Ethnopharmacology of Hyptis capitata

Authors

DOI:

https://doi.org/10.14719/pst.1602

Keywords:

Hyptis capitata, Ethnobotany, Antioxidant, Antibacterial, Anticancer

Abstract

Hyptis capitata is one of the important traditional medicinal plants, in which different parts of the plant are used in various countries in treating several diseases. This review was conducted to present a comprehensive overview of distribution, taxonomic characters, ethnobotany and the various pharmacological properties of H. capitata This review presents scientific information about pharmacological potentials of H. capitata as a medicinal ingredient and its opportunities to be developed and utilized more broadly. The literature review was carried out on both abstracts and full articles, further analyzed and included in this review. H. capitata is used to treat various diseases such as fever, digestive disorders and open wounds. The pharmacological study of H. capitata showed that this plant has the potential to be developed as an antioxidant, antibacterial, antiviral and anticancer. Due to being widely used by the community, further studies regarding the pharmacological potential and the safety parameters of H. capitata are needed.

Downloads

Download data is not yet available.

References

Harley RM. Revision of generic limits in Hyptis Jacq. (Labiatae) and its allies. Botanical Journal of the Linnean Society. 1988;98(2):87-95. https://doi.org/10.1111/j.1095-8339.1988.tb016972.

de SáS, Fiuza TS, Borges LL, Ferreira HD, Tresvenol LMF, Ferri FH, Rezende MH, Paula JR. Chemical composition and seasonal variability of the essential oils of leaves and morphological analysis of Hyptis carpinifolia. Revista Brasilleira de Farmacognosi. 2016;26:688-93. https://doi.org/10.1016/j.bjp.2016.05.011

McNeil M, Facey P, Porter R. Essential oils from the Hyptis genus- a review (1909-2009). Natural Product Communications. 2011;6(11):1775-96. https://doi.org 10.1177/1934578X1100601149.

Kubitzki K, Kadereit JW. Flowering Plants Dicotyledons. In The Families and Genera of Vascular Plants. Springer: Germany. 2004. https://doi.org/10.1007/978-3-662-07257-8

Harley RM, Pastore JFB. A generic revision and new combinations in the Hyptidinae (Lamiaceae), based on molecular and morphological evidence. Phytotaxa. 2012;58:1-55. https://doi.org/10.11646/phytotaxa.58.1.1

Luzuriaga-Quichimbo CX, Blanco-Salas J, Cerón-Martínez CE, Stankovi? MS, Ruiz-Téllez T. On the possible chemical justification of the ethnobotanical use of Hyptis obtusiflora in Amazonian Ecuador. Plants. 2018;7(4):1-8. https://doi.org/10.3390/plants7040104.

Bhuiyan MNI, Begum J, Nandi NC. Chemical component studies on the leaf and inflorescence essential oil of Hyptis brevipes (Poit.). Journal Medical Plants Researches. 2010;4:2128–31.

Pachkore GL, Dhale DA, Dharasurkar N. Antimicrobial and phytochemical screening of Hyptis suaveolens (L.Poit) Lamiaceae. International Multidisciplinary Research Journal. 2012; 1(4):01-03.

Caldas GFR, Oliveira ARdS, Arau´jo AV, Quixabeira DCA, Silva-Neto JdC et al. Gastroprotective and ulcer healing effects of essential oil of Hyptis martiusii Benth. (Lamiaceae). PLoS ONE. 2014; 9(1): e84400. doi:10.1371/journal.pone.0084400

Arifin Z, Suzery M, Cahyono B. Kandungan minyak atsiri daun Hyptis pectinata Poit dari Jawa Barat. Seminar Nasional II USM. 2017;1:541–46.

Abedini A. Evaluation biologique et phytochimique des substances naturelles d’Hyptis atrorubens Poit. (Lamiaceae), Sélectionnée par un Criblage d’extraits de 42 plantes [Thesis]. Français:Université du Droit et de la Santé - Lille II. 2013.

Coelho-De-souza AN et al. The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice. Brazilian Journal Medical and Biological Research. 2021;54:1–9. http://dx.doi.org/10.1590/1414-431X20209422.

Anonymousa. Hyptis alata. Plant Database [Internet]. [cited 3 March 2022]. Available from: https://www.wildflower.org/plants/result.php?id_plant=hyal.

Picking D, Delgoda R, Boulogne I, Mitchell S. Hyptis verticillata Jacq: a review of its Traditional Uses, phytochemistry, pharmacology and toxicology. Journal of Ethnopharmacology. 2013; 147(1):16-41. https://doi.org/10.1016/j.jep.2013.01.039.

