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Extraction of Synephrine from Waste Peels of Citrus sinensis and Green Synthesis of Gold Nanoparticles from it against Dermatophytes

Authors

Ayat Subhi Jadou Department of Biology, Collage of Science, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0002-9901-8755
Rusol AL-Bahrani Department of Biology, Collage of Science, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0009-3314-4928

DOI:

https://doi.org/10.14719/pst.3248

Keywords:

AuNps, Citrus sinensis, Dermatophyte, Synephrine

Abstract

The main object of the current work was to determine the antifungal efficiency of secondary metabolites product called synephrine that extracted from Citrus sinesis peels and the ability of synephrine to biosynthesis gold nanoparticles from HAucl4 which consider environmentally favourable method, then determine their activity against pathogenic human dermatophyte. The identification of synephrine done by Thin layer chromatography (TLC), High Performance Liquid Chromatography (HPLC) and The Fourier Transform Infrared (FTIR). The characterization of gold nanoparticles by using Ultra Violet-Visible Spectroscopy (UV-Vis), Field – Emission Scanning Electron Microscopy (FESEM) and Fourier Transform Infrared (FTIR), confirmed the biosynthesis of gold nanoparticles in diameter and morphology for AuNps biosynthesis by C. sinensis was 9.7-31 (nm) rounded to oval shape. The synephrine and AuNps that formed use it against some dermatophytes Trichophyton mentographytes, Trichophyton rubrum and Microsporum canis, the activity of synephrine against T. mentographytes at (10, 15 and 20 mg/mL) give less inhibition effect as compare with antifungal effect, while M. canis in 15 mg/mL show best effect than antifungal and for gold nanoparticles most concentration effective was (20 mg/mL).

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References

Segal E, Elad D. Human and zoonotic dermatophytoses: Epidemiological aspects. Frontiers in Microbiology. 2021;12. https://doi.org/10.3389/fmicb.2021.713532

Hossain CM, Ryan LK, Gera M, Choudhuri S, Lyle N, Ali KA et al. Antifungals and drug resistance. Encyclopedia. 2022;2(4):1722-37. https://doi.org/10.3390/encyclopedia2040118

Chanyachailert P, Leeyaphan C, Bunyaratavej S. Cutaneous fungal infections caused by dermatophytes and non-dermatophytes: An updated comprehensive review of epidemiology, clinical presentations and diagnostic testing. Journal of Fungi. 2023;9(6):669. https://doi.org/10.3390/jof9060669

Stohs SJ, Shara M, Ray SD. p-synephrine, ephedrine, p-octopamine and m-synephrine: Comparative mechanistic, physiological and pharmacological properties. Phytotherapy Research. 2020;34(8):1838-46. https://doi.org/10.1002/ptr.6649

Zhang Y, You Z, Liu L, Duan S, Xiao A. Electrochemical determination of synephrine by using nafion/UiO-66/graphene-modified screen-printed carbon electrode. Current Research in Food Science. 2022;5:1158-66. https://doi.org/10.1016/j.crfs.2022.07.008

Ruiz-Moreno C, Del Coso J, Giráldez-Costas V, González-García J, Gutiérrez-Hellín J. Effects of p-synephrine during exercise: A brief narrative review. Nutrients. 2021;13(1):233. https://doi.org/10.3390/nu13010233

Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry. 2019;12(7):908-31. https://doi.org/10.1016/j.arabjc.2017.05.011

Svendsen C, Walker LA, Matzke M, Lahive E, Harrison S, Crossley A et al. Key principles and operational practices for improved nanotechnology environmental exposure assessment. Nature Nanotechnology. 2020;15(9):731-42. https://doi.org/10.1038/s41565-020-0742-1

Rabha B, Bharadwaj KK, Boro N, Ghosh A, Gogoi SK, Varma RS et al. Cheilocostus speciosus extract-assisted naringenin-encapsulated poly-?-caprolactone nanoparticles: Evaluation of anti-proliferative activities. Green Chemistry. 2021;23(19):7701-11. https://doi.org/10.1039/D1GC02260A

Andleeb A, Andleeb A, Asghar S, Zaman G, Tariq M, Mehmood A et al. A systematic review of biosynthesized metallic nanoparticles as a promising anti-cancer-strategy. Cancers. 2021;13(11):2818. https://doi.org/10.3390/cancers13112818

Jasim AR, Hussein A, Nasser A. Phytochemical investigation of synephrine in the fruit peels of Iraqi sour orange. World J Pharm Pharm Sci. 2016;5:246.

Muneeswari VS, Karthick S, Akanksha D, Sushma G, Hasheem SA, Vasimunni S et al. Extraction and identification of phytochemical active constituents in leaves of Catharanthus roseous, Carica papaya and Piper betel by using TLC method. World Journal of Pharmaceutical Research. 2022;11(10):891-937.

