Comparative analysis of medicinal plants from Kurdistan region-Iraq for chemical constituents and bioactivities

Anwer N. Mamdoh; Lazgin A. Jamil; Faiq H.S. Hussain

doi:10.14719/pst.3582

Authors

Anwer N. Mamdoh Medical Laboratory Technology Department, College of Health and Medical Techniques, Duhok Polytechnic University, Kurdistan Region – Iraq https://orcid.org/0009-0005-7036-4285
Lazgin A. Jamil Chemistry Department, Faculty of Science, University of Zakho, Kurdistan Region – Iraq https://orcid.org/0000-0002-3703-7363
Faiq H.S. Hussain Medical Analysis Department, Applied Science Faculty, Tishk International University, Erbil, Kurdistan Region – Iraq https://orcid.org/0000-0003-1987-8422

DOI:

https://doi.org/10.14719/pst.3582

Keywords:

Medicinal plants, phytochemicals, elemental analysis, antibacterial activity, antioxidant activity, ICP analysis

Abstract

The medicinal plants in Kurdistan-Iraq are used widely for the treatment of many diseases. Therefore, it is very interesting to look after the components of these plants as they are involved directly in the therapy. The collected samples from Dohuk City in the Kurdistan Region of Iraq were Adiantum capillus-veneris, Polygonum avicular, Urtica dioca, Tribulus terretris, Artemisis splendens Willd, Scirpus lacustris, Mentha longifolia, Thymus kotschyanus, Achillea santolina and Anthenis des champs. The elemental contents of these samples were evaluated by inductively coupled plasma mass spectrometry (ICP-MS). The antibacterial and antioxidant activities were identified for the methanolic extracts of these plants. This study aims to identify the components, evaluate elemental content and analyze the biological activities of certain medicinal plants used in the region. The qualitative analysis of the phytochemical by screening out the methanolic extract of the collected samples showed the presence of phenolic compounds, proteins, fatty acids, amino acids, anthraquinones, alkaloids, tannins, flavonoids, saponins and steroids. Furthermore, the extracts have been analyzed to determine the presence of elements. The most abundant elements of the total 29 elements analyzed for the plant samples were iron, manganese, potassium and magnesium. This finding is important for potential drug discovery.

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References

Oladeji O. The characteristics and roles of medicinal plants: Some important medicinal plants in Nigeria. Natural Products: An Indian Journal. 2016;12(3):102.

Asif M. Bioactive phytochemical constituents of some edible fruits of myrtaceae family. American Journal of Nutrition Research. 2015;1(1):1-17.ID: 20150619.

Rashed M. Trace elements in some wild plants from the shores of the high dam lake and the adjacent desert, as determined by atomic absorption spectroscopy. Journal of Arid Environments. 1995;29(2):185-97. https://doi.org/10.1016/S0140-1963(05)80089-8.

Welna M, Klimpel M, Zyrnicki W. Investigation of major and trace elements and their distributions between lipid and non-lipid fractions in Brazil nuts by inductively coupled plasma atomic optical spectrometry. Food Chemistry. 2008;111(4):1012-15. https://doi.org/10.1016/j.foodchem.2008.04.067.

Harmankaya M, Özcan MM, Al Juhaimi F. Mineral contents and proximate composition of Pistacia vera kernels. Environmental Monitoring and Assessment. 2014;186:4217-21. https://doi.org/10.1007/s10661-014-3692-y.

Potortì AG, Bua GD, Turco VL, Tekaya AB, Beltifa A, Mansour HB et al. Major, minor and trace element concentrations in spices and aromatic herbs from Sicily (Italy) and Mahdia (Tunisia) by ICP-MS and multivariate analysis. Food Chemistry. 2020;313:126094. https://doi.org/10.1016/j.foodchem.2019.126094.

N Mamdoh A, A Jamil L, HS Hussain F. A systematic review on traditional use, phytochemical and pharmacological properties of some medicinal plants growing in Kurdistan region–Iraq. Eurasian Journal of Science and Engineering. 2023;9(2). https://doi.org/10.23918/eajse.v9i2p4.

Sher Z, Hussain F, Saleem M. Macro-mineral status at three phenological stages of some range shrubs of Gadoon hills, district Swabi, Khyber Pakhtunkhwa, Pakistan. Pak J Bot. 2012;44(2):711-16.

Ngoci S, Mwendia C, Mwaniki C. Phytochemical and cytotoxicity testing of Indigofera lupatana Baker f. Journal of Animal and Plant Sciences. 2011;11(1):1364-73.

Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer. Pharmacological Reviews. 2000;52(4):673-751.

Ksouri R, Megdiche W, Debez A, Falleh H, Grignon C, Abdelly C. Salinity effects on polyphenol content and antioxidant activities in leaves of the halophyte Cakile maritima. Plant Physiology and Biochemistry. 2007;45(3-4):244-49. https://doi.org/10.1016/j.plaphy.2007.02.001.