Zellner BD et al. Screening of the odour-activity and bioactivity of the essential oils of leaves and flowers of Hyptis passerina Mart. from the Brazilian Cerrado. Journal of Brazilian Chemical Society. 2009;20:322–32. https://doi.org/10.1590/S0103-50532009000200018

Jiménez-Romero E M et al. Ethnobotanical study and commercialization of Medicinal Plants in the Murocomba Protected Forest and its Influence Area in the valencia canton, Ecuador. Ciencia Tecnologia Agropecuaria. 2019;20:491–506. https://doi.org/10.21930/rcta.vol20num3art:1597.

Ladan Z, Amupitan JO, Okonkwo EM, Aimola IA, Habila N. Antimicrobial potency of Hyptis spicigera leaf extracts against some pathogenic microorganisms. Journal of Medicinal Plant Researches. 2009;3:902–05.

da Silva AC, de Souza PE, Amaral DC, Zeviani WM, Pinto JEBP. Óleos essenciais de Hyptis marrubioides, Aloysia gratissima e Cordia verbenacea reduz o progresso da Ferrugem asiática da soja. Acta Scientiarum Agronomy. 2014;36:159–66. https://doi.org/10.4025/actasciagron.v36i2.17441.

Anonymousb. Hyptis lanceolata Poir. [family Labiatae]. Global Plants [Internet]. [cited 2022 March 2]. Available from: htpps://[lants.jstor.org/stable/10.5555/al.ap.upwta.320.

Kashiwada Y, Wang HK, Nagao T, Kitanaka S, Yasuda I, Fujioka T et al. Anti-AIDS agents, 30. Anti-HIV activity of oleanolic acid, pomolic acid and structurally related triterpenoids. Journal of Natural Products. 1988;61(9):1090–95. https://doi.org/10.1021/np9800710.

Sumitha V, Murugan K, Mini I. Physico-chemical and phytochemical evaluation of a medicinal herb Hyptis capitata Jacq. (Lamiaceae). Trends in Bioscince. 2018; 11(7):1188-93.

Facey PC, Porter RB, Williams LA. The chemical composition and insecticidal activity of the essential oils from Jamaican Hyptis capitata Jacq. In Biologically Active Natural Products for 21st Century. India: Research Signpost; 2006. p.13-19.

Kobayasi K. 1952. Studies on the components of the leaves of Hyptis capitata Jacq. Pharmaceutical Society Japan.1952;72(1):1-3. https://doi.org/10.1248/yakushi1947.72.1_1

To’bungan N, Jati WN, Zahida F. Acute toxicity of knop weed leaves etanolic extract of Hyptis capitata Jacq. using brine shrimp lethality test (BSLT) method. Sciscitatio. 2020;1(2):64–69. https://doi.org/10.21460/sciscitatio.2020.12.30.

Setyawati T, Narulita S, Bahri IP, Raharjo GT. A guide book to invasive alien plant spesies in indonesia. Indonesia: Development and Innovation Agency Ministry of Environment and Forestry Republic of Indonesia. 2014.

Datar MN, Lakshminarasimhan P, Rao PSN. Hyptis capitata Jacq. (Lamiaceae)-a new record for northern Western Ghats. Indian J Forest. 2007;30(3):355–56.

Khairiyah N, Anam S, Khumaidi A. Studi etnofarmasi tumbuhan berkhasiat obat pada suku Banggai di kabupaten Banggai Laut, provinsi Sulawesi Tengah. Galenika Journal of Pharmacy. 2016;2(1):1-7. https://doi.org/10.22487/j24428744.2016.v2.i1.5224

Pasorong YS, Tambaru E, Umar MR, Masniawati A. Identifikasi tumbuhan berkhasiat obat dan potensi pemanfaatannya pada beberapa desa di sekitar gunung Sesean kabupaten Toraja Utara [Thesis]. Makassar: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Hasanuddin. 2015.

Anonymousc. Philippine Medical Plants [Internet]. [cited 2021 September 18]. Available from: http://www.stuartxchange.org/Botonesan.

Wiart C. Antiparasitic asian medicinal plants in the clade Lamiids. In: Medicinal plants in Asia and Pacific for Parasitic infections. USA: Academic press. 2021;p.365-460. https://doi.org/10.1016/B978-0-12-816811-0.00010-X

Arif MM. Essential oil composition of Pogostemon paniculatus and Hyptis [Thesis]. India:University of Calicut. 2007.

Anonymousd. Weed Plants Australia [Internet]. [cited 2021 September 8]. Available from: https://keyserver.lucidcentral.org/ Hyptis capitata.

