Moringa oleifera Lam.: A comprehensive review on its potential for diabetes management and beyond

Authors

DOI:

https://doi.org/10.14719/pst.3458

Keywords:

Moringa oleifera, diabetes, insulin, cosmetic

Abstract

Diabetes is a metabolic disease characterized by deregulated insulin levels and hyperglycemia. The global healthcare system widely acknowledges the use of medicinal plants as therapeutic agents. One such traditional plant with antidiabetic properties is Moringaoleifera, which has been used for centuries.M.oleifera,due to its important bioactive compounds such asflavonoid, carotenoidandpolyphenols,is used totreatvariousailments,includingdiabetes, cancer, kidney problemsandbacterial and viral infections. This review summarizes the applications of M.oleiferaanditsmechanismsforpreventingdiabetes. Additionally, it explores the influences of M.oleifera in treating diabetes, with a specific focus on its mechanism and effectiveness in reducing insulin levels and managing the conditions. The objectives of this review aretopresentsthe most recent information and elucidate the mechanism by which M.oleiferapreventsdiabetes. Additionally, it provides a thorough analysis of M.oleifera’sapplicationsasanatural treatment and its industrial uses. The reviewhighlightscurrentknowledge gapsandsuggests areas for further research. In conclusion, this study enhancesourunderstanding of the comprehensive applications of M.oleifera,advancing knowledge and help to preventdiabetes-related complications.

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References

He B sai, Wang X, Zhang Y, Gao C, Wu C kai, Guo S ruiet al. Anti-oxidant, anti-inflammatory and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin. Journal of Functional Foods Journal. 2022;95(June):105168. https://doi.org/10.1016/j.jff.2022.105168

Liu R, Liu J, Huang Q, Liu S, Jiang Y. Moringa oleifera: A systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity. Journal of Pharmacy and Pharmacology. 2022;74(3):296-320. https://doi.org/10.1093/jpp/rgab131

Padayachee B, Baijnath H. An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of Moringa oleifera. South African Journal of Botany. 2020;129:304-16. Available from: https://doi.org/10.1016/j.sajb.2019.08.021

Gharsallah K, Rezig L, Msaada K, Chalh A, Soltani T. Chemical compositionand profile characterization of moringa oleifera seed oil. South African Journal of Botany. 2021;137:475-82. https://doi.org/10.1016/j.sajb.2020.11.014

Ayobami AL, Kade EA, Oladimeji KA, Kehinde S, Gurpreet K. Anti-diabetic potential of aqueous extract of Moringa oleifera , Ocimum gratissimum and Vernonia amygdalina in alloxan-induced diabetic rats. BioRxiv Journal.2020;https://doi.org/10.1101/2020.08.09.242941

Meireles D, Gomes J, Lopes L, Hinzmann M, Machado J. A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: Integrative approach on conventional and traditional Asian medicine. Advances in Traditional Medicine. 2020;20(4):495-515. Available from: https://doi.org/10.1007/s13596-020-00468-0

Su X, Lu G, Ye L, Shi R, Zhu M, Yu X et al. Moringa oleifera Lam.: A comprehensive review on active components, health benefits and application. Royal Society of Chemistry. 2023;13(35):24353-84. DOI: 10.1039/d3ra03584k

Mthiyane FT, Dludla PV, Ziqubu K. A review on the antidiabetic properties of Moringa oleiferaextracts?: Focusing on oxidative stress and inflammation as main therapeutic targets.Frontiers in Pharmacology. 2022July; Volume 13:Article 940572. doi: 10.3389/fphar.2022.940572

Haryanti E, Kedokteran F, Wijaya U, Surabaya K. The use of Moringa oleiferapowder to prevent pancreatic organ cell damage in pregnant mice with Diabetes mellitus.International Journal of Current Science Research and Review. 2022;05(04):952-57. DOI: 10.47191/ijcsrr/V5-i4-11

Luthfiyani D, Pradana C, Rahmi EP, Muti AF. Hypoglycemic effect of Moringa oleiferaaqueous extract in diabetic animal studies?: A mechanisms review.Advances in Health Sciences Research. 2021;33(ICoSIHSN 2020):620-24. https://doi.org/10.2991/ahsr.k.210115.117

Lam M, Aziz I, Saqib QN, Younus M, Ali E, Imran Met al. Physicochemical , antidiarrheal and antidiabetic potential of super food ( Moringa oleifera Lam .). Pakistan Journal of Pharmaceutical Sciences. 2021;(March):723-29. doi.org/10.36721/PJPS.2021.34.2.SUP.723-729.1

