Hepatoprotective potency of Lagenandra toxicaria and Ariopsis peltata against CCl4 induced liver fibrosis in Wistar rats

Authors

  • B Akarsha Department of Applied Botany, Mangalore University, Mangalore, Konaje – 574 199, India
  • G Krishnakumar Department of Applied Botany, Mangalore University, Mangalore, Konaje – 574 199, India
  • Prasanna Shama Khandige Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences Nitte (Deemed to be University) Mangalore. Deralakatte – 575 018, India

DOI:

https://doi.org/10.14719/pst.1691

Keywords:

Lagenandra toxicaria, Ariopsis peltata, GC-MS, Liver fibrosis, anti-inflammatory

Abstract

Lagenandra toxicaria (LT) and Ariopsis peltata (AP) belongs to the family Araceae. LT is being traditionally used to cure bilious symptoms and wound healing. AP leaves are edible and the rhizome has medicinal value. With such a wide range of medicinal applications, it's essential to scientifically authenticate traditional usage and find the plant's bioactive components. Here, we have examined the anti-inflammatory and hepatoprotective potency of these plant extracts. The in-vivo liver fibrosis was induced in Wistar male rats using CCl4 and was treated with various concentrations of the methanol and water extracts of the plant rhizomes. In the in-vitro anti-inflammatory assay, LT methanol extract showed 42 % protection at 600 mg/ml which is higher than the other extracts. Among the AP and LT extracts, the 600 mg/kg methanol extract of LT treated rats showed a decreased (p<0.05) serum alanine/aspartate aminotransferase and total bilirubin levels. The plant extract brought about an amelioration of CCl4 induced pathological effects and a significant reduction in the severity of inflammation, fatty metamorphosis, necrosis and liver fibrosis. Overall, the results suggest that LT rhizome could be effective in the treatment of liver fibrosis. It is possible that this is related to the presence of anti-inflammatory and antioxidant chemicals such as 9-octadecenamide, flavonoids and phenols in the extract.

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Published

09-09-2022 — Updated on 01-10-2022

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1.
Akarsha B, Krishnakumar G, Khandige PS. Hepatoprotective potency of Lagenandra toxicaria and Ariopsis peltata against CCl4 induced liver fibrosis in Wistar rats. Plant Sci. Today [Internet]. 2022 Oct. 1 [cited 2024 Nov. 21];9(4):855-66. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/1691

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Research Articles