Potential Roles of Phytochemicals in Combating Severe Acute Respiratory Syndrome Coronavirus Infection

Harsh Pant; Vishesh  Kumar; Bhoopander Giri; Qiang-Sheng  Wu; Vijaya  Lobo; Ishwar  Singh; Anuradha  Sharma

doi:10.14719/pst.1525

Authors

Harsh Pant CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, 226016, India https://orcid.org/0000-0001-5909-6455
Vishesh Kumar Department of Botany, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, 250001, India https://orcid.org/0000-0002-0672-1971
Bhoopander Giri Department of Botany, Swami Shraddhanand College, University of Delhi, Delhi, 110036, India https://orcid.org/0000-0002-5510-4021
Qiang-Sheng Wu College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China https://orcid.org/0000-0002-3405-8409
Vijaya Lobo Department of Botany, St. Xavier’s College (Autonomous), Mumbai, Maharashtra, 400001, India https://orcid.org/0000-0002-1083-6050
Ishwar Singh Department of Botany, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, 250001, India https://orcid.org/0000-0001-6251-4419
Anuradha Sharma Department of Botany, Hindu College, University of Delhi, New Delhi, 110007, India https://orcid.org/0000-0002-7517-6700

DOI:

https://doi.org/10.14719/pst.1525

Keywords:

COVID-19, Herbal Drugs, Phytochemicals, Phytomedicine, SARS-CoV-2

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of the current ongoing global pandemic COVID-19 is yet far away from the clutches of contemporary western medicines. With the lack of conventional drugs for this deadly disease the scope for the development of herbal formulations and Ayurvedic medication is finding a sound basis in the current scenario. The past two years has witnessed detailed and focused investigations on the biologically active constituents derived from a range of medicinal plants and their potential antiviral properties against SARS-CoV-2. The promising results of these investigations have intrigued the medical and plant experts in pharmacognosy enough to consider herbal medicines and plant-based products as they are more effective in combating the COVID-19 crisis. However, a large-scale application of the same would require more focused and thorough research on this matter. This review is an attempt to describe the current and future prospects of using medicinal plants and herbal compounds as natural and sustainable alternative for treating COVID-19. The current article evaluates the various strong evidences from biochemical and molecular studies that have been investigated so far in the development of herbal formulations to combat COVID-19 with detailed focus on the most potential phytochemicals of medicinal plants studied in this regard namely Withania somnifera (L.) Dunal, Cinchona officinalis L., Curcuma longa L., Ocimum sanctum L., Azadirachta indica A. Juss., and Tinospora cordifolia (Willd) Miers.

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