Nilamsari RV, Adharini WI, Lestari ND, Tsuboi H, Rifa M. Combination Moringa oleifera extract and ifalmin as potential formulation of preventing inflammation in diabetic mice model.The Journal of Experimental Life Sciences. 2020;10(1). https://doi.org/10.21776/ub.jels.2019.010.01.07

Anthonia A, Chuks N, Amarachi C ndukwe P, Nnah IS. Serum biochemical changes in alloxan-induced diabetic rats and ameliorative effects of Moringa oleifera and Morinda lucidaleaf extracts. Traditional Medicine Journal. 2022April;27:15-23. DOI: 10.22146/mot.69945

Nwanjo HU, Nwosu DC, Obeagu EI. Evaluation of enzyme antioxidants in streptozocin induceddiabetic rats treated with Moringa oleifera leaf powder . European of Biomedical and Pharmaceutical Sciences. 2020November;7(11):285-88.

Waterman C, Graham JL, Arnold CD, Stanhope KL, Tong JH, Jaja-chimedza Aet al. Moringa isothiocyanate-rich seed extract delays the onset of diabetes in UC davis type-2 Diabetes mellitus rats. Scientific Reports. 2020;1-7. Available from: http://dx.doi.org/10.1038/s41598-020-65722-6

Akhtar N, Hayee S, Nawaz F, Idnan M. Awareness regarding dengue prevention and control in periurban union councils of Tehsil Rawalpindi.Pakistan Biomedical Journal.2022;(c):10-3. DOI:https://doi.org/10.54393/pbmj.v5i1.237

Laksmitawati D, Marwati U, Widowati W, Noverina R, Suciati T, Faried A. Combined treatment effect of topical CM-hWJMSCs and oral Moringa oleifera extract on wound healing of diabetic rat. Journal of Medical Sciences. 2023;11:23-30.https://doi.org/10.3889/oamjms.2023.7551

Mansour M, Arisha A, AlGamal M, Elsayed A, Saad S, El Bohi K. Effect of Moringa oleifera leaves extract-senps conjugate administration on testicular toxicity induced by melamine in rats. Zagazig Veterinary Journal. 2020 Jun 1;48(2):213-27.https://doi.org/10.21608/zvjz.2020.20447.1089

Ruth OO. In vitro inhibitory potentials of ethanolic extract of Moringa oleifera flower against enzymes activities linked to diabetes. Journal of Herbmed Pharmacology. 2021;10(4):408-14. doi: 10.34172/jhp.2021.48

Elendu MU, Uko OE, Kalu AA, Barry IC. Ameliorative effect of aqueous leaf extract of Moringa oleifera on diabetes induced appetite and testicular weight loss in wistar rats. GSC Advanced Research and Reviews. 2022;2-5. https://doi.org/10.30574/gscarr.2022.13.1.0249

Sissoko L, Diarra N, Nientao I, Stuart B, Togola A, Willcox MLet al. Moringa oleifera leaf powder for type 2 diabetes?: A pilot clinical trial.Journal Complement Alternal Medical. 2020;17:29-36. https://doi.org/10.21010/ajtcam.v17i2.3

Aljazzaf B, Regeai S, Elghmasi S, Alghazir N, Balgasim A, Ismail IMH et al. Evaluation of antidiabetic effect of combined leaf and seed extracts of Moringa oleifera (Moringaceae) on alloxan-induced diabetes in mice?: A biochemical and histological study.Oxidative Medicine and Cellular Longevity. 2023;2023. https://doi.org/10.1155/2023/9136217

Akter T, Rahman MA, Moni A, Apu MAI, Fariha A, Hannan MAet al. Prospects for protective potential of Moringa oleifera against kidney diseases. Plants. 2021;10(12). doi.org/10.3390/plants10122818

Barhoi D, Upadhaya P, Barbhuiya SN, Giri A, Giri S. Aqueous extract of Moringa oleiferaexhibit potential anticancer activity and can be used as a possible cancer therapeutic agent: A study involving in vitro andin vivoapproach.Journal of the American College of Nutrition. 2021;40(1):70-85. Available from: https://doi.org/10.1080/07315724.2020.1735572

Moremane MM, Abrahams B, Tiloke C. Moringa oleifera: A review on the antiproliferative potential in breast cancer cells. Current Issues in Molecular Biology. 2023;45(8):6880-902. doi.org/10.3390/cimb45080434

Mumtaz MZ, Kausar F, Hassan M, Javaid S, Malik A. Anticancer activities of phenolic compounds from Moringa oleifera leaves: In vitro and in silico mechanistic study. Mumtaz et al. Beni-Suef University Journal of Basic and Applied Sciences. 2021;10(1).https://doi.org/10.1186/s43088-021-00101-2

