Effects of Matricaria aurea extract in excisional wound healing on albino rats
DOI:
https://doi.org/10.14719/pst.4633Keywords:
Matricaria aurea, medicinal plants, fusidic acid cream, wound healingAbstract
The Asteraceae herbal plant Matricaria aurea (Loefl.) Sch.Bip is well known for its use in treating gastrointestinal, cardiac, pulmonary, rheumatologic and many other ailments; nevertheless, wound care has not yet received scientific validation. This study was done to evaluate the efficacy of M. aurea topical formulation on the rate of wound healing and contraction and the histopathological properties of the healing tissue in a rat model of an excisional wound. A total of 45 male rats with excisional wounds were enrolled in the study. The rats were divided into three groups, each with 15 male rats weighing approximately 200–250 g. The first group received treatment with M. aurea, the second group received fusidic acid cream and the third group received normal saline. The treatment was administered for 15 days while photographs were taken every other day, the diameters were measured and a histopathologic examination was conducted. There was a significant accelerated effect for wound healing, as evidenced by the inflammatory cells and diameters reducing to almost the same degree in the M. aurea and fusidic acid groups as compared to the control group (p<0.05). In vivo, the healing of wounds in albino Wister rats is demonstrated by the ethanolic extract of M. aurea. The findings, which show enhanced contraction, epithelization and tensile strength, significantly imply that wound healing promotion and acceleration can be achieved based on faster healing as compared to negative control and similar to standard control (fusidic acid) wounds.
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Rybinski B, Franco-Barraza J, Cukierman E. The wound healing, chronic fibrosis and cancer progression triad. Physiol Genomics 2014; 46: 223- 44. https://doi.org/10.1152/physiolgenomics.00158.2013.
Dilshad S, Jalill A, Fadhil A. The Wound healing potential of Iraqi Origanum Majorana L n-Hexane and Ethyl Acetate fractions in a rat model of excisional wound repair: Pre-clinical test. Journal of Research in Medical and Dental Science 2023; 11: 237- 42.
Mohsin Jebur MA, Hashim NG, Hamoudi Al-Obeidi SR. Mast cell, IL-1 Beta and IL-6 Toxicology 2020; (University of Baghdad).
Pormohammad A, Monych N, Ghosh S, Turner D, Turner R. Nanomaterials in wound healing and infection control. Antibiotics 2021; 10: 473. https://doi.org/10.3390/antibiotics10050473
Gushiken LFS, Beserra FP, Bastos JK, Jackson CJ and Pellizzon CH. Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. Life (Basel) 2021; 11 20210707. DOI: 10.3390/life11070665.
Ahmad I, Wahab S, Nisar N, Dera AA, Alshahrani MY, et al. Evaluation of antibacterial properties of Matricaria aurea on clinical isolates of periodontitis patients with special reference to red-complex bacteria. Saudi Pharm J 2020; 28: 1203-1209. 20200817. DOI: 10.1016/j.jsps.2020.08.010
Qnais EY. The analgesic effect of the ethanolic extract of Matricaria aurea. Turkish Journal of Biology 2011; 35: 347-52. https://doi.org/10.3906/biy-0909-22
Alhusaynei AJ, Nayyef HD. Platelet parameters in nonthrombocytopenic preeclampsia: A Case-control study. Journal of the Faculty of Medicine Baghdad 2023; 65. https://doi.org/10.32007/jfacmedbagdad.2084
Ayla ?, Günal MY, Say?n ?akul AA, Biçero?lu Ö, Özdemir EM, et al. Effects of Prunus spinosa L. fruits on experimental wound healing. Medeniyet Med J 2017; 32: 152-58. https://doi.org/10.5222/MMJ.2017.152
Walia H, Kumar S and Arora S. Comparative antioxidant analysis of hexane extracts of Terminalia chebula Retz. Prepared by maceration and sequential extraction method. Journal of Medicinal Plants Research 2011; 5.
Shareef B, Qadhi H, Ahmed S. Antioxidant effects of selenium nanoparticles prepared from eruca sativa extract on Ketoconazole -Induced testicular oxidative damage in male rats. Journal of the Faculty of Medicine Baghdad 2024; 66: 58-66. https://doi.org/10.32007/jfacmedbagdad.6612174
Sharma G, Gadhiya J, Dhanawat M. Textbook of cosmetic formulations. Department of Pharmacy, Mewar University, Rajasthan-312 2018; 901.
Okur ME, Ayla ?, Çiçek Polat D, Günal MY, Yolta? A, et al. Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits. J Pharm Pharmacol 2018; 70: 1401-413. 20180709. https://doi.org/10.1111/jphp.12977
Najim SM, Fadhil AA, Abdullah MN, Hammodi LE. Estimation of the healing effects of the topical use of MEBO and hyaluronic acid gel in the burned rats. Journal of Advanced Pharmacy Education and Research 2022; 12: 91-97. https://doi.org/10.51847/JO4odidwgl
Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 2007; 39: 175-91. 2007/08/19. https://doi.org/10.3758/BF03193146
Charan J, Kantharia ND. How to calculate sample size in animal studies? Journal of pharmacology & pharmacotherapeutics 2013; 4: 303-06. 2013/11/20. https://doi.org/10.4103/0976-500X.119726
Niknam S, Tofighi Z, Faramarzi MA, Abdollahifar MA, Sajadi E, et al. Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L. Daru 2021; 29: 133-45. 20210509. https://doi.org/10.1007/s40199-021-00392-x
Yousefbeyk F, Hemmati G, Gholipour Z, Ghasemi S, Evazalipour M, et al. Phytochemical analysis, antioxidant, cytotoxic and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip). Z Naturforsch C J Biosci 2022; 77: 331- 42. https://doi.org/10.1515/znc-2021-0269
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