Rosa damascena, commonly known as the Damask rose, is a plant of beauty and medicinal significance. This review explores its botanical characteristics, chemical composition and diverse pharmacological activities. Rosa damascena rich in phytochemicals like anthocyanins, flavonoids and essential oils and demonstrates a wide range of therapeutic properties. Studies have shown its potential in antimicrobial, antioxidant, antidiabetic, analgesic and anti-inflammatory applications. The plant also shows promise in promoting cardiovascular health, respiratory issues and neurological functions. Its relaxing and soothing properties make it valuable in aromatherapy and stress management. Clinical studies support its efficacy in treating conditions such as sexual dysfunction, pain and apnea in premature newborns. While current evidence is promising, further research is needed to fully understand its mechanisms of action, optimize dosages and explore potential drug interactions. This comprehensive review underscores the significant therapeutic potential of Rosa damascena in complementary and alternative medicine.