Sesame (Sesamum indicum L.) is a crucial oilseed crop, yet it currently achieves only about 25% of its genetic yield potential. To harness the full potential of sesame, it is essential to develop well-defined phenotypes and crop architectures that exhibit a more effective source-sink relationship tailored to the specific cropping environment. Numerous physiological constraints hinder yield optimization, including indeterminate growth, poor source-sink relationships, flower drop, low seed retention and capsule and seed shattering. Notably, these constraints are interactions between nutrient and plant growth regulators, both significantly influence the growth and overall productivity of sesame. Sesame cultivation is currently limited by low yields due to a lack of production strategies. This study suggested improving sesame productivity through the application of nutrients and plant growth regulators. Future research programs need to develop the best research strategies for economic and sustainable development.