Olax dissitiflora Oliv. (small-fruited olax): Current status and future prospects as medicinal plant
DOI:
https://doi.org/10.14719/pst.3589Keywords:
Indigenous pharmacopeia, Olacaceae, Olax dissitiflora, Santalales, traditional medicine, tropical AfricaAbstract
Olax dissitiflora Oliv. (O. dissitiflora) has several medicinal uses, some of them known since prehistoric times. The present review compiles existing knowledge of the chemical and pharmacological properties, current medicinal uses, and further use potential and applications of O. dissitiflora. Multiple searches on existing literature on the medicinal, phytochemistry and pharmacological properties of O. dissitiflora were conducted in online databases such as Scopus, JSTOR, PubMed, Google Scholar and Science Direct as well as using pre-electronic literature sources obtained from the university library. This study showed that the bark, leaves, roots and twigs of O. dissitiflora are used as aphrodisiac, emetic, mosquito repellent and purgative, and as traditional medicines against dental problems, gonorrhoea, hernia, venereal diseases and wounds. The phytochemical evaluation of the plant revealed that it contains reducing sugars, alkaloids, flavonoids, phenolic compounds, quinones, saponins, steroids, tannins, terpenoids, 21-epimachaerinic acid, oleanolic acid, hederagenin, oleanolic acid 3-O-glucuronide, amphotericin, santalbic acid, exocarpic acid and octadic-9,11-diynoic acid. The pharmacological assessments showed that the crude extracts and phytochemical compounds isolated from the species have antibacterial, antifungal, antiplasmodial, larvicidal and adulticidal activities. The collected ethnomedicinal and ethnopharmacological properties of O. dissitiflora documented in this review will assist to understand the therapeutic relevance and potential of the species as well as providing baseline data required for ethnopharmacological assessments required in the discovery of novel plant-based health products. There is also need for more studies focusing on phytochemistry, pharmacological properties and toxicological evaluations, in vivo and clinical research on O. dissitiflora to compliment and validate the ethnomedicinal properties of the species.
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References
Malécot V, Nickrent DL. Molecular phylogenetic relationships of Olacaceae and related Santalales. Syst Bot. 2008;33:97-106. https://doi.org/10.1600/036364408783887384
Nickrent DL, Malécot V, Vidal-Russell R, Der JP. A revised classification of Santalales. Taxon. 2010;59:538-58. https://doi.org/10.1002/tax.592019
Christenhusz MJM, Fay MF, Chase MW. Plants of the World: An illustrated encyclopedia of vascular plant families. Royal Botanic Gardens, Kew, Richmond. 2017. https://doi.org/10.7208/chicago/9780226536705.001.0001
Sleumer HO. Flora Neotropica. New York Botanical Garden Press on behalf of Organization for Flora Neotropica. 1984;38:1-158. https://www.jstor.org/stable/i400127
Rogers ZS, Malécot V, Sikes KG. A synoptic revision of Olax L. (Olacaceae) in Madagascar and the Comoro Islands. Adansonia. 2006;28(1):71-100.
Chimponda T, Mukanganyama S. Antimycobacterial activities of selected medicinal plants from Zimbabwe against Mycobacterium aurum and Corynebacterium glutamicum. Trop Biomed. 2010;27:595-610.
Sule MI, Hassan HS, Pateh UU, Ambi AA. Triterpenoids from the leaves of Olax mannii Oliv. Nigerian J Basic Appl Sci. 2011;19(2):193-96.
