The paper explores the relationship between energy use, economic growth and emission rates for Asian giants such as China, India and Japan. As these countries are the regional economic powers and also the major global carbon emitters, it is inevitable to conduct a research study to find the possible relationship between energy use, emission and growth among these countries by the panel data analysis over the period from 1991 to 2020. Higher energy usage increases greenhouse gas (GHG) emissions in countries, with agricultural sectors, Foreign Direct Investment (FDI) and urban populations contributing significantly. Energy use influences economic growth and emission levels, positively affecting GHG emissions. Furthermore, current initiatives taken by these three Asian superpowers for net zero carbon emission and relevant suggestions are also highlighted for emission reduction without compromising the economic growth and sustainable use of energy resources.