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Review Articles

Vol. 12 No. 3 (2025)

Nutritional, ethno-medicinal and pharmacological characteristics of Persian walnut (Juglans regia L.)

DOI
https://doi.org/10.14719/pst.6594
Submitted
8 December 2024
Published
14-08-2025 — Updated on 27-08-2025
Versions

Abstract

The majority of walnut harvested in Kashmir originated from seedling-grown trees. Notably, walnuts only nut crop with substantial economic value in the region of Jammu and Kashmir. Approximately 71 % of the worlds' walnut production comes from countries situated along the historical silk route, which collectively host a significant portion of both cultivated and wild walnut orchards. Walnuts are grown commercially almost across the globe for its high demand and nutritional importance. Rich in protein and essential fatty acids, particularly Omega-3, walnuts are considered a highly nutritious nut crop and are often referred to as “Imperial Nuts” due to their remarkable health benefits. Various plant parts viz. leaves, roots, stem and fruits contain several bioactive compounds such as polyphenolic chemicals, flavonoids and alkaloids. One notable compound found in walnuts is juglone, a significant anti-cancer agent known for its therapeutic potential. . Walnuts have long been used in traditional and Ayurveda medicine for treating a variety of human health issues, including hair fall and skin illness. This systematic review compiles and synthesizes existing information regarding the nutritional composition, ethno-medicinal and traditional uses, phytochemistry, and pharmacological significance of walnut.

