Sesame (Sesamum indicum L.), often referred to as the "Queen of oilseeds," is one of the world's most traditional oilseed crops. A field experiment was conducted during 2021 and 2022 at V. O. Chidambaranar Agricultural College and Research Institute, Killikulam to investigate the effect of various media compositions on the performance of sesame seedlings grown for transplanting. The experiment followed a randomized block design with five treatments and four replications. Observations including seed germination percentage, shoot length, number of leaves, root length, root volume and vigour index were recorded. In the preliminary experiment, among the media combinations, the results showed that T4 recorded the highest seed germination percentage (82.30 %), shoot length (18.8 cm), number of leaves (5.2), root length (2.9 cm), root volume (0.15 cc) and vigour index (1786), while the lowest values were recorded in the control (T5) with no media application. So that red earth, sand and vermicompost (1:1:2) media used for raising different age of seedling transplanted in the main field. Ridge planting of 20 days old sesame seedlings (T4) for transplanting resulted significantly higher dry matter production of 2888 kg ha-1, crop growth rate of 3.96 g m-2 day-1, relative growth rate of 0.016 g g-1 day-1 from 60 DAT to harvest and a seed yield of 901 kg ha-1 compared to all other treatment combinations.