This paper unveils the outcomes of an extensive research endeavor investigating the impact of climate change on the state of Glycyrrhiza glabra L. (Fabaceae). coenopopulation. The ontogenetic structure of the coenopopulation was studied using the generally accepted method. Coenopopulations were classified based on the systems developed by A. A. Uranova and O. V. Smirnova, L. A. Zhivotovsky utilizing the “delta-omega” concept. Ecological density was determined according to the method outlined by W. Odum. Geobotanical descriptions were carried out using standard 100 m2 plots by established protocols as outlined in Field Geobotany methodologies. The representative ontogenetic spectrum is left-sided and has an absolute maximum in one of the pre-reproductive groups. The coenopopulations deviated from the typical left-sided spectrum culminating in the senile stage. Individual density within the studied coenopopulations ranged from 0.6 to 7.17 individuals/m2. In comparison, ecological density varied from 0.85 to 8.1 individuals/m2. According to the “delta-omega” classification, G. glabra coenopopulations comprised mature (CP 5), transitional (CP 4) and old individuals (CP 1, 2, 3, 6). The decline of G. glabra along the Amu Darya River appears primarily attributable to two factors: intensive changes in water availability, potentially including significant shifts in channel location, and the extensive utilization and economic development of tugai forests for agricultural purposes.