References

  1. 1. Manning WE. The classification within the Juglandandaceae. Ann Mo Bot Gard. 1978;59:1058‒87. https://doi.org/10.2307/2398782
  2. 2. Ahmad N, Singh SR, Rashid M, Mir H. Walnut. In: Dhillon WS, editor. Fruit production in India. New Delhi: Narendra Publishing House; 2018. p. 662‒72
  3. 3. Verma G, Sharma VA. A scientific update on Juglans regia Linn. Asian J Pharm Res Dev. 2020;8(3):166‒75. https://doi.org/10.22270/ajprd.v8i3.741
  4. 4. Food and Agriculture Organization. Walnut area and production data [Internet]. Rome: The Institute; 2024[updated 2024; cited 2025] Available from: http://www.fao.org
  5. 5. National Horticulture Board. Walnut area and production of India [Internet]. Gurugram: The Institute; 2024 [updated 2024; cited 2025] Available from: http://nhb.gov.in
  6. 6. Mir GM, Nisar O, Iqbal U. Scientific processing of walnuts necessary for amazing health benefits. J Chem Sci. 2016;6(8):783‒93.
  7. 7. Khan SA, Bhatia S, Tripathi N. Entomological studies of chaeto-proctaodata, an important pest on walnut trees (Juglans regia L.) in Kashmir valley. J Acad and Indus Res. 2013;2(6):378‒81.
  8. 8. Raja G, Shaker IA, Sailaja I, Swaminathan R, Kondaveeti SB, Saleem BS. Nutritional analysis of nuts extract of Juglans regia L. Int J Bioassays. 2012;1:68‒73. https://doi.org/10.21746/ijbio.2012.10.001
  9. 9. Gajendra M, Sharique A. A recent update on the medicinal properties and use of aloe vera in the treatment of various ailments. Biosci Biotech Res Commun. 2016;9(2):273‒88.
  10. https://doi.org/10.21786/bbrc/9.1/15
  11. 10. Al-Snaf AE. Chemical constituents, nutritional, pharmacological and therapeutic importance of Juglans regia- a review. IOSR J Pharm. 2018;8(11):1‒21.
  12. 11. Girzu M, Carnat A, Privat AM, Fialip J, Carnat AP, Lamaison JL. Sedative effect of walnut leaf extract and Juglone, an isolated constituent. Pharm Biol. 1998.
  13. https://doi.org/10.1076/phbi.36.4.280.4580
  14. 12. Sharma M, Sharma M, Sharma M. A comprehensive review on ethnobotanical, medicinal and nutritional potential of walnut (Juglans regia L.). Proceed Ind Nat Sci Acad. 2022;88:601–16. https://doi.org/10.1007/s43538-022-00119-9
  15. 13. Khattak P, Khalil TF, Bibi S, Jabeen H, Muhammad N, Khan MA, et al. Juglans regia (walnut tree) bark in dentistry. Pak Bio Med J. 2022;5(2):152‒56.
  16. https://doi.org/10.54393/pbmj.v5i1.201
  17. 14. Hassan GA, Bilal AT, Ahmad TA, Wani S, Irshad N. Economic and ethno-medicinal uses of Juglans regia L. in Kashmir Himalaya. Unique J Ayurvedic And Herbal Med. 2013;1(3):64–67.
  18. 15. Gupta A, Behl T, Panichyupakaranan P. A review of phytochemistry and pharmacology profile of Juglans regia. Obes Med. 2019;16:1‒7. https://doi.org/10.1016/j.obmed.2019.100142
  19. 16. Jung-Hynes B, Reiter RJ, Ahmad N. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res. 2010;48(1):9‒19. https://doi.org/10.1111/j.1600-079X.2009.00729.x
  20. 17. Mediavilla MD, Sanchez-Barcelo EJ, Tan DX, Manchester L, Reiter RJ. Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem. 2010;17(36):4462‒81. https://doi.org/10.2174/092986710794183015
  21. 18. Muthaiyah B, Musthafa E, Lee M, Chauhan M, Kaur V, Chauhan K. Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer’s disease. J Alzheimer’s Dis. 2014;42(4):1397‒05.
  22. https://doi.org/10.3233/JAD-140675
  23. 19. Subhan S, Bagchi M. Phytopharmaceuticals for brain health. CRC Press. Boca Raton;2017. 464 https://doi.org/10.1201/9781315152998
  24. 20. Wu S, Mo R, Wang R, Li Q, Shen D, Liu Y. Identification of key antioxidants of free, esterified and bound phenolics in walnut kernel and skin. Foods. 2023;12:825. https://doi.org/10.3390/foods12040825
  25. 21. Zhang YG, Kan H, Chen SX, Thakur K, Wang S, Zhang JG, et al. Comparison of phenolic compounds extracted from diaphragma juglandis fructus, walnut pellicle and flowers of Juglans regia using methanol, ultrasonic wave and enzyme assisted extraction. Food Chem. 2020;321:126672. https://doi.org/10.1016/j.foodchem.2020.126672
  26. 22. Fukasawa R, Miyazawa T, Abe C, Bhaswant M, Toda M. Quantification and comparison of nutritional components in oni walnut (Juglans ailanthifolia Carr.), hime walnut (Juglans subcordiformis Dode.) and cultivars. Horticulturae. 2023;9:122. https://doi.org/10.3390/horticulturae9111221
  27. 23. Rahimipanah M, Hamedi M, Mirzapour M. Antioxidant activity and phenolic contents of Persian walnut (Juglans regia L.) green husk extract. Afr J Food Sci Technol. 2010;1:105‒11.
  28. 24. Zhang Z, Liao L, Moore J, Wua T, Wang Z. Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem. 2009;113:160‒65.
  29. https://doi.org/10.1016/j.foodchem.2008.07.061
