Skip to main navigation menu Skip to main content Skip to site footer

Research Articles

Vol. 13 No. 3 (2026)

The anti-icteric effect of Rhamnus alaternus L.: Ethnomedicinal and commercial perspectives

DOI
https://doi.org/10.14719/pst.12346
Submitted
18 October 2025
Published
26-05-2026 — Updated on 03-07-2026
Versions

Abstract

An ethnomedicinal survey was conducted to document knowledge about the traditional uses of Rhamnus alaternus L., which is renowned for its varied therapeutic properties and widely distributed throughout the Mediterranean basin, notably in Morocco. This study aims to highlight the place of this species in traditional medicine in our region through an ethnomedicinal survey, in addition to evaluate its socio-economic value for the first time. The ethnomedicinal and socio-economic studies were conducted using a questionnaire and carried out among 172 informants in four areas of the province of Taza-Morocco, over the period of April 2022 to June 2023. The results revealed that R. alaternus is known to the surveyed population by 3 vernacular names: “Amlilas”, “Tamsissalt” and “El Oud El Ahmar”. This study showed that knowledge about the therapeutic usage of the plant was limited, as only 31.39 % of informants confirmed its use to treat icteric syndrome. Furthermore, this study indicated that the traditional use of this plant provides a source of income for herbalists through its sale in 2 forms: dried and fresh, with prices ranging from 30 MAD / 2.77 € to 35 MAD / 3.23 € per kg and from 3 MAD / 0.28 € to 5 MAD / 0.46 € per packet respectively. This study showed that R. alaternus has significant traditional therapeutic and economic value but is limited among herbalists. The therapeutic power of this species encourages further research to take advantage of its benefits and provide a basis for its safe use.