Sultan R, Ahmed A, Wei L, Saeed H, Islam M, Ishaq M. The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches. BMC Complementary Medicine and Therapies. 2023;23(1):1-17. https://doi.org/10.1186/s12906-023-04198-z

Akintelu SA, Folorunso AS, Oyebamiji AK. Phytochemical and antibacterial investigation of Moringa oleifera seed: Experimental and computational approaches. Eclética Química Journal. 2021;46(2):17-25. DOI: 10.26850/1678-4618eqj.v46.2.2021.p17-25

Santos LMM, Silva PM, Moura MC, Carvalho Junior AR, Amorim PK, Procópio TFet al. Anti-candida activity of the water-soluble lectin from Moringa oleifera seeds (WSMoL). Journal de Mycologie Medicale. 2021;31(2). https://doi.org/doi:10.1016/j.mycmed.2020.101074

Fajri M. The potential of Moringa oleifera as immune booster against COVID 19. Earth and Environmental Science. 2021;807(2):17-21. doi:10.1088/1755-1315/807/2/022008

Athikomkulchai S, Tunit P, Tadtong S, Jantrawut P, Sommano SR, Chittasupho C. Moringa oleifera seed oil formulation physical stability and chemical constituents for enhancing skin hydration and antioxidant activity. Cosmetics. 2021;8(1):1-18. https://doi.org/ 10.3390/cosmetics8010002

Bhalla N, Ingle N, Patri SV, Haranath D. Phytochemical analysis of Moringa Oleifera leaves extracts by GC-MS and free radical scavenging potency for industrial applications. Saudi Journal of Biological Sciences. 2021;28(12):6915-28. https://doi.org/10.1016/j.sjbs.2021.07.075

Xu Y, Chen G, Guo M. Potential anti-aging components from Moringa oleifera leaves explored by affinity ultrafiltration with multiple drug targets. Frontiers in Nutrition. 2022;9(May):1-13. doi: 10.3389/fnut.2022.854882

Llorent-Martínez EJ, Gordo-Moreno AI, Fernández-de Córdova ML, Ruiz-Medina A. Preliminary phytochemical screening and antioxidant activity of commercial Moringa oleiferafood supplements. Antioxidants. 2023;12(1). doi.org/10.3390/antiox12010110

Hodas F, Zorzenon MRT, Milani PG. Moringa oleifera potential as a functional food and a natural food additive: A biochemical approach. Annals of the Brazilian Academy of Sciences. 2021;93:1-18. DOI 10.1590/0001- 3765202120210571.

Valdivié-Navarro M, Martínez-Aguilar Y, Mesa-Fleitas O, Botello-León A, Betancur Hurtado C, Velázquez-Martí B. Review of Moringa oleifera as forage meal (leaves plus stems) intended for the feeding of non-ruminant animals. Animal Feed Science and Technology. 2020February;260:114338. https://doi.org/10.1016/j.anifeedsci.2019.114338

Nudel A, Cohen R, Abbo S, Kerem Z. Developing a nutrient-rich and functional wheat bread by incorporating Moringa oleifera leaf powder and gluten. Food Science and Technology. 2023May;187:115343. Available from: https://doi.org/10.1016/j.lwt.2023.115343

Mashamaite CV, Pieterse PJ, Mothapo PN, Phiri EE. Moringa oleifera in South Africa: A review on its production, growing conditions and consumption as a food source. South African Journal of Science. 2021;117(3-4):1-7. https://doi.org/10.17159/ sajs.2021/8689

Ueda Yamaguchi N, Cusioli LF, Quesada HB, Camargo Ferreira ME, Fagundes-Klen MR, Salcedo Vieira AMet al. A review of Moringa oleifera seeds in water treatment: Trends and future challenges. Process Safety andEnvironmental Protection. 2021April;147:405-20. https://doi.org/10.1016/j.psep.2020.09.044

Hamadeen HM, Elkhatib EA, Badawy MEI, Abdelgaleil SAM. Green low cost nanomaterial produced from Moringa oleifera seed waste for enhanced removal of chlorpyrifos from wastewater: Mechanism and sorption studies. Journal of Environmental Chemical Engineering. 2021;9(4):105376. Available from: https://doi.org/10.1016/j.jece.2021.105376

Alam MW, Pandey P, Khan F, Souayeh B, Farhan M. Study to investigate the potential of combined extract of leaves and seeds of Moringa oleifera in groundwater purification. International Journal of Environmental Research and Public Health. 2020;17(20):1-13. doi:10.3390/ijerph17207468

