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Plant Science Today (PST)

Review Articles

Vol. 12 No. Sp2 (2025): Current Trends in Plant Science and Microbiome for Sustainability

Pharmaceutically important bioactive natural products from marine microbes

DOI
https://doi.org/10.14719/pst.6492
Submitted
3 December 2024
Published
17-05-2025

Abstract

Secondary metabolites obtained from marine biodiversity have varied bioactive compounds that possess various properties of pharmaceutical relevance. The diversity in chemical and molecular forms imparts these metabolites tremendous pharmacological significance. So many diseases are still untreatable due to the non-availability of proper medicines. The novel drugs isolated from the marine microbes which are not yet explored will provide an extraordinary, advanced approach to drug discovery. The novelty in drug development owing to the presence of such bioactive compounds has led to exploring new horizons pertaining to diseases and their treatment. These metabolites also serve as an important tool in the field of agriculture as biocides for crop improvement. Nowadays, much of the research is being focused on alternative sources of energy, in which algae are contributing a great deal. Thus, these metabolites play a pivotal role in various industries in the production of commercial products that are beneficial for mankind. Much of the research still needs to be done in this field as most of the marine microbes are not easily accessible due to the ocean depths. If such microbes can be isolated from the deep ocean, then novel research will pave the drug discovery to treat those ailments which are not possible till date. Even a lot of study is needed in the area of bioprospecting for the advancements in isolation and characterization of potential compounds. If we can isolate the potent compound, we will not only be able to prevent the occurrence of such lethal diseases but also be able to save human lives. The present review focuses on the important metabolites extracted from the marine microbes and their pharmacological significance, which owe special significance to the medical community and drug development.

