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Plant Science Today (PST)

Review Articles

Early Access

Integrated strategies against biotic and abiotic stress: A physiological and molecular roadmap for sustainable food security

DOI
https://doi.org/10.14719/pst.9645
Submitted
26 May 2025
Published
07-01-2026

Abstract

  Global agriculture faces the dual challenge of increasing food production amidst accelerating climate change. This review hypothesizes that an integrated understanding and management of the complex interplay between biotic (e.g., pathogens) and abiotic (e.g., salinity, drought) stresses is fundamentally more effective than addressing each stressor in isolation. The urgency of this investigation is underscored by the critical need for resilient crops capable of withstanding multiple, concurrent environmental challenges. Through a critical review of existing literature, we explore the interconnected physiological and molecular mechanisms governing plant responses to combined stresses, focusing on the crosstalk between defense signaling pathways, metabolic regulation and antioxidant machinery. This reveals a significant knowledge gap in studies addressing the synergistic or antagonistic outcomes of co-occurring stresses. This review presents a breakthrough by revealing overlooked interdisciplinary connections, paving the way for integrated management strategies that merge advanced plant breeding (e.g., CRISPR-Cas9), bio stimulant application and precision agriculture. Key business opportunities lie in developing "smart" cultivars and inputs that respond effectively to environmental cues. Future research should focus on translating molecular insights into economically viable field applications. We conclude that this integrated approach is the cornerstone of achieving sustainable food security.