References

  1. 1. Henry M. The essential role of liver functioning in metabolism, detoxification and overall health: insights from modern medicine. J Clin Gastroenterol Hepatol. 2024;8(4):35.
  2. 2. Bessaguet F, Desmoulière A. Le foie. Actual Pharm. 2021;60(605):57–61.
  3. 3. Wang J, Wang H, Yang X, Wang K, Zhang Y. Recent advances in the role of polysaccharides in liver diseases: a review. Front Pharmacol. 2025;16:1535717. https://doi.org/10.3389/fphar.2025.1535717
  4. 4. Baudin B. Biochemical exploration of the liver in 2017. Rev Francoph Lab. 2017;2017(490):25–33. https://doi.org/10.1016/S1773-035X(17)30076-X
  5. 5. Blok BK. Liver and biliary tract disease. In: Emergency medicine secrets e-book. 20th ed. 2021. p. 215.
  6. 6. Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in central India: a review. Ann Hepatol. 2019;18(5):658–72. https://doi.org/10.1016/j.aohep.2019.05.003
  7. 7. Kumar V, Abbas AK, Aster JC. Robbins and Cotran pathologic basis of disease. 10th ed. Philadelphia: Elsevier Health Sciences; 2020.
  8. 8. Aniba R, Dihmane A, Raqraq H, Ressmi A, Nayme K, Timinouni M, et al. Ethnobotanical insights into the traditional use of six medicinal plants in Morocco: therapeutic applications, indigenous knowledge and scientific valorization. Ethnobot Res Appl. 2025;32:1–23. http://doi.org/10.32859/era.32.34.1-23
  9. 9. Hoummani H, Chebaibi M, Awgni D, Achour S. Perception of the use of herbal medicine by the population of the region of Fès-Boulemane. Cah Santé Méd Thérapeutique. 2023;32(1–2):36–42. https://doi.org/10.1684/sanmt.2023.148
  10. 10. Bhattacharyya R, Medhi KK, Borthakur SK, Borkataki S. An ethnobotanical study of medicinal plants used against jaundice by tea tribes of Morigaon district, Assam (India). J Nat Remedies. 2020;20(1):16–28. https://doi.org/10.18311/jnr/2020/23879
  11. 11. Zolfigol A, Eftekhari Z. Phytotherapy in jaundice: Cotoneaster horizontalis medicinal plant for jaundice in traditional medicine. Plant Biotechnol Persa. 2024;7(2). https://doi.org/10.61186/pbp.7.2.2
  12. 12. Jenča A, Mills D, Ghasemi H, Saberian E, Jenča A, Karimi Forood AM, et al. Herbal therapies for cancer treatment: a review of phytotherapeutic efficacy. Biol Targets Ther. 2024;18:229–55. https://doi.org/10.2147/BTT.S484068
  13. 13. Gulias J, Traveset A, Riera N, Mus M. Critical stages in the recruitment process of Rhamnus alaternus L. Ann Bot. 2004;93(6):723–31. https://doi.org/10.1093/aob/mch100
  14. 14. Aït Youssef M. Medicinal plants of Kabylia. Paris: Ibis Press; 2006. p. 278–79
  15. 15. Bhouri W, Boubaker J, Kilani S, Ghedira K, Chekir-Ghedira L. Flavonoids from Rhamnus alaternus L. (Rhamnaceae): kaempferol 3-O-β-isorhamninoside and rhamnocitrin 3-O-β-isorhamninoside protect against DNA damage in human lymphoblastoid cell and enhance antioxidant activity. South Afr J Bot. 2012;80:57–62. https://doi.org/10.1016/j.sajb.2012.02.005
  16. 16. Ben Ammar R, Kilani S, Bouhlel I, Skandrani I, Naffeti A, Boubaker J, et al. Antibacterial and cytotoxic activities of extracts from (Tunisian) Rhamnus alaternus (Rhamnaceae). Ann Microbiol. 2007;57(3):453. https://doi.org/10.1007/BF03175089
  17. 17. Ben Ammar R, Kilani S, Bouhlel I, Ezzi L, Skandrani I, Boubaker J, et al. Antiproliferative, antioxidant and antimutagenic activities of flavonoid-enriched extracts from (Tunisian) Rhamnus alaternus L.: combination with the phytochemical composition. Drug Chem Toxicol. 2008;31(1):61–80. https://doi.org/10.1080/01480540701688725
  18. 18. Lachkar N, Lamchouri F, Toufik H. Socio-economic position of Chamaerops humilis L. var. argentea Andre in the province of Taza (North East Morocco) and impact of the new Moroccan law n° 77-15 on environmental preservation. Ethnobot Res Appl. 2020;20. https://doi.org/10.32859/era.20.32.1-14
  19. 19. Boulfia M, Lamchouri F, Lachkar N, Khabbach A, Zalaghi A, Toufik H. Socio-economic value and ethnobotanical study of Moroccan wild plant: Leopoldia comosa L. bulbs. Ethnobot Res Appl. 2021;21:1–17.
  20. 20. Lachkar N, Lamchouri F, Toufik H. Ethnopharmacological survey, mineral and chemical content, in vitro antioxidant and antibacterial activities of aqueous and organic extracts of Chamaerops humilis L. var. argentea Andre leaves. Biomed Res Int. 2022;2022:1–27. https://doi.org/10.1155/2022/1091247
  21. 21. Mahtal A, Lamchouri F, Toufik H. Morchella esculenta (L.) Pers. wild of the province of Taza, Morocco: ethnomedicinal and socio-economic survey and perspectives. Trop J Nat Prod Res. 2024;8(11). https://doi.org/10.26538/tjnpr/v8i11.9
  22. 22. Mehdioui R, Kahouadji A. Ethnobotanical study among the population living near the Amsittène forest: the case of the commune of Imi n’Tlit (Essaouira Province). Bull Inst Sci Rabat Sect Sci Vie. 2007;(29):11–20.
  23. 23. Benkhnigue O, Zidane L, Fadli M, Elyacoubi H, Rochdi A, Douira A. Ethnobotanical study of medicinal plants in the region of Mechraâ Bel Ksiri (Gharb Region of Morocco). Acta Bot Barcinonensia.2010;191–216.
  24. 24. Anyinam C. Ecology and ethnomedicine: exploring links between current environmental crisis and indigenous medical practices. Soc Sci Med. 1995;40(3):321–9. https://doi.org/10.1016/0277-9536(94)E0098-D
  25. 25. Khouchlaa A, Tijane M, Chebat A, Hseini S, Kahouadji A. Ethnopharcological survey of plants used in the treatment of urinary lithiasis in Morocco. Phytotherapy. 2017;15(5):274–87. https://doi.org/10.1007/s10298-016-1073-4