  30. 25. Fukuda T, Ito H, Yoshida T. Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. Bio Factors. 2004;2:251–53. https://doi.org/10.1002/biof.552210148
  31. 26. Emira N, Mejdi S, Najla T, Hafedh H, Riadh K, Eulogio V, et al. Antibacterial, anticandidal and antioxidant activities of Salvador arersica and Juglans regia L. extracts. J Med Plant Res. 2011;5(17):4138‒46.
  32. 27. Mohammed N, Kasim H, Hussein AS, Emad AM, Hassan AM, Mohammed AJ. Antifungal activity of alcoholic extract of Juglans regia against phyto pathogenic Rhizoctonia solani. Chem Res J. 2018;3(4):105–09.
  33. 28. Hiroshi S, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, et al. Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactos amine hepato protective hydrolyzable tannins in the kernel pellicles of walnut. J Agric Food Chem. 2008;56:4444–49. https://doi.org/10.1021/jf8002174
  34. 29. Parivash R, Najmeh K, Sedigheh A, Mahbubeh S. Anti-diabetic effects of walnut oil on alloxan-induced diabetic rats. Afr J Pharmacy Pharmacol. 2011;5(24):2655–61. https://doi.org/10.5897/AJPP11.480
  35. 30. Ruijun W. Antitumor effects and immune regulation activities of a purified polysaccharide extracted from Juglans regia. Int J Biol Macromol. 2015;72:771–75.
  36. https://doi.org/10.1016/j.ijbiomac.2014.09.026
  37. 31. Rosaria A, Floriana D, Giuseppe AM, Simone R, Adriana G, Aldo S, et al. Anti-bacterial and anti-biofilm activities of walnut pellicle extract (Juglans regia L.) against coagulase-negative staphylococci. Nat Prod Res. 2021;35(12):2076‒81. https://doi.org/10.1080/14786419.2019.1650352
  38. 32. Akram E, Jalal ZM, Pejmanm SR, Somayeh O. Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats. Pharm Biol. 2013;51(5):558‒65.
  39. https://doi.org/10.3109/13880209.2012.749920
  40. 33. Ksenija K, Vanja T, Miroslav S, Snezana C. Antioxidant activity of Juglans regia L. Juglandaceae pericarp originated from Sumadija region. Pons Med J. 2019;16(1):3–8.
  41. https://doi.org/10.5937/pomc16-18072
  42. 34. Verma R, Padalia R, Chauhan A, Thul S, Phytochemical analysis of the leaf volatile oil of walnut tree (Juglans regia L.) from western Himalaya. Ind Crops Prod. 2013;42:195‒201. https://doi.org/10.1016/j.indcrop.2012.05.032.x
  43. 35. Jamshid M, Khalil S, Hamdollah D, Bahram M. Anti-diabetic effects of an alcoholic extract of Juglans regia in an animal model. Turk J Med Sci. 2011;41(4):685–91.
  44. 36. Hubert S, Grzegorz C. Anti-fungal activity of Juglans regia leaf extract against Candida albicans isolates. Pol J Environ Stud. 2015;24(3):1339–48. https://doi.org/10.15244/pjoes/34671
  45. 37. Deshpande RR, Kale AR, Ruikar AD, Panvalkar PS, Kulkarni AA, Deshpande NR, et al. Antimicrobial activity of different extracts of Juglans regia L. against oral microflora. Int J Pharm Sci. 2011;3:200‒01.
  46. 38. Poyrazolu EC, Biyik H. Antimicrobial activity of the ethanol extracts of some plants natural growing in Aydin Turkey. Afr J Microbiol Res. 2010;4:2318‒23.
  47. 39. Raheleh J, Mahmood S, Ghafari M, Salami M, Kourosh V, Houri S, et al. Antioxidant and anticancer activities of walnut (Juglans regia L.) protein hydrolysates using different proteases. Plant Foods Hum Nutr. 2016;71:402–09. https://doi.org/10.1007/s11130-016-0576-z
  48. 40. Claudia SG, Carlos C, Veronique N, Maria IP. Health benefits of walnut polyphenols: An exploration beyond their lipid profile. Critical Rev in Food Sci and Nutri. 2015;57(16):3373‒83. https://doi.org/10.1080/10408398.2015.1126218
  49. 41. Logan AC. Omega-3 fatty acids and major depression: a primer for mental health professionals. Lipids in Health and Disease. 2004;3(1):25. https://doi.org/10.1186/1476-511X-3-25
  50. 42. Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. 2010;31(4):533‒42. https://doi.org/10.1093/carcin/bgp205
  51. 43. Chao SH, Greenleaf AL, Price DH. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly block transpiration. Nucleic Acid Res. 2001;29(3):767‒73. https://doi.org/10.1093/nar/29.3.767
  52. 44. Arya AK, Arora M, Singh FMA. A review on pharmacological activity of Juglans regia. Int J Pharm. 2020;7(1):1‒11. https://doi.org/10.13040/IJPSR.0975-8232.x
  53. 45. Sara HS, Reza RA. Morphometric study of the effect of walnut (Juglans regia) leaf extract on cerebrum malformation in offsprings of diabetic rats. Biomed and Pharmacol J. 2015;8(1):467‒75. https://doi.org/10.13005/bpj/636
  54. 46. Teymouri SM, Montaser KS, Ghafarzadegan R, Haji AR. Antidiabetic effects of Juglans regia leave’s methanolic extract on alloxan-induced male wisrar rats. J Med Plants. 2010;9(34):142‒49.
  55. 47. Rathore JP, Kumar A, Sharma N. Conventional and contemporary uses of walnut in the modern era. Popular Kheti. 2017;5(4):118‒21.

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