Nwaigwe CU, Madubunyi II, Udem SC, Nwaigwe SO. Methanolic root extract of Olax viridis protects the liver against acetaminophen-induced liver damage. Res J Med Plant. 2012;6(5):395-405. https://doi.org/10.3923/rjmp.2012.395.405
Pertuit D, Mitaine-Offer A-C, Miyamoto T, Tanaka C, Delaude C, Lacaille-Dubois M-A. Triterpene saponins of the root bark of Olax obtusifolia De Wild. Phytochem. 2018;28:174-78. https://doi.org/10.1016/j.phytol.2018.09.018
Nguyen HT, Vo NT, Huynh ST, Do LT, Aree T, Tip-Pyang S et al. A sesquiterpenoid tropolone and 1,2,3,4-tetrahydronaphthalene derivatives from Olax imbricata roots. Fitoterapia. 2019;132:1-6. https://doi.org/10.1016/j.fitote.2018.11.007
Majumder R, Adhikari L, Dhara M. Olax psittacorum (Lam.) Vahl. (Olacaceae): Current status and future prospects as an herbal plant. Advances Trad Med. 2022;22:251-58. https://doi.org/10.1007/s13596-020-00493-z
Johnsy MF, Komala M. Olax scandens: The plant of the researchers: A review. Int J Res Pharm Sci. 2021;12(1):504-07. https://doi.org/10.26452/ijrps.v12i1.4096
Tsakem B, Ponou KB, Tchegnitegni TB, Fouedjou TR, Siwe-Noundou X, Krause RWM et al. The genus Olax: Traditional uses, phytochemistry and biological activities. In: Siwe-Noundou X, editor, Natural Products Chemistry of Botanical Medicines from Cameroonian Plants. CRC Press, Florida. 2021; pp. 1-22.
Vo TN, Luong TD, Le TP, Trinh KS. Control of obesity, blood glucose and blood lipid with Olax imbricata Roxb. root extract in high-fat diet-induced obese mice. J Toxicol. 2022;2:7781723. https://doi.org/10.1155/2022/7781723
Zareen N, Venkatesh S, Rao VVB, Kiran AR. A comprehensive review of Olax scandens Roxb. (Dheniaani). Pharmacog Rev. 2023;16(32):154-60. https://doi.org/10.5530/097627870311
Pertuit D, Sautour M, Miyamoto T, Delaude C, Kapundu M, Lacaille-Dubois M-A, Mitaine-Offer A-C. Oleanolic acid glycosides from two species of Olax: Olax wildemanii and Olax subscorpioidea. Phytochem Letters. 2024;60:14-18. https://doi.org/10.1016/j.phytol.2024.01.011
Schmidt E, Lötter M, McCleland W. Trees and shrubs of Mpumalanga and Kruger National Park. Jacana Media, Johannesburg. 2017.
Hutchinson J, Dalziel JM. Olacaceae. In: Hutchinson J, Dalziel JM, editors, Flora of West tropical Africa, 2nd edition, parts 1 and 2, Crown Agents for Oversea Governments and Administrations, London. 1958; pp. 644-49.
Osuntokun OT, Omolola AY. Efficacy of Nigerian medicinal plant (Olax subscorpioidea Oliv.) root extract against surgical wound isolates. Am J Microbiol Biochem. 2019;2(1):1-11.
Adekunle YA, Samuel BB, Fatokun AA, Nahar L, Sarker SD. Olax subscorpioidea Oliv. (Olacaceae): An ethnomedicinal and pharmacological review. J Nat Prods Disc. 2022;1:673. https://doi.org/10.24377/jnpd.article673
Palmer E, Pitman P. Trees for southern Africa covering all known indigenous species in Republic of South Africa, South West Africa, Botswana, Lesotho and Swaziland. AA Balkema, Cape Town. 1972.
Quattrocchi U. CRC world dictionary of plant names: Common names, scientific names, eponyms, synonyms and etymology. Volume iii M-Q. CRC Press, Boca Raton. 2023. https://doi.org/10.1201/b22802
Garcia JG. Olacaceae (family 48). In: Exell AW, Fernandes A, Wild H, editors, Flora Zambesiaca, volume 2, part 1. University Press, Glasgow. 1963; pp. 328-36.
Lucas GL. Olacaceae (family 46). In: Milneredhead E, Polhill RM, editors, Flora of Tropical East Africa volume 9, Whitefriars Press, London. 1968; pp. 1-16.
Palgrave MC. Keith coates palgrave trees of southern Africa. Struik Publishers, Cape Town. 2002.
Germishuizen G, Meyer NL. Plants of southern Africa: An annotated checklist. Strelitzia 14, National Botanical Institute, Pretoria. 2003.
