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Plant Science Today (PST)

Research Articles

Early Access

Studies on anti-microbial activity of Quisqualis indica L. plant extracts on urinary tract infection causing pathogens

DOI
https://doi.org/10.14719/pst.9324
Submitted
7 May 2025
Published
09-01-2026

Abstract

The ornamental plant, Quisqualis indica L. has several pharmacognistic properties. The anti-bacterial activity of the plant extracts against common bacteria causing Urinary tract infections (UTIs) were determined. In this study, Quisqualis Indica L. plant samples were collected during the spring season from Kalahandi District of Odisha. The different solvent extracts of the medicinal plant, Q. indica were used for determining the anti-bacterial activity against human pathogenic micro-organisms isolated from samples of patients having UTIs. In all, urine samples from 110 patients having UTIs were analyzed. Antibiotic susceptibility of gram-positive and gram-negative bacterial isolates was studied. The Molsoft tool was used to identify the drug likeness score of each compound. Escherichia coli was observed in 57 %, Pseudomonas aeruginosa in 17 %, Staphylococcus aureus in 15 % and Klebsiella pneumoniae in 10 % of the samples. Escherichia coli was the most predominant bacteria isolated from UTIs. Seven bacterial strains were used in the study namely Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pyogenes and Acinetobacter baumannii. The extracts of Q. indica have significant anti-bacterial properties against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus pyogenes causing the UTIs. The compounds mainly Phytol, Trans-sequalene, Tocoferol, Vitamin-E-acetate and stigmasterol have higher drug likeness scores. Our study has reported the structural configuration of the extracts having higher drug-likeness score with a potential for future therapeutic drug against the UTIs. This study focusses on UTIs and the phytochemical analysis has been evaluated with drug likeness score.