References

  1. 1. Ray RV. Effects of pathogens and disease on plant physiology. In: Agrios' plant pathology. Academic Press; 2024:63-92.
  2. https://doi.org/10.1016/B978-0-12-822429-8.00002-9
  3. 2. Agrios GN. Plant pathology. 5th ed. Elsevier Academic Press; 2005.
  4. 3. Gill SS, Tuteja N. Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Plant Physiol Biochem. 2010;48(12):909-30. https://doi.org/10.1016/j.plaphy.2010.08.016
  5. 4. Savary S, Willocquet L, Esker PD. Disease impacts and appraisal of yield losses. In: Plant pathology. Springer; 2019:3-14.
  6. 5. Al-Abedy AN, Al-Fadhal FA, Karem MH, Al-Masoudi Z, Al-Mamoori SA. Genetic variability of different isolates of Rhizoctonia solani Kühn isolated from Iranian imported potato tubers (Solanum tuberosum L.). Int J Agric Stat Sci. 2018;14(2):587-98.
  7. 6. Ekwomadu TI, Mwanza M. Fusarium fungi pathogens, identification, adverse effects, disease management and global food security: A review of the latest research. Agriculture. 2023;13(9):1810. https://doi.org/10.3390/agriculture13091810
  8. 7. Al-Salami I, Al-Gwaree RN, Al-Abedy AN. Genetic relationship among some isolates of Rhizoctonia solani isolated from some infected tomato plants (Solanum lycopersicum L). J Glob Pharma Technol. 2019;11(7):379-85.
  9. 8. Al-Abedy AN, Abdalmoohsin RG, Al-Taey DK. Genetic diversity of Tomato yellow leaf curl virus isolates and the effect of virus on the hormones content of tomato (Solanum lycopersicum) plants. Res Crops. 2021;22(2):347-55.https://doi.org/10.31830/2348-7542.2021.078
  10. 9. Islam MM, El-Sappah AH, Ali HM, Zandi P, Huang Q, Soaud SA, et al. Pathogenesis-related proteins (PRs) countering environmental stress in plants: A review. S Afr J Bot. 2023;160:414-27. https://doi.org/10.1016/j.sajb.2023.07.031
  11. 10. Mahdi MS, Ali MB, Al-Abedy AN. Genetic variability of the mite Varroa destructor isolated from honey bees in Iraq and some Middle Eastern countries. Indian J Forensic Med Toxicol. 2020;14(1):1-7.
  12. 11. Alhissnawi MS, Karrem AA, Al-Abedy AN. Molecular identification of dwarf honey bees (Apis florea Fabricius) distributed in the eastern region of Iraq. IOP Conf Ser: Earth Environ Sci. 2024;1371(3):032046. https://doi.org/10.1088/1755-1315/1371/3/032046
  13. 12. Délye C, Jasieniuk M, Le Corre V. Evolution of herbicide resistance in weeds: Mechanisms and risks. Front Plant Sci. 2013;4:339. https://doi.org/10.3389/fpls.2013.00339
  14. 13. Al-Abedy AA, Musawi BA, Isawi HA, Abdalmoohsin RG. Morphological and molecular identification of Cladosporium sphaerospermum isolates collected from tomato plant residues. Braz J Biol. 2021;82. https://doi.org/10.1590/1519-6984.237428
  15. 14. Al-Abedy AN, Abdalmoohsin RG, Odeh AA, Al-Salami I. Evaluation of the potential of some Trichoderma spp. isolates, nanoparticles (MgO NPs) and the fungicide Butanol in controlling seedling damping-off and seeds decay caused by Fusarium brachygibbosum in tomatoes. J Agric Stat Sci. 2021;17:1661-71.
  16. 15. Mahmood AM, Al-Abedy AN. Effect of some species of Trichoderma spp. and the chemical fungicide Topsin M in control of the disease of seed rot and seedling damping-off of okra caused by Fusarium culmorum. Int J Agric Stat Sci. 2021;1:1701-10.
  17. 16. Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci. 2002;7(9):405-10. https://doi.org/10.1016/S1360-1385(02)02312-9
  18. 17. Wu G. Amino acids: Metabolism, functions and nutrition. Amino Acids. 2009;37(1):1-17. https://doi.org/10.1007/s00726-009-0269-0
  19. 18. Al-Masoudi FN, Shannan RG, Alasadi FKK. Effect of potassium supplementation and foliar spraying with ascorbic acid on some yield characteristics of wheat plants. 5th International Conference of Modern Technologies in Agricultural Sciences, IOP Conf Ser: Earth Environ Sci. 2024;1371:052054. https://doi.org/10.1088/1755-1315/1371/5/052054
  20. 19. Neamah SK, Alwan SL, Al-Abedy AN. Molecular diagnosis of new Aspergillus niger isolates causing degradation of pomegranate (Punica granatum) trees in Iraq. Plant Cell Biotechnol Mol Biol. 2020;21(1-2):79-84.
  21. 20. Hickey LT, German SE, Pérez-Wuales J, Major GO, Rebetzke GJ, Voss-Fels KP. Breeding for adaptation to climate change. Annu Rev Plant Biol. 2019;70:489-525.