  26. 26. Bouallala M, Bradai L, Messouda A. Diversity and use of spontaneous plants of the northern Algerian Sahara in the Saharan pharmacopoeia: the case of the Souf region. Rev ElWahat Pour Rech Etudes. 2014;7(2):18–26.
  27. 27. High Commission for Planning (HCP). Interactive platform of the 2024 general population and housing census (RGPH 2024). Rabat (Morocco): High Commission for Planning; 2024 [cited 2026 Jan 9]. https://www.hcp.ma/Plateforme-interactive-du-RGPH-2024_a4026.html
  28. 28. Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. J Ethnopharmacol. 2002;83(3):251–65. https://doi.org/10.1016/S0378-8741(02)00253-2
  29. 29. Nekkaa A, Benaissa A, Mutelet F, Canabady-Rochelle L. Rhamnus alaternus plant: extraction of bioactive fractions and evaluation of their pharmacological and phytochemical properties. Antioxidants. 2021;10(2):300. https://doi.org/10.3390/antiox10020300
  30. 30. Harrison V. The newborn baby. 5th ed. Cape Town: Juta Academic; 2008. p. 332
  31. 31. Stables D, Rankin J. Physiology in childbearing: with anatomy and related biosciences. 3rd ed. Edinburgh: Baillière Tindall; 2010. 792 p.
  32. 32. Willis L. Professional guide to pathophysiology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2019. p. 684
  33. 33. Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. The role of medicinal plants in therapy. Bull Organ Mond Santé. 1986;64(2):159–75.
  34. 34. Aichour S, Mouffouk C, Benkhaled M, Haba H. Phytochemical composition, antioxidant, cytotoxic, haemolytic and antibacterial activities of aerial parts of Rhamnus alaternus. Herba Pol. 2023;69(3):15–28. https://doi.org/10.5604/01.3001.0053.8860
  35. 35. Bouhlel Chatti I, Krichen Y, Horchani M, Maatouk M, Trabelsi A, Lassoued MA, et al. Anthraquinones from Rhamnus alaternus L.: a phytocosmetic ingredient with photoprotective and antimelanogenesis properties. Chem Biodivers. 2024;21(1):e202300876. https://doi.org/10.1002/cbdv.202300876
  36. 36. Benchiha W, Mahroug S, Aoued L, Bouterfas K. Antihepatotoxic activity of extracts from the leaves of Rhamnus alaternus L. (Rhamnaceae). Phytotherapy. 2017;15(1):10–5. https://doi.org/10.1007/s10298-015-1012-5
  37. 37. Sourabie TS, Ouedraogo N, Sawadogo R, Yougbare N, Nikiema J, Guissou I, et al. Evaluation of the anti-icterus effect of crude powdered leaf of Argemone mexicana Linn. (Papaveraceae) against CCl₄-induced liver injury in rats. Int J Pharma Sci Res. 2012;3(10):491–6.
  38. 38. Maity S, Nag N, Chatterjee S, Adhikari S, Mazumder S. Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice. J Physiol Biochem. 2013;69(3):467–76. https://doi.org/10.1007/s13105-013-0234-y
  39. 39. Kannan N, Sakthivel KM, Guruvayoorappan C. Protective effect of Acacia nilotica (L.) against acetaminophen-induced hepatocellular damage in Wistar rats. Adv Pharmacol Sci. 2013;2013:1–9. https://doi.org/10.1155/2013/987692
  40. 40. Camara MK, Camara AK, Dore A, Bangoura MD, Diane S, Loua J, et al. Ethnobotanical study of plants used in the traditional treatment of hemorrhoids in the Kpèlè (Lola) region of Guinea. Pharmacopoeia Traditional African Medicine. 2024;23(1):146–59.
  41. 41. Nkounkou GSM, Ntandou GFN, Peneme BML, Massengo AB, Ouamba JM, Abena AA. Ethnobotanical survey and effects of the aqueous extract of the rhizomes of Anchomanes difformis Blume (Araceae) on guinea pig uterine motility. Pharmacopoeia Med Tradit Afr. 2017;18(2):13–20.
  42. 42. Hami H, Soulaymani A, Skalli S, Mokhtari A, Sefiani H, Soulaymani R. Atractylis gummifera L. poisoning: data from the Moroccan Poison Control and Pharmacovigilance Center. Bull Soc Pathol Exot. 2011;104(1):53–7. https://doi.org/10.1007/s13149-010-0102-8
  43. 43. Belarbi N, Rhalem N, Soulaymani A, Hami H, Mokhtari A, Soulaymani Bencheikh RB. Intoxication par Atractylis gummifera L. au Maroc (1992–2008). Antropo. 2013;30:97–104.
  44. 44. Bandadi FZ, Lachhab Z, Moukafih B, El Marrakchi S, Achour S, El Kartouti A. Phytotherapy in intestinal transit problems in adults: what are the most common plants used in medicine? Health Care Medical Therapeutics. 2024;33(1):10–8. https://doi.org/10.1684/sanmt.2024.242
  45. 45. Birane D, Samba MM, Rahimi M, Macoumba D, Jules D, Ndongo D, et al. Characterization of the ornamental flora of the Dakar region (Senegal). J Appl Biosci. 2019;138:14029–41. https://dx.doi.org/10.4314/jab.v138i1.3
  46. 46. Bentabet N, Rajaa R, Sakina N. Ethnobotanical survey and inventory of medicinal plants used in the treatment of dermatological diseases in the city of Ain Temouchent. J Appl Biosci. 2022;170(1):17704–19.
  47. 47. Kapemba AM, Mukenge JCN, Bafue MK, Aseke AE. Determinants of non-timber forest product consumption in the city of Kananga: the case of Gnetum africanum. Int J Account Finance Audit Manag Econ. 2023;4(2-2):237–58. https://doi.org/10.5281/ZENODO.7811198
  48. 48. Ngbolua JPKTN, Djolu R, Masengo C, Iteku J, Mpiana P, Mudogo JC. Ethno-medical and socio-economic values of Irvingia tenuinucleata in Gbado-Lite, Democratic Republic of Congo. Rev Marocaine Sci Agron Vét. 2023;11(1):40–8.
  49. 49. Delville J, Dijon X, Mercier M, Tonglet R, Van der Linden B. Knowledge of the poor. Louvain-la-Neuve: Ed. Working with the social; 1996.

Downloads

Download data is not yet available.