A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19
DOI:
https://doi.org/10.14719/pst.2020.7.3.831Keywords:
SARS-CoV-2 Rasayana dravyas Ashwagandha Suvarna prashana AYUSH–64, AYUSH–64, Suvarna prashana, Ashwagandha, Rasayana dravyas, SARS-CoV-2Abstract
The Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome Coronavirus-2 (SARS CoV-2) infection attacking mainly on the immune system of a body. It is a potentially fatal disease that is of public health and economy concern globally. In December 2019, COVID-19 outbreak occurred in Wuhan city, Hubei Province, China furthermore spread worldwide. Research is underway in many countries to develop effective vaccines and drugs for the COVID-19. In Ayurveda, Acharya Charaka explained the concept of an epidemic condition in Janapadodhwans Adhayay and combating of these diseases is to be done by Panchakarma (five procedures of purification), Rasayana Chikitsa (immune-modulators therapy) and Sadvritta (good conduct). Rasayan dravyas (immuno modulators drugs) of Ayurveda can be used for health promotion, immune-modulation, prevention and reduce disease burden from COVID-19. Drugs such as Ashwagandha (Withania somnifera (L.) Dunal), Guduchi (Tinospora cordifoloia (Willd.) Miers), Amalaki (Phyllanthus emblica L.), Mulethi (Glycyrrhiza glabra L.), Shatavari (Asparagus racemosus Willd), Chireta (Andrographis paniculata (Burm.f.) Nees), Tulsi (Ocimum sanctum L.) Punarnava (Boerhaavia diffusa L.) and Pippali ((Piper longum L.) For symptom management of COVID-19 like illness Agastya Haritaki, Anutaila, AYUSH–64 can be used. Scientific research on these drugs may reveal the new approach for the prevention and management of COVID-19. The main aim of this article is to review research which has already conducted and currently being carried out on the herbal plant for their immunomodulation property which have a possible application in the prevention and treatment of COVID-19.
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References
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21. Patwardhan B, Chavan-Gautam P, Gautam M, Tillu G, Chopra A, Gairola S, et al. Ayurveda rasayana in prophylaxis of COVID-19. Curr Sci. 2020; 118:1158-60.
22. Kindler E, Thiel V, Weber F. Interaction of SARS and MERS coronaviruses with the antiviral interferon response. Adv Virus Res. 2016; Vol. 96: 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006
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24. Osakwe CE, Bleotu C, Chifiriuc MC, Grancea C, Otelea D, Paraschiv S, et al. TH1/TH2 cytokine levels as an indicator for disease progression in human immunodeficiency virus type 1 infection and response to antiretroviral therapy. Roum Arch Microbiol Immunol. 2010;69(1):24-34
25. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 87: 18-22. https://doi.org/10.1016/j.bbi.2020.03.031
26. Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: The reality and challenges. J. Microbiol. Immunol. Infect. 2020; 43(3) 436-443. https://doi.org/10.1016/j.jmii.2020.03.034
27. Hashemi SR, Davoodi H. Herbal plants as new immuno-stimulator in poultry industry: a review. Asian Journal of Animal and Veterinary Advances. 2012; 7(2):105-16. https://doi.org/10.3923/ajava.2012.105.116.
28. Mahima , Anu Rahal, Rajib Deb, Shyma K. Latheef, Hari Abdul Samad, et al. Immunomodulatory and Therapeutic Potentials of Herbal, Traditional/Indigenous and Ethnoveterinary Medicines. Pakistan Journal of Biological Sciences. 2012; 15(16):754-74. https://doi.org/10.3923/pjbs.2012.754.774
29. Tiwari R, Chakraborty S, Saminathan M, Dhama K, Singh SV. Ashwagandha (Withania somnifera): Role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: A review. Journal of Biological Sciences. 2014; 14 (2):77-94. https://doi.org/10.3923/jbs.2014.77.94
30. Gautam M, Diwanay SS, Gairola S, Shinde YS, Jadhav SS, Patwardhan BK. Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. International immunopharmacology. 2004; 4 (6):841-9. https://doi.org/10.1016/j.intimp.2004.03.005
31. Kumar R, Rai J, Kajal NC, Devi P. Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis. Indian Journal of Tuberculosis. 2018; 65 (3):246-51. https://doi.org/10.1016/j.ijtb.2017.05.005.
32. Akhtar S. Use of Tinospora cordifolia in HIV infection. Indian Journal of Pharmacology. 2010; 42(1):57. https://doi.org/10.4103/0253-7613.62402.
33. Upadhyaya R, Pandey RP, Sharma V, Verma Anita K. Assessment of the multifaceted immunomodulatory potential of the aqueous extract of Tinospora cordifolia. Research Journal of Chemical Sciences. 2011; 1(6): 71-79.
34. Mainzen Prince PS, Padmanabhan M, Menon VP. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan?induced diabetic liver and kidney. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2004; 18 (9):785-7. https://doi.org/10.1002/ptr.1567
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Niraj S, Varsha S. A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19. Plant Sci. Today [Internet]. 2020 Jul. 18 [cited 2024 Nov. 21];7(3):417-23. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/831
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