Phytotherapy for seizure: An overview of the most important indigenous Iranian medicinal plants with anticonvulsant properties
DOI:
https://doi.org/10.14719/pst.2019.6.4.557Keywords:
medicinal plants, seizureAbstract
The statistics show that more than fifty million people worldwide suffer from seizure and epilepsy, and most of them are resistant to antiepileptic drugs. The causes of seizure attacks are different, including various diseases of the nervous system, infections, tumors, brain trauma, congenital diseases, fever, toxicity and metabolic factors. Currently, drugs such as phenytoin, phenobarbital, carbamazepine, valproic acid and diazepam are used to treat epileptic seizures, which in turn lead to side effects. Studies have shown that the use of natural and herbal antiseptic agents has beneficial and protective effects. In this review article, the most important indigenous Iranian medicinal plants used to treat seizures are reported. Information to conduct this review article has been obtained using the search terms seizure, neurological lesion, phytotherapy, Iran, medicinal plants, extracts and essential oils to retrieve articles indexed in databases such as Scopus, Scientific Information Database, Magiran, Google Scholar and other Persian databases. The relevant articles were further reviewed for medicinal plants with anticonvulsant properties. Based on the results, medicinal plants such as Peganum harmala, Lavandula officinalis, Matricaria chamomilla, Tanacetum sonbolii, Launaea acanthodes, Ocimum basilicum, Salvia sahendica, Ruta graveolens, Elaeagnus angustifolia, Ziziphora tenuior, Heracleum persicum and Scrophularia striata are among the most important medicinal plants in Iran with anticonvulsant effect.
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References
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2. White H.S., Significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 1997; 38(Suppl. 1): 9-17. https://doi.org/10.1111/j.1528-1157.1997.tb04523.x
3. Lott RS, Mcauley JW. Seizure disorders. In: Koda Kimble MA. Yourg LY. Applied therapeutics: the clinical use of drugs. 7th ed. Baltimore: Lippincott Williams & Wilkins; 2001: 52-102.
4. Porter RJ, Meldrum BS. Katzung BG. Antiseizure drugs. In: Basic and clinical pharmacology. New York: Lange Medical Books. McGraw Hill 2001; 345-48.
5. McNamara JO Cellular and molecular basis of epilepsy. J Neuro Sci 1994; 14(6): 3413-25 https://doi.org/10.1523/JNEUROSCI.14-06-03413.1994
6. Olney J. Excitatory amino acids and neuropsychiatric disorders. Biological Psychiatry 1989; 26: 505-25. https://doi.org/10.1016/0006-3223(89)90072-3
7. Blumcke I, Beck H, Lie AA, Wiestler OD. Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res 1999; 36: 205-23. https://doi.org/10.1016/S0920-1211(99)00052-2
8. Crvey PM. Drug's action in the central nervous system. New York, Oxford University Press, 1998: 201.
9. Leung AY and Foster S. Encyclopedia of common natural ingredients. New York, Willey Interscience Publication 1996: 145-7, 368-71, 382-83.
10. Westbrook GL, Lothman EW. Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity. Brain Res 1983; 273: 97-109. https://doi.org/10.1016/0006-8993(83)91098-3
11. Reyes-Garcia V. The relevance of traditional knowledge systems for ethnopharmacological research: theoretical and methodological contributions. J Ethnobiol Ethnomed. 2010;6:32 https://doi.org/10.1186/1746-4269-6-32
12. Shoohani B, Hemati AA, Taheri Moghadam M. Effects of Scrophularia striata extract on Wound Healing in Rabbit. J Ilam Univ Med Sci 2010; 17(4): 9-16.
13. Kim HJ, Jee EH, Ahn KS, Choi HS, Jang YP. Identification of marker compounds in herbal drugs on TLC with DART-MS. Arch Pharm Res 2010; 33(9): 1355-59. https://doi.org/10.1007/s12272-010-0909-7
14. Faryadian S, Sydmohammadi A, Khosravi A., Kashiri M, Faryadayn P, Abasi N. Aqueous extract of Echlum amoenum elevate CSF serotonin and dopamine level in depression rat. Biomedical and Pharmacology Journal 2014; 7(1): 137-42
15. Valadi, A., Nasri, S., Abbasi, N., Amin, G.R. Antinociceptive and anti-inflammatory effects of hydroalchoholic extract of Anethum graveolens L. seed. Journal of Medicinal Plants 2010; 9(34):124-30.
16. Bahmani, M., Khaksarian, M., Rafieian-Kopaei, M., Abbasi, N. Overview of the therapeutic effects of origanum vulgare and Hypericum perforatum based on Iran's ethnopharmacological documents. Journal of Clinical and Diagnostic Research 2018; 12(7): 1-4. https://doi.org/10.7860/JCDR/2018/34177.11728
17. Shokri Z, Khoshbin M, Koohpayeh A, Abbasi N, Bahmani F, Rafieian-Kopaei, M, Beyranvand F. Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants. International Journal of Green Pharmacy 2018; 12(3): 473-82.
18. Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, Asadollahi K. Protective effects of smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: Involvement of benzodiazepine and opioid antagonists. Journal of Biological Regulators and Homeostatic Agents 2017; 31(3):683-89.
19. Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM.The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus. Journal of Microbiology 2018; 56(2): 128-37
s://doi.org/10.1007/s12275-018-7444-5
20. Hijikata Y, Yasuhara A, Yoshida Y, Sento S. Traditional Chinese medicine treatment of epilepsy. The Journal of alternative and complementary medicine 2006; 12: 673-77. https://doi.org/10.1089/acm.2006.12.673
21. Hashemi A, Nayebi A, Sadegi MR, Faramarzi A, Delazar A, Rezazadeh H. Study of the methanolic extract of Peganum seeds on convulsion induced by strychnine in swiss mice. Pharmaceutical Sciences 2009; 15(3): 257-62.
22. Rahmati B, Khalili M, Roghani M, Ahghari P. Anticonvulsant effect of hydro-alcoholic extract of Lavandula officinalis on seizures in pentylenetetrazol-induced kindling model in male mice. Daneshvar Medicine 2012; 19 (98): 25-32.
23. Rostampour M, Aghaei I, Solatani B, Khakpour B. Effect of Matricaria chamomile hydroalhcholic extract on PTZ induced seizure in male mice. J guilan Uni Med Sci 2014; 23 (89): 8-14.
24. Naderi F, Azhdari-ZarmehriH, Erami E, Sonboli A, Sofiabadi M, Mohammad-Zadeh M. The effect of Tanacetum sonbolii hydroalcholic extract on PTZ induced seizures in male Mice. J Med Plants 2012; 44; 11(4): 193-201.
25. Karimidokht shahrbabaki A, Oryan SH, Parivar K. Anticonvulsant activity of ethanolic extract and aqueous fraction of Launaea acanthodes gum in comparison with diazepam in mice. JQUMS 2009; 13(1): 50: 14-20.
26. Modaresi M, Pouriyanzadeh A. Effect of Ocimum basilicum hydro alcoholic extract against pentylenetetrazole-induced seizure in mice. Yasouj Uni Med Sci J 2013; 18(8): 80: 615-22.
27. Azhdari-Zarmehri H, Naderi F, Erami E, Mohammad-Zadeh M. Effects of Salvia sahendica hydroalcoholic extract on PTZ induced seizure in male mice. Koomesh 2013; 14 (4): 497-504.
28. Keihanian F, M. Rostampour Vajari, A. Saeidynia, A.R. Elmieh. Effect of Ruta graveolens hydro-alcoholic extract on pentylenetetrazole-induced seizure in male Mice. J Babol Univ Med Sci 2012; 14(4): 30-36. https://doi.org/10.1055/s-0032-1321336
29. Mirazi N, Hosseini AK. Effects of hydroethanolic extract of Elaeagnus angustifolia on pentylenetetrazole induced seizure in male mice. Medical Journal of Tabriz University of Medical Sciences and Health Services 2014; 36(1): 74-81.
30. Piri H, Alimohammadi B, Saeidi F, Naderi F, Azhdari-Zarmehri H. Anticonvulsant activity of hydro-alcoholicextract of Ziziphora tenuior L. on pentylenetetrazol induced seizure in mice. Journal of Sabzevar University of Medical Sciences 2016; 23(1): 151-60.
31. Saeidi F, Azhdari Zarmehri H, Alimohammadi B1, Erami E. The Effect of hydroalcoholic extract of Heracleum persicum on pentylenetetrazol induced seizure in mice. Zanjan Uni Med Sci 2014; 21(86): 45-55.
32. Alimohammadi B., B, Azhdari-Zarmehri H, Sofiabadi M, Moslem A.R. Anticonvulsant effect of hydroalcoholic extract of Scrophularia striata Boiss. on pentylenetetrazol-induced seizure in mice. Kerman Uni Med Sci 2015; 21(3): 207-18.
33. Muhi-eldeen Z, Al-Shamma KJ, Al- Hussainy TM, Al- Kaissi EN, Al-Daraji AM, Ibrahim H. Acute toxicological studies on the extract of Iraqi Peganum harmala in rats. European Journal of Scientific Research 2008; 22: 494-500.