Islam Z, Islam SMR, Hossen F, Mahtab-Ul-Islam K, Hasan MR, Karim R. Moringa oleifera is a prominent source of nutrients with potential health benefits. International Journal of Food Science. 2021;2021(June 2013). https://doi.org/10.1155/2021/6627265

Ma ZF, Ahmad J, Zhang H, Khan I, Muhammad S. Evaluation of phytochemical and medicinal properties of Moringa (Moringa oleifera) as a potential functional food. South African Journal of Botany journal. 2020;129:40-46. https://doi.org/10.1016/j.sajb.2018.12.002

Fu X, Su J, Hou L, Zhu P, Hou Y, Zhang Ket al. Physicochemical and thermal characteristics of Moringa oleifera seed oil. Advanced Composites and Hybrid Materials. 2021;4(3):685-95. Available from: https://doi.org/10.1007/s42114-021-00302-4

Mohanty M, Mohanty S, Bhuyan SK, Bhuyan R. Phytoperspective of Moringa oleifera for oral health care: An innovative ethnomedicinal approach. Phytotherapy Research. 2021;35(3):1345-57. https://doi.org/10.1002/ptr.6896

García P, Peñalver R, Nieto G. Beneficios para la salud de los usos y aplicaciones de Moringa oleifera en productos de panadería. Plants. 2021;1-17. https://www.mdpi.com/2223-7747/10/2/318/htm#B6-plants-10-00318. https://doi.org/10.3390/plants10020 318

Alia F, Putri M, Anggraeni N, Syamsunarno MRAA. The potency of Moringa oleifera Lam. as protective agent in cardiac damage and vascular dysfunction. Frontiers in Pharmacology. 2022;12(January):1-18. doi: 10.3389/fphar.2021.724439

Granella SJ, Bechlin TR, Christ D, Coelho SRM, Paz CH de O. An approach to recent applications of Moringa oleifera in the agricultural and biofuel industries. South African Journal of Botanyt. 2021;137:110-16. https://doi.org/10.1016/j.sajb.2020.10.006

Gu X, Yang Y, Wang Z. Nutritional, phytochemical, antioxidant, ?-glucosidase and ?-amylase inhibitory properties of Moringa oleifera seeds.South African Journal of Botany. 2020;133(October 2015):151-60. Available from: https://doi.org/10.1016/j.sajb.2020.07.021

Chen GL, Xu YB, Wu JL, Li N, Guo MQ. Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents. Food Chemistry. 26 2020;333. https://doi.org/10.1016/j.foodchem.2020.127478

Anzano A, Ammar M, Papaianni M, Grauso L, Sabbah M, Capparelli Ret al. Moringa oleifera Lam.: A phytochemical and pharmacological overview. Horticulturae. 2021;7(10):1-25. doi.org/10.3390/horticulturae7100409

Giuberti G, Rocchetti G, Montesano D, Lucini L. The potential of Moringa oleifera in food formulation: A promising source of functional compounds with health-promoting properties. Current Opinion in Food Science. 2021;42:257-69. https://doi.org/10.1016/j.cofs.2021.09.001

Mubeen N, Mona Hassan S, Sharif Mughal S, Khurram Hassan S, Ibrahim A, Hassan Het al. Vitality and implication of natural products from Moringa oleifera: An eco-friendly approach. Computational Biology and Bioinformatics. 2020;8(2):72. doi: 10.11648/j.cbb.20200802.16

Ramamurthy S, Thiagarajan K, Varghese S, Rajeshkumar, Karthick BP, Varadarajan Set al. Assessing the in vitroantioxidant and anti-inflammatory activity of Moringa oleiferacrude extract. The Journal of Contemporary Dental Practice. 2022;23(4):437-42. https://doi.org/10.5005/jp-journals-10024-3323

Jadhav V, Bhagare A, Ali IH, Dhayagude A, Lokhande D, Aher Jet al. Role of Moringa oleifera on green synthesis of metal/metal oxide nanomaterials. Journal of Nanomaterials. 2022;2022. https://doi.org/10.1155/2022/2147393

Yang M, Tao L, Kang XR, Li LF, Zhao CC, Wang ZLet al. Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities. Food Chemistry: X. 2022;14(May):100322. https://doi.org/10.1016/j.fochx.2022.100322

Avilés-Gaxiola S, León-Félix J, Jiménez-Nevárez YB, Angulo-Escalante MA, Ramos-Payán R, Colado-Velázquez Jet al. Antioxidant and anti-inflammatory properties of novel peptides from Moringa oleifera Lam. leaves. South African Journal of Botany. 2021;141:466-73. https://doi.org/10.1016/j.sajb.2021.05.033