Lovett JC, Ruffo CK, Gereau RE, Taplin JR. Field guide to the moist forest trees of Tanzania. Society for Environmental Exploration, London. 2006.
Wild H. Geobotanical anomalies in Rhodesia: 1: The vegetation of copper bearing soils. Kirkia. 1969;7(1):1-71.
Ribeiro A, Romeiras MM, Tavares J, Faria MT. Ethnobotanical survey in Canhane village, District of Massingir, Mozambique: Medicinal plants and traditional knowledge. J Ethnobiol Ethnomed. 2010;6:33. https://doi.org/10.1186/1746-4269-6-33
Van Wyk B, Van Wyk P. Field guide to trees of southern Africa. Struik Publishers, Cape Town. 2013. https://doi.org/10.4081/pb.2012.br1
Bundschuh TV, Hahn K, Wittig R. The medicinal plants of the woodlands in northern Malawi (Karonga district). Flora Veg Sudano-Sambesica. 2011;14:3-8. https://doi.org/10.21248/fvss.14.13
Assane RSS, Cuinica LG, Bell V, Chabite IT, Fernandes TH. An appraisal of plants used as health foods in Mozambique. European J Appl Sci. 2023;11(2):44-60. https://doi.org/10.14738/aivp.112.14059
Fox FW, Norwood Young ME. Food from the Veld. Delta Books, Johannesburg. 1982.
Welcome AK, Van Wyk B-E. An inventory and analysis of the food plants of southern Africa. S Afr J Bot. 2019;122:136-79. https://doi.org/10.1016/j.sajb.2018.11.003
Arnold TH, Prentice CA, Hawkes LC, Snyman EE, Tomalin M, Crouch NR, Pottas-Bircher C. Medicinal and magical plants of southern Africa: An annotated checklist. Strelitzia 13. National Botanical Institute, Pretoria. 2002.
Izidine SA. Licuáti forest, Mozambique: Flora, utilization and conservation. MSc Dissertation. University of Pretoria, Pretoria. 2003.
Manuel L, Bechel A, Noormahomed EV, Hlashwayo DF, Madureira MC. Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique. Heliyon. 2020;6:e05746. https://doi.org/10.1016/j.heliyon.2020.e05746
Nicosia E, Valenti R, Guillet A, Mondlane TSM, Malatesta L, Odorico D et al. An ethnobotanical survey in the Limpopo National Park, Gaza province, Mozambique: Traditional knowledge related to plant use. Rendiconti Lincei Sci Fisiche Naturali. 2022;33:303-18. https://doi.org/10.1007/s12210-022-01063-y
Gelfand M, Mavi S, Drummond RB, Ndemera B. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Mambo Press, Gweru. 1985.
Neuwinger HD. African traditional medicine: A dictionary of plant use and applications with supplement: Search system for diseases. Medpharm Scientific Publishers, Stuttgart. 2000.
Mavundza EJ. Mosquitocidal activity against Anopheles arabiensis of plants used as mosquito repellents in South Africa, PhD Thesis, University of Kwazulu-Natal, Pietermaritzburg. 2014. https://doi.org/10.1186/1475-2875-13-173
Mavundza EJ, Chukwujekwu JC, Maharaj R, Finnie JF, Van Heerden FR, Van Staden J. Identification of compounds in Olax dissitiflora with larvacidal effect against Anopheles arabiensis. S Afr J Bot. 2016;102:1-3. http://dx.doi.org/10.1016/j.sajb.2015.06.013
Hilonga S, Otieno JN, Ghorbani A, Pereus D, Kocyan A, de Boer H. Trade of wild-harvested medicinal plant species in local markets of Tanzania and its implications for conservation. S Afr J Bot. 2019;122:214-24. https://doi.org/10.1016/j.sajb.2018.08.012
Greenway PJ. A Swahili botanical English dictionary of plant names. Government Printer, Dar-es-Salaam. 1939.
Brenan JPM, Greenway PJ. Checklist of the forest trees and shrubs of the British empire, No 5. Tanganyika territory Part 1. Imperial Forestry Institute, Oxford. 1949.
