Sugarcane requires adequate water and nutrients for growth and development to produce profitable productivity. Providing optimum water during the growth period increases cane yield through the effective utilization of nutrients. Subsurface drip irrigation is designed to supply the required moisture to the root zone. Sustainable sugarcane initiative under subsurface drip irrigation is gaining importance because of the benefits of water and nutrient use efficiencies. However, varietal or location-specific optimization of moisture and nutrient requirements is warranted to enhance productivity in an ecosystem. Therefore, field experiments in split plot design were conducted at Sugarcane Research Station, Melalathur, Vellore district (Northwestern zone of Tamil Nadu) to optimize suitable irrigation regime and fertilizer levels for the sugarcane variety CoG 7 under the sustainable sugarcane initiative approach. Irrigation regimes in the main plot and nutrient levels in subplots were imposed. The main plot comprised of four irrigation regimes I1: Subsurface drip at 75 % PE - Irrigation once in two days; I2: Subsurface drip at 100 % PE - Irrigation once in two days; I3: Farmers practice – surface irrigation and subplot consist of N1: 100 % of recommended dose of NPK ha-1 through water-soluble, N2: 125 % of recommended dose of NPK ha-1 through water soluble, N3: 100 % of recommended dose of NPK ha-1 through urea, super phosphate and MOP and N4: 125 % of recommended dose of NPKha-1 through urea, super and MOP. These treatments were replicated thrice. The experiments were conducted for 6 years. The combined result revealed that sub-surface drip irrigation at 100 % PE once in two days and application of 125 % of RDF of NPK ha-1 through water soluble fertilizers recorded the highest cane yield.