  22. 21. Aljuaifari WA, Alshimaysawe UA, Mohammed AE, Al-Abedy AN. Evaluate the ability of Syntaxin genes to enhance resistance against Fusarium virguliforme and Heterodera glycines. IOP Conf Ser: Earth Environ Sci. 2019;388(1):012014. https://doi.org/10.1088/1755-1315/388/1/012014
  23. 22. Mnati MA, Dewan MM, Al-Abedy AN, Altaie A. Morphological and molecular identification of Fusarium spp. and Macrophomina phaseolina isolated from cowpea plants (Vigna unguiculata). Int J Agric Stat Sci. 2021;17(2).
  24. 23. Al-Abedy AN, Al-Shujairi KA, Al-Salami I, Ashfaq M, Al-Musawi BH. Genetic variation among some isolates of Tomato yellow leaf curl virus and its control using some biological control fungi and nanoparticles. Int J Agric Stat Sci. 2021;17(1):229-36.
  25. 24. Meteab HR, Kadhim JH, Al-Abedy AN, Al-Musawi BH. Effect of some biological control fungi on life stages of the two-spot spider mite Tetranychus urticae Koch (Acari: Tetranychidae) on eggplant. IOP Conf Ser: Earth Environ Sci. 2022;1060(1):012110.
  26. https://doi.org/10.1088/1755-1315/1060/1/012110
  27. 25. Al-Sharmani HR, Al-Kalabi HH, Al-Abedy AN. Efficacy of rice husks compost and Trichoderma harzianum on Rhizoctonia solani and its effect on seeds germination and seedling health. IOP Conf Ser: Earth Environ Sci. 2019;388(1):012002. https://doi.org/10.1088/1755-1315/388/1/012002
  28. 26. Odeh A, Abdalmoohsin RG, Al-Abedy AN. Molecular identification of Fusarium brachygibbosum and some isolates of Trichoderma spp. Int J Pharm Res. 2021;13(1):1390-6.
  29. 27. Yadav S, Malik K, Moore JM, Kamboj BR, Malik S, Malik VK, et al. Valorisation of agri-food waste for bioactive compounds: Recent trends and future sustainable challenges. Molecules. 2024;29(9):2055. https://doi.org/10.3390/molecules29092055
  30. 28. Al-Shugeairy ZK, Alogaidi FF, Al-Abedy AN. Using a new method to induce targeted genetic mutations in Potato virus Y (PVY). J Agric Stat Sci. 2021;17(1):2123-31.
  31. 29. Tyczewska A, Twardowski T, Woźniak-Gientka E. Agricultural biotechnology for sustainable food security. Trends Biotechnol. 2023;41(3):331-41. https://doi.org/10.1016/j.tibtech.2022.08.002
  32. 30. FAO. International standards for phytosanitary measures. Rome: Food and Agriculture Organization of the United Nations; 2017.
  33. 31. OECD. Trade facilitation indicators. Paris: OECD Publishing; 2018.
  34. 32. Al-Abedy AN, Al-Janabi RG, Al-Tmeme ZA, Salim AT, Ashfaq M. Molecular characterization of novel isolates of Rhizoctonia solani, Trichoderma atroviride and Fusarium spp. isolated from different plants and cutting woods in Iraq. Pak J Bot. 2020;52(3):1-10. https://doi.org/10.30848/PJB2020-3(29)
  35. 33. Muteab MM, Al-Abedy AN. Genetic diversity of Trichoderma spp. isolated from soils in the Iraqi environment. Agric Sci Dig. 2025:1-8.
  36. https://doi.org/10.18805/ag.DF-734
  37. 34. Karem MH, Al-Abedy AN, Kadhim JH. Effect of Tomato yellow leaf curl virus (TYLCV) on the content of some mineral elements in the fruits of some tomato (Solanum lycopersicum L.) genotypes. IOP Conf Ser: Earth Environ Sci. 2023;1259(1):012093. https://doi.org/10.1088/1755-1315/1259/1/012093
  38. 35. Karem MH, Al-Abedy AN, Kadhim JH. Effect of Tomato yellow leaf curl virus (TYLCV) infection of some tomato (Solanum lycopersicum L.) genotypes on fruits content of lycopene and some vitamins. IOP Conf Ser: Earth Environ Sci. 2023;1259(1):012092.
  39. https://doi.org/10.1088/1755-1315/1259/1/012092
  40. 36. Al-Shammari SQ, Al-Abedy AN, Farhood AN. Effect of Cucumber mosaic virus infection on the chemical content of some genotypes of tomato plant (Solanum lycopersicum L.). IOP Conf Ser: Earth Environ Sci. 2023;1262(3):032046.
  41. https://doi.org/10.1088/1755-1315/1262/3/032046
  42. 37. Al-Shammari SQ, Al-Abedy AN, Farhood AN. Effect of Cucumber mosaic virus infection on certain mineral elements, vitamin C, carbohydrates and enzymes of some tomato cultivars. IOP Conf Ser: Earth Environ Sci. 2023;1262(3):032049.
  43. https://doi.org/10.1088/1755-1315/1262/3/032049
  44. 38. Nicolopoulou-Stamati P, Maipas S, Kotampasi C, Stamatis P, Hens L. Chemical pesticides and human health: The state of the art. Front Public Health. 2016;4:148. https://doi.org/10.3389/fpubh.2016.00148