References

  1. Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012;2:303–36. https://doi.org/10.3390/metabo2020303
  2. Blunt JW, Carroll AR, Copp BR. Marine natural products. Nat Prod Rep. 2018;35:8–53. https://doi.org/10.1039/C7NP0
  3. A
  4. Mora C, Tittensor DP, Adl S, Simpson AGB, Worm B. How many species are there on earth and in the ocean? PLoS Biol. 2011;9(8):e1001127. https://doi.org/10.1371/journal.pbio.1001127
  5. Wahl M, Goecke F, Labes A, Dobretsov S, Weinberger F. The second skin: ecological role of epibiotic biofilms on marine organisms. Front Microbiol. 2012;3:292. https://doi.org/10.3389/fmicb.2012.00292
  6. Ganzera, M, Choudhary MI, Khan IA. Quantitative HPLC analysis of withanolides in Withania somnifera. Fitoterapia. 2003;74:68–76. https://doi.org/10.1016/S0367-326X(02)00325-8
  7. Valentao, P, Fernandes E, Carvalho F, Andrade PB, Seabra RM, Bastos ML. Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine. 2003;10 (6-7):517–22. https://doi.org/10.1078/094471103322331485
  8. Yang, CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001;21(1):381–406. https://doi.org/10.1146/annurev.nutr.21.1.381
  9. Croft KD. The chemistry and biological effects of flavonoids and phenolic acids. Ann NY Acad Sci. 1998;854(1):435–42. https://doi.org/10.1111/j.1749-6632.1998.tb09922.x
  10. Parr AJ, Bolwell GP. Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile. J Sci Food Agric. 2000;80(7):985–1012. https://doi.org/10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.3.CO;2-Z
  11. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol. 2005;16(1):77–84. https://doi.org/10.1097/00041433-200502000-00013
  12. Majer P, Neugart S, Krumbein A, Schreiner M, Hideg E. Singlet oxygen scavenging by leaf flavonoids contributes to sunlight acclimation in Tilia platyphyllos. Environ Exp Bot. 2014;100:1–9. https://doi.org/10.1016/j.envexpbot.2013.12.
  13. Ziberna L, Fornasaro S, Cvorovic J, Tramer F, Passamonti S. Bioavailability of flavonoids: the role of cell membrane transporters. In: Watson RR, Preedy VR,Zibadi S, editors. Polyphenols in Human Health and Disease. Vol 1.San Diego: Academic Press; 2014. 489–511. https://doi.org/10.1016/B978-0-12-398456-2.00037-2
  14. Andersen OM, Jordheim M. Chemistry of flavonoid-based colors in plants. In: Mander L, Liu HW, editors. Comprehensive Natural Products II: Chemistry and Biology, Elsevier Science; 2010. p. 547–614. https://doi.org/10.
  15. /B978-008045382-8.00086-1
  16. Saric T, Rogosic J, Zupan I, Beck R, Bosnic S, Sikic Z, et al. Anthelmintic effect of three tannin-rich Mediterranean shrubs in naturally infected sheep. Small Rumin Res. 2015;123(1):179–82. https://doi.org/10.1016/j.smallrumres.2014.
  17. 012
  18. Waterhouse A. Wine phenolics. Ann N Y Anad Sci. 2002;957(1):21–36. https://doi.org/10.1111/j.1749-6632.2002.tb0
  19. x
  20. Shahat AA, Marzouk MS. Tannins and related compounds from medicinal plants of Africa. Med Plant Res Africa. 2013;13:479–555. https://doi.org/10.1016/B978-0-12-405927-6.00013-8
  21. Figueroa-Espinoza MC, Zafimahova A, Alvarado PGM, Dubreucq E, Poncet-Legrand C. Grape seed and apple tannins: emulsifying and antioxidant properties. Food Chem. 2015;178:38–44. https://doi.org/10.1016/j.foodchem.
  22. 01.056
  23. Seabra RM, Andrade PB, Valentão P, Fernandes E, Carvalho F, Bastos ML. In: Fingerman M, Nagabhushanam R, editors. Biomaterials from aquatic and terrestrial organisms. Science Publishers: Enfield, NH, USA; 2006. p. 115–74.
  24. Gordon M, Cragg DJ. Newman natural products: a continuing source of novel drug leads. Biochem Biophys Acta. 2013;1830:3670–95. https://doi.org/10.1016/j.bbagen.2013.02.008
  25. Chauhan A, Basniwal RK, Narwadia SC. Cyanobacteria: an emerging source for antibacterial, antimycobacterial and antifungal properties. Sci Arch. 2020;1(1):35–41. https://doi.org/10.47587/SA.2020.1104
  26. Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A. Marine antifungal theonellamides target 3?-hydroxysterol to activate Rho1 signalling. Nat Chem Biol. 2010;6:519–26. https://doi.org/10.1038/nchembio.387.
  27. Luesch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH. Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. J Am Chem Soc. 2001;123(23):5418–23. https://doi.org/10.1021/ja010453j
  28. Reich E, Blatter A, Meier B. TLC for the analysis of herbal drugs - A critical review of the status and proposal for improvement of monographs. Pharmeuropa. 2003;15(3):424–30.
  29. Talukdar AD, Choudhury MD, Chakraborty M, Dutta K. Phytochemical screening and TLC profiling of plant extracts of Cyathea gigantea (Wall. ex. Hook.) Haltt. and Cyathea brunoniana. Wall.ex. Hook (Cl. & Bak.). Assam Univ J Sci Technol. 2010;5(1):70–4.
  30. Giordano D, Coppola D, Russo R, Denaro R, Giuliano L, Lauro FM, et al. Marine microbial secondary metabolites: Pathways, evolution and physiology. Adv Microb Physiol. 2015;66:357–428. https://doi.org/10.1016/bs.ampbs.2015.04.
  31. El-Shafei R, Hegazy H, Acharya B. A review of antiviral and antioxidant activity of bioactive metabolites of macroalgae within an optimized extraction method. Energies. 2021;14:3092. https://doi.org/10.3390/en14113092
  32. Singh M, Shrivastava JN, Bhutani S, Bhasin S, Mehra A, Suyal DC. Industrial Importance of Marine Algae. In: Soni R, Suyal DC, Morales-Oyervides L, Fouillaud M, editors. Current Status of Marine Water Microbiology. Springer, Singapore; 2023. p. 367–80. https://doi.org/10.1007/978-981-99-5022-5_16
