Phytotherapy: Herbal medicine in the management of Diabetes mellitus
DOI:
https://doi.org/10.14719/pst.2017.4.4.347Keywords:
Diabetes mellitus, Trigonella foenum-graecum, Syzygium cumini, Salvadora persica, Terminalia chebulaAbstract
Despite considerable progress in the treatment of the diabetes with synthetic drugs, the search for effective, safe and inexpensive drugs is ongoing from herbs, since they offer a wide range of antidiabetic agents. Antidiabetic studies using in silico, in vitro and in vivo aspect of different medicinal plant products (Trigonella foenum-graecum, seeds; Syzygium cumini, seeds; Salvadora persica, leaves and Terminalia chebula, seeds) were reviewed. The objective of the study was to compare these medicinal plants for their hypoglycemic effect and phytochemical composition in order to find out most feasible and efficient antidiabetic agent. In this regard, the article is going to look at the phytochemical profile and the antihyperglycaemic properties and toxicity studies of the various fractions isolated from these plants. Studies claimed that all crude as well as partially purified fractions showed an antidiabetic effect hence are potent antidiabetic agents, but maximum effect observed in case of fraction isolated from Syzygium cumini and Salvadora persica.
Downloads
References
2. Chen M, Yan X, Chen Y, Zhao C. Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity. Journal of Food and Nutrition Sciences 2017; 5 (2):23-27. doi: 10.11648/j.jfns.20170502.11
3. Tiwari B K, Pandey K B, Abidi A B, Rizvi S I. Markers of oxidative stress during diabetes mellitus. Journal of Biomarkers 2013; 2013:1-9. doi: 10.1155/2013/378790
4. Ogurtsova K, da Rocha Fernandes J D, Huang Y, Linnenkamp U, Guariguata L, Cho N H, Cavan D, Shaw J E, Makaroff L E. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice 2017; 128:40-50. doi: 10.1016/j.diabres.2017.03.024
5. Samyal M L, Ahuja A, Ahmed Z. Evaluation of Antidiabetic Activity of Isolated Compound from Ougeinia oojeinensis Bark Extract in Diabetic Rats. UK Journal of Pharmaceutical and Biosciences 2014;2(5):27-33. doi: 10.20510/ukjpb/2/i5/91121
6. Singab A N, Youssef F S, Ashour M L. Medicinal plants with potential antidiabetic activity and their assessment. Medicinal Aromatic Plants 2014; 3 (1):1-12.
7. Mamun-or-Rashid A N, Hossain M S, Hassan B N, Dash M K, Sapon A, Sen M K. A review on medicinal plants with antidiabetic activity. Journal of Pharmacognosy and Phytochemistry 2014; 3(4):149-59.
8. Wang L, Ma C, Wipf P, Liu H, Su W, Xie X Q. TargetHunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database. The AAPS journal 2013; 15(2):395-406. doi: 10.1208/s12248-012-9449-z
9. Bansode T S, Gupta A G, Chaphalkar S R, Salalkar B K. Integrating in-silico and in-vitro approaches to screen the antidiabetic drug from Trigonella foenum graecum Linn.International Journal of Biochemistry Research & Review 2016;14(3): 1-10. doi: 10.9734/IJBCRR/2016/29875
10. Bansode T S, Gupta A G, Salalkar B K. In silico and in vitro assessment on antidiabetic efficacy of secondary metabolites from Syzygium cumini (L.) Skeels. Plant Science Today 2016; 3 (4):360-367. doi: 10.14719/pst.2016.3.4.264
11. Bansode T S, Salalkar B K. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology 2016;5: 127-136.
12. Vijayaprakash S, Langeswaran K, Kumar S G, Revathy R, Balasubramanian M P. Nephroprotective significance of kaempferol on mercuric chloride induced toxicity in Wistar albino rats. Biomedicine & Aging Pathology 2013; 3 (3):119-24. doi: 10.1016/j.biomag.2013.05.004
13. Lee J, Kim J H. Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro. PloS One 2016; 11 (5):e0155264. doi: 10.1371/journal.pone.0155264
14. Weisburg J H, Schuck A G, Reiss S E, Wolf B J, Fertel S R, Zuckerbraun H L, Babich H. Ellagic acid, a dietary polyphenol, selectively cytotoxic to HSC-2 oral carcinoma cells. Anticancer research.2013; 33 (5):1829-36.
15. Barch D H, Rundhaugen L M, Pillay N S. Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene. Carcinogenesis 1995; 16 (3):665-8. doi: 10.1093/carcin/16.3.665
16. Bansode T S, Salalkar B K. Strategies in the design of antidiabetic drugs from Terminalia chebula using in silico and in vitro approach. MicroMedicine 2016; 4 (2): 60-67.
17. Bansode T S, Gupta A, Shinde B, Salalkar B K. Partial purification and antidiabetic effect of bioactive compounds isolated from medicinal plants. MicroMedicine 2017; 5 (1): 1-7.
18. Gupta A, Chaphalkar S R. Haemolytic activities and anti-diabetic effect of Terminalia arjuna and Emblica officinalis. European Journal of Pharmaceutical and medical research 2016; 3 (6):334–338.
19. Gupta A, Chaphalkar S R. Antidiabetic activity of Calotropis gigantea in human whole blood. Journal of Disease and Global Health 2016; 6(3): 107-112.
20. Elekofehinti O O. Saponins: Anti-diabetic principles from medicinal plants–A review. Pathophysiology 2015; 22(2):95-103. doi: 10.1016/j.pathophys.2015.02.001
21. Liu X, Kim J K, Li Y, Li J, Liu F, Chen X. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. The Journal of nutrition 2005; 135(2):165-171.
22. Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutrition & metabolism 2015; 12(1):60. doi: 10.1186/s12986-015-0057-7
Downloads
Published
How to Cite
Issue
Section
License
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