Williamson J. Useful plants of Malawi. University of Malawi. Zomba. 1975.
Ghiurghi A, Dondeyne S, Bannerman J. Chimanimani national reserve: Management plan. Ministry of Tourism, Maputo. 2010.
Mavundza EJ, Maharaj R, Finnie JF, Kabera G, Van Staden J. An ethnobotanical survey of mosquito repellent plants in uMkhanyakude district, KwaZulu-Natal province, South Africa. J Ethnopharmacol. 2011;137:1516-20. https://doi.org/10.1016/j.jep.2011.08.040
Sitoe E, Van Wyk B-E. An inventory and analysis of the medicinal plants of Mozambique. J Ethnopharmacol. 2024;319:117137. https://doi.org/10.1016/j.jep.2023.117137
Napote QJ, Zeferino FA, Cumbane PJ, Sitoe AEJ, Manhique AJ, Madivate CM de O. Characterization of clays and mussiro (Olax dissitiflora Oliver) stem for the production of face mask. Brazilian J Dev. 2022;8(8):58888-906. https://doi.org/10.34117/BJDV8N8-262
Gabetta B, Martinelli EM, Mustich G. Plants of Mozambique V: Triterpenes of Olax dissitiflora. Fitoterapia. 1974;45:3-5.
Mavundza EJ, Maharaj R, Chukwujekwu JC, Finnie JF, Van Staden J. Larvicidal activity against Anopheles arabiensis of 10 South African plants that are traditionally used as mosquito repellents. S Afr J Bot. 2013;88:86 89. http://dx.doi.org/10.1016/j.sajb.2013.05.007
Mavundza EJ, Maharaj R, Chukwujekwu JC, Finnie JF, Van Staden J. Screening for adulticidal activity against Anopheles arabiensis in ten plants used as mosquito repellent in South Africa. Malaria J. 2014;13:173. http://dx.doi.org/10.1186/1475-2875-13-173
Dubale S, Kebebe D, Zeynudin A, Abdissa N, Suleman S. Phytochemical screening and antimicrobial activity evaluation of selected medicinal plants in Ethiopia. J Exp Pharmacol. 2023;15:51-62. http://dx.doi.org/10.2147/JEP.S379805
Chaachouay N, Zidane L. Plant-derived natural products: A source for drug discovery and development. Drugs Drug Cand. 2024;3:184-207. https://doi.org/ 10.3390/ddc3010011
Quintieri L, Caputo L, Nicolotti O. Recent advances in the discovery of novel drugs on natural molecules. Biomedicines. 2024;12:1254. https://doi.org/10.3390/ biomedicines12061254
Alemu M, Lulekal E, Asfaw Z, Warkineh B, Debella A, Abebe A et al. Antibacterial activity and phytochemical screening of traditional medicinal plants most preferred for treating infectious diseases in Habru district, North Wollo Zone, Amhara region, Ethiopia. PLoS One. 19(3):e0300060. https://doi.org/10.1371/journal. pone.0300060
Halim MBA, Eid HH, El Deeb KS, Metwally GF, Masoud MA, Ahmed-Farid OA, El Messiry HM. The study of wound healing activity of Thespesia populnea L. bark, an approach for accelerating healing through nanoparticles and isolation of main active constituents. BMC Complement Med Ther. 2024;24:85. https://doi.org/10.1186/s12906-024-04343-2
Mosoh DA, Khandel AK, Verma SK, Vendrame WA. Phytochemical analysis and enhanced production of alkaloids in non-dormant corm-derived callus of Gloriosa superba (L.) using plant growth regulators and abiotic elicitors. Plant Cell Tiss Organ Cult. 2024;156:89. https://doi.org/10.1007/s11240-023-02674-5
Bombardelli E, Morazzoni P, Cristoni A, Seghizzi R. Pharmaceutical and cosmetic formulations with antimicrobial activity. United States Patent No. US 6267996B1; 2001.
Bombardelli E, Cristoni A, Morazzoni P, Seghizzi R. Pharmaceutical and cosmetic compositions with antiacne activity. Russian Agency for Patents and Trademarks No. RU 94022017A1; 2002.
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