  33. Ata A, Ackerman J, Radhika P. Cladixazole: a novel sesquiterpene from a marine soft coral of genus Cladiella. Tetrahedron Lett. 2003;44:6951–3. https://doi.org/10.1016/S0040-4039(03)01712-X
  34. Lee Y, Jang KH, Jeon JE, Yang YW, Sim CJ. Cyclic Bis- 1,3-dialkylpyridiniums from the Sponge Haliclona sp. Mar Drugs. 2012;10:2126–37. https://doi.org/10.3390/md10092126
  35. Mona S, Malyan SK, Saini N, Deepak B, Pugazhendhi A, Kumar SS. Towards sustainable agriculture with carbon sequestration and greenhouse gas mitigation using algal biochar. Chemosphere. 2021;275:129. https://doi.org/10.1016/j.chemosphere.2021.129856
  36. Jimenez PC, Ferreira EG, Araujo LA, Guimaraes LA, Sousa TS, Pessoa OD. Cytotoxicity of actinomycetes associated with the ascidian Eudistomavannamei (Millar, 1977), endemic of the northeastern coast of Brazil. Lat Am J Aquat Res. 2018;41(S2):335–43. https://doi.org/10.3856/vol41-issue2-fulltext-12
  37. Carter NJ, Susan JK. Trabectedin: a review of its use in the management of soft tissue sarcoma and ovarian cancer. Drugs. 2007;67(15):2257–76. https://doi.org/10.2165/00003495-200767150-00009
  38. Khoo KS, Chew KW, Yew GY, Leong WH, Chai YH, Show PL, et al. Recent advances in the downstream processing of microalgae lipid recovery for biofuel production. Bioresour Technol. 2020;304:122996. https://doi.org/10.1016/
  39. j.biortech.2020.122996
  40. Nunes MC, Graca C, Vlaisavljevic S, Tenreiro A, Sousa I, Raymundo A. Microalgal cell disruption: effect on the bioactivity and rheology of wheat bread. Algal Res. 2020;45:101749. https://doi.org/10.1016/j.algal.2019.101749
  41. Sansone C, Brunet C, Noonan DM, Albini A. Marine algal antioxidants as potential vectors for controlling viral diseases. Antioxidants. 2020;9:392. https://doi.org/10.3390/antiox9050392
  42. Sagar S, Mandeep K, Kenneth PM. Antiviral lead compounds from marine sponges. Mar. Drug. 2010;8:2619–38.
  43. https://doi.org/10.3390/md8102619
  44. Mioso R, Francisco JTM, Ranilson de SB, Flavio VPB, De V, Barbara OS, et al. Cytotoxic compounds derived from marine sponges. A review (2010–2012). Molecules. 2017;22:208. https://doi.org/10.3390/molecules22020208
  45. Matz C, Webb JS, Schupp PJ, Phang SY, Penesyan A, Egan S, et al. Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense. PLoS one. 2008;3:e2744. https://doi.org/10.1371/journal.pone.0002744
  46. Zheng, L, Chen H, Han X, Lin W, Yan X. Antimicrobial screening and active compound isolation from marine bacterium nj6-3-1 associated with the sponge Hymeniacidon perleve. World J Microbiol Biotechnol. 2005;21:201–6.
  47. https://doi.org/10.1007/s11274-004-3318-6
  48. Nicolaou, KC, Lim YH, Becker J. Total synthesis and absolute configuration of the bisanthraquinone antibiotic be-43472b. Angew Chem Int Ed. 2009;48:3444–8. https://doi.org/10.1002/anie.200900058
  49. Kamei Y, Isnansetyo A. Lysis of methicillin-resistant Staphylococcus aureus by 2,4-diacetylphloroglucinol produced by Pseudomonas sp. AMSN isolated from a marine alga. Int J Antimicrob Agents. 2003;21:71–4. https://doi.org/10.
  50. /S0924-8579(02)00251-0
  51. Kim MY, Sohn JH, Ahn JS, OH H. Alternaramide, a cyclic depsipeptide from the marine-derived fungus Alternaria sp. Sf-5016. J Nat Prod. 2009;72:2065–68. https://doi.org/10.1021/np900464p
  52. Maya SP, Kong F, Jeffrey JE, Daniel AA, Paola SA, Valerie BS. Novel alpha-pyrones produced by a marine Pseudomonas sp. F92s91: taxonomy and biological activities. J Antibiot. 2003;56:1033–44. https://doi.org/10.7164/
  53. antibiotics.56.1033
  54. Isnansetyo A, Kamei Y. B. Anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of mc21-b, an antibacterial compound produced by the marine bacterium Pseudoalteromonas phenolica O-BC30T. Int J Antimicrob Agents. 2009;34:131–5. https://doi.org/10.1016/j.ijantimicag.2009.02.009
  55. Gao C, Tian HXP, Qi SH, Luo XM, Wang P, Zhang S. Antibacterial and antilarval compounds from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. J Antibiot. 2010;63:191–3. https://doi.org/
  56. 1038/ja.2010.7
  57. Gorajana A, Venkatesan M, Vinjamuri S, Kurada VVSNB, Peela S, Jangam P, et al. Resistoflavine, a cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7. Microbiol Res. 2007;162:322–327.
  58. https://doi.org/10.1016/j.micres.2006.01.012
  59. Rickards RW, Rothschild JM, Willis AC, Chazal NM de, Kirk J, Kirk K, et al. Calothrixins a and b, novel pentacyclic metabolites from calothrix cyanobacteria with potent activity against malaria parasites and human cancer cells. Tetrahedron. 1999;55:13513. https://doi.org/10.1016/S0040-4020(99)00833-9
  60. Burja AM, Banaigs B, Abou-mansour E, Burgess JG, Wright PC. Marine cyanobacteriaa- the prolific source of natural products. Tetrahedron. 2001;57:9347–77. https://doi.org/10.1016/S0040-4020(01)00931-0
  61. Xie LW, Jiang SM, Zhu HH, Sun W, Ouyang YC, Dai SK, et al. Potential inhibitors against Sclerotinia sclerotiorum, produced by the fungus Myrothecium sp. Associated with the marine sponge Axinella sp. Eur J Plant Pathol. 2008;122:571–8. https://doi.org/10.1007/s10658-008-9326-x
  62. Zhang Y, Li XM, Wang CY, Wang BG. A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13. Chin Chem Lett. 2007;18:951–3. https://doi.org/10.1016/j.cclet.2007.05.
  63. Wang F, Fang Y, Zhu T, Zhang M, Lin A, Gu Q, et al. Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus. Tetrahedron. 2008;64:7986–91.https://doi.org/10.1016/j.tet.2008.
  64. 013

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