Patnaik PS, Ramanaiah M, Ramaraju B. Quantitative determination of essential and trace element content of some medicinal plants by ICP-MS technique. Research Journal of Pharmacy and Technology. 2019;12(4):1595-600. http://dx.doi.org/10.5958/0974-360X.2019.00265.8.

Mahmoudi H, Zare Fahim N, Alikhani MY, Shokoohizadeh L. Investigation of antimicrobial effect of berberine on ciprofloxacin and imipenem resistance Acinetobacter baumannii isolated from Hamadan hospitals. Iranian Journal of Medical Microbiology. 2020;14(1):44-54. http://dx.doi.org/10.30699/ijmm.14.1.44.

Kinsou LDC. Review of literature and phytochimic screening of medicinal plants used in the traditional treatment of brain diseases in Africa. Journal of Phytopharmacy. 2019;9(6):e5285. https://doi.org/10.7439/ijpp.

N'Guessan K, Kadja B, Zirihi GdN, Traoré D, Aké-Assi L. Phytochemical screening of some medicinal plants used in Ivory Coast country Krobou (Agboville, Ivory Coast). Sciences and Nature. 2009;6(1):1-15. http://dx.doi.org/10.4314/scinat.v6i1.48575.

Bekro Y-A, Mamyrbekova J, Boua BB, Bi FT, Ehile EE. Etude ethnobotanique et screening phytochimique de Caesalpinia benthamiana (Baill.) Herend. et Zarucchi (Caesalpiniaceae). Sciences and Nature. 2007;4(2):217-25.https://doi.org/10.4314/scinat.v4i2.42146.

Kancherla N, Dhakshinamoothi A, Chitra K, Komaram RB. Preliminary analysis of phytoconstituents and evaluation of anthelminthic property of Cayratia auriculata (in-vitro). Maedica. 2019;14(4):350.https://doi.org/10.26574/maedica.2019.14.4.350.

Harkin J. Book review: Biochemistry of phenolic compounds. Edited by JB Harborne. Wiley Online Library; 1966.

Harborne A. Phytochemical methods a guide to modern techniques of plant analysis. Springer Science & Business Media; 1998.

Evans WC. Trease and Evans' pharmacognosy: Elsevier Health Sciences; 2009.

Dewanto V, Wu X, Liu RH. Processed sweet corn has higher antioxidant activity. Journal of Agricultural and Food Chemistry. 2002;50(17):4959-64.https://doi.org/10.1021/jf0255937.

Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mutation Research. 2005;579(1-2):200-13. https://doi.org/10.1016/j.mrfmmm.2005.03.023.

Sharma OP, Bhat TK. DPPH antioxidant assay revisited. Food Chemistry. 2009;113(4):1202-05.https://doi.org/10.1016/j.foodchem.2008.08.008.

Devillers J, Steiman R, Seigle-Murandi F. The usefulness of the agar-well diffusion method for assessing chemical toxicity to bacteria and fungi. Chemosphere. 1989;19(10-11):1693-700.https://doi.org/10.1016/0045-6535(89)90512-2.

Sharififar F, Moshafi M, Mansouri S, Khodashenas M, Khoshnoodi M. In-vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss. Food Control. 2007;18(7):800-05.https://doi.org/10.1016/j.foodcont.2006.04.002.

Mehta S, Soni N, Satpathy G, Gupta RK. Evaluation of nutritional, phytochemical, antioxidant and antibacterial activity of dried plum (Prunus domestica). Journal of Pharmacognosy and Phytochemistry. 2014;3(2):166-71.

Pohl HR, Wheeler JS, Murray HE. Sodium and potassium in health and disease. Met Ions Life Sci. 2013;13:29-47.https://doi.org/10.1007/978-94-007-7500-8_2.

Au C, Benedetto A, Aschner M. Manganese transport in eukaryotes: The role of DMT1. Neurotoxicology. 2008;29(4):569-76.https://doi.org/10.1016/j.neuro.2008.04.022.

Nazir R, Khan M, Masab M, Rehman HU, Rauf NU, Shahab S et al. Accumulation of heavy metals (Ni, Cu, Cd, Cr, Pb, Zn, Fe) in the soil, water and plants and analysis of physico-chemical parameters of soil and water collected from Tanda Dam Kohat. Journal of Pharmaceutical Sciences and Research. 2015;7(3):89.

Sabry MIE, Stino FK, El-Ghany WAA. Copper: benefits and risks for poultry, livestock and fish production. Tropical Animal Health and Production. 2021;53:1-14. https://doi.org/10.1007/s11250-021-02915-9.

Zdrojewicz Z, Popowicz E, Winiarski J. Nickel-role in human organism and toxic effects. Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2016;41(242):115-18.