial activity and cytotoxicity effect of green mediated silver nanoparticles and its coating into mini implants. Annals of Phytomedicine. 2020;9(1):207-12. http://dx.doi.org/10.21276/ap.2020.9.1.27

Williamson MP, McCormik TG, Nance CL, Shearer WT. Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4 potential for HIV -1 therapy. Journal of Allergy and Clinical Immunology. 2006;118(6):1369-74. https://doi.org/10.1016/j.jaci.2006.08.016

Fassina, Gianfranco, Buffa, Anna, Roberto Benelli, Oliviero Varnier, et al. Polyphenolic antioxidant epigallocatechin-3-gallate green tea as a candidature anti HIVagent. AIDS. 2002; 16(6):939-41. https://doi.org/10.1097/00002030-200204120-00020

Farhad Mollashahi N, Bokaeian M, Farhad Mollashahi L, Afrougheh A. Antifungal efficacy of green tea extract against Candida albicans biofilm on tooth substrate. Journal of Dentistry (Tehran). 2015;12(8):592-98. PMID27123019

Miki UI, Yasuda H, Shibata M, Maruyama T, Horita H, Yasuda T, et al. Effect of tea catechins for halitosis and their application to chewing gum. Food and Agricultural Organization of the United Nations. Journal of the Japanese Society for Food Science and Technology. 1991;38(12):1098-102. https://doi.org/10.3136/nskkk1962.38.1098

Sakanaka S, Aizawa M, Kim M, Yamamoto T. Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. Bioscience, Biotechnology Biochemistry. 1996;60(5):745-49. https://doi.org/10.1271/bbb.60.745

Parvez MAK, Saha K, Rahman J, Munmun RA, Rahman MA, Dey SK, et al. Antibacterial activities of green tea crude extracts and synergistic effects of epigallocatechin gallate (EGCG) with gentamicin against MDR pathogens. Heliyon. 2019;5(7):e02126. https://doi.org/10.1016/j.heliyon.2019.e02126

Kazuto Matsunga, Thomas Klein, Herman Friedman, YoshimasaYamamoto. Epigallocatechin gallate, a potential immunomodulatory agent of tea components, diminishes cigarette smoke condensate induced suppression of anti-Legionella pneumophilia activity and cytokine responses of alveolar macrophages. Clinical Diagnostic Laboratory Immunology. 2002;9(4):864-71. https://doi.org/10.11282FCDLI.9.4.864-871.2002

Cho YS, Schiller NL, Kahng HY, Oh KH. Cellular responses and proteomic analysis of Escherichia coli exposed to green tea polyphenols. Curr Microbiol. 2007;55(6):501-06. https://doi.org/ 10.1007/s00284-007-9021-8.

Jeon J, Kim JH, Lee CK, Oh CH, Song HJ. The antimicrobial activity of (-) epigallocatechin 3 gallate and green tea extract against Psuedomonas aeruginosa and Eschericha coli isolated from skin wounds. Annals of Dermatology. 2014;26(5):564-69. https://doi.org/10.5021/ad.2014.26.5.564

Ben Lagha A, Haas B, Grenier D. Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum. Sci Rep. 2017;7:44815. https://doi.org/10.1038/srep44815.

Wang Y, Ma S. Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASH) system enzymes as potential agents. Chem Med Chem. 2013;8(10):1589-608. https://doi.org/10.1002/cmdc.201300209

Zhang YM, Rock CO. Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase. J Biol Chem. 2004;23;279(30):30994-1001. https://doi.org/ 10.1074/jbc.M403697200.

Zhao WH, Hu ZQ, Hara Y, Shimamura T. Inhibition by epigallocatechin gallate (EGCg) of conjugative R plasmid transfer in Escherichia coli. J Infect Chemother. 2001;7(3):195-97. https://doi.org/ 10.1007/s101560100035.

Lee KM, Yeo M, Choue JS, Jin JH, Park SJ, Cheong JY, et al. Protective mechanism of epigallocatechin -3- gallate against Helicobacter pylori induced gastric epithelial cytotoxicity via the blockage of TLR-4 signalling. Heliobacter. 2004;9(6):632-42. https://doi.org/10.1111/j.1083-4389.2004.00281.x

Lee Ji-Hye, Jin Sun Shim, Mi-Sook Chung, seung-Talk Lim, Kyung Hyun Kim. In-vitro antiadhesive activity of green tea extract against pathogen adhesion. Phytotherapy Research. 2009;23(4):460-66. https://doi.org/10.1002/ptr.2609

Khaleel AK, Shaari RB, Nawi MAA, Al-Yassiri AMH. Adverse effects of green tea on public health the untold whole story. Systematic Reviews in Pharmacy. 2020;11(9):883-87. https://dx.doi.org/10.31838/srp.2020.9.128

Romain Gloro, Isabelle Hourmand- Ollivier, Brigitte Mosquet, et al. Fulminant hepatitis during self medication with hydroalcoholic extract of green tea. Europeon Journal of Gastroenterology and Hepatology. 2005;17(10):1135-37. https://doi.org/ 10.1097/00042737-200510000-00021

Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, et al. Protective effects of green tea extract on human cervical lesion. European Journal of Cancer Prevention. 2003;12(5):383-90. https://doi.org/10.1097/00008469-203/00007.

Jain A, Manghani C, Kohli S, Nigham D, Rani V. Tea and human health. The Dark Shadows, Toxicology Letters. 2013;220(1):82-87. https://doi.org/ 10.1016/j.toxlet.2013.04.010.

Schwalfenberg G, Genuis SJ, Rodushkin I. The benefits and risk of consuming brewed tea: Beware of toxic element contamination. Journal of Toxicology. 2013;https://doi.org/10.1155/2013/370460

Are there health benefit to drinking green tea. By Dn Brennan, WebMD Editorial Contributors; September 29, 2020.

Khan N, Mukhtar H. Tea and health studies in humans. Curr Pharm Des. 2013;19(34):6141-47. https://doi.org/ 0.2174/1381612811319340008.

Green tea - Clinical review medically reviewed by drugs .com; Dec19, 2022.

Chandrima Das, Aranab Baanerjee, Sirshendu Chatterjee, Moumita Saha. A review of health benefits of tea. Implications of the biochemical properties of the bioactive constituents. Current Research in Nutrition and Food Science. 2022;doi:http://dx.doi.org/10.12944/CRNFSJ.10.2.5

Published

30-09-2024 — Updated on 01-10-2024

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Joseph S, Nallaswamy D, S R, Dathan P, Ismail S, Jacob J, Rasheed N. A glimpse through the origin, composition and biomedical applications of green tea and its polyphenols: A review. Plant Sci. Today [Internet]. 2024 Oct. 1 [cited 2024 Nov. 21];11(4). Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3297

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