34. Bown D. Encyclopedia of Herbs and Their Uses. New York: DK Publishing, Inc., 1995; 265.
35. Shi C, Chen S, Wang G, Liao J, Chen C. Vasorelaxant effect of Harman. European Journal of Pharmacology 2000; 390: 319-25. https://doi.org/10.1016/S0014-2999(99)00928-0
36. Salah SM, Jager AK. Screening of traditionally used Lebanese herbs for neurological activities. Journal of Ethnopharmacology 2005; 97(1): 145-49. https://doi.org/10.1016/j.jep.2004.10.023
37. Shahriyari H, Ersali A, Rahmanifard M. Anticonvulsant effect of Lavandula officinalis in two epilepsy animal model. Journal of Iran Medical Basic Sciences 2004; 8(3):172-78.
38. Merabani M, Modirian E, Ebrahimabadi AR, Shahnavaz S, Vafazadeh S, Heidari MR. The effect of hydro methanolic extract of Lavandula vera DC and Cuscuta epithymum Murr on the seizure induced by pentylene tetrazole in mice. Kerman: Physiology and Pharmacology Research Center 2006; 14(1): 25-35.
39. Barazandeh MM. Essential oil composition of Lavandula latifolia Medik from Iran. J Essent Oil Res 2002; 103: 4-12. https://doi.org/10.1080/10412905.2002.9699784
40. Sofiabad M, Esmaeili MH, Haghdoost- Yazdi H, Azhdari-Zarmehri H. The prenatal consumption of aqueous extract of Glycyrrhiza glabra, improves memory retrieval in mice. J. Medicinal Plants 2011; 10 (38): 49-54
41. Esmaeili MA, Sonboli A and Ayyari Noushabadi M. Antioxidant and protective properties of six Tanacetum species against hydrogen peroxide-induced oxidative stress in K562 cell line: A comparative study. Food Chem. 2010;121(1): 148-55. https://doi.org/10.1016/j.foodchem.2009.12.022
42. Fernandez SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GA, Paladini AC, et al. Central nervous system depressant action offlavonoid glycosides. Eur. J. Pharmacol 2006; 539:168-76. https://doi.org/10.1016/j.ejphar.2006.04.004
43. Marder M and Paladini AC. GABAA-receptor ligands of flavonoid structure. Curr. Top. Med. Chem 2002; 2: 853-67. https://doi.org/10.2174/1568026023393462
44. Johnston GA. GABAA receptor channel pharmacology. Curr. Pharm. Des 2005; 11: 1867-85. https://doi.org/10.2174/1381612054021024
45. Smsam Shariat A. Agenda of Medicinal Plants Laboratory. Isfahan University Press, 1989; 18-20.
46. Ruffels J and Griffin M. Activation of ERK1/2, JNK and PKBby hydrogen peroxide in human SHSY5Y neuroblastoma cells: Role of ERK1/2in H2O2-induced cell death. European Journal of Pharmacology 2004; 483: 163-73. https://doi.org/10.1016/j.ejphar.2003.10.032
47. Mahmodi Y, Yasa N. Investigation of chemical structure of L. acanthodes (Bioss) O. Kontz flavonoids. La. Pharmacology faculty, Tehran University, 1995; Tez number; 3346.
48. Kasture VS, Deshmukh VK, Chopde CT. Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals. Phytother Res 2002; 16(5): 455-60. https://doi.org/10.1002/ptr.971
49. Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties . Food Chem 2005; 91: 131-37. https://doi.org/10.1016/j.foodchem.2004.05.056
50. Momen Tonekaboni M. Tohfatolmomenin. 1st ed. Corrected by Rahimi R, Shams Ardakani MR, Farjadmand F. Tehran: Nashr Shahr Publications 2007; 241-42.
51. Ahmadiani A, Hosseiny J, Semnanian S, Javan M, Saeedi F, Kamalinejad M, et.al. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. Journal of Ethnopharmacology 2000; 72: 287-92. https://doi.org/10.1016/S0378-8741(00)00222-1
52. Wang Q, Ruan Xi, Huang JH, YAN Q.Ch. Intraspecific genetic relationship analyses of Elaeagnus angustifolia based on RP-HPLC biochemical markers. Journal of Zhejiang University SCIENCE B 2006; 7(4): 272-78. https://doi.org/10.1631/jzus.2006.B0272
53. Hosseinzadeh H, Ramezani M, Namjo N. Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice. Journal of Ethnopharmacology 2003; 84(2-3): 275- 78. https://doi.org/10.1016/S0378-8741(02)00331-8
54. Gurbuz I, Ustun O, Yesilada E, Sezik E, Kutsal O. Antiulcerogenic activity of some plants used as folk remedy in Turkey. J Ethnopharmacol 2003; 88(1): 93-97. https://doi.org/10.1016/S0378-8741(03)00174-0
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01-10-2019
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Farzan B, Shahsavari S, Abbaszadeh S, Teimouri H. Phytotherapy for seizure: An overview of the most important indigenous Iranian medicinal plants with anticonvulsant properties. Plant Sci. Today [Internet]. 2019 Oct. 1 [cited 2024 Nov. 21];6(4):367-72. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/557
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