Nwachukwu CF. Partial elucidation on the remedial effect of stem-bark extract of Moringa oleifera on diabetic rats. GSC Biological and Pharmaceutical Sciences. 2021;15(02):111-16. DOI: https://doi.org/10.30574/gscbps.2021.15.2.0118

Gondo HK. Moringa oleifera decrease blood sugar level and blood pressure in pregnant diabetic rats. Journal of Advanced Pharmacy Education and Research. 2021;11(2):88-91. https://doi.org/10.51847/FDGccLKxoF

Jayamol MANU, Ashley R, Nithya J, Shijina S. Effect of combination of aqueous leaf extracts of Psidium guajavaLinn. and Moringa oleifera Lam. on diabetes mellitus.International Journal of Pharmacy and Pharmaceutical Sciences. 2020;12(7):2-5. DOI: http://dx.doi.org/10.22159/ijpps.2020v12i7.36823

Onyeabo C, Anyiam PN, Egbuonu ACC, Odika C, Egba SI, Nnana OOet al. Natural products-characterized Moringa oleifera leaves methanolic extract and anti-diabetic properties mechanisms of its fractions in streptozotocin-induced diabetic rats. The Nigerian Journal of Pharmacy.2022;18-29. https://doi.org/10.51412/psnnjp.2022.2

Alshalmani SK. Phytochemical screening, antibacterial and anti-diabetic activities of Moringa oleifera cultivated in east region of Libya. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2021;1(4):15-19. https://doi.org/10.5281/zenodo.58059027

Sonia G, Ligia ED, Jurado C, Iturmendi N, Nova E. Moringa oleiferaleaf supplementation as a glycemic control strategy in subjects with prediabetes. Nutrients. 2022;1-15. https://doi.org/10.3390/nu14010057

Ayuwardani N, Hariningsih Y. Effectiveness of combination of Moringaleaf extract (Moringa oleifera Lamk.) and papaya seed extract (Carica papaya L .) in reducing blood sugar levels of diabetic rats. Pharmacy Education. 2021;21:215-19. https://doi.org/10.46542/pe.2021.212.215219

Gopalakrishnan L, Doriya K, Santhosh D. Moringa oleifera?: A review on nutritive importance and its medicinal application. Food Science and Human Wellness. 2016;5(2):49-56. http://dx.doi.org/10.1016/j.fshw.2016.04.001

T Setyawati, R Adawiyah, RM Walanda, Riski, R Chandra. Effectiveness of Moringa oleifera on triglyceride levels in diabetic wistar rats (Rattus norvegicus) induced with streptozotocin (STZ). Earth and Environmental Science. 2022;1075:012020. doi:10.1088/1755-1315/1075/1/012020

Trigo C, Castelló ML, Soriano MDOMD, García-Mares FJ, Soriano MD. Moringa oleifera?: An unknown crop in developed countries change. Foods. 2021;10(1):31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824577/

Li C, Dong Z, Zhang B, Huang Q, Liu G, Fu X. Structural characterization and immune enhancement activity of a novel polysaccharide from Moringa oleifera leaves. Carbohydrate Polymers. 2020;234:115897. https://doi.org/10.1016/j.carbpol.2020.115897

Xiao X, Wang J, Meng C, Liang W, Wang T, Zhou Bet al. Moringa oleifera Lam. and its therapeutic effects in immune disorders. Frontiers in Pharmacology. 2020December;11:1-9. doi: 10.3389/fphar.2020.566783

Kerdsomboon K, Chumsawat W, Auesukaree C. Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals and metalloid in Saccharomyces cerevisiae. Chemosphere. 2021;270(xxxx):128659. https://doi.org/10.1016/j.chemosphere.2020.128659

Omodanisi EI, Aboua GY, Oguntibeju OO. Therapeutic potentials and pharmacological properties of Moringa oleifera Lam. in the treatment of diabetes mellitus and related complications. Tropical Journal of Pharmaceutical Research. 2017July;16:1737-46. http://dx.doi.org/10.4314/tjpr.v16i7.35

Jamil Ahmad, Imran Khan, Renald Blundell. Moringa oleifera and glycemic control?: A review of current evidence and possible mechanisms. Phytotherapy Research. 2019March;1-8. DOI: 10.1002/ptr.6473

Published

11-08-2024 — Updated on 18-08-2024

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Kazimi R, Saxena D. Moringa oleifera Lam.: A comprehensive review on its potential for diabetes management and beyond. Plant Sci. Today [Internet]. 2024 Aug. 18 [cited 2024 Nov. 5];11(3). Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/3458

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