Efficient nutrient management is essential to enhance maize productivity while conserving soil fertility. Soil test crop response (STCR)-based targeted yield equations enable soil- and yield-specific fertilizer recommendations; however, their validation across agroclimatic zones and with emerging inputs, such as nano di-ammonium phosphate (nano-DAP), remains limited. This study evaluated the transferability of STCR prescriptions using conventional fertilizers, nano-DAP and farmyard manure (FYM) in farmers' fields in the Southern Transition Zone (STZ) (Shivamogga), Karnataka. A rabi 2024 verification trial was conducted using the maize hybrid MAH 14-5 in a randomized complete block design (RCBD) with seven treatments: STCR targets (90 and 100 q ha-1) ± FYM, general recommended dose (GRD), soil fertility rating (SFR) and control. STCR NPK + FYM (100 q ha-1) recorded the highest kernel yield (97.82 q ha-1) and stover yield (145.75 q ha-1), along with maximum nitrogen (N), phosphorus (P) and potassium (K) uptake (302.72, 23.48 and 155.98 kg ha-1, respectively). Integrated STCR + FYM treatments also achieved a superior response yardstick (24.00 kg kg-1) and improved nutrient-use efficiency indices (AE-N: 40; RE-N: 0.70). All treatments recorded value cost ratio (VCR) > 2, confirming the economic feasibility of the integrated treatment. Nutrient balance analysis indicated positive K balance but consistent P depletion and variable N balances, highlighting the need for organic amendments. Soil test crop response -based nutrient management, particularly when combined with FYM and nano-DAP, improved yield, nutrient uptake and efficiency, demonstrating its applicability across zones and emphasizing the need for long-term P management strategies.