  45. 39. Garrett KA, Dendy SP, Frank EE, Rouse MN, Travers SE. Climate change effects on plant disease: Genomes to ecosystems. Annu Rev Phytopathol. 2006;44:489-509. doi:10.1146/annurev.phyto.44.070505.143422.
  46. https://doi.org/10.1146/annurev.phyto.44.070505.143420
  47. 40. Kumar A. Plant diseases and nutritional security: An Indian perspective. J Plant Dis Prot. 2019;126(1):1-17.
  48. 41. Al-Shujairi KA, Albehadlli HK, Kamaluddin ZN, Al-Abedy AN, Al-Taey DK. Genetic variation among some Sclerotinia sclerotiorum isolates causing white mold disease in eggplants (Solanum melongena). Int J Agric Stat Sci. 2022;18(1):399-407.
  49. 42. Chakraborty S, Newton AC. Climate change, plant diseases and food security: An overview. Plant Pathol. 2011;60(1):2-14. https://doi.org/10.1111/j.1365-3059.2010.02411.x
  50. 43. Alasadi FK, Khudair QH, Al Semmak. Hormones of maize crop as affected by potassium fertilization, water quality and ascobin foliar application. Kerbala Int J Mod Sci. 2020;6:246-50. https://doi.org/10.33640/2405-609X.1534
  51. 44. Al-Fadhal FA, Al-Abedy AN, Al-Janabi MM. Molecular identification of novel isolates of Rhizoctonia solani Kühn and Fusarium spp. (Matsushima) isolated from petunia plants (Petunia hybrida L.). Plant Arch. 2018;18(1):703-11.
  52. 45. Cushnie TPT, Lamb AJ. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005;26(5):343-56. https://doi.org/10.1016/j.ijantimicag.2005.09.002
  53. 46. Dar RA, Shahnawaz M, Ahanger MA, Majid IU. Exploring the diverse bioactive compounds from medicinal plants: A review. J Phytopharm. 2023;12(3):189-95. https://doi.org/10.31254/phyto.2023.12307
  54. 47. Walters DR, Walsh D, Newton AC, Lyon GD. Induced resistance for plant disease control: Maximizing the efficacy of resistance elicitors. Pest Manag Sci. 2009;65(7):683-92. https://doi.org/10.1002/ps.1738
  55. 48. Rates SMK. Plants as source of drugs. Toxicon. 2001;39(5):603-13. https://doi.org/10.1016/S0041-0101(00)00154-9
  56. 49. Alasadi FK, Khudair QH, Al Semmak. Effect of potassium fertilizer, irrigation water type and foliar application of ascobin on activity of some antioxidant enzymes of Zea mays L. AIP Conf Proc. 2019;2144:020013. https://doi.org/10.1063/1.5123070
  57. 50. Al-Musawi BH, Al-Abedy AN. Genetic variability analysis of some selected rice (Oryza sativa L.) genotypes in Iraq. Int J Agric Stat Sci. 2020;16(1):191-7.
  58. 51. Munir I, Rizwan M, Ahmad R, Ali S, Hussain A, Zia-ur-Rehman M. Nano-enabled strategies for plant disease management: Current status and future perspectives. J Nanobiotechnol. 2023;21(1):1-28. https://doi.org/10.1186/s12951-022-01728-8
  59. 52. Okeke ES, Nweze EJ, Ezike TC, Nwuche CO, Ezeorba TPC, Nwankwo CEI. Silicon-based nanoparticles for mitigating the effect of potentially toxic elements and plant stress in agroecosystems: A sustainable pathway towards food security. Sci Total Environ. 2023;898:165446. https://doi.org/10.1016/j.scitotenv.2023.165446
  60. 53. Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, et al. Plants for improved human nutrition. Trends Biotechnol. 2002;20(8):351-5. https://doi.org/10.1016/S0167-7799(02)02080-2
  61. 54. Schop S. Exploring mature plant resistance to control yellowing viruses in sugar beet [dissertation]. Wageningen: Wageningen University and Research; 2024.
  62. 55. Jassim SJ, Al-Salami I, Al-Shujairi KA, Al-Abedy AN. Molecular diagnosis of some isolates of Fusarium solani isolated from potato tubers (Solanum tuberosum L.). Int J Agric Stat Sci. 2021;17:171-5.
  63. 56. Jubair AF, Alwan SL, Al-Abedy AN. Genetic variability of different isolates of Fusarium spp. isolated from imported banana fruits Musa spp. Plant Arch. 2020;20(2).
  64. 57. Kamaluddin ZN, Merjan AF, Al-Abedy AN. Decreased Rhizoctonia solani growth rate in vitro with concentrations of olive and conocarpus leaves extract. Int J Agric Stat Sci. 2021;17(1):1943-8.
  65. 58. Ullah I, Yuan W, Khalil HB, Khan MR, Lak F, Uzair M, et al. Understanding Botrytis cinerea infection and gray mold management: A review paper on deciphering the rose's thorn. Phytopathol Res. 2024;6(1):42. https://doi.org/10.1186/s42483-024-00262-9

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