References

  1. 1. Tan CW, Chlebicki MP. Urinary tract infections in adults. Singapore Med J. 2016;57(9):485-92. https://doi.org/10.11622/smedj.2016153
  2. 2. Walsh C, Collyns T. The pathophysiology of urinary tract infections. Surgery (Oxford). 2017;35(6):293-8. https://doi.org/10.1016/j.mpsur.2017.03.007
  3. 3. Franco AV. Recurrent urinary tract infections. Best Pract Res Clin Obstet Gynaecol. 2005;19(6):861-73. https://doi.org/10.1016/j.bpobgyn.2005.08.003
  4. 4. Das S. Natural therapeutics for urinary tract infections – a review. Future J Pharm Sci. 2020;6(1):1-3. https://doi.org/10.1186/s43094-020-00086-2
  5. 5. Hameed IH, Al-Rubaye AF, Kadhim MJ. Antimicrobial activity of medicinal plants and urinary tract infections. Int J Pharm Clin Res. 2017;9(1):44-50. https://doi.org/10.25258/ijpcr.v9i1.8262
  6. 6. Hameed IH, Al-Rubaye AF, Kadhim MJ. Urinary tract infections: characterization and herbal antimicrobial activity: a review. Int J Curr Pharm Rev Res. 2017;8(2):184-91. https://doi.org/10.25258/ijcprr.v8i02.9201
  7. 7. Barik BS, Das S, Hussain T. Pharmacognostic properties of Quisqualis indica Linn against human pathogenic microorganisms: an insight review. Eur J Med Plants. 2020;31(20):87-103. https://doi.org/10.9734/ejmp/2020/v31i2030369
  8. 8. Ursu O, Rayan A, Goldblum A, et al. Understanding drug-likeness. Wiley Interdiscip Rev Comput Mol Sci. 2011;1:760-81. https://doi.org/10.1002/wcms.52
  9. 9. Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat Rev Drug Discov. 2007;6:881-90. https://doi.org/10.1038/nrd2445
  10. 10. Li B, Wang Z, Liu Z, Tao Y, Sha C, He M, et al. DrugMetric: quantitative drug-likeness scoring based on chemical space distance. Brief Bioinform. 2024;25(4):bbae321. https://doi.org/10.1093/bib/bbae321
  11. 11. Biodiversity of Kalahandi and Nuapada district of Odisha. 1-223.
  12. 12. Sahu RK, Sahoo AK, Sadangi N, Singh K, Nahak G. Ethnomedicinal plants resource of Orissa. Vol I. Kalahandi. 1-500.
  13. 13. Pandey A, Tripathi S. Concept of standardization, extraction and pre-phytochemical screening strategies for herbal drug. J Pharmacogn Phytochem. 2014;2(5):1-6.
  14. 14. Akhtar N, Mirza B. Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arab J Chem. 2018;11(8):1223-35. https://doi.org/10.1016/j.arabjc.2015.01.013
  15. 15. Oyaert M, Van Meensel B, Cartuyvels R, Frans J, Laffut W, Vandecandelaere P, et al. Laboratory diagnosis of urinary tract infections: towards a BILULU consensus guideline. J Microbiol Methods. 2018;146:92-9. https://doi.org/10.1016/j.mimet.2018.02.006
  16. 16. Dash M, Padhi S, Mohanty I, Panda P, Parida B. Antimicrobial resistance in pathogens causing urinary tract infections in a rural community of Odisha, India. J Fam Community Med. 2013;20(1):20-6. https://doi.org/10.4103/2230-8229.108180
  17. 17. Sood S, Gupta R. Antibiotic resistance pattern of community acquired uropathogens at a tertiary care hospital in Jaipur, Rajasthan. Indian J Community Med. 2012;37(1):39-44. https://doi.org/10.4103/0970-0218.94023
  18. 18. Chowdhury S, Parial R. Antibiotic susceptibility patterns of bacteria among urinary tract infection patients in Chittagong, Bangladesh. SMU Med J. 2015;2(1):114-26.
  19. 19. Saha S, Nayak S, Bhattacharyya I, Saha S, Mandal A, Chakraborty S, et al. Understanding the patterns of antibiotic susceptibility of bacteria causing urinary tract infection in West Bengal, India. Front Microbiol. 2014;5:463-69. https://doi.org/10.3389/fmicb.2014.00463
  20. 20. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 30th ed. CLSI supplement M100. 2020:1-13.
  21. 21. Mishra MP, Rath S, Swain SS, Ghosh G, Das D, Padhy RN. In vitro antibacterial activity of crude extracts of nine selected medicinal plants against UTI causing MDR bacteria. J King Saud Univ Sci. 2017;29(1):84-95. https://doi.org/10.1016/j.jksus.2015.05.007
  22. 22. Prakash D, Saxena RS. Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in urban community of Meerut city, India. Int Sch Res Notices. 2013;2013. https://doi.org/10.1155/2013/749629
  23. 23. Mishra MP, Padhy RN. In vitro antibacterial efficacy of 21 Indian timber-yielding plants against multidrug-resistant bacteria causing urinary tract infection. Osong Public Health Res Perspect. 2013;4(6):347-57. https://doi.org/10.1016/j.phrp.2013.10.007
  24. 24. Mukherjee D, Chandra G. Flower extracts of Quisqualis indica as novel antibacterial agent against some pathogenic bacteria. Ann Pharmacol Pharm. 2017;2(4):1040-45.
  25. 25. Kulshreshtha M, Srivastava G, Singh MP. Pharmacognostical, antioxidant activity and high performance thin layer chromatography studies on leaves of Quisqualis indica Linn. Curr Trad Med. 2018;4(1):53-67. https://doi.org/10.2174/2215083804666180118095645
  26. 26. Agarwal A, Prajapati R, Raza SK, Thakur LK. GC-MS analysis and antibacterial activity of aerial parts of Quisqualis indica plant extracts. Indian J Pharm Educ. 2017;51:329-36. https://doi.org/10.5530/ijper.51.2.39
  27. 27. Shaheen G, Akram M, Jabeen F, Ali Shah SM, Munir N, Daniyal M, et al. Therapeutic potential of medicinal plants for the management of urinary tract infection: a systematic review. Clin Exp Pharmacol Physiol. 2019;46(7):613-24. https://doi.org/10.1111/1440-1681.13092
  28. 28. Kumar RS, Parameshwari V. Studies on efficiency of medicinal plants against bacteria isolated from urinary tract infection. Int J Curr Microbiol Appl Sci. 2017;6(1):258-63. https://doi.org/10.20546/ijcmas.2017.601.031
  29. 29. Manandhar S, Luitel S, Dahal RK. In vitro antimicrobial activity of some medicinal plants against human pathogenic bacteria. J Trop Med. 2019;2019:1-5. https://doi.org/10.1155/2019/1895340
  30. 30. Velu G, Palanichamy V, Rajan AP. Phytochemical and pharmacological importance of plant secondary metabolites in modern medicine. In: Bio-organic phase in natural food: an overview. Cham: Springer; 2018:135-56. https://doi.org/10.1007/978-3-319-74210-6_8
  31. 31. Kumari P, Kumari C, Singh PS. Phytochemical screening of selected medicinal plants for secondary metabolites. Int J Life Sci Sci Res. 2017;3(4):1151-57. https://doi.org/10.21276/ijlssr.2017.3.4.9
  32. 32. Hussein RA, El-Anssary AA. Plant secondary metabolites: the key drivers of the pharmacological actions of medicinal plants. Herbal Med. 2019;1:13-28. https://doi.org/10.5772/intechopen.76139

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