Sun Y, Xia X, Yuan G, Zhang T, Deng B, Feng X et al. Stachydrine, a bioactive equilibrist for synephrine, identified from four citrus chinese herbs. Molecules. 2023;28(9):3813. https://doi.org/10.3390/molecules28093813

Yadav B, Singla A, Srivastava N, Gupta P. Pharmacognostic and phytochemical screening of Datura stramonium by TLC and GC-MS: A forensic approach. Biomedical and Pharmacology Journal. 2021;14(4):2221-26. https://doi.org/10.13005/bpj/2320

Ahmed S, Saifullah, Ahmad M, Swami BL, Ikram S. Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. Journal of Radiation Research and Applied Sciences. 2016;9(1):1-7. https://doi.org/10.1016/j.jrras.2015.06.006

Barnawi N, Allehyani S, Seoudi R. Biosynthesis and characterization of gold nanoparticles and its application in eliminating nickel from water. Journal of Materials Research and Technology. 2022;17:537-45. https://doi.org/10.1016/j.jmrt.2021.12.013

Mayeen A, Shaji LK, Nair AK, Kalarikkal N. Chapter 12 - Morphological characterization of nanomaterials. In: Mohan Bhagyaraj S, Oluwafemi OS, Kalarikkal N, Thomas S editors. Characterization of Nanomaterials: Woodhead Publishing. 2018;p.335-64. https://doi.org/10.1016/B978-0-08-101973-3.00012-2

Rautela A, Rani J, Debnath M. Green synthesis of silver nanoparticles from Tectona grandis seeds extract: Characterization and mechanism of antimicrobial action on different microorganisms. Journal of Analytical Science and Technology. 2019;10(1):5. https://doi.org/10.1186/s40543-018-0163-z

Wens A, Geuens J. In vitro and in vivo antifungal activity of plant extracts against common phytopathogenic fungi. Journal of BioScience and Biotechnology. 2022;11(1):15-21.

Jayaseelan C, Rahuman AA, Kirthi AV, Marimuthu S, Santhoshkumar T, Bagavan A et al. Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012;90:78-84. https://doi.org/10.1016/j.saa.2012.01.006

Park J, Lim D-H, Lim H-J, Kwon T, Choi J-s, Jeong S et al. Size dependent macrophage responses and toxicological effects of Ag nanoparticles. Chemical Communications. 2011;47(15):4382-84. https://doi.org/10.1039/c1cc10357a

Eid MM. Characterization of nanoparticles by FTIR and FTIR-microscopy. Handbook of Consumer Nanoproducts. Singapore: Springer Singapore. 2021;p.1-30. https://doi.org/10.1007/978-981-15-6453-6_89-1

McKeny P, Nessel T, Zito P. Antifungal antibiotics. [Updated 2021 Nov 15]. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing. 2022.

Al-Zubaidi AM, Abd MM, Al-Bahrani RM. The antagonistic effect of biosynthesized nanoparticles from aqueous extract of Agaricus bisporus on some pathogenic plant fungi. HIV Nursing. 2022;22(2):113-15.

Jalal H, Buchanich JM, Roberts MS, Balmert LC, Zhang K, Burke DS. Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016. Science. 2018;361(6408):eaau1184. https://doi.org/10.1126/science.aau1184

Jadou A, Al-Shahwany AW. Biogenic synthesis and characterization of silver nanoparticles using some medical plants and evaluation of their antibacterial and toxicity potential. Journal of AOAC International. 2019;101(6):1905-12. https://doi.org/10.5740/jaoacint.17-0500

Bribi N. Pharmacological activity of alkaloids: A review. Asian Journal of Botany. 2018;1(1):1-6.

Joseph J, Keren DS, Raghavi R, Mary SA, Aruni W. Green synthesis of silver nanoparticles using Phyllanthus amarus seeds and their antibacterial activity assessment. Biomedical and Biotechnology Research Journal (BBRJ). 2021;5(1):35-38. https://doi.org/10.4103/bbrj.bbrj_139_20

Yass M, Al-Haddad A, Ali MJM, Jaafar A, Veres M. Effectiveness of green synthesized zinc oxide nanoparticles against extensively drug-resistant Klebsiella pneumoniae. Biomedical and Biotechnology Research Journal (BBRJ). 2023;7(3):497-503.

Kubacka A, Diez MS, Rojo D, Bargiela R, Ciordia S, Zapico I et al. Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium. Scientific Reports. 2014;4(1):4134. https://doi.org/10.1038/srep04134

Widatalla HA, Yassin LF, Alrasheid AA, Ahmed SAR, Widdatallah MO, Eltilib SH et al. Green synthesis of silver nanoparticles using green tea leaf extract, characterization and evaluation of antimicrobial activity. Nanoscale Advances. 2022;4(3):911-15. https://doi.org/10.1039/D1NA00509J

Kadiyala U, Turali-Emre ES, Bahng JH, Kotov NA, VanEpps JS. Unexpected insights into antibacterial activity of zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus (MRSA). Nanoscale. 2018;10(10):4927-39. https://doi.org/10.1039/C7NR08499D

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Published

31-03-2024

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01-04-2024 (2)
31-03-2024 (1)

How to Cite

Jadou AS, AL-Bahrani R. Extraction of Synephrine from Waste Peels of Citrus sinensis and Green Synthesis of Gold Nanoparticles from it against Dermatophytes. Plant Sci. Today [Internet]. 2024 Mar. 31 [cited 2024 Nov. 8];. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3248

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