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Plant Science Today (PST)

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Early Access

Global landscape of biflavonoid bioactivity studies (1992–2024): A bibliometric and mechanistic overview

DOI
https://doi.org/10.14719/pst.9911
Submitted
8 June 2025
Published
04-05-2026
Versions

Abstract

Biflavonoids are a unique class of polyphenolic compounds known for their diverse biological activities, including antioxidant, anti-inflammatory, anticancer and antimicrobial effects. Recent years have seen a surge in research investigating the therapeutic potential and molecular mechanisms of biflavonoids. This bibliometric review provides a comprehensive overview of the research landscape surrounding biflavonoids and their biological activities. Ultimately, this bibliometric analysis guides future research directions, pinpoints gaps in the literature and underscores the growing importance of biflavonoids in medicinal and pharmaceutical science. This study employs a bibliometric analysis of 742 publications on biflavonoid activity from 1992 to 2024, utilising data from multidisciplinary sources. The results reveal an annual growth rate of 5.06 %, with a peak in publications in 2022. Research output in this field spans ten primary disciplines, with the highest contributions from medicinal chemistry, pharmacology and biochemistry, indicating its multidisciplinary nature. Keyword analysis indicates that biflavonoid research has evolved from early studies focused on isolation and structural characterisation toward advanced investigations emphasising antioxidant activity, gene regulation, apoptosis and neuroprotective mechanisms. The co-occurrence network analysis identifies six thematic clusters, emphasising areas such as antioxidant mechanisms, anti-inflammatory pathways and neurodegenerative protection. This bibliometric analysis provides a comprehensive overview of the research landscape, highlighting the dynamic growth, collaborative networks and emerging trends in biflavonoid research, paving the way for further investigations into their therapeutic potential.

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