To’bungan N. Utilization and phytochemical screening of knobweed (Hyptis capitata Jacq.) leaves infusion. Biota?: Jurnal Ilmiah Ilmu-Ilmu Hayati. 2020;5(3):149–54. https://doi.org/10.24002/biota.v5i3.3520

Anonymouse.. Hyptis capitata (PROSEA) [Internet]. 2016 [cited 2021 September 12]. Available from: https://uses.plantnet-project.org/e/index.php?title=Hyptis_capitata_(PROSEA)&oldid=218094.

Biswas A, Bari MA, Roy M, Bhadra SK. Inherited folk pharmaceutical knowledge of tribal people in the Chittagong hill tracts, Bangladesh. Indian Journal of Traditional Knowledge. 2010;9(1):77–89.

Otero R, Fonnegra R, Jiménez SL, Núñez V, Evans N, Alzate SP et al. Snakebites and ethnobotany in the northwest region of Colombia. Part I: Traditional use of plants. Journal of Ethnopharmacology. 2000;71(3):493–504. https://doi.org/10.1016/S0378-8741(00)00243-9

Almtorp GT, Hazell AC, Torssell KBG. A lignan and pyrone and other constituents from Hyptis capitata. Phytochemistry. 1991;30(8):2753–56. https://doi.org/10.1016/0031-9422(91)85137-O.

DeFilipps RA, Maina SL, Crepin J. Medicinal plants of the Guianas (Guyana, Surinam, French Guiana) [Internet]. [cited 2021 September 20]. Available from: https://naturalhistory.si.edu/.

Thoppil JE, Jose J. Chemical composition of essential oil in two ethnomedicinal species of Hyptis. Acta Pharmaceutica. 1955;45(4):551–53.

Rizki R, Nursyahra N, Fernando O. Study of weeds as traditional medicinal plants used by indigenous people of west pasaman, Indonesia. Journal of Tropical Horticulture. 2019;2(2):81–85. https://doi.org/10.33089/jthort.v2i2.21

Mustofa FI, Rahmawati N, Aminullah. Medicinal plants and practices of rongkong traditional healers in South Sulawesi, Indonesia. Biodiversitas. 2020;21(2):642–51. https://doi.org/10.13057/biodiv/d210229

Anggraeni HRE. Jenis-jenis tumbuhan berpotensi obat di desa Bambapuang kabupaten Enrekang [Thesis]. Indonesia: Universitas Hasanuddin. 2017.

Indrayanto G. Produksi metabolit sekunder dengan teknik kultur jaringan. dalam buku risalah seminar nasional metabolit sekunder. 1987. (Ed.) Suwijiyo Pramono, D. Gunawan dan C.J. Soegiarto. Yogyakarta: PAU Bioteknologi UGM. 1987;p.32 – 44.

Rupa D, Sulistyaningsih CY, Dorly,Ratnadewi. Identification of secretory structure, histochemistry and phytochemical compound of medical plant Hyptis capitata Jacq. Biotropia. 2017;24(2):94–103. https://doi.org/10.11598/btb.201

Aththorick TA, Berutu L. Ethnobotanical study and phytochemical screening of medicinal plants on Karonese people from North Sumatra, Indonesia. Journal of Physics: Conference Series. 2018;1116(5):1-11. https://doi.org/10.1088/1742-6596/1116/5/052008

Mitchell SA, Ahmad MH. A review of medicinal plant research at the university of the West Indies, Jamaica, 1948-2001. West Indian Medical Journal. 2006;55(4):243-69. https://doi.org/10.1590/S0043-31442006000400008

Russo M, Coppola V, Giannetti E, Buonavolontà R, Piscitelli A, Staiano A. Oral administration of tannins and flavonoids in children with acute diarrhea: A pilot, randomized, control-case study. Italian Journal of Pediatrics. 2018;44(1):4-9. https://doi.org/10.1186/s13052-018-0497-6

Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. Journal of Nutritional Science. 2016;5(e47):1–15. https://doi.org/10.1017/jns.2016.41

Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira, FS, Fattori V, Casagrande R, Verri WA. Therapeutic potential of flavonoids in pain and inflammation: Mechanisms of action, pre-clinical and clinical data and pharmaceutical development. Molecules. 2020;25(3):1-35. https://doi.org/10.3390/molecules25030762

Jun M, Fu HY, Hong J, Wan X, Yang CS, Ho CT. Comparison of antioxidant activities of isoflavones from kudzu root (Pueraria lobata Ohwi). Journal of Food Science. 2003;68(6):2117–22. http://doi.org/ 10.1111/j.1365-2621.2003.tb07029.x

Wilson DW, Nash P, Singh H, Griffiths K, Singh R, De Meester F et al. The role of food antioxidants, benefits of functional foods and influence of feeding habits on the health of the older person: An overview. Antioxidants. 2017;6(4):1–20. https://doi.org/10.3390/antiox6040081.

Foti MC. Antioxidant properties of phenols. Journal of Pharmacy and Pharmacology. 2007;59(12): 1673-85. https://doi.org/10.1211/jpp.59.12.0010

Zuliani NE, Erwin, Kusuma IW. Test of antioxidant activity (DPPH Method) of methanol extract and its fractions from leaves of Knobweed (Hyptis capitata Jacq.). Jurnal Atomik. 2019;4(1):36-40.

Kusuma IW, Rahmini, Arung ET, Pramono AY, Erwin, Supomo. Biological activities and phytochemicals of Hyptis capitata grown in east kalimantan, Indonesia. Journal of Applied Biology and Biotechnology. 2020;8(2);58–64. https://doi.org/10.7324/JABB.2020.80210

Xu DH, Huang YS, Jiang DQ, Yuan K. The essential oils chemical compositions and antimicrobial, antioxidant activities and toxicity of three Hyptis species. Pharmaceutical Biology. 2013;51(9):1125-30. https://doi.org/10.3109/13880209.2013.781195

Agarwal K,Varma R. Antioxidant activity and Phytochemical analysis of Hyptis suaveolens (L.) Poit. Journal of Advanced Pharmacy Education and Research. 2013;3(4);541–49.

Haryanti S, Widiastuti Y. Aktivitas Sitotoksik pada Sel MCF-7 dari Tumbuhan Indonesia untuk Pengobatan Tradisional Kanker Payudara. Media Litbangkes. 2017;27(4):247–54. https://doi.org/10.22435/mpk.v27i4.5010.247-254

Yamagishi T, Zhang DC, Chang JJ, McPhail DR, McPhail AT, Lee KH. The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B. Phytochemistry. 1988;27(10):3213–16. https://doi.org/10.1016/0031-9422(88)80028-1

Poonkodi K, Karthika J, Tamilselvi V, Anitha R, Vasanthamani S. Chemical composition of essential oils of Hyptis suaveolens (L.) Poit and its In vitro anticancer activity. Journal of Pharmacy Research. 2017;1(5):410-13.

Meyer BN, Ferrigni NR, Putnam JE. Brine shrimp: A convenient general bioassay for active plant constituents. Planta Medica. 1982;45(1):31–34. https://doi.org/10.1055/s-2007-971236

Harmita, Radji M. Buku Ajar Analisis Hayati. Jakarta: Erlangga. 2008; p.76-77.

Ogbole OO, Segun PA, Adeniji AJ. In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts. BMC Complementary and Alternative Medicine. 2017;17(1):1–10. https://doi.org/10.1186/s12906-017-2005-8.

Yahya SAS, Harso W, Jannah M. Profil toksikologis ekstrak daun tumbuhan Baka-Baka (Hyptis capitata Jacq.) pada hati tikus putih (Rattus norvegicus). Biocelebes. 2020;14(1):10–21. https://doi.org/10.22487/bioceb.v14i1.15082.

To’bungan N, Jati WN, Zahida F. Acute toxicity of ethanolic extract of Hyptis capitata Jacq. stem using brine shrimp lethality test (BSLT) method. Biota?: Jurnal Ilmiah Ilmu-Ilmu Hayati. 2021;6(1),52. https://doi.org/10.24002/biota.v6i1.3577

Sumitha V, Mini I, Nair LS. Larvicidal efficacy of Hyptis capitata Jacq. against Culex quinquefasciatus mosquito (Culicidae). International Journal of Mosquito Research. 2021;8(4):42–46.

Li R, Tang G, Liu X, Li J, Wang D, Ji S. An ethnopharmacological review of Hyptis suaveolens (L.) Poit. Tropical Journal of Pharmaceutical Research. 2020;19(7):1541–50. https://doi.org/10.4314/tjpr.v19i7.29.

Published

02-05-2022 — Updated on 01-07-2022

Versions

How to Cite

1.
To’bungan N, Widyarini S, Nugroho LH, Pratiwi R. Ethnopharmacology of Hyptis capitata. Plant Sci. Today [Internet]. 2022 Jul. 1 [cited 2024 Nov. 21];9(3):593-600. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/1602

